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Selected AbstractsChallenges of antiangiogenic cancer therapy: trials and errors, and renewed hopeJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Issue 3 2007Miguel Ángel Medina ,,Introduction ,,What can we learn from the previous failures? ,,Signs of hope ,,Another turn of the screw: a surrogate marker, at last ,,Future avenues for the vascular therapy of cancer Abstract Angiogenesis inhibition has been proposed as a general strategy to fight cancer. However, in spite of the promising preclinical results, a first generation of antiangiogenic compounds yielded poor results in clinical trials. Conceptual errors and mistakes in the design of trials and in the definition of clinical end-points could account for these negative results. In this context of discouraging results, a second generation of antiangiogenic therapies is showing positive results in phases II and III trials at the beginning of the twenty-first century. In fact, several combined treatments with conventional chemotherapy and antiangiogenic compounds have been recently approved. The discovery and pharmacological development of future generations of angiogenesis inhibitors will benefit from further advances in the understanding of the mechanisms involved in human angiogenesis. New styles of trials are necessary, to avoid missing potential therapeutic effects. Different clinical end-points, new surrogate biomarkers and methods of imaging will be helpful in this process. Real efficacy in clinical trials may come with the combined use of antiangiogenic agents with conventional chemotherapy or radiotherapy, and combinations of several antiangiogenic compounds with different mechanisms of action. Finally, the existing antiangiogenic strategies should include other approaches such as vascular targeting or angioprevention. [source] Clinical governance in practice: closing the loop with integrated audit systemsJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 2 2006L. TAYLOR ba hons rmn Clinical governance has been acknowledged as the driving force behind National Health Service (NHS) reform since the government white paper outlined a new style of NHS in the UK in 1997. The framework of clinical governance ensures that NHS organizations are accountable for continually improving the quality of their services and safeguarding high standards of care by creating an environment in which excellence in clinical care will develop. A major component of a clinical governance framework requires utilizing audit procedures, which assess the effectiveness of current systems and ultimately direct continual quality improvement. This paper describes the audit component of a local clinical governance framework designed for a unit based within an NHS trust, which has utilized a multidisciplinary approach to assess the effectiveness of a newly commissioned service and its impact on the residents and staff. The unit is a 12-bedded, low-secure-intensive rehabilitation unit for clients with severe and enduring mental illness. Using recognized and standardized psychometric outcome measures, information was collected on clinical symptoms, social functioning, social behaviour, quality of life, relationship quality with named nurses and medication side-effects. Additionally, confidential staff measures were included to assess levels of burnout, identify expressed emotion and assess staff perception of models of illness. The paper includes a comprehensive account of how managerial commitment, teaching processes and application of technology ensured prompt data collection and maintained the momentum through the audit timescale. Data analysis and presentation of data in both clinical reviews and in senior management meetings within the unit are discussed. Findings highlight the full integration of the audit system into the processes of the unit. Clinically, the paper highlights the enhancement of the knowledge base of the client group and the influence on clinical decision-making processes and care delivery as a result of the audit. Brief clinical examples are given. In conclusion, the impact of the audit on unit strategy and organizational efficiency are discussed to highlight the importance of closing the audit loop and completing the cycle of clinical governance. The audit system has positive implications for replication in other services. [source] ROMAN REPLICATIONS OF GREEK ART AT THE VILLA DELLA FARNESINAART HISTORY, Issue 2 2006STÉPHANIE WYLER The decoration of the Villa of the Farnesina, designed in early Augustean Rome, displays a complex system of artistic and religious references to Greek culture. By means of an eclectic collection of artistic replications and emulations spread out through art galleries painted in trompe l'oeil, artists and owner reached a new style based on the appropriation of the conquered world, very carefully organized into a cultural hierarchy. The arts of classical Athens, embodied not only stylistically, but also thematically, are reproduced as framed pictures, whereas those of Hellenistic Egypt are integrated into the imitation of architecture. Dionysiac imagery functions as a paradigm of this system, at least in the preserved part of the villa: instead of losing divine prestige after Augustus's victory at Actium and his assumption of sole power in 31 BCE, Dionysos appears as one of the main keys to the whole decoration , as a sign of Greek cultures, assimilated for their familiar exoticism, into the new imperial language. [source] Globalisation, governance and post-structural political economy: Perspectives from AustralasiaASIA PACIFIC VIEWPOINT, Issue 1 2007Richard Le HeronArticle first published online: 23 MAR 200 Abstract: The paper argues that post-structural political economy (PSPE) offers geography and geographers interesting potential for the development of a style of geographic inquiry that has qualities that may be constitutive of progressive spaces. This new style of inquiry is seen as adding to the repertoire of political strategies and potential geographies of responsibility and extending notions of ethical behaviours. Issues relating to the assemblage of PSPE as a distinctive approach to knowledge production are considered and situated in the Australasian context. Discussion focuses especially on insight about the use of PSPE derived from three illustrative research case studies (a project on learning challenges in sheep meat and dairy supply chain realignment, tensions around fisheries management in New Zealand and an international workshop series on the topic of governmentality). The case studies provide a lens on the socio-spatial relationships between globalisation and governance and interrogate the value of PSPE for understanding the connections between individual choices, governing practices and the construction of the globalising economy. The PSPE approach if actively incorporated into research processes may have important implications for future relationships between social responsibility, national economic development and globalisation. [source] An integrated analysis of prospects for advanced coal-fired power technology in ChinaASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 3 2010Aijun Li Abstract With energy-saving and pollution abatement policy becoming stricter and stronger, advanced coal-fired power technology will undoubtedly play a significant role in China for the new style in industrialization of power industry. In order to forecast coal consumption for power generation from the view of Chinese economic development, firstly this paper simulates total energy consumption and loss during energy transformation in 2030 by computable general equilibrium model. Then power generation by various advanced coal-fired power technologies such as air pollution controlling, green coal-fired power and combined heat and power (CHP) in 2030 is estimated, thus their effects on abatement of air pollution emissions are assessed. Finally, some policy suggestions are given for developing highly efficient and super clean coal-fired power technology in China. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd. [source] Haploid all the way: a new style of asexuality revealed in animalsBIOESSAYS, Issue 2 2002Véronique Perrot Weeks et al(1) recently reported that they had found a species of mites where the parthenogenetic females are haploid. They show that this is caused by intracellular bacteria that turn genetic haploid males into haploid females. I discuss these findings and attempt to place these observations in evolutionary context. BioEssays 24:114,118, 2002. © 2002 Wiley Periodicals, Inc. [source] Anthropology at the Edge of Words: Where Poetry and Ethnography MeetANTHROPOLOGY & HUMANISM, Issue 1 2010Kent Maynard SUMMARY Anthropology has seen major challenges regarding methods, epistemologies, and how one writes ethnographically. As practicing ethnographers and poets, we focus on one among many vibrant new styles of anthropological scholarship: ethnographic poetry. As poetry appears more regularly in scholarly venues, anthropologists may wonder how to create ethnographic poetry and toward what end. To address this, we begin with definitions of ethnographic poetry in relation to ethnography and ethnopoetics. We then consider how poetry may help anthropologists to write insightfully about how we and other people live. Drawing on our own poetry, and that of others, we explore how form affects meaning and ethnographic insight. [source] New Spaces in Accra: transnational housesCITY & SOCIETY, Issue 1 2003Deborah Pellow Accra has been Ghana's primate city since the British moved their administrative headquarters there in 1877. The city took shape under British site planning and like many colonial cities, it developed a spatial layout that distinguished different neighborhoods, such as the old core, the European section, and the Muslim zongo or stranger area. Accra's Sabon Zongo ("new zongo") was founded in the first decade of the 20th century, as a refuge for migrant Hausa who had been living in the original zongo in the city's core. House ownership continues to confer status in the community but there is little room left for building. Hausa transmigrants from Sabon Zongo have been going abroad and remitting money back home, largely to build homes in the new peri-urban margins of Accra. This paper focuses upon the latter phenomenon , the new styles of houses they are building, the process this involves, and how these styles may accommodate worldview, lifestyle and behaviors different from those with which these men were raised in Sabon Zongo. [transmigration, housing, Ghana] [source] | |||||||||||||