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Multicomponent Reactions (multicomponent + reaction)
Selected AbstractsSynthesis of Pyridodiazepinediones by Using the Ugi Multicomponent ReactionEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 28 2010An M. Van den Bogaert Abstract Benzodiazepines show a broad spectrum of biological activities. In an ongoing effort to extend molecular diversity in this type of systems, we developed a strategy for synthesizing3,4-dihydro-1H -pyrido[2,3- e][1,4]diazepine-2,5-dione compounds starting from 2-hydroxynicotinic acid and by using an Ugi reaction as a key step in the synthesis. We opted to use 2-isocyanophenyl benzoate instead of Armstrong's convertible isocyanide in this multicomponent reaction. [source] Convenient Synthesis of Tetrahydro-,-carbolines and Tetrahydroquinolines through a Chemo- and Regioselectivity Switch by a Brønsted Acid Catalyzed, One-Pot, Multicomponent ReactionEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 26 2010Hong-Gang Cheng Abstract An efficient, one-pot, multicomponent reaction of aldehydes 1, p -methoxyaniline (2a), and 2-vinylindoles 3 was developed. This approach provides a practical approach to synthetically and biologically significant tetrahydro-,-carboline and tetrahydroquinoline derivatives in good yields through a chemo- and regioselectivity switch, which can be tuned by simply changing the substituent on the indole component under identical reaction conditions. [source] Facile Preparation of 3-Amino-4-(arylamino)-1H -isochromen-1-ones by a New Multicomponent ReactionEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 5 2005Till Opatz Abstract Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H -isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an ,-aminonitrile and subsequent cyclization through nucleophilic attack of the ortho -carboxylate at the nitrile carbon. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source] Copper-Catalyzed Efficient Multicomponent Reaction: Synthesis of Benzoxazoline-Amidine DerivativesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 16 2009Yongjia Shang Abstract We have developed an efficient copper-catalyzed method for the synthesis of the benzoxazoline-amidine derivatives. The protocol uses inexpensive copper(I) iodide as the catalyst, and furnished the expected product in good to excellent yields by a three-component reaction of sulfonyl azides, terminal alkynes and Schiffs' bases in terahydrofuran (THF) at room temperature for 8,h in the presence of triethylamine. This novel synthetic protocol is selective, efficient and general. A plausible mechanism for this process is proposed. [source] ChemInform Abstract: One-Step Synthesis of Thiazolo[3,2-a]pyridines by a Multicomponent Reaction of ,-Enaminonitriles, ,,,-Unsaturated Aldehydes, and 2-Aminothiol Hydrochlorides.CHEMINFORM, Issue 35 2010Monica Perez-Perrino Abstract Although the synthetic interest for the multicomponent preparation of the title thiazolopyridines is evident, the stereochemical control is rather low. [source] ChemInform Abstract: Copper-Catalyzed Efficient Multicomponent Reaction: Synthesis of Benzoxazoline-Amidine Derivatives.CHEMINFORM, Issue 10 2010Yongjia Shang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Microwave-Assisted Multicomponent Reaction for the Synthesis of New and Significative Bisfunctional Compounds Containing Two Furo[3,4-b]quinoline and Acridinedione Skeletons.CHEMINFORM, Issue 49 2009Xing-Han Wang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo- and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines.CHEMINFORM, Issue 35 2009Feng Sha Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: N,N-Dimethylamino-Functionalized Basic Ionic Liquid Catalyzed One-Pot Multicomponent Reaction for the Synthesis of 4H-Benzo[b]pyran Derivatives under Solvent-Free Condition.CHEMINFORM, Issue 31 2009Lu Chen Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: An Efficient and Green Synthesis of 3,3,-Benzylidenebis(4-hydroxy-6-methylpyridin-2(1H)-one) Derivatives Through Multicomponent Reaction in Ionic Liquid.CHEMINFORM, Issue 5 2009Daqing Shi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Microwave-Assisted Combinatorial Synthesis of Hexa-Substituted 1,4-Dihydropyridines Scaffolds Using One-Pot Two-Step Multicomponent Reaction Followed by a S-Alkylation.CHEMINFORM, Issue 42 2008Ming Li Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyanamide: A Convenient Building Block to Synthesize 4-Aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidine Systems via a Multicomponent Reaction.CHEMINFORM, Issue 40 2008R. Hulme Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of Pyrazolo[3,4-b]pyridine Derivatives Through Multicomponent Reaction in Ionic Liquid.CHEMINFORM, Issue 26 2008Xin Ying Zhang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: One-Pot Synthesis of 4-(Alkylamino)-1- (arylsulfonyl) -3-benzoyl-1,5-dihydro-5-hydroxy-5-phenyl-2H-pyrrol-2-ones via a Multicomponent Reaction.CHEMINFORM, Issue 19 2008Abdolali Alizadeh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: New End-on Thiolactone Scaffold by an Isocyanide-Based Multicomponent Reaction.CHEMINFORM, Issue 18 2008Barbara Beck Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of Nicotinamide and Isonicotinamide Derivatives via Multicomponent Reaction of Alkyl Isocyanides and Acetylenic Compounds in the Presence of Nicotinic or Isonicotinic Acid.CHEMINFORM, Issue 2 2008Abdolali Alizadeh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Design and Synthesis of New and Significative Bifunctional Compounds Containing Two Pyrazolo[3,4-b]pyridine Nucleis Through Multicomponent Reaction under Microwave Irradiation.CHEMINFORM, Issue 47 2007Shujiang Tu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] One-Step Synthesis of Heterocyclic Privileged Medicinal Scaffolds by a Multicomponent Reaction of Malononitrile with Aldehydes and Thiols.CHEMINFORM, Issue 36 2007Nikolai M. Evdokimov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Ugi Multicomponent Reaction Followed by an Intramolecular Nucleophilic Substitution: Convergent Multicomponent Synthesis of 1-Sulfonyl 1,4-Diazepan-5-ones and of Their Benzo-Fused Derivatives.CHEMINFORM, Issue 31 2007Luca Banfi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Adamantane 11-,-HSD-1 Inhibitors: Application of an Isocyanide Multicomponent Reaction.CHEMINFORM, Issue 11 2007J. T. Link Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] A Novel Isocyanide-Based Multicomponent Reaction: An Easy Access to Substituted Propionamides and Succinimides.CHEMINFORM, Issue 27 2006Maxim A. Mironov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Simultaneous Assembly of the ,-Lactam and Thiazole Moiety by a New Multicomponent Reaction.CHEMINFORM, Issue 50 2002Juergen Kolb Abstract For Abstract see ChemInform Abstract in Full Text. [source] Multicomponent Reactions of Furan-2,3-diones: Synthesis and Characterizations of Furo[3,2- c]pyran-4-onesHELVETICA CHIMICA ACTA, Issue 7 2010rfan Koca Abstract Furo[3,2- c]pyran-4-ones, which possess a natural-product skeleton, are synthesized via a simple, one-pot, three-component reaction of furan-2,3-diones with dialkyl acetylenedicarboxylates and Ph3P. [source] Multicomponent Reactions of 1,3-Cyclohexanediones and Formaldehyde in Glycerol: Stabilization of Paraformaldehyde in Glycerol Resulted from using Dimedone as SubstrateADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 2-3 2010Minghao Li Abstract Glycerol has proved to be an effective promoting medium for many multicomponent reactions of 1,3-cyclohexanediones and formaldehyde. Styrenes, amines, 2-naphthol, 4-hydroxy-6-methyl-2-pyrone and 4-hydroxy-1-methyl-2-quinolone could easily react with 1,3-cyclohexanediones and paraformaldehyde in glycerol under catalyst-free conditions to afford a variety of complex skeletons in fair to excellent yields. In these reactions, glycerol not only showed a significant promoting effect on the reaction yields but also endowed the reaction system with many typical properties of green chemistry, such as cheap, renewable, recyclable and biodegradable solvent, good safety and easy separation of product. The promoting effect of glycerol for the three-component reaction of styrene, dimedone and paraformaldehyde could be attributed to a restricted formation of the methylene intermediate in glycerol. During the reaction, a physical shell, which is mainly composed of a by-product generated in the beginning of the reaction, might be formed in the surface of paraformaldehyde and plays a key role in controlling the formation of the intermediate by means of restricting the decomposition of paraformaldehyde. [source] Trapping of Active Methylene Intermediates with Alkenes, Indoles or Thiols: Towards Highly Selective Multicomponent ReactionsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 18 2009Yanlong Gu Abstract In this paper, a basic method to access new multicomponent reactions (MCRs) is reported. The mechanism of these MCRs is based on the trapping of methylene intermediates, formed in situ by reaction of formaldehyde with electron-rich carbons, with alkene, thiol or indole derivatives. According to our strategy, a wide range of valuable skeletons has been obtained in a one-pot reaction, thus allowing a minimization of waste, cost and labor. The presented methodology exhibits a broad substrate scope and electron-rich carbons in the ,-position of a hydroxy or carbonyl group were found to be particularly efficient. More generally, this work offers new tools for creating molecular complexity and diversity from one of the simplest organic building blocks, formaldehyde. [source] Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions,ANGEWANDTE CHEMIE, Issue 31 2010Anass Znabet Ideal kombiniert: Optisch reine 3,4-disubstituierte 1-Pyrroline, die aus entsprechenden meso -Pyrrolidinen durch biokatalytische Desymmetrisierung mit Monoaminoxidase,N (MAO-N) erhalten wurden, reagieren mit Carbonsäuren und Isocyaniden in einer Ugi-Mehrkomponentenreaktion hoch diastereoselektiv zu substituierten Prolylpeptiden mit großer Bedeutung in der Pharmazie. [source] Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of ,-Hydroxyketones with a Quaternary Carbon Stereocenter,ANGEWANDTE CHEMIE, Issue 12 2010Xiao-Yu Guan Dr. Gemeinsam sind sie stark: Ein Aryldiazoacetat, H2O und ein ,,,-ungesättigtes 2-Acylimidazol reagieren mit ausgezeichneter Selektivität zu ,-Hydroxyketonen mit einem quartären Kohlenstoffstereozentrum, wenn alle drei im Schema gezeigten Katalysatorkomponenten vorhanden sind. Der Michael-Additionsschritt lief nicht ab, wenn eine ähnliche Reagensmischung nur mit dem [Rh2(OAc)4]-Katalysator behandelt wurde. OTf=Triflat, Ts=p -Tosyl. [source] Titelbild: Multicomponent Reactions for the Synthesis of Complex Piperidine Scaffolds (Angew. Chem.ANGEWANDTE CHEMIE, Issue 32 200932/2009) Mehrkomponentenreaktionen führen effizient zu mono- und polycyclischen Piperidinen, gängigen Substrukturen biologisch aktiver Naturstoffe. L. Ghosez et,al. zeigen in ihrer Zuschrift auf S.,5994,ff., dass das Substitutionsmuster und die Konfiguration der Piperidinringe maßgeschneidert werden können, was das Erzeugen struktureller, funktioneller und konfigurativer Vielfalt bei der Synthese von Alkaloiden ermöglichen sollte. [source] The Efficient One-Pot Reaction of up to Eight Components by the Union of Multicomponent Reactions,ANGEWANDTE CHEMIE, Issue 32 2009Niels Elders E=MCR2! Orthogonale funktionelle Gruppen mit einzigartiger Kompatibilität mit Lösungsmitteln und anderen funktionellen Gruppen ermöglichen die Kombination mehrerer Mehrkomponenten-Reaktionen in Eintopfprozessen. Die entsprechenden 5- und 6CRs sowie eine neuartige 8CR liefern in einer einzigen Reaktion und in bis zu 80,% Ausbeute sehr komplexe Produkte mit bis zu neun neuen Bindungen und elf Diversitätspunkten (siehe Bild). [source] Multicomponent Reactions for the Synthesis of Complex Piperidine Scaffolds,ANGEWANDTE CHEMIE, Issue 32 2009Wei Zhu Dr. Auf direktem Weg zur Diversität: Mehrkomponentenreaktionen führen effizient zu Piperidinen mit vielfältigen Gerüsten, Funktionalisierungsmustern und stereochemischen Eigenschaften (siehe Schema, X=OR, NR2). Eine Verknüpfung der Säurechlorid-Komponente mit dem Dienophil ergibt über eine intramolekulare Diels-Alder-Reaktion der in situ erzeugten Azadiene polycyclische Piperidine. [source] | ||||||||||||||||||||||