			Home About us Contact

Microwave Ablation (microwave + ablation)

Distribution by Scientific Domains

Medical Sciences	60%

Selected Abstracts

The histological features of microwave coagulation therapy: an assessment of a new applicator design

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 1 2003
Benjamin Swift
Abstract. Microwave ablation of tumours within the liver may become an adjunct or alternative to resection in patients with primary or secondary cancers. This technique combines the benefits of a large, localized coagulative effect with a single insertion of the applicator, in a significantly shorter time than comparable treatments. A new range of microwave applicators were developed and tested in animal models and both ex-vivo and in-vivo specimens of human liver at resection. At laparotomy, the applicator tip was inserted into normal liver parenchyma and tumours, with each specimen subjected to irradiation for 180 s or more and at varying power outputs. On sectioning an area of spherical blanching was observed around the applicator cavity. Microscopically a zone of coagulative necrosis was seen adjacent to the site of probe insertion. Damage to blood vessels and bile ducts occurred distal to the probe cavity suggesting the passage of heated fluid, a finding that was diminished by temporary occlusion of the hepatic vasculature (a Pringle manoeuvre). Ultra-structural damage was confirmed within the burn zone and selected liver enzymes were shown to be functioning beyond this region. We suggest this indicates the surrounding liver parenchyma is functioning normally and therefore the volume of microwave-induced damage is controllable. We are confident that the new applicator design will allow the effective treatment of larger tumours in a safe and controlled manner with a single application of energy. [source]

Microwave ablation after perforation of the uterus: Use of laparoscopic guidance

AUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 2 2009
Jane E. HIRST
No abstract is available for this article. [source]

Loco-regional treatment of hepatocellular carcinoma,

HEPATOLOGY, Issue 2 2010
Riccardo Lencioni
Loco-regional treatments play a key role in the management of hepatocellular carcinoma (HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation has shown superior anticancer effects and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomized controlled trials, and is currently established as the standard method for local tumor treatment. Novel thermal and nonthermal techniques for tumor ablation,including microwave ablation, irreversible electroporation, and light-activated drug therapy,seem to have potential to overcome the limitations of radiofrequency ablation and warrant further clinical investigation. Transcatheter arterial chemoembolization (TACE) is the standard of care for patients with asymptomatic, noninvasive multinodular tumors at the intermediate stage. The recent introduction of embolic microspheres that have the ability to release the drug in a controlled and sustained fashion has been shown to significantly increase safety and efficacy of TACE with respect to conventional, lipiodol-based regimens. The available data for radioembolization with yttrium-90 suggests that this is a potential new option for patients with HCC, which should be investigated in the setting of randomized controlled trials. Despite the advances and refinements in loco-regional approaches, the long-term survival outcomes of patients managed with interventional techniques are not fully satisfactory, mainly because of the high rates of tumor recurrence. The recent addition of molecular targeted drugs with antiangiogenic and antiproliferative properties to the therapeutic armamentarium for HCC has prompted the design of clinical trials aimed at investigating the synergies between loco-regional and systemic treatments. The outcomes of these trials are eagerly awaited, because they have the potential to revolutionize the treatment of HCC. (HEPATOLOGY 2010;) [source]

Experimental studies on microwave ablation in vitro animal tissues with microwave percutaneous coagulator

MICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 9 2008
Wenquan Che
Abstract The principle and geometry of the microwave percutaneous coagulator system are investigated in this article; the main parts of the system are briefly introduced. A large number of experiments on porcine liver are carried out, and the temperature distribution within the liver are measured and illustrated, for cases of different injected microwave power and ablation time. In addition, the ablation areas in cases of different input microwave powers are also measured. All these results indicate the potential validity of this system on medical treatment of liver cancer of human body. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 2426,2430, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23694 [source]

Studies on microwaves in medicine and biology: From snails to humans

BIOELECTROMAGNETICS, Issue 3 2004
James C. Lin
Abstract This d'Arsonval Medal acceptance presentation highlights several research themes selected from Dr. Lin's published works, focusing on the microwave portion of the nonionizing electromagnetic spectrum. The topics discussed include investigation of microwave effects on the spontaneous action potentials and membrane resistance of isolated snail neurons, effects on the permeability of blood brain barriers in rats, the phenomenon and interaction mechanism for the microwave auditory effect (the hearing of microwave pulses by animals and humans), the development of miniature catheter antennas for microwave interstitial hyperthermia treatment of cancer, the application of transcatheter microwave ablation for treatment of cardiac arrhythmias, and the use of noninvasive wireless technology for sensing of human vital signs and blood pressure pulse waves. The paper concludes with some observations on research and other endeavors in the interdisciplinary field of bioelectromagnetics. Bioelectromagnetics 25:146,159, 2004. © 2004 Wiley-Liss, Inc. [source]