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Medicinal Applications (medicinal + application)
Selected AbstractsSynthesis and biological application of glycopolymersJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 22 2007Yoshiko Miura Abstract Saccharides on the cell surfaces participate in a number of biochemical phenomena via the protein,saccharide interaction. Synthetic glycopolymers mimic the function of the cell-surface saccharides and efficiently interact with proteins, cells, and pathogens based on the multivalent effect. Since the biological functions of saccharides are paid much attention, the glycopolymers are being increasingly explored as biomaterials for medicinal application and tissue engineering. This review presents a practical approach of glycopolymers. The glycopolymers were prepared by the facile syntheses of poly(vinyl saccharide)s and the physical and biological properties were introduced. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5031,5036, 2007 [source] Metal Complexes of 4,11-Dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid) , Thermodynamic and Formation/Decomplexation Kinetic StudiesEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 24 2009Ivona Svobodová Abstract The macrocyclic ligand with two methylphosphonic acid pendant arms, 4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid) (1,8-H4Me2te2p, H4L3), was synthesized by a new simple approach. The product of the reaction of quarternized formaldehyde cyclam aminal with the sodium salt of diethyl phosphite was hydrolyzed to give a very high yield of the title ligand. The (H6L3)2+ cation in the solid state is protonated on all ring nitrogen atoms and on each phosphonate group. In the solid-state structure of [Cu(H3L3)][Cu(H2L3)]PF6·3H2O, neutral as well as positively charged complex species are present. Molecular structures of both species are very similar having the copper(II) ion in a coordination environment between square-pyramidal and trigonal-bipyramidal arrangements (, = 0.43 and 0.48) with one pendant arm non-coordinated. The ligand forms stable complexes with transition-metal ions showing a high selectivity for divalent copper atoms. The formation of complexes of the ligand with CuII, ZnII and CdII is fast, confirming the acceleration of complexation due to the presence of the strongly coordinating pendant arms. Acid-assisted decomplexation is fast for all three metal ions. Therefore, the copper(II) complex is not suitable for medicinal applications employing copper radioisotopes, but the title ligand motive can be employed in copper(II) separation. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Recent developments in carbohydrate-decorated targeted drug/gene deliveryMEDICINAL RESEARCH REVIEWS, Issue 2 2010Hailong Zhang Abstract Targeted delivery of a drug or gene to its site of action has clear therapeutic advantages by maximizing its therapeutic efficiency and minimizing its systemic toxicity. Generally, targeted drug or gene delivery is performed by loading a macromolecular carrier with an appropriate drug or gene, and by targeting the drug/gene carrier to specific cell or tissue with the help of specific targeting ligand. The emergence of glycobiology, glycotechnology, and glycomics and their continual adaptation by pharmaceutical scientists have opened exciting avenue of medicinal applications of carbohydrates. Among them, the biocompatibility and specific receptor recognition ability confer the ability of carbohydrates as potential targeting ligands for targeted drug and gene delivery applications. This review summarizes recent progress of carbohydrate-decorated targeted drug/gene delivery applications. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 270,289, 2010 [source] Vinyl sulfones: Synthetic preparations and medicinal chemistry applicationsMEDICINAL RESEARCH REVIEWS, Issue 6 2006D. Christopher Meadows Abstract Vinyl sulfones have long been known for their synthetic utility in organic chemistry, easily participating in 1,4-addition reactions and cycloaddition reactions. This functional group has also recently been shown to potently inhibit a variety of enzymatic processes providing unique properties for drug design and medicinal chemistry. This review includes traditional methods used for the synthesis of vinyl sulfones, but focuses mainly on newer reactions applied to vinyl sulfones, including olefin metathesis, conjugate reduction, asymmetric dihydroxylation (AD), and the use of vinyl sulfones to arrive at highly functionalized targets, all illustrating the rich and versatile chemistry this group can efficiently perform. In addition, geminal disulfones are discussed with respect to their formation, reactions, and medicinal applications of this underutilized functional group. © 2006 Wiley Periodicals, Inc. Med Res Rev [source] Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer AgentsCHEMISTRY - AN ASIAN JOURNAL, Issue 11 2008Abstract The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure,activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed. [source] | ||||||||||