Home About us Contact
|
Home About us Contact | ||
|
|
||
Measurements Used (measurement + used)
Selected AbstractsT2-Weighted and T2 Relaxometry Images in Patients with Medial Temporal Lobe EpilepsyJOURNAL OF NEUROIMAGING, Issue 3 2006Ana Carolina Coan MD ABSTRACT Purpose. Quantification of increased T2-weighted MRI signal that is associated with hippocampal sclerosis (HS) can be performed through (1) mean of hippocampal signal in single-echo T2 MRI and (2) hippocampal T2 relaxometry. It is not clear whether these two techniques are equivalent. In this study, we compare the hippocampal signal, detected by single-echo T2 quantification and by T2 relaxometry, in patients with medial temporal lobe epilepsy (MTLE). Methods. We studied magnetic resonance images from 50 MTLE patients and 15 healthy subjects. We compared the quantification of a T2 signal from single echo images to T2 relaxometry, both obtained from a manually traced region of interest (ROI) in coronal slices involving the whole hippocampus. Repeated measures ANOVA was used to evaluate the differences in the distribution of the Z -scores from single-echo T2 quantification and T2 relaxometry within subjects. Results. We observed a significant difference between the measurements obtained from single-echo T2 quantification and T2 relaxometry (P < .001). Measurements from head, body, and tail of the hippocampus were different (P=.04), with a significant interaction between anatomic location and type of measurement used (P= .008). Post hoc paired comparisons revealed that T2 relaxometry yielded greater Z -scores for the body (P= .002) and tail (P < .0001). Conclusions. For each subject with MTLE, T2 relaxometry was able to detect a higher signal in the body and tail of the hippocampus compared to single-echo T2. This is a possible indicator that T2 relaxometry is more sensitive in detecting T2 abnormalities within the body and tail of the hippocampus in patients with MTLE. [source] Quality of Reporting of Clinical Trials of Dogs and Cats and Associations with Treatment EffectsJOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 1 2010J.M. Sargeant Background: To address concerns about the quality of reporting of randomized controlled trials, and the potential for biased treatment effects in poorly reported trials, medical journals have adopted a common set of reporting guidelines, the Consolidated Standards of Reporting Trials (CONSORT) statement, to improve the reporting of randomized controlled trials. Hypothesis: The reporting of clinical trials involving dogs and cats might not be ideal, and this might be associated with biased treatment effects. Animals: Dogs and cats used in 100 randomly selected reports of clinical trials. Methods: Data related to methodological quality and completeness of reporting were extracted from each trial. Associations between reporting of trial features and the proportion of positive treatment effects within trials were evaluated by generalized linear models. Results: There were substantive deficiencies in reporting of key trial features. An increased proportion of positive treatment effects within a trial was associated with not reporting: the method used to generate the random allocation sequence (P < .001), the use of double blinding (P < .001), the inclusion criteria for study subjects (P= .003), baseline differences between treatment groups (P= .006), the measurement used for all outcomes (P= .002), and possible study limitations (P= .03). Conclusions and Clinical Importance: Many clinical trials involving dogs and cats in the literature do not report details related to methodological quality and aspects necessary to evaluate external validity. There is some evidence that these deficiencies are associated with treatment effects. There is a need to improve reporting of clinical trials, and guidelines, such as the CONSORT statement, can provide a valuable tool for meeting this need. [source] Monitoring across Sectors: Examining the Effect of Nonprofit and For-Profit Contractor Ownership on Performance Monitoring in State and Local ContractsPUBLIC ADMINISTRATION REVIEW, Issue 5 2010Anna A. Amirkhanyan What is the effect of contractors' nonprofit and for-profit ownership on the scope and nature of performance measurement used by government agencies? Quantitative and qualitative data were generated through semistructured interviews administered to a sample of state and local public agencies and private contractors across five jurisdictions. The findings of this study suggest that monitoring officers working with nonprofit rather than for-profit contractors are more likely to rely on qualitative performance data and examine equitable access to services, contractors' reputation, and compliance with industry rules and regulations. Although organizational ownership may not be well understood by practitioners, performance appears to be conceptualized differently across sectors. The author calls for a better understanding of the impact of the identified differences in performance measurement on the effectiveness of contract monitoring. [source] Measuring sexual size dimorphism in birdsIBIS, Issue 3 2003Julian G. Greenwood Numerous studies have examined sexual size dimorphism in birds and speculated upon the reasons for its existence. Whilst most studies have focused on individual species or groups of related species, a few have attempted to disentangle the various hypotheses that have been put forward to explain its occurrence. Typical of the latter studies is that by Jehl and Murray (1986), in which they argued that sexual size dimorphism was primarily the result of sexual selection (see also Bennett & Owens 2002). Although some studies have looked at patterns in sexual size dimorphism without calculating a figure to represent the difference (e.g. Amadon 1959), most have examined measurements of birds and used these to calculate such a figure. Traditionally in such studies, measurements used have included wing-length, culmen-length, tarsus-length and mass, although McGillivray (1989) took the sum of 18 skeletal measurements and used their male and female means to determine sexual size dimorphism. Wing-length has commonly been used to determine sexual size dimorphism, although lack of repeatability of measurements may render it less useful than skeletal measurements like tarsus-length as in studies of Dunlin Calidris alpina (Blomqvist et al. 1997) and Savannah Sparrows Passerculus sandwichensis (Rising & Somers 1989); however, Gosler et al. (1998) found wing-length measurements to be more repeatable than other metrics in a group of 27 passerines. [source] Robust diagnosis and fault-tolerant control of distributed processes over communication networksINTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, Issue 8 2009Sathyendra Ghantasala Abstract This paper develops a robust fault detection and isolation (FDI) and fault-tolerant control (FTC) structure for distributed processes modeled by nonlinear parabolic partial differential equations (PDEs) with control constraints, time-varying uncertain variables, and a finite number of sensors that transmit their data over a communication network. The network imposes limitations on the accuracy of the output measurements used for diagnosis and control purposes that need to be accounted for in the design methodology. To facilitate the controller synthesis and fault diagnosis tasks, a finite-dimensional system that captures the dominant dynamic modes of the PDE is initially derived and transformed into a form where each dominant mode is excited directly by only one actuator. A robustly stabilizing bounded output feedback controller is then designed for each dominant mode by combining a bounded Lyapunov-based robust state feedback controller with a state estimation scheme that relies on the available output measurements to provide estimates of the dominant modes. The controller synthesis procedure facilitates the derivation of: (1) an explicit characterization of the fault-free behavior of each mode in terms of a time-varying bound on the dissipation rate of the corresponding Lyapunov function, which accounts for the uncertainty and network-induced measurement errors and (2) an explicit characterization of the robust stability region where constraint satisfaction and robustness with respect to uncertainty and measurement errors are guaranteed. Using the fault-free Lyapunov dissipation bounds as thresholds for FDI, the detection and isolation of faults in a given actuator are accomplished by monitoring the evolution of the dominant modes within the stability region and declaring a fault when the threshold is breached. The effects of network-induced measurement errors are mitigated by confining the FDI region to an appropriate subset of the stability region and enlarging the FDI residual thresholds appropriately. It is shown that these safeguards can be tightened or relaxed by proper selection of the sensor spatial configuration. Finally, the implementation of the networked FDI,FTC architecture on the infinite-dimensional system is discussed and the proposed methodology is demonstrated using a diffusion,reaction process example. Copyright © 2008 John Wiley & Sons, Ltd. [source] Terahertz spectroscopy to identify the polymorphs in freeze-dried mannitolJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 2 2010Reshmi Chakkittakandy Abstract We show how terahertz time-domain spectroscopy (THz-TDS) in the range from 0.1 to 7.5,THz can be used to identify the polymorphs of Mannitol, a frequently used excipient in the freeze drying industry. The results are subsequently used to study the effect that different freeze drying techniques have on the formation of these polymorphs. We find that, depending on the freeze-drying technique, the Mannitol either crystallizes in the , form, or in a mixture of both the , form and the , form. The results are in agreement with conventional X-ray diffraction measurements used to identify the polymorphs. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:932,940, 2010 [source] In vivo quantification of regional myocardial blood flow: Validity of the fast-exchange approximation for intravascular T1 contrast agent and long inversion time,MAGNETIC RESONANCE IN MEDICINE, Issue 2 2006Marlene Wiart Abstract In the present study we investigated the effects of water exchange between intra- and extravascular compartments on absolute quantification of regional myocardial blood flow (rMBF) using a saturation-recovery sequence with a rather long inversion time (TI, 176 ms) and a T1 -shortening intravascular contrast agent (CMD-A2-Gd-DOTA). Data were acquired in normal and ischemically injured pigs, with radiolabeled microsphere flow measurements used as the gold standard. Five water exchange rates (fast, 6 Hz, 3 Hz, 1 Hz, and no exchange) were tested. The results demonstrate that the fast-exchange approximation may be appropriate for rMBF quantification using the described experimental setting. Relaxation rate change (,R1) analysis improved the accuracy of the analysis of rMBF compared to the MR signal. In conclusion, the current protocol could provide sufficient accuracy for estimating rMBF assuming fast exchange and a linear relationship between signal and tissue concentration when quantification of precontrast T1 is not an option. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc. [source] Assessment of weight changes during and after pregnancy: practical approachesMATERNAL & CHILD NUTRITION, Issue 1 2008Amanda R. Amorim Abstract The usefulness of routine prenatal weight measurements in predicting pregnancy outcomes is still a controversial issue. Comparisons among studies and the interpretation of research findings are complicated due to the variety of indicators applied to express maternal weight changes during and after pregnancy. A review of literature was conducted to clarify the definitions and examine the strengths and limitations of methods for measuring gestational weight gain (WG) and postpartum weight changes. The reasons for weak correlations or non-significant associations between gestational WG and maternal and neonatal outcomes were probably owing to poor quality of obstetrics records and selection of wrong indicators to compute gestational WG. The choice of an indicator depends on clinical and research purpose, availability and reliability of data and cost. Considering the health implication of gestational WG, it is necessary to take into account the measurements used as initial and final weight, accuracy of gestational age estimation and the inclusion of fetal weight as part of maternal WG. Regardless of the indicators used to compute the weight changes after delivery, attention is drawn to the approach for designating prepregnancy weight, the time frame of postpartum weight measurements and the use of overlapping variables, which results in bias (part,whole correlation). It is necessary to address criticisms on the accuracy of prenatal weight measurements and the way of expressing the maternal weight changes during and after pregnancy in order to have reliable results from research. [source] | ||||||||||