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MCI Subjects (mci + subject)

Distribution by Scientific Domains

Medical Sciences	60%

Selected Abstracts

White matter vascular lesions are related to parietal-to-frontal coupling of EEG rhythms in mild cognitive impairment

HUMAN BRAIN MAPPING, Issue 12 2008
Claudio Babiloni
Abstract Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0,30 visual rating scale). EEG rhythms of interest were , (2,4 Hz), , (4,8 Hz), ,1 (8,10.5 Hz), ,2 (10.5,13 Hz), ,1 (13,20 Hz), and ,2 (20,30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at ,, ,1, ,2, and ,1 in MCI V+ (high vascular load; N = 42; MMSE = 26) than in MCI V, group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions. Hum Brain Mapp 2008. © 2007 Wiley-Liss, Inc. [source]

Effects of Alzheimer's disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving test

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 3 2009
Cristina Frittelli
Abstract Objective To assess the effects of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) on simulated car driving ability. Methods Twenty patients with a probable AD of mild severity (Clinical Dementia Rating, CDR,=,1) were compared with 20 subjects with MCI (CD,=,0.5), and a group of age-matched neurologically normal controls on a driving simulation task. Measures of driving competence included the length of run, the number of infractions (omission of stop at pedestrian crossings, speed limits violation), the number of stops at traffic lights, the mean time to collision, and the number of off-road events. Results in the driving competence measures were correlated with scores obtained from simple visual reaction times and mini-mental state examination (MMSE). Results The patients with mild AD performed significantly worse than MCI subjects and controls on three simulated driving measures, length of run and mean time to collision (p,<,0.001), and number of off-road events (p,<,0.01). MCI subjects had only a significantly shorter time-to-collision than healthy controls (p,<,0.001). Simple visual reaction times were significantly longer (p,<,0.001) in patients with AD, compared to MCI and healthy controls, and showed a borderline significant relation (p,=,0.05) with simulated driving scores. Driving performance in the three groups did not significantly correlate with MMSE score as measure of overall cognitive function. Conclusions Mild AD significantly impaired simulated driving fitness, while MCI limitedly affected driving performance. Unsafe driving behaviour in AD patients was not predicted by MMSE scores. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia

ANNALS OF NEUROLOGY, Issue 1 2003
Xianlin Han PhD
We recently noted a profound decline in brain sulfatides (ST) in subjects who died with incipient dementia due to Alzheimer's disease. Herein, we measured ST levels in cerebrospinal fluid in cognitively normal elderly and in subjects with mild cognitive impairment due to incipient demenia of the Alzheimer type. There was a significant decrease in cerebrospinal fluid ST and in the ST to phosphatidylinositol ratio in MCI subjects. The ST to phosphatidylinositol ratio accurately differentiated very mildly impaired subjects from controls on an individual basis. The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease. Ann Neurol 2003;54:115,119 [source]

EEG synchronization in mild cognitive impairment and Alzheimer's disease

ACTA NEUROLOGICA SCANDINAVICA, Issue 2 2003
C. J. Stam
Objectives , To compute the synchronization likelihood of multichannel electroencephalogram (EEG) data in Alzheimer (AD) patients, subjects with mild cognitive impairment (MCI) and subjects with subjective memory complaints (SC). Material and methods , EEGs (200 Hz sample frequency; 21 channels; average reference) were recorded in 10 AD patients (two males; age 76.2; SD 9.36; range 59,86), 17 subjects with MCI (eight males; age 77.41; SD 6.25; range 62,88) and 20 subjects with SCI (11 males; age 68.9; SD 12.96; range: 51,89). The synchronization likelihood, a novel type of coherence measure, was computed, comparing each channel with all other channels, for the 2,6, 6,10, 10,14, 14,18, 18,22 and 22,50 Hz band. Results , The synchronization likelihood was significantly decreased in the 14,18 and 18,22 Hz band in AD patients compared with both MCI subjects and healthy controls. Lower beta band synchronization correlated with lower Mini-Mental state examination (MMSE) scores. Conclusion , Loss of beta band synchronization occurs early in mildly affected AD patients and correlates with cognitive impairment. [source]