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Market Introduction (market + introduction)
Selected AbstractsAssessment of Fuel-Cell-Based Passenger CarsFUEL CELLS, Issue 3 2004T. Grube Abstract Highly efficient energy conversion systems with fuel cells for vehicles, as well as for stationary and portable applications, are currently being discussed all over the world. Fuel cell technology is expected to help reduce primary energy demand and emissions of limited and climate-relevant pollutants. The high flexibility of fuel cell systems with respect to energy carriers opens up possibilities of modifying the energy sector in the long term. Introducing new fuels based on low-carbon, or in the long term carbon-free, energy carriers can contribute to reducing greenhouse gas emissions as well as locally and regionally active atmospheric pollutants. The use of hydrogen as feed gas for fuel cells on the basis of it being a non-fossil, renewable energy, leads to special benefits with respect to conserving resources and climate protection, but at present still represents a medium- to long-term prospect. A major milestone on the road to market success for all energy conversion systems with fuel cells is the reduction of costs. The definition of the ,appropriate" fuel represents a serious obstacle to the market introduction of fuel-cell-powered vehicles. Presenting data from a well-to-wheel analysis of various vehicle fuel systems at FZJ this article aims to discuss the potential benefits of future vehicle concepts with fuel cells in terms of primary energy use and greenhouse gas emissions. Results from a comparison of international studies on this subject will be used to identify relevant assumptions that lead to different answers in the evaluation process. [source] Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases,HEPATOLOGY, Issue 1 2009Allen D. Brinker Telithromycin is the first of a new class of ketolide antibiotics with increased activity against penicillin-resistant and erythromycin-resistant pneumococci. This agent received approval by the United States Food and Drug Administration (FDA) in 2004 for treatment of upper and lower respiratory infections. Following market introduction, spontaneous reports of telithromycin-associated hepatotoxicity, including frank liver failure, were received. To address these reports, an ad hoc group with expertise in spontaneous adverse events reporting and experience in evaluating drug-induced liver injury was formed, including members of the FDA, other federal agencies, and academia. The primary objective of this group was to adjudicate case reports of hepatic toxicity for causal attribution to telithromycin. After an initial screening of all cases of liver injury associated with telithromycin reported to FDA as of April 2006 by one of the authors, 42 cases were comprehensively reviewed and adjudicated. Five cases included a severe outcome of either death (n = 4) or liver transplantation (n = 1); more than half were considered highly likely or probable in their causal association with telithromycin. Typical clinical features were: short latency (median, 10 days) and abrupt onset of fever, abdominal pain, and jaundice, sometimes with the presence of ascites even in cases that resolved. Concurrence in assignment of causality increased after agreement on definitions of categories and interactive discussions. Conclusion: Telithromycin is a rare cause of drug-induced liver injury that may have a distinctive clinical signature and associated high mortality rate. Consensus for attribution of liver injury to a selected drug exposure by individual experts can be aided by careful definition of terminology and discussion. (HEPATOLOGY 2009;49:250-257.) [source] Changes in prescribed drug doses after market introductionPHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 6 2002Eibert R. Heerdink PhD Abstract Purpose The establishment of recommended dosing regimens has always been a difficult aspect of drug development. This paper examines the extent to which postmarketing prescribing deviates from initially recommended dosing regimens. We used the World Health Organization's (WHO) periodically updated compilation of the ,Defined Daily Dose' (DDD) to reflect prevailing patterns of prescribing in national markets. The aim of this study was to evaluate DDD changes over time (1982,2000) and to identify possible determinants of these changes. Methods Data on DDD changes were obtained from the WHO's Oslo Collaborating Centre. We performed a case,control analysis in which we compared drugs with (cases) and without (controls) postmarketing changes in DDD on possible determinants associated with DDD change. Results We found 115 instances of a change of DDD in the period 1982,2000 (45 (39.1%) increases and 70 (60.9%) decreases). Antibiotics showed the greatest number of changes in DDD: predominantly increases in the 1980s, while the 1990s were dominated by decreases in DDD of mostly cardiovascular drugs. Conclusion Changes in DDD reflect the outcome of a melange of forces, including misconceptions of dose requirements during pre-market development of drug and postmarketing changes in pharmacotherapeutic knowledge, clinical concepts, economic forces, and, in the case of anti-infective agents, changing patterns of resistance/sensitivity of target microorganisms to the anti-infective agent(s) in question. Copyright © 2002 John Wiley & Sons, Ltd. [source] Assessment of hidden and future customer needs in Finnish business-to-business companiesR & D MANAGEMENT, Issue 4 2001Hannu Kärkkäinen The development of new products should be based on the needs expected to exist even several years ahead , at the moment of market introduction and during the whole lifecycle of the product. To develop successful new products in the toughening business environment, companies should be able to surpass customers' expectations and to assess emerging customer needs proactively. Early, thorough understanding of the customer's real needs, including the assessment of hidden and future customer needs and requirements, plays a very important role in the successful development of new products. The purpose of our paper is to study the assessment of new (hidden and future) customer needs for product development in Finnish business-to-business companies. We have carried out a survey in 93 Finnish business-to-business companies and SBUs to study their common problems in the assessment of unrecognized customer needs and potentially effective ways in clarifying new customer needs and dealing with important problems. On the basis of the results, we propose several possible ways to facilitate the assessment of unrecognized customer needs. [source] Progress in the Development of a High Performance Airborne Digital SensorTHE PHOTOGRAMMETRIC RECORD, Issue 96 2000P. Fricker Joint development work by LH Systems and Deutsches Zentrum für Luft- und Raumfahrt (German Aerospace Center) has produced encouraging results using forward, nadir and backward looking linear arrays on the focal plane to provide panchromatic imagery and geometric information, supplemented by further arrays to acquire multispectral imagery suitable for both high precision photogrammetric mapping and image processing for interpretative purposes. The geometric characteristics of line scanner imagery necessitate line-by-line rectification for aircraft tilts and shifts. Satisfactory execution of this process is enhanced by using supplementary data from high performance, on-board GPS and inertial measurement systems. Similarly, high demands are placed on other sub-systems, such as the camera mount, lens, electronics and storage technology. In addition to rectification for aircraft tilts and shifts, rectification for terrain characteristics is also required in order to generate colour and false colour composite images, since the various multispectral arrays are in different places on the focal plane. The special geometry affects triangulation. Thereafter, the imagery can be processed using existing software packages from both photogrammetry and remote sensing. The concept has been demonstrated in several successful test flights and the production model is scheduled for market introduction at the ISPRS Congress in July 2000. The imagery from the new sensor will fulfil many market requirements between the highest resolution film imagery (<0.1 m) and high resolution space imagery (1m to 10 m). The sensor's unique blend of multispectral information with high quality geometric information will give rise to numerous new applications. [source] Cross-linked agarose for separation of low molecular weight natural products in hydrophilic interaction liquid chromatographyBIOTECHNOLOGY JOURNAL, Issue 5 2010Tianwei Tan Abstract Following its market introduction in 1982, the cross-linked 12% agarose gel media Superose 12 has become widely known as a tool for size exclusion chromatography of proteins and other biological macromolecules. In this review it is shown that, when appropriate mobile phases are used, Superose possesses adsorption properties similar to that of traditional media for hydrophilic interaction liquid chromatography (HILIC). This is illustrated by the separation and purification of low molecular weight compounds such as polyphenols including active components of traditional Chinese medicinal herbs and green tea. Structural features of the cross-linked agarose that likely cause the observed adsorption effects are discussed aswell. These are identified as being primarily ether bonds acting as strong hydrogen bond acceptors as well as hydrophobic residues originating from the cross-linking reagents. [source] | ||||||||||