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Many Other Aspects (many + other_aspect)
Selected AbstractsHeparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complicationsDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 6 2001Karin Conde-Knape Abstract Proteoglycans are ubiquitous extracellular proteins that serve a variety of functions throughout the organism. Unlike other glycoproteins, proteoglycans are classified based on the structure of the glycosaminoglycan carbohydrate chains, not the core proteins. Perlecan, a member of the heparan sulfate proteoglycan (HSPG) family, has been implicated in many complications of diabetes. Decreased levels of perlecan have been observed in the kidney and in other organs, both in patients with diabetes and in animal models. Perlecan has an important role in the maintenance of the glomerular filtration barrier. Decreased perlecan in the glomerular basement membrane has a central role in the development of diabetic albuminuria. The involvement of this proteoglycan in diabetic complications and the possible mechanisms underlying such a role have been addressed using a variety of models. Due to the importance of nephropathy among diabetic patients most of the studies conducted so far relate to diabetes effects on perlecan in different types of kidney cells. The various diabetic models used have provided information on some of the mechanisms underlying perlecan's role in diabetes as well as on possible factors affecting its regulation. However, many other aspects of perlecan metabolism still await full elucidation. The present review provides a description of the models that have been used to study HSPG and in particular perlecan metabolism in diabetes and some of the factors that have been found to be important in the regulation of perlecan. Copyright © 2001 John Wiley & Sons, Ltd. [source] ,MOVING AROUND': THE SOCIAL AND SPATIAL MOBILITY OF YOUTH IN LUSAKAGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2008Katherine V. Gough ABSTRACT Claims have recently been made for a ,mobilities paradigm' which is challenging the relative ,a-mobile' focus of much of the social sciences. The agenda drawn up for this mobilities paradigm is clearly based on Northern trends with little consideration of the South. African populations have always been mobile but little is known about the mobility of urban populations and in particular of the youth, who constitute a large proportion of the population. This paper explores the daily and residential mobility of young people in Lusaka building upon interviews held with low- and middle-income youth. The aim is to contribute to discussions of: how mobility varies by gender and class; the links between spatial mobility and social and economic mobility; the nature of the relationship between patterns of mobility and residential structure; and how examining mobility can illuminate many other aspects of young people's lives. Overall the picture emerging from Lusaka is rather bleak. In a context of spiralling economic decline and rising HIV/AIDS rates, the social mobility of youth is predominantly downwards which is reflected in the residential and daily mobility patterns of the young people. There is a strong link between young people's mobility and their livelihoods, an aspect of mobility that is widespread in the South but largely overlooked by the emerging mobilities paradigm. [source] The medical emergency team: does it really make a difference?INTERNAL MEDICINE JOURNAL, Issue 11 2003M. Cretikos Abstract Hospital systems are failing the critically ill. This has been well documented in many countries around the world, with detailed reports of suboptimal care prior to intensive care and high rates of serious adverse events, including death. These events are potentially preventable, but insufficient attention has been directed towards developing solutions to these important problems to date. The medical emergency team (MET) is a system approach that promotes early and appropriate intervention in the care of critically ill hospital patients. The benefits of the MET in terms of absolute in-patient mortality and cardiac arrest rates are not yet well-defined, although preliminary studies are promising. The MET does provide a potentially beneficial impact on many other aspects of patient care. These benefits include: (i) facilitating an integrated and coordinated approach to patient care across the hospital, (ii) increasing awareness of at-risk patients, (iii) encouraging early referral of seriously ill patients to clinicians with expertise in critical care and (iv) providing a foundation for quality initiatives for hospital-wide care of the seriously ill. The MET also empowers nursing staff and junior medical staff to call for immediate assistance in cases where they are seriously concerned about a patient, but may not have the experience, knowledge, confidence or skills necessary to manage them appropriately. (Intern Med J 2003; 33: 511,514) [source] An empirical study of rules for well-formed identifiersJOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 4 2007Dawn Lawrie Abstract Readers of programs have two main sources of domain information: identifier names and comments. In order to efficiently maintain source code, it is important that the identifier names (as well as comments) communicate clearly the concepts they represent. Deißenböck and Pizka recently introduced two rules for creating well-formed identifiers: one considers the consistency of identifiers and the other their conciseness. These rules require a mapping from identifiers to the concepts they represent, which may be costly to develop after the initial release of a system. An approach for verifying whether identifiers are well formed without any additional information (e.g., a concept mapping) is developed. Using a pool of 48 million lines of code, experiments with the resulting syntactic rules for well-formed identifiers illustrate that violations of the syntactic pattern exist. Two case studies show that three-quarters of these violations are ,real'. That is, they could be identified using a concept mapping. Three related studies show that programmers tend to use a rather limited vocabulary, that, contrary to many other aspects of system evolution, maintenance does not introduce additional rule violations, and that open and proprietary sources differ in their percentage of violations. Copyright © 2007 John Wiley & Sons, Ltd. [source] The Diagnostic Utility of an Electronic Nose: Rhinologic ApplicationsTHE LARYNGOSCOPE, Issue 9 2002Erica R. Thaler MD Abstract Objective/Hypothesis The thesis explores the applicability of electronic nose technology in medical decision-making. Specifically, the studies undertaken in the thesis were designed to test the ability of the electronic nose to assist in diagnostic questions encountered in the field of rhinology. Study Design Three separate studies were undertaken. All involved analysis of specimens by the electronic nose, obtained either in vitro or in vivo: known matched sets of cerebrospinal fluid and serum, bacterial samples from known plated specimens, and culture swabs taken from patients suspected of having rhinosinusitis who also had a matched standard bacterial culture taken from the same site. The goal of analysis was to determine whether the electronic nose was able to identify or categorize specimens or groups of specimens. Methods Each specimen was tested using the organic semiconductor-based Cyranose 320 electronic nose. Data from the 32-element sensor array were subjected to principal-component analysis to depict differences in odorant patterns. Distinction of specimens was identified by calculation of Mahalanobis distance. Results The electronic nose was able to distinguish serum from cerebrospinal fluid in pure isolates as well as in isolates collected on small cottonoid pledgets at amounts of 0.2 mL or greater. It was also able to distinguish between control swabs and bacterial samples as well as among bacterial samples collected in vitro. Preliminary work suggests that it may be able to distinguish between presence and absence of bacterial infection in specimens collected on nasal swabs. Conclusions The electronic nose is able to distinguish reliably between cerebrospinal fluid and serum sampled in small amounts, may be able to identify presence and type of bacterial pathogen in vitro, and is able to identify presence or absence of bacteria on nasal swabs. Because this information is available immediately, the electronic nose may be a powerful new technology for diagnostic use, not only for rhinologic purposes but in many other aspects of medicine as well. [source] | ||||||||||