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Many Different Aspects (many + different_aspect)
Selected AbstractsDiagnosis, clinical features and molecular assessment of the dysfibrinogenaemiasHAEMOPHILIA, Issue 5 2008M. HILL Summary., Hereditary dysfibrinogenaemia is characterized by the presence of functionally abnormal plasma fibrinogen. Dysfibrinogenaemia is a heterogeneous disorder associated with different mutations throughout the three genes that code for the fibrinogen sub-units, affecting many different aspects of fibrinogen/fibrin activity. Dysfibrinogenaemia may be discovered during the investigation of individuals who present with bleeding or thombosis, or may be found in individuals during routine coagulation screening. More specialized coagulation tests may confirm the diagnosis of dysfibrinogenaemia but do not reliably distinguish between the different fibrinogen variants and are not usually useful in predicting bleeding or thrombotic risk. Advances in molecular diagnostics have facilitated the investigation of the molecular causes of fibrinogen disorders. Several ,hot spot' areas have been identified where mutations causing a high proportion of cases of dysfibrinogenaemia are found (A,Arg16 and ,Arg275). Molecular diagnostics have also shown that many fibrinogen variants share the same causative mutation. There is a discrepancy between the quality of the molecular and functional data available for each mutation and the clinical information on individuals and their family members. However, there are accumulating data that the ,hot spot' mutations accounting for 60,80% of cases of dysfibringenaemia are not associated with a significant bleeding or thrombosis in the absence of other risk factors. Rapid screening for these mutations may provide reassurance for patients in the presurgical setting. [source] Statistical descriptions of channel networks and their shapes on non-vegetated hillslopes in Kemmerer, WyomingHYDROLOGICAL PROCESSES, Issue 10 2003D. A. Raff Abstract Erosion prediction tools are essential for many different aspects of land management. In this paper we examine the applicability of scaling relationships developed for river networks for the description of hillslope erosion channel networks. Eight erosion channel networks were studied on mine spoil sites in Kemmerer, Wyoming. We analysed these networks using well-known geomorphological relationships such as Horton's laws and Melton's law. An analysis of the erosion channel hydraulic geometry described by a series of power functions was also conducted. We found that the network geometry resembles larger river networks, and that the cross-sectional shapes of individual erosion channels exhibit statistical characteristics of their larger river counterparts. Copyright © 2003 John Wiley & Sons, Ltd. [source] Strategic Teaching: Student Learning through Working the ProcessINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 2 2010Nancy Spanbroek The designers of our future built environment must possess intellectual tools which will allow them to be disciplined, flexible and analytical thinkers, able to address and resolve new and complex problems. In response, an experimental and collaborative design studio was designed to inspire and build on students' knowledge and their creative thinking abilities through a series of explorative exercises and modelling. The learning experience of students undertaking this studio was enabled and guided by a collaboration of teachers experienced in both teaching and creative practice. A series of guest creative practitioners joined the studio's intensive 10-week hands-on workshop sessions within which students undertook set exercises. These creative research workshops then served to inform subsequent design development of the students' work through planning and documentation over a period of 4 weeks. Strategic teaching is central to the creative development process. The driving educational belief, as idea and practice, is that by bringing ideas to life in design, by working with full-scale three-dimensionality, students are able to cement their commitment to ,working the process', towards becoming excellent designers. This ambitious strategy enables students to work on the many different aspects of the design problem towards meeting their design outcome at the highest level of resolution and intent. Through a combination of pragmatic tasks , writing and developing design briefs , and visual tasks , evidence gathering and analysis of design through photographic, modelling and diagramming exercises , students were encouraged to think outside and beyond the ,normal' realm of design practice. [source] Dimensions and elements of people's mental models of an information-rich Web spaceJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 11 2010Yan Zhang Although considered proxies for people to interact with a system, mental models have produced limited practical implications for system design. This might be due to the lack of exploration of the elements of mental models resulting from the methodological challenge of measuring mental models. This study employed a new method, concept listing, to elicit people's mental models of an information-rich space, MedlinePlus, after they interacted with the system for 5 minutes. Thirty-eight undergraduate students participated in the study. The results showed that, in this short period of time, participants perceived MedlinePlus from many different aspects in relation to four components: the system as a whole, its content, information organization, and interface. Meanwhile, participants expressed evaluations of or emotions about the four components. In terms of the procedural knowledge, an integral part of people's mental models, only one participant identified a strategy more aligned to the capabilities of MedlinePlus to solve a hypothetical task; the rest planned to use general search and browse strategies. The composition of participants' mental models of MedlinePlus was consistent with that of their models of information-rich Web spaces in general. [source] ALSPAC,The Avon Longitudinal Study of Parents and ChildrenPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 1 2001Golding ALSPAC (The Avon Longitudinal Study of Parents and Children, formerly the Avon Longitudinal Study of Pregnancy and Childhood) was specifically designed to determine ways in which the individual's genotype combines with environmental pressures to influence health and development. To date, there are comprehensive data on approximately 10 000 children and their parents, from early pregnancy until the children are aged between 8 and 9. The study aims to continue to collect detailed data on the children as they go through puberty noting, in particular, changes in anthropometry, attitudes and behaviour, fitness and other cardiovascular risk factors, bone mineralisation, allergic symptoms and mental health. The study started early during pregnancy and collected very detailed data from the mother and her partner before the child was born. This not only provided accurate data on concurrent features, especially medication, symptoms, diet and lifestyle, attitudes and behaviour, social and environmental features, but was unbiased by parental knowledge of any problems that the child might develop. From the time of the child's birth many different aspects of the child's environment have been monitored and a wide range of phenotypic data collected. By virtue of being based in one geographic area, linkage to medical and educational records is relatively simple, and hands-on assessments of children and parents using local facilities has the advantage of high quality control. The comprehensiveness of the ALSPAC approach with a total population sample unselected by disease status, and the availability of parental genotypes, provides an adequate sample for statistical analysis and for avoiding spurious results. The study has an open policy in regard to collaboration within strict confidentiality rules. [source] | ||||||||||