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Many Differences (many + difference)
Selected AbstractsBody size and invasion success in marine bivalvesECOLOGY LETTERS, Issue 2 2002Kaustuv Roy The role of body size in marine bivalve invasions has been the subject of debate. Roy et al. found that large-bodied species of marine bivalves were more likely to be successful invaders, consistent with patterns seen during Pleistocene climatic change, but Miller et al. argued that such selectivity was largely driven by the inclusion of mariculture species in the analysis and that size-selectivity was absent outside of mariculture introductions. Here we use data on non-mariculture species from the north-eastern Pacific coast and from a global species pool to test the original hypothesis of Roy et al. that range limits of larger bivalves are more fluid than those of smaller species. First, we test the hypothesis that larger bivalve species are more successful than small species in expanding their geographical ranges following introduction into new regions. Second, we compare body sizes of indigenous and non-indigenous species for 299 of the 303 known intertidal and shelf species within the marine bivalve clade that contains the greater number of non-mariculture invaders, the Mytilidae. The results from both tests provide additional support for the view that body size plays an important role in mediating invasion success in marine bivalves, in contrast to Miller et al. Thus range expansions in Recent bivalves are consistent with patterns seen in Pleistocene faunas despite the many differences in the mechanisms. [source] Transatlantic constitutionalism: Comparing the United States and the European UnionEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 4 2004SERGIO FABBRINI The European Union has more to learn from the American experience of constitutionalism than from any of its own Member States. Like the United States, the European Union will have a frame of government constitution that will try to order a system of multiple and concurrent communities of interests, as happened in America, and designed by an indirectly elected assembly. The European Union and the United States will continue to manifest many differences in other crucial aspects of their institutional and cultural development. However, although constrained by their respective historical and institutional paths, their constitutional evolution is making the Atlantic Ocean less wide than it used to be. [source] Contemplating the murine test tube: lessons from natural killer cells and Cryptococcus neoformansFEMS YEAST RESEARCH, Issue 4 2006Kaleb J. Marr Abstract Murine experimentation has provided many useful tools, including the ability to knockout or over-express genes and to perform experiments that are limited by ethical considerations. Over the past century, mice have imparted valuable insights into the biology of many systems, including human immunity. However, although there are many similarities between the immune response of humans and mice, there are also many differences; none is more prominent than when examining natural killer cell biology. These differences include tissue distribution, effector molecules, receptor repertoire, and cytokine responses, all of which have important implications when extrapolating the studies to the human immune responses to Cryptococcus neoformans. [source] Benzodiazepines prescription in Dakar: a study about prescribing habits and knowledge in general practitioners, neurologists and psychiatristsFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 3 2006Amadou Moctar Dièye Abstract Benzodiazepines are relatively well-tolerated medicines but can induce serious problems of addiction and that is why their use is regulated. However, in developing countries like Senegal, these products are used without clear indications on their prescription, their dispensation or their use. This work focuses on the prescription of these medicines with a view to make recommendations for their rational use. Benzodiazepine prescription was studied with psychiatrists or neurologists and generalists in 2003. Specialist doctors work in two Dakar university hospitals and generalists in the 11 health centres in Dakar. We did a survey by direct interview with 29 of 35 specialists and 23 of 25 generalists. All doctors were interviewed in their office. The questionnaire focused on benzodiazepine indications, their pharmacological properties, benzodiazepines prescribed in first intention against a given disease and the level of training in benzodiazepines by doctors. Comparisons between specialists and generalists were made by chi-square test. Benzodiazepines were essentially used for anxiety, insomnia and epilepsy. With these diseases, the most benzodiazepines prescribed are prazepam against anxiety and insomnia and diazepam against epilepsy. About 10% of doctors do not know that there is a limitation for the period of benzodiazepine use. The principal reasons of drugs choice are knowledge of the drugs, habit and low side effects of drugs. All generalists (100%) said that their training on benzodiazepines is poor vs. 62.1% of specialists, and doctors suggest seminars, journals adhesions and conferences to complete their training in this field. There are not many differences between specialists and generalists except the fact that specialists prefer prazepam in first intention in the insomnia treatment where generalists choose bromazepam. In addition, our survey showed that specialists' training in benzodiazepines is better than that of generalists. Overall, benzodiazepine prescription poses problems particularly in training, and national authorities must take urgent measures for rational use of these drugs. [source] Foreign Policy Gaps between Citizens and LeadersINTERNATIONAL STUDIES QUARTERLY, Issue 3 2000Benjamin I. Page Persistent gaps between the policy preferences of leaders and those of citizens are problematic from the point of view of democratic theory. Examination of the foreign policy preferences of samples of citizens and leaders from seven Chicago Council on Foreign Relations (CCFR) surveys between 1974 and 1998 reveals many differences of 30, 40, and even 50 percentage points. Often a majority of the public has disagreed with a majority of leaders. Some of the same gaps have persisted over the full 24-year period of these surveys. The pattern of gaps is considerably more complicated than a simple difference in degree of commitment to internationalism. Citizens have generally put a higher priority than leaders on expanding domestic programs like Social Security, crime fighting, and health care, and have been more eager to cut foreign economic aid. But there have not been substantial gaps with respect to defense spending or military aid. More members of the public than leaders emphasize foreign policy goals related to protecting Americans' jobs and ensuring Americans' health and physical security (e.g., from terrorism, drugs, and epidemic diseases). Citizens have been more reluctant than leaders to use U.S. troops in most circumstances, but the opposite is true of situations involving Latin America. Citizens have been more willing to bomb than to commit troops, though not indiscriminately so, and many more citizens than leaders oppose selling weapons abroad. Fewer members of the public than leaders have favored most kinds of cooperative relationships with adversary countries. But more members of the public than leaders generally support the United Nations, and more favor multilateralism in general. About the same number of citizens as leaders have supported NATO. Some of these gaps may reflect lower levels of attention to foreign affairs and lower levels of information among the public than among leaders, but many of the gaps may instead reflect different values and interests. In cases where the public is ill-informed, persistent gaps suggest a failure of leaders to educate and persuade. Where public opinion is well-informed and deliberative, democratic theory would seem to call for responsiveness by policymakers. [source] STRATEGY AND SHAREHOLDER VALUE CREATION: THE REAL OPTIONS FRONTIERJOURNAL OF APPLIED CORPORATE FINANCE, Issue 2 2000Martha Amram The current interest in real options reflects the dramatic increase in the uncertainty of the business environment. Viewed narrowly, the real options approach is the extension of financial option pricing models to the valuation of options on real (that is, nonfinancial) assets. More broadly, the real options approach is a way of thinking that helps managers formulate their strategic options,the future opportunities that are created by today's investments,while considering their likely effect on shareholder value. But if the real options framework promises to link strategy more closely to shareholder value creation, there are some major challenges on the frontier of application. In the first part of this paper, the authors tackle the question, "What is really new about real options, and how does the approach differ from other wellestablished ways to make strategic decisions under uncertainty?" This article provides a specific definition of real options that relies on the ability to track marketpriced risk. Using examples from oil exploration and pharmaceutical drug development, the authors also show how specific features of the industry and the application itself determine the usefulness of the real options approach. The second part of the paper addresses the question: Given the many differences between real and financial options, how should a real options application be framed? The authors examine the use of real options in the valuation of Internet companies to demonstrate the required judgment and tradeoffs in the framing of real options applications. The case of Webvan, an online grocer, is used to illustrate the inter-action between strategy, execution, and valuation. [source] Notification of patients with acute flaccid paralysis since certification of Australia as polio-freeJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 8 2004K Whitfield Objective: Surveillance of patients presenting with acute flaccid paralysis (AFP) is the World Health Organization (WHO) recommended method for the detection of incident cases of poliovirus infection. Australia was certified free of circulating poliovirus in 2000 but is required to continue AFP surveillance until global certification. Although Australia reached the WHO nominated surveillance target in 2000 and 2001, it was not reached in 2002. Notification rates between states have been variable. We aim to investigate the difference in notification rates by state to determine whether different rates reflect different patterns of disease or different approaches to reporting. Methods: Notification rates were reviewed by state for the years 1997,2002. The completeness of case ascertainment was reviewed from published studies. Key informants described differences in AFP reporting in states with consistent differences in notification rates. Results: Australia achieved 75% of the WHO surveillance target for AFP cases between 1997 and 1999 and 98% between 2000 and 2002. After 2000, Queensland achieved 150% of its target while Victoria achieved less than 50%. New South Wales reached its target over the entire 6 years but other states and territories were not as consistent. Although the formal process for AFP reporting is uniform throughout Australia, many differences in approach were identified between Victoria and Queensland. Conclusion: Maintaining AFP surveillance at the required WHO standard will be more likely in Australia if the populous states are able to notify cases at the same rate as Queensland (since 2000) and New South Wales (in general). [source] Effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technologyJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 2 2009Xiaowei Zeng Abstract Objectives We have used microarray technology to detect the effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats. Methods Male Sprague-Dawley rats (180,200 g) were randomly divided into three groups: sham-operated; coronary artery ligation; and coronary artery ligation plus administration of Guanxin No.2 decoction (10.0 g raw materials/kg per day by gavage). The experiment was carried out on day seven after ligation. Key findings We found that the gene expression using microarray technology showed many differences in the border infarcted left ventricular area compared with the remote noninfarcted left ventricular area after administration of Guanxin No.2 decoction. Conclusions Guanxin No.2 decoction has a long history in treating ischaemic cardiomyopathy in China, but the molecular mechanism has been unclear. In this study we found that some important genes may have contributed to the cardioprotective effect of Guanxin No.2 decoction. [source] Theories of Practical ReasonMETAPHILOSOPHY, Issue 4 2002Eric Wiland Leading theories of practical reason can be grouped into one of four families: psychologism, realism, compatibilism, and Aristotelianism. Although there are many differences among the theories within each family, I ignore these in order to ask which family is most likely to deliver a satisfactory philosophical account of reasons for action. I articulate three requirements we should expect any adequate theory of practical reason to meet: it should account for (1) how reasons explain action, (2) how reasons justify action, and (3) how an agent can act for the reason that justifies her action. Only the Aristotelian theory, however, can meet all three requirements. It avoids the problems that plague the other theories by grounding reasons neither in psychological states nor in facts totally independent of the agent in question, but in the nature of the kind of creature the agent is. Our explanations of action need descend to the biographical only when explaining why a human being does not act in ways characteristic of her kind. The Aristotelian view of practical reason, then, appears to be the most promising program for future work. [source] Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometryRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 22 2006Shun-jun Xu Cortex Moutan is a well-known traditional Chinese medicine derived from Paeonia suffruticosa ANDREWS. However, root cortices of P. delavayi and P. decomposita also are used under the name of this drug in some regions such as Yunnan and Sichuan Provinces, respectively. In order to make a comparison of their chemical constituents, the compounds of the three Paeonia species were analyzed by high-performance liquid chromatography-diode array detection/electrospray ionization and quadrupole-time-of-flight tandem mass spectrometry (HPLC-DAD/ESI-MS2). A total of 50 compounds were observed in the 50% (v/v) methanolic extracts, including 17 monoterpenes, 14 galloyl glucoses, 10 acetophenones, 5 phenolic acids, 3 flavonoids and 1 triterpene. These chemical constituents were separated on a C18 column and identified or tentatively characterized based on UV spectra and MS fragmentation behavior. The chemical compositions of the three Paeonia species were found to have many differences. Paeonol was the predominant constituent of P. suffruticosa and P. decomposita, while P. delavayi contained albiflorin and more galloyl glucoses than the other two Paeonia species. Most of these identified compounds have been reported from P. delavayi and P. decomposita for the first time. The ESI-MS fragmentation behavior of monoterpene glycosides, acetophenones and galloyl glucoses was also investigated successively, and appropriate characteristic pathways were proposed. The large differences in chemical compounds among the three Paeonia species strongly encouraged further comparison of the bioactivities of these three species. Copyright © 2006 John Wiley & Sons, Ltd. [source] Altered behaviour in spotted hyenas associated with increased human activityANIMAL CONSERVATION, Issue 3 2003Erin E. Boydston To investigate how anthropogenic activity might affect large carnivores, we studied the behaviour of spotted hyenas (Crocuta crocuta) during two time periods. From 1996 to 1998, we documented the ecological correlates of space utilization patterns exhibited by adult female hyenas defending a territory at the edge of a wildlife reserve in Kenya. Hyenas preferred areas near dense vegetation but appeared to avoid areas containing the greatest abundance of prey, perhaps because these were also the areas of most intensive livestock grazing. We then compared hyena behaviour observed in 1996,98 with that observed several years earlier and found many differences. Female hyenas in 1996,98 were found farther from dens, but closer to dense vegetation and to the edges of their territory, than in 1988,90. Recent females also had larger home ranges, travelled farther between consecutive sightings, and were more nocturnal than in 1988,90. Finally, hyenas occurred in smaller groups in 1996,98 than in 1988,90. We also found several changes in hyena demography between periods. We next attempted to explain differences observed between time periods by testing predictions of hypotheses invoking prey abundance, climate, interactions with lions, tourism and livestock grazing. Our data were consistent with the hypothesis that increased reliance on the reserve for livestock grazing was responsible for observed changes. That behavioural changes were not associated with decreased hyena population density suggests the behavioural plasticity typical of this species may protect it from extinction. [source] Structure and lability of archaeal dehydroquinaseACTA CRYSTALLOGRAPHICA SECTION F (ELECTRONIC), Issue 10 2008Natasha N. Smith Multiple sequence alignments of type I 3-dehydroquinate dehydratases (DQs; EC 4.2.1.10) show that archaeal DQs have shorter helical regions than bacterial orthologs of known structure. To investigate this feature and its relation to thermostability, the structure of the Archaeoglobus fulgidus (Af) DQ dimer was determined at 2.33,Å resolution and its denaturation temperature was measured in vitro by circular dichroism (CD) and differential scanning calorimetry (DSC). This structure, a P212121 crystal form with two 45,kDa dimers in the asymmetric unit, is the first structural representative of an archaeal DQ. Denaturation occurs at 343 ± 3,K at both low and high ionic strength and at 349,K in the presence of the substrate analog tartrate. Since the growth optimum of the organism is 356,K, this implies that the protein maintains its folded state through the participation of additional factors in vivo. The (,,)8 fold is compared with those of two previously determined type I DQ structures, both bacterial (Salmonella and Staphylococcus), which had sequence identities of ,30% with AfDQ. Although the overall folds are the same, there are many differences in secondary structure and ionic features; the archaeal protein has over twice as many salt links per residue. The archaeal DQ is smaller than its bacterial counterparts and lower in regular secondary structure, with its eight helices being an average of one turn shorter. In particular, two of the eight normally helical regions (the exterior of the barrel) are mostly nonhelical in AfDQ, each having only a single turn of 310 -helix flanked by ,-strand and coil. These `protohelices' are unique among evolutionarily close members of the (,,)8 -fold superfamily. Structural features that may contribute to stability, in particular ionic factors, are examined and the implications of having a Tm below the organism's growth temperature are considered. [source] | |||||||||||||||||||