Home  About us  Contact
 

Mannich Reaction (mannich + reaction)

Distribution by Scientific Domains
Chemistry100%
Distribution within Chemistry
Organic Chemistry80%
General & Introductory Chemistry14%
2 Other Subdomains6%

Kinds of Mannich Reaction

  • asymmetric mannich reaction
    		•
  • enantioselective mannich reaction
    		•

    Selected Abstracts

    Effect of Varying the Anionic Component of a Copper(I) Catalyst on Homologation of Arylacetylenes to Allenes by the Mannich Reaction

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 1 2008
    Vipan Kumar
    Abstract The effect of varying the anionic component of a copper(I) catalyst in the homologation of terminal arylacetylenes to allenes by the Mannich reaction was investigated. Varying amounts of allenes, Mannich bases and dimers were obtained depending on the nature of the anionic component of the copper catalyst. On the other hand, Eglinton,Glaser dimerizations were achieved in high yields with 0.5 equiv. of triethylamine. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

    Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N -Tosylimines using Copper(I)/TF-BiphamPhos Complex

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
    Gang Liang
    Abstract The direct asymmetric Mannich reaction of glycine Schiff bases with N -tosylimines has been developed with the tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH3CN)4BF4]/TF-BiphamPhos complex. This catalytic system performs well over a broad range of substrates, furnishing anti -adducts of various ,,,-diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity. [source]

    Axially Chiral Phosphine-Oxazoline Ligands in Silver(I)- Catalyzed Asymmetric Mannich Reaction of Aldimines with Trimethylsiloxyfuran

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 17 2009
    Hong-Ping Deng
    Abstract A new asymmetric catalytic system for the Mannich reaction of aldimines with trimethylsiloxyfuran is described. The combination of an axially chiral phosphine-oxazoline ligand (S)-2-[(R)-2,-(diphenylphosphino)-1,1,-binaphthyl-2-yl]-4-phenyl-4,5-dihydrooxazole with silver acetate and 2,2,2-trifluoroacetic acid is a very effective catalytic system in the asymmetric Mannich reaction of various aldimines with trimethylsiloxyfuran in dichloromethane at ,78,°C, affording the corresponding adducts in up to 99% yield, 99:1 (dr) and 99% ee (major diastereoisomer) under mild conditions. [source]

    Asymmetric Synthesis of ,,,-Diaminophosphonic Acid Derivatives with a Catalytic Enantioselective Mannich Reaction

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 14-15 2009
    Robert Djiokeng Momo
    Abstract Optically active ,,,-diaminophosphonic acid derivatives were obtained from the catalytic enantioselective Mannich reaction of phosphoglycine Schiff bases with N -Boc-imines, generated in situ from ,-amido sulfones. [source]

    Phase-Transfer-Catalyzed Enantioselective Mannich Reaction of Malonates with ,-Amido Sulfones

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 15 2006
    Francesco Fini
    Abstract The highly enantioselective reaction between in situ generated, Cbz-protected azomethines and malonates in the presence of 150 mol,% of potassium carbonate (50,% w/w) and 1 mol,% of quinine-derived quaternary ammonium bromides as phase-transfer organocatalysts has been developed. This study reports a novel approach for the asymmetric Mannich-type reaction and a wide range of azomethines, including those derived from enolizable aldehydes, is tolerated by the present system. The adducts, obtained in excellent yields with ee up to 98,%, are suitable precursors of optically pure ,-amino acids. [source]

    Asymmetric Mannich Reaction of Fluorinated Ketoesters with a Tryptophan-Derived Bifunctional Thiourea Catalyst,

    ANGEWANDTE CHEMIE, Issue 41 2009
    Xiao Han
    Fluorierte quartäre Stereozentren: Der neuartige difunktionelle Katalysator 1, der von natürlichem Tryptophan abgeleitet ist, vermittelt die hoch enantioselektive Mannich-Reaktion von ,-Fluor-,-ketoestern zu fluorierten chiralen Molekülen mit vicinalen quartären und tertiären stereogenen Zentren. Ein ungewöhnliches ,-Fluor-,-lactam wurde ebenfalls mit dieser Methode synthetisiert (siehe Schema; Boc=tert -Butoxycarbonyl). [source]

    ChemInform Abstract: The Broensted Acid Catalyzed, Enantioselective Vinylogous Mannich Reaction.

    CHEMINFORM, Issue 26 2010
    Marcel Sickert
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Dual Organocatalytic Ion-Pair Assemblies: A Highly Efficient Approach for the Enantioselective Oxa-Michael,Mannich Reaction of Salicylic Aldehydes with Cyclohexenones.

    CHEMINFORM, Issue 21 2010
    Ai-Bao Xia
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: A Novel Construction of 2-Benzazepine Scaffold Based on TiCl4 -Mediated Tandem Mannich Reaction , Aromatic Electrophilic Substitution.

    CHEMINFORM, Issue 18 2010
    Liangxi Li
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Lipase-Catalyzed Direct Mannich Reaction in Water: Utilization of Biocatalytic Promiscuity for C,C Bond Formation in a "One-Pot" Synthesis.

    CHEMINFORM, Issue 45 2009
    Kun Li
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: A New Mild Base-Catalyzed Mannich Reaction of Hetero-Arylamines in Water: Highly Efficient Stereoselective Synthesis of ,-Aminoketones under Microwave Heating.

    CHEMINFORM, Issue 33 2009
    Wen-Juan Hao
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Microwave-Assisted Mannich Reaction of 2-Hydroxy-chalcones.

    CHEMINFORM, Issue 32 2009
    Xiaowu Dong
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Broensted Acid Catalyzed, Enantioselective, Vinylogous Mannich Reaction of Vinylketene Silyl N,O-Acetals.

    CHEMINFORM, Issue 6 2009
    David S. Giera
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Carbohydrate-Based Tolylsulfonyl Hydrazines: Effective Catalysts for the Mannich Reaction and the Syntheses of Bisindolylalkanes in Water.

    CHEMINFORM, Issue 40 2008
    Peng Wu
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Asymmetric Mannich Reaction of Dicarbonyl Compounds with ,-Amido Sulfones Catalyzed by Cinchona Alkaloids and Synthesis of Chiral Dihydropyrimidones.

    CHEMINFORM, Issue 18 2008
    Sha Lou
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Specific Example of the Mannich Reaction in the Series of 5-Acetyl-6-aminoacenaphthene and Its Derivatives.

    CHEMINFORM, Issue 3 2008
    A. N. Antonov
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    Eco-Friendly Synthesis of Novel Lariat Ethers via Mannich Reaction under Solventless Conditions.

    CHEMINFORM, Issue 44 2007
    Hashem Sharghi
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    A Facile Solvent-Free One-Pot Three-Component Mannich Reaction of Aldehydes, Amines and Terminal Alkynes Catalyzed by CuCl2.

    CHEMINFORM, Issue 36 2007
    Ali Sharifi
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    An Enantioselective Broensted Acid-Catalyzed Enamine Mannich Reaction.

    CHEMINFORM, Issue 27 2007
    A Louise Tillman
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Covert Mannich Reaction via Carbon Transfer.

    CHEMINFORM, Issue 14 2007
    Huan Gu
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Direct-Type Catalytic Three-Component Mannich Reaction in Aqueous Media.

    CHEMINFORM, Issue 9 2007
    Thierry Ollevier
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Highly Efficient One-Pot Three-Component Mannich Reaction in Water Catalyzed by Heteropoly Acids.

    CHEMINFORM, Issue 37 2006
    Najmodin Azizi
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Microwave-Assisted, Solvent-Free Synthesis of 1-(,- or ,-Hydroxynaphthyl)-1,2,3,4-tetrahydroisoquinolines by the Mannich Reaction.

    CHEMINFORM, Issue 36 2006
    Istvan Szatmari
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    The Stereoselective Synthesis of ,-Substituted ,-Amino Secondary Alcohols Based on the Proline-Mediated, Asymmetric, Three-Component Mannich Reaction and Its Application to the Formal Total Synthesis of Nikkomycins B and Bx.

    CHEMINFORM, Issue 12 2006
    Yujiro Hayashi
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Synthesis of Pentafluorophenylmethylamines via Silicon Mannich Reaction.

    CHEMINFORM, Issue 45 2005
    Alexander D. Dilman
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Synthesis of Chiral Vicinal Diamines by Highly Diastereoselective Three-Component Phenolic Mannich Reaction: Temperature-Dependent Stereodivergency.

    CHEMINFORM, Issue 37 2005
    Christophe Rondot
    No abstract is available for this article. [source]

    ChemInform Abstract: Novel Triheterocyclic Systems by Mannich Reaction on 3-Arylsydnones: Synthesis of 3-Aryl-4-[2,-(8,,-hydroxy-7,,-quinolinylmethylamino)-thiazol-4,-yl] sydnones and 3-Aryl-4-[2,-(3,,-acetyl-2,,-hydroxybenzylamino)-thiazol-4,-yl]sydnones as Possible Antimicrobial Agents.

    CHEMINFORM, Issue 50 2001
    Shanta G. Mallur
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Asymmetric Synthesis of ,-Substituted ,-Methyl-,-amino Esters by Mannich Reaction of (S,S)-(+)-Pseudoephedrine Acetamide Derived Enolate with Imines.

    CHEMINFORM, Issue 27 2001
    Jose L. Vicario
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Intramolecular Mannich Reaction for Synthesis of Imidazo-[2,1-b]-1,3,5-thiadiazines and 1,2,4-Triazino[3,2,b]-1,3,5-thiadiazines.

    CHEMINFORM, Issue 6 2001
    Zeinab A. Hozien
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    Theoretical Study on the Mechanism of the Petasis-type Boronic Mannich Reaction of Organoboronic Acids, Amines, and , -Hydroxy Aldehydes

    CHINESE JOURNAL OF CHEMISTRY, Issue 1 2010
    Jingcong Tao
    Abstract The mechanism of a typical Petasis-type boronic mannich reaction (the styrylboronic acid, dibenzylamine, and , -hydroxylpropionaldehyde) has been investigated using density functional theory calculations. According to our calculations, the reaction is most likely to proceed through the following steps: 1) the nucleophilic addition of the amine to the aldehyde to form the carbinolamine; 2) the dehydration of the carbinolamine; 3) the formation of the tetra-coordinated borate intermediate; 4) the CC bond formation by the intramolecular transfer of the styryl group; 5) the hydrolysis of the resulting intermediate to give the final products. The highest point on the energy profile is the transition state for the CC bond formation (118.8 kJ·mol,1 above the reactants in ethanol). Our results can give reasonable explanations on some experimental facts observed for many Petasis-type boronic Mannich reactions. [source]