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Selected AbstractsAdvancing Firm Growth Research: A Focus on Growth Mode Instead of Growth RateENTREPRENEURSHIP THEORY AND PRACTICE, Issue 2 2010Alexander McKelvie The development of firm growth research has been notably slow. In this paper, we argue that a major reason for this lack of development is the impatience of researchers to prematurely address the question of "how much?" before adequately providing answers to the question "how?" On the basis of an extensive review of the literature, we suggest how growth research can advance by changing focus to growth mode (organic, acquisition, hybrid). Toward this end, we provide a research agenda that helps establish the types of questions that growth researchers can ask within this new focus. [source] The issue of gender within computing: reflections from the UK and ScandinaviaINFORMATION SYSTEMS JOURNAL, Issue 2 2001Maxine Robertson Abstract. Thispaper explores some of the reasons that may underlie the gender segregation and declining levels of female participation within the field of computing in Europe during the 1990s in both the professional (industrial) and academic spheres. The interrelationships between three areas , communicative processes, social networks and legitimizing claims to knowledge overlaid by gendered-power relations , are used to analyse and explain the existing situation. The paper draws upon statistical data to explore the extent of gender segregation and then focuses on the authors' own experiences within the UK and Scandinavia in order to explore some of the underlying causes. While direct discrimination does still occur, the paper suggests that indirect, deep-rooted discrimination is the major reason for the situation that currently exists. Drawing upon our own experiences in academia and business and acknowledging the importance of the institutional context, the paper offers a number of recommendations as to how the current situation may be improved. We suggest first that consideration is given to the pedagogical design and marketing of computing courses so that individuals are initially attracted to computing from far more diverse backgrounds, approaches and interests than at present. Second, we suggest that those with influence in the field reflect upon the constitution and behaviours of the informal networks in which they are involved and seek to include female researchers more actively here. Finally we suggest that consideration is given in more general terms to how the field may become more gender neutral and, thus, more inclusive in the future. Masculine discourses and ,hard' skills have dominated within computing for too long and contribute significantly to the declining participation of women within computing. [source] Mobbing against nurses in the workplace in TurkeyINTERNATIONAL NURSING REVIEW, Issue 3 2010S.Y. Efe msn EFE S.Y. & AYAZ S. (2010) Mobbing against nurses in the workplace in Turkey. International Nursing Review57, 328,334 Aim:, The aim of the study was to determine whether the nurses have been exposed to mobbing or not, and to reveal the causes of the mobbing between 3 November 2008 and 31 December 2008. Methods:, This research was a mixed method study involving survey and focus group interviews. The sample was calculated using sample calculation formula, and 206 nurses were included in the survey study. Four focus group interviews were later carried out with 16 nurses. The survey method and semi-structured question form were used to collect data. The percentage and chi-square were used to evaluate the quantitative data, and for the analysis of the qualitative data, descriptive analyses were made through direct quotations from the nurses' statements. Findings:, According to the mobbing scale, 9.7% of the nurses had been exposed to mobbing, but according to their own declarations, 33% had been exposed. Some of the nurses (25.2%) who expressed that they had been exposed to mobbing reported that the executor of mobbing was the head nurse and 9.2% said that the reason for mobbing was ,communication problems'. Nurses under 25 years of age and those who work in intensive care units are apparently exposed to mobbing more frequently than others (P < 0.05). Conclusions:, It is suggested that head nurses' mobbing behaviours should be determined and they should be educated about leadership. Nurses should be educated about assertiveness to prevent mobbing. The necessary measures should be adopted to solve the ,communication problems', which are shown as a major reason for mobbing. [source] Perceived support from healthcare practitioners among adults with type 2 diabetesJOURNAL OF ADVANCED NURSING, Issue 7 2010Bjørg Oftedal oftedal b., karlsen b. & bru e. (2010) Perceived support from healthcare practitioners among adults with type 2 diabetes. Journal of Advanced Nursing,66(7), 1500,1509. Abstract Title.,Perceived support from healthcare practitioners among adults with type 2 diabetes. Aim., This paper is a report of a study of how adults with type 2 diabetes perceive different attributes of support provided by healthcare practitioners and how various attributes of support can influence people's motivation to self-manage their disease. Background., Motivational problems seem to be a major reason for poor diabetes management. According to well-known theories of motivation, expectations of being able to perform certain behaviours are a key element. Different attributes of support from healthcare practitioners are likely to influence such expectations. To date, no researchers have specifically examined how people with type 2 diabetes perceive different attributes of support from healthcare practitioners and how these may influence their motivation to manage their disease themselves. Methods., A descriptive/explorative qualitative design and focus groups were used to collect data. The sample consisted of 19 adults with type 2 diabetes, and the data were collected in 2007 and analysed using qualitative content analysis. Findings., Five themes were identified, reflecting perceived attributes of support from healthcare practitioners: (1) an empathetic approach, (2) practical advice and information, (3) involvement in decision-making, (4) accurate and individualized information and (5) ongoing group-based support. Conclusion., Healthcare practitioners may strengthen the self-management motivation among adults with type 2 diabetes by enhancing expectations of being able to perform the necessary diabetes care, and through the provision of empathetic, individualized, practical and ongoing group-based support. [source] Agricultural Land in Vietnam: Markets Tempered by Family, Community and Socialist PracticesJOURNAL OF AGRARIAN CHANGE, Issue 3 2006BENEDICT J. TRIA KERKVLIET Since the late 1980s, markets involving agricultural land have emerged in the Socialist Republic of Vietnam. One major reason is that collective farms, previously a central feature of the country's political economy, ended. And a major reason for that was villagers' everyday politics gnawed the underpinnings of the collectives until they collapsed. Rural households, for the most part, wanted to farm separately. Today they do. Land is not privatized, however. Farming households have land use rights, not ownership. This tempers markets, as do other conditions arising from contending schools of thought in Vietnam about how land should be used, distributed and regulated. [source] The uptake of applied ecologyJOURNAL OF APPLIED ECOLOGY, Issue 1 2002S. J. Ormerod Summary 1We asked 229 authors who have published recently in the Journal of Applied Ecology (1999,2001) whether their papers made management or policy recommendations and whether they had evidence of consequent uptake. 2A total of 108 respondents working in the UK (34%), Europe (30%), the Americas (12%), Australasia (11%), Asia (7%) and Africa (6%) reported on 110 papers. They represented agro-ecosystems (35%), temperate forests or woodlands (16%), savanna, grass or arid lands (11%), rivers or wetlands (10%), estuaries or marine systems (7%) and tropical forests (5%). The major organisms were invertebrates (27%), birds (24%), mammals (21%) and higher plants (21%). Topics apparently under-represented in recent coverage include ecosystem science, urban areas, soils, mountain systems, fish, amphibians and lower organisms such as algae. 3Almost all papers (99%) carried recommendations and for 57% there was evidence of uptake in the broad categories of ,environmental management or models', ,information, training and education' and ,monitoring and assessment'. Most uptake involved large geographical scales through habitat or species management plans (32% of cases), effects on reserve design or designation (6%), and effects on agri-environmental policy (5%). The development of further research (11%), the communication of methods to other ecologists (9%), the dissemination of recommendations to practitioners or agencies (7%), and uptake in training or education (5%) were important uses of information. 4Prestige from publication in the Journal of Applied Ecology aided several authors in convincing end-users of research value. User involvement in research as participants or funders was widespread (> 42% of papers), a fact which almost certainly promotes uptake along with the parallel dissemination of management messages. We view applied issues as an important interface between end-users and ecologists of value to ,both' communities but suggest that improved communication will further benefit the sponsorship and application of ecological science. 5The major reason offered for lack of uptake was that it was still too soon after publication (21% of respondents). Costs, difficulty of implementation, the scale of the problem, and ,challenges to existing thinking' each figured in more than one response. 6For some respondents, papers were led by curiosity rather than the need for direct application. Several authors published in the Journal to share ideas internationally, or said that recommendations were general, conceptual or long-term rather than specific. The editors of the Journal of Applied Ecology recognize the seminal importance of contributions that affect policy incrementally and conceptually as much as those with specific application. 7These data provide evidence that ecological science is aiding environmental management and policy across a wide range of regions, ecosystems and types of organisms; rather than merely detecting problems, applied ecology is offering solutions both directly and more diffusely through conceptual advance. We invite the user community to offer their own perspectives about the value of research-led publications such as this Journal, about how links between researchers and users might be strengthened, and about how the uptake of applied ecology might be further advanced. [source] Is local provenance important in habitat creation?JOURNAL OF APPLIED ECOLOGY, Issue 6 2001David M. Wilkinson Summary 1Many habitat creation schemes specify that biological material of local provenance should be used in reintroductions. This has come to be the ,text book' approach. However, very little discussion of the theory underlying this idea has been published in the scientific literature. This paper aims to initiate this much-needed discussion. 2A major reason for the use of local provenance is the claimed importance of conserving locally adapted genotypes, which are assumed to show high fitness. Using both genetic arguments and a consideration of Quaternary environmental change I argue that this reason will seldom be important. 3I make tentative suggestions of when local provenance is likely to be important and when it can be given a low priority in habitat creation schemes. [source] Effect of trehalose on survival of Bradyrhizobium japonicum during desiccationJOURNAL OF APPLIED MICROBIOLOGY, Issue 3 2003J.G. Streeter Abstract Aims: A major reason for the ineffectiveness of legume inoculants in the field is the rapid death of rhizobia because of desiccation. The major purpose of this study was to identify conditions under which ,,, -trehalose would improve survival of Bradyrhizobium japonicum during desiccation. Methods and Results: Trehalose was added to cultures just prior to desiccation or was supplied to bacteria during the 6-day growth period. A wide variety of trehalose concentrations was tested. Trehalose added to cultures at the time of desiccation improved survival slightly, but trehalose loading during growth was much more effective in protection against desiccation. Growth of bacteria with 3 mmol l,1 trehalose increased trehalose concentration in cells by about threefold and increased survival of cells placed on soya bean [Glycine max (L.) Merr.] seeds by two- to four-fold after 2 or 24 h. Average of overall results indicate that growth of bacteria with trehalose in the medium resulted in a 294% increase in survival after 24 h of desiccation. The concentration of trehalose in cells was very highly correlated with survival of bacteria. When trehalose-loaded cells were suspended in buffer or water, 60,85% of cellular trehalose was lost in about 1 h and, in spite of these losses, survival during desiccation was not reduced. Conclusions: Accumulation of trehalose in the cytoplasm is critical to the survival of B. japonicum during desiccation. Increasing the periplasmic concentration of trehalose is also beneficial but is not so critical as the concentration of trehalose in the cytoplasm. Because B. japonicum cannot utilize trehalose as a carbon source, cells can be loaded with trehalose by providing the disaccharide during the growth period. Significance and Impact of the Study: Although it may not be practical to use trehalose as a carbon source in inoculant production, it may be possible to engineer greater trehalose accumulation in rhizobia. Trehalose concentration in cells should be a useful predictor of survival during desiccation. [source] EFFECTS of THERMAL TREATMENTS ON TEXTURE of SOY PROTEIN ISOLATE TOFUJOURNAL OF FOOD PROCESSING AND PRESERVATION, Issue 4 2000LEE KAH HUI Effects of three thermal treatments; boiling at 100C and retorting at 110 and 121C, on texture of soy protein isolate tofu were studied for a range of heating times. Retorted tofu showed a shrinkage of 18,25% of its original size and a loss of 6,12% of its original moisture. Tofu processed at high temperatures and long heating times developed higher values of texture profile parameters than tofu processed at lower temperature and shorter heating times. the thermal treatment of tofu at elevated conditions also caused an increase in sensory hardness and a decrease in moistness and overall acceptability of the tofu. the increase in texture profile values appeared to be mirrored by a decrease in protein solubility in 1% sodium dodecyl sulfate solvent and a reduction in moisture content of the tofu. the formation of disulfides linkages at elevated temperatures and during heating at 100C stabilized protein aggregates that were initially formed by hydrophobic interactions. Formation of the disulfides and shrinkage of tofu as a result of moisture loss were suggested as the major reason for decreased sensory values of thermally processed soy protein isolate tofu. [source] Diffuse In-Stent RestenosisJOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 6 2001HANS STÖRGER M.D. Stent restenosis, especially the diffuse pattern, has developed into a significant clinical and economical problem. It has been estimated that up to 250,000 patients developed in-stent restenosis in 2,000 alone, two thirds of them can be expected to have diffuse in-stent restenosis, which is difficult to treat because of high recurrence rates. None of the conventionally available interventional treatment modalities provides optimal long-term results. Intravascular radiation therapy is currently the only effective percutaneous therapy, for combating in-stent restenosis. Late thrombotic complications have largely been eliminated by extended antiplatelet regimens. Geographical miss, a major reason for recurrence of in-stent restenosis after brachytherapy, can be reduced by an improved radiation technique. The first preliminary data on drug-eluting stents, showing only minimal neointimal proliferation at 6-month postimplantation, could represent a major breakthrough in the quest to solve restenosis. [source] WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence: Analysis of Demographic, Behavioral, Physiologic, and Drinking Variables That Contribute to Dependence and Seeking TreatmentALCOHOLISM, Issue 7 2002Jason Glanz Background Discussions between the World Health Organization (WHO) and the International Society on Biomedical Research on Alcoholism (ISBRA) identified the need for a multiple-center international study on state and trait markers of alcohol abuse and alcohol dependence. The reasoning behind the generation of such a project included the need to understand the alcohol use characteristics of diverse populations and the performance of biological markers of alcohol use in a variety of settings throughout the world. A second major reason for initiating this study was to collect DNA for well-structured and stratified association studies between genetic markers and/or "candidate" genes and behavioral/physiological phenotypes of importance to predisposition to alcohol dependence. Methods An extensive interview instrument was developed with leadership from the U.S. National Institute on Alcohol Abuse and Alcoholism (NIAAA). The instrument was translated from English to Finnish, French, German, Japanese, and Portuguese (Brazilian). One thousand eight hundred sixty-three subjects were recruited at five clinical centers (Montreal, Canada; Helsinki, Finland; Sapporo, Japan; São Paulo, Brazil; and Sydney, Australia). The subjects responded to the structured interview and provided blood and urine samples for biochemical analysis. This article focuses on the demographic characteristics of the study subjects, their drinking habits, alcohol-dependence characteristics, comorbid psychiatric and other drug variables, and predictors for seeking treatment for alcohol dependence. Multiple logistic regression models were constructed and used to explore variables that contribute to various levels of alcohol consumption, to a diagnosis of alcohol dependence, and to seeking treatment for alcohol dependence. ANOVA with post hoc comparisons, ,2, and Pearson moment calculations were used as necessary to assess additional relationships between variables. Results A number of factors previously noted in disparate studies were confirmed in our analysis. Men consumed more alcohol than women, Asians consumed less alcohol than whites or Blacks, alcohol-dependent subjects consumed more alcohol than nondependent subjects, alcohol consumption increased with age, and an increased level of education (university or postgraduate education) reduced the percentage of such individuals in the category designated as heavy drinkers (>210 g alcohol/week) and in the group who were currently in treatment for dependence. However, our analysis allowed for much more detailed comparisons; for example, although men drank more than women on a g/day basis, the differences were less pronounced on g/kg/day basis, and alcohol-dependent women drank equal amounts of alcohol as alcohol-dependent men on a g/kg/day basis. Antisocial personality characteristics or reports of trouble sleeping when an individual stops drinking were associated with higher alcohol intake. The most important of the tested factors that contributed to a DSM-IV diagnosis of dependence, however, was the report of anxiety if an individual stopped drinking. In terms of the various criteria within the DSM-IV criteria for alcohol dependence, no one criterion seemed to be prominent for individuals who sought alcohol dependence treatment, but the higher the number of criteria met by the individual, the higher was the probability that he or she would be in treatment. Conclusions This initial report is the beginning of the "data mining" of this rich data set. The cross-national/cross-cultural aspects of this study allowed for multiple comparisons of variables across several ethnic/racial groups and allowed for assessment of biochemical markers for alcohol intake and predisposition to alcohol dependence in diverse settings. [source] Educational Neuroscience: Defining a New Discipline for the Study of Mental RepresentationsMIND, BRAIN, AND EDUCATION, Issue 3 2007Dénes Sz ABSTRACT, Is educational neuroscience a "bridge too far"? Here, we argue against this negative assessment. We suggest that one major reason for skepticism within the educational community has been the inadequate definition of the potential role and use of neuroscience research in education. Here, we offer a provisional definition for the emerging discipline of educational neuroscience as the study of the development of mental representations. We define mental representations in terms of neural activity in the brain. We argue that there is a fundamental difference between doing educational neuroscience and using neuroscience research results to inform education. While current neuroscience research results do not translate into direct classroom applications, educational neuroscience can expand our knowledge about learning, for example, by tracking the normative development of mental representations. We illustrate this briefly via mathematical educational neuroscience. Current capabilities and limitations of neuroscience research methods are also considered. [source] Management Strategies for Complex Adaptive Systems Sensemaking, Learning, and ImprovisationPERFORMANCE IMPROVEMENT QUARTERLY, Issue 2 2007Reuben R. McDaniel Jr. Misspecification of the nature of organizations may be a major reason for difficulty in achieving performance improvement. Organizations are often viewed as machine-like, but complexity science suggests that organizations should be viewed as complex adaptive systems. I identify the characteristics of complex adaptive systems and give examples of management errors that may be made when these characteristics are ignored. Command, control and planning are presented as managerial tasks that come to the fore when a machine view of organizations dominates thinking. When we treat organizations as complex adaptive systems the focus of managerial activity changes, and sensemaking, learning and improvisation become appropriate strategies for performance improvement. Each of these is defined and described. A modest research agenda is presented. [source] State Abortion Policy and the Long-Term Impact of Parental Involvement LawsPOLITICS & POLICY, Issue 2 2010MARSHALL H. MEDOFF This paper presents empirical evidence that the enactment of parental involvement laws by states is a major reason for the steady decline in the incidence of abortion that has occurred in the United States since 1981. Parental involvement laws reduced the likelihood of teen minor females (under 18 years of age) having unwanted pregnancies by altering their frequency of unprotected sexual activity or contraceptive use. This change in teen minors' pregnancy avoidance behavior is found to be perpetuated over adult women's childbearing span of 18-44 years of age. Parental involvement laws are estimated to account for approximately one-third of the decline in the abortion rates of adult women of childbearing age over the period 1982-2000. The empirical results remain robust even after controlling for outliers, interstate migration, regional effects, and the presence of a waiting period. Este artículo presenta evidencia empírica de que la promulgación, al nivel de entidades federativas, de leyes de involucramiento de los padres, es una razón importante para la continua disminución en la incidencia de abortos que ha ocurrido en los Estados Unidos desde 1981. Estas leyes llamadas "Parental Involvement Laws" redujeron la incidencia de embarazos entre menores adolescentes (con menos de 18 años de edad) al disminuir la frecuencia de la actividad sexual no protegida de las mismas. Este cambio en el comportamiento en la prevención del embarazo en las menores adolescentes es perpetuada en mujeres adultas en edad fértil de los 18 a los 44 años de edad. Se estima que dichas leyes son la causa de aproximadamente 1/3 de la disminución en los índices de aborto entre mujeres adultas en edad fértil en el periodo de 1982-2000. Los resultados empíricos se mantienen robustos aun después de controlar los valores atípicos, la migración entre estados, efectos regionales, y la presencia de un periodo de espera. [source] Can We Increase the Estimative Value of Semen Assessment?*REPRODUCTION IN DOMESTIC ANIMALS, Issue 2006H Rodríguez-Martínez Contents Estimating the fertility of a semen sample or of the male from where it has been collected by simple assessment of in vitro sperm characteristics is still difficult, owing to the variable correlations that laboratory results achieve with in vivo fertility. A major reason behind these variations is the fact that the ejaculate and the artificial insemination (AI)-doses it generates are composed of a diverse sperm population. Such heterogeneity is reflected both in differences of intactness of attributes needed for fertilization, such as motility or morphology, but also in the relative ability of spermatozoa to prevail fertile over time, handling and exposure to different stimuli, all of which account for innate variations in fertilizing ability among doses, ejaculates and sires. However, methods are already available to select sub-populations of intact spermatozoa which can be tested for their degree of competence for fertilization and whose estimative power is promising, allowing the elimination of cases of sub-fertility, particularly in bovine. Examples of these methods are the separation of viable spermatozoa by swim-up or discontinuous gradient centrifugation, followed by testing the ability of the selected spermatozoa to dose-response/time sustain capacitation and acrosome reaction induction. Finding how large a sperm population with non-compensable attributes for fertilization and ability to display and sustain stimuli is, perhaps by a quick screening of membrane integrity and stability by multi-parametric methods, would allow, provided the particular male produces this sub-population in a repeatable manner, for a better estimation of fertility. [source] Poverty Intensity in AustraliaTHE AUSTRALIAN ECONOMIC REVIEW, Issue 3 2000J. R. Rodgers Even though poverty indices with axiomatically sound properties have been advocated for several decades, most empirical studies of poverty in Australia and elsewhere continue to use the crude, but easily understood, head-count ratio. The difficulty of interpreting the axiomatically more desirable indices is a major reason why their use has been resisted in applied poverty measurement. This paper demonstrates how the more sophisticated poverty indices can be converted into a form that is readily interpreted as a measure of poverty intensity of a group, relative to the population to which the group belongs. The resulting poverty-intensity index is easy to understand and it retains the axiomatic properties of the poverty index on which it is based. We apply the method to Australian data. Poverty measures reported previously in the literature are converted into measures of poverty intensity and interpreted accordingly. We also calculate and interpret some new measures of poverty and poverty intensity using the 1996,97 Income and Housing Costs Survey, Australia (Australian Bureau of Statistics 1997). It is hoped our procedure will lead to wider use of poverty indices that are theoretically superior to the head-count ratio. [source] Treatment of autoimmune ovarian disease by co-administration with mouse zona pellucida protein 3 and DNA vaccine through induction of adaptive regulatory T cellsTHE JOURNAL OF GENE MEDICINE, Issue 7 2008Jinyao Li Abstract Background Autoimmune ovarian disease (AOD) caused by auto-reactive T cells is considered a major reason for human premature ovarian failure, which affects 5% of women worldwide. Methods and Results To develop an effective treatment for AOD, we showed that the co-administration of mouse zona pellucida protein 3 (mZP3) protein and DNA vaccine encoding the mZP3 was able to meliorate AOD in an AOD murine model induced by the mZP3. We observed that established AOD in mice reverted to a normal ovarian morphology without notable T-cell infiltration in the co-administrated group; whereas mice in the control groups developed severe AOD. The amelioration appears to be antigen specific because other co-administration combinations failed to reverse AOD and correlates with significant reductions of pathogenic T-cell responses and productions of tumor necrosis factor-, and interferon-,. Furthermore, the melioration is apparently associated with the induction of mZP3 specific regulatory T cells that exhibit a phenotypic CD4+CD25,FoxP3+IL-10+ in the co-administrated group, which can be transferred to reverse AOD in vivo. Conclusions Thus, co-administration of mZP3 DNA and protein vaccines can be used to treat established AOD, and may provide a novel immunotherapy strategy to treat other autoimmune diseases. Copyright © 2008 John Wiley & Sons, Ltd. [source] Pond-to-pond variability in post-larval shrimp, Litopenaeus vannamei, survival and growth in inland low-salinity waters of west AlabamaAQUACULTURE RESEARCH, Issue 16 2009Luke A Roy Abstract Despite the recent success of Alabama shrimp farmers in culturing the Pacific white shrimp, Litopenaeus vannamei, in inland low-salinity waters there is large variability in growth and survival among ponds. Farmers suspect that high mortality occurs during the first weeks of culture following stocking of postlarvae (PL). In order to determine the effect of pond ionic composition on PL growth and survival, three trials were carried out at a shrimp farm. Trials 1 and 2 evaluated PL growth and survival over 21- and 28-day periods, respectively, using static water from different production ponds. Trial 3 evaluated growth and survival over 7, 14, 21 and 28 days using water from one production pond. Results suggest that initial mortality (8,10%) is attributed to the acclimation process and occurs immediately following stocking. Pond-to-pond variations in ionic profiles could be a contributing factor but are not likely the major reason for variable ,survival'. Mortalities after stocking appear to occur quickly as there were no differences in survival from 7 to 28 days post stock. Variable survival is likely due to a combination of reasons including environmental factors, but is largely due to poor handling of PL and stocking errors that produce perceived reductions in survival. [source] Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endotheliumBIOFACTORS, Issue 1 2009John X. Wilson Abstract Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. In animal models of sepsis, intravenous ascorbate injection increases survival and protects several microvascular functions, namely, capillary blood flow, microvascular permeability barrier, and arteriolar responsiveness to vasoconstrictors and vasodilators. The effects of parenteral ascorbate on microvascular function are both rapid and persistent. Ascorbate quickly accumulates in microvascular endothelial cells, scavenges reactive oxygen species, and acts through tetrahydrobiopterin to stimulate nitric oxide production by endothelial nitric oxide synthase. A major reason for the long duration of the improvement in microvascular function is that cells retain high levels of ascorbate, which alter redox-sensitive signaling pathways to diminish septic induction of NADPH oxidase and inducible nitric oxide synthase. These observations are consistent with the hypothesis that microvascular function in sepsis may be improved by parenteral administration of ascorbate as an adjuvant therapy. © 2009 International Union of Biochemistry and Molecular Biology, Inc. [source] On Strategy and Management Control: The Importance of Classifying the Strategy of the BusinessBRITISH JOURNAL OF MANAGEMENT, Issue 3 2000Magnus Kald The point of departure for this paper is a number of contingency-theory studies on the relationship between business strategy and the design and use of management control. In these studies strategy has been operationalized in different ways , a major reason why the findings are ambiguous and difficult to integrate. Thus there is a strong need for a common frame of reference for classifying business strategy. In view of the multifaceted nature of the concept of strategy, however, it is neither desirable nor possible to arrive at a single method of classification that would be appropriate in all situations. Rather, the task is to integrate different strategic variables such as strategic pattern, strategic position and strategic mission. In this paper we show how these three variables may be assumed to influence, and be influenced by, what characterizes changes in strategy and how business units manage their product offerings. Unlike most previous studies in the field, this paper discusses how the strategic variables taken together may be assumed to influence the classification of strategy and thus the design and use of the management-control system. Our deductive analysis, and the hypotheses used in connection with it, show that studies which consider only one strategic variable may lead to erroneous conclusions about the relationship between strategy and management control. [source] Reproducibility of Diagnosis and Its Influence on the Distribution of Lung Cancer by Histologic Type in Osaka, JapanCANCER SCIENCE, Issue 1 2000Seiichiro Yamamoto The histologic types of lung cancer cases diagnosed in 1979,1980 (n=799) and 1987 (n=587) were independently reviewed by two pathologists in order to investigate the reproducibility of the diagnosis of the histologic type when the WHO classification (1981) was used. The specimens from 354 surgical cases and biopsy or cytology specimens from 1032 non-surgical cases were reviewed. The inter-observer agreement was 87.9% (k=0.79) for surgical cases and 81.4% (k=0.72) for non-surgical cases. When compared to the original diagnosis, the agreement was 86.8% (k=0.78) for surgical and 86.4% (k=0.79) for non-surgical cases in 1979,1980 and the agreement was 92.8% (k=0.87) for surgical and 89.1% (k=0.83) for non-surgical cases in 1987. By histologic type, no difference in the agreement was observed except for large cell carcinoma. The distribution of histologic types after the review differed only slightly (less than 6%) from the original distribution. This suggests that in Osaka, Japan, the diagnosis based on the WHO classification (1981) had only a limited influence on the distribution of histologic types, and is not a major reason for the changing trends in lung cancer incidence by histologic type. [source] Factors Associated with Helmet Use among Motorcycle Users in Karachi, PakistanACADEMIC EMERGENCY MEDICINE, Issue 4 2008Imran Khan MBBS Abstract Objectives:, Wearing a helmet is the single most effective measure for preventing head injuries in motorcycle users. The authors undertook this study to estimate compliance and determine reasons for noncompliance with helmet use among motorcyclists in their community. Methods:, This was a cross-sectional survey of motorcyclists in three large randomly selected public-access parking spaces across Karachi, Pakistan's largest city. Questions covered personal demographics, frequency of helmet use, reasons for use or nonuse, and knowledge of local helmet laws. Analysis was based on frequencies and group comparisons using chi-square test or independent sample t-test. Results:, Of the 300 (100% male) subjects, 169 (56%) reported using helmets regularly. Users listed injury prevention (78%) as the major reason for compliance, while nonusers listed physical discomfort (44%) and limited vision (25%) as the leading reasons for noncompliance. In univariate analysis, helmet users were significantly better educated than nonusers and were more likely to believe that helmets are protective (p = 0.002) and that passengers should also wear helmets (p < 0.001). The significance of these variables persisted in multivariate analysis. Several other variables (such as mean age, marital status, and knowledge of helmet laws) did not differ between users and nonusers. Conclusions:, Helmets are underused by motorcyclists in the authors' community. This study underscores the need for improved helmet design, public understanding, intense public education, and rigorous law enforcement in raising compliance with helmet use and minimizing the risk of preventable trauma. [source] How to Achieve Confidence in Drug Discovery and Development: Managing Risk (from a Reductionist to a Holistic Approach)CHEMMEDCHEM, Issue 6 2009Annette Bakker Dr. Abstract Confidence in mechanism: Creating a more holistic understanding of disease pathophysiology and an early confidence in the mechanism under investigation could help facilitate the selection of not only the most appropriate targets but also the best mechanisms for disease intervention and how to select and optimise the best compounds. Drug target and candidate selection are two of the key decision points within the drug discovery process for which all companies use certain selection criteria to make decisions on which targets to accept into their discovery pipelines and which compounds will pass into development. These steps not only help define the overall productivity of every company but they are also decisions taken without full predictive knowledge of the risks that lie ahead or how best to manage them. In particular, the process of selecting new targets does not normally involve full evaluation of the risk(s) in the mechanism under investigation (the modulation of the target), which may result in an inability to fully connect in,vitro and animal model results to the disease (clinical) setting. The resulting poor progression statistics of many compounds in the clinic is at least partially the result of a lack of understanding of disease pathophysiology. Notably, the lack of efficacy is still a major reason for failure in the clinic.1 Creating a more holistic understanding of disease pathophysiology and an early confidence in the mechanism under investigation could help facilitate the selection of not only the most appropriate targets but also the best mechanisms for disease intervention and how to select and optimise the best compounds. [source] Facilitating the hyphenation of CIEF and MALDI-MS for two-dimensional separation of proteinsELECTROPHORESIS, Issue 15 2010Chang Cheng Abstract Both CIEF and MALDI-MS are frequently used in protein analysis, but hyphenation of the two has not been investigated proportionally. One of the major reasons is that the additives (such as carrier ampholytes and detergent) in CIEF severely suppress the MALDI-MS signal, which hampers the hyphenation of the two. In this paper, we develop a simple means to alleviate the above signal-suppressing effect. We first deposit 1,,L of water onto a MALDI-MS target, deliver a fraction of CIEF-separated protein (,0.1,,L) to the water droplet, evaporate the solvent, add 0.5,,L of MALDI matrix to the sample spot, dry the matrix and move the target plate to a MALDI-TOF-MS for mass spectrum measurement. We optimize the droplet volume and the laser-ablation region. Under the optimized conditions, we improve the S/N by two- to tenfold. We also apply this method for 2-D separations of standard proteins and apolipoprotein A,I, a membrane protein expressed in Escherichia coli cells. [source] Anaemia after renal transplantationEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 2005M. Lorenz Abstract Anaemia is a frequent complication among long-term renal transplant recipients. A prevalence of approximately 40% has been reported in several studies. If renal function declines to stage 5 kidney disease, the prevalence of anaemia in kidney transplants is even higher. A positive correlation between haemoglobin concentration and creatinine clearance has been reported, which is a function of endogenous erythropoietin production by the functioning graft. Inflammation related to a retained kidney graft may cause hypo-responsiveness to erythropoietic agents once kidney transplant recipients return to dialysis. Furthermore, the use of azathioprine, mycophenolate mofetil and sirolimus may be associated with post-transplant anaemia. Along with erythropoietin deficiency, depletion of iron stores is one of the major reasons for anaemia in the kidney transplant population. The proportion of hypochromic red blood cells appears to be a useful parameter to measure iron supply and utilization as well as to estimate mortality risks in kidney transplant recipients. While anaemia is an important cardiovascular risk-factor after transplantation, our data suggest that anaemia is not associated with mortality and graft loss. Nevertheless, inadequate attention is paid so far to the management of anaemia after renal transplantation. A promising future aspect for risk reduction of cardiovascular disease includes the effect of erythropoietic agents on endothelial progenitor cells. [source] Evidence-Based Recommendations for the Assessment and Management of Sleep Disorders in Older PersonsJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2009AGSF, Harrison G. Bloom MD Sleep-related disorders are most prevalent in the older adult population. A high prevalence of medical and psychosocial comorbidities and the frequent use of multiple medications, rather than aging per se, are major reasons for this. A major concern, often underappreciated and underaddressed by clinicians, is the strong bidirectional relationship between sleep disorders and serious medical problems in older adults. Hypertension, depression, cardiovascular disease, and cerebrovascular disease are examples of diseases that are more likely to develop in individuals with sleep disorders. Conversely, individuals with any of these diseases are at a higher risk of developing sleep disorders. The goals of this article are to help guide clinicians in their general understanding of sleep problems in older persons, examine specific sleep disorders that occur in older persons, and suggest evidence- and expert-based recommendations for the assessment and treatment of sleep disorders in older persons. No such recommendations are available to help clinicians in their daily patient care practices. The four sections in the beginning of the article are titled, Background and Significance, General Review of Sleep, Recommendations Development, and General Approach to Detecting Sleep Disorders in an Ambulatory Setting. These are followed by overviews of specific sleep disorders: Insomnia, Sleep Apnea, Restless Legs Syndrome, Circadian Rhythm Sleep Disorders, Parasomnias, Hypersomnias, and Sleep Disorders in Long-Term Care Settings. Evidence- and expert-based recommendations, developed by a group of sleep and clinical experts, are presented after each sleep disorder. [source] Elimination disorders in people with intellectual disabilityJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 10 2008E. Van Laecke Incontinence in children with intellectual and physical disabilities is an underestimated problem in paediatric urology. Literature is scarce, often limited to the incidence and urodynamics, and seldom focused on treatment and prevention. Lack of interest and knowledge of this population are the major reasons why urologists know so little. Very often continence difficulties are accepted and even expected in children with intellectual disabilities. The published prevalence of urinary incontinence in children with intellectual and physical disabilities varies between 23% and 86%. In our experience the prevalence ranges from 60% to 65%. The vast majority of these children have bladder dysfunction, showing overactive detrusor and sphincter dyssynergia on video-urodynamic examination. The uroflow pattern is disturbed in over 65% of these children but is not correlated with the degree of urinary incontinence. Over 70% of the children have reduced bladder capacity. This is due to low bladder compliance and restricted fluid intake which effects urinary incontinence and is an important cause of constipation. Constipation is a common problem in intellectual and physical disabled children and there is a correlation between constipation and urinary incontinence. Children with intellectual disability, particularly those with a greater degree of disability need more time to become continent than typically developing children. Children with mild intellectual disability do not differ significantly from typically developing children with regard to nocturnal enuresis and faecal continence but they are more prone to urinary incontinence during the day. Greater mobility is associated with a higher incidence of continence. Some factors that influence continence, such as intellectual and motor capacity cannot easily be influenced but others, such as bladder capacity, detrusor overactivity and fluid intake, are treatable. It is importance that children with intellectual and physical disabilities suffering urinary incontinence are referred for assessment and treatment to increase their quality of life. [source] High infant and child mortality rates in Orissa: an assessment of major reasonsPOPULATION, SPACE AND PLACE (PREVIOUSLY:-INT JOURNAL OF POPULATION GEOGRAPHY), Issue 3 2006Jalandhar Pradhan Abstract Infant and child mortality rates in Orissa are the highest among the Indian states. This is surprising, given other demographic indicators, such as the relatively rapid fertility decline and the quite high levels of antenatal care coverage in this state compared with other comparatively poor states. In this article, the macro- and micro-level determinants of high infant and child mortality are assessed using multivariate logistic regression analyses. The results demonstrate that the major contributors to the high infant and child mortality rates are the extremely low levels of health sector investments and the associated quality of care. Copyright © 2006 John Wiley & Sons, Ltd. [source] ORIGINAL ARTICLE: Predictors of Inflammatory Breast Diseases During Lactation , Results of a Cohort StudyAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 1 2010Achim Wöckel Problem, Inflammatory breast diseases during lactation are major reasons for early weaning. Method of study, A prospective cohort study was performed to examine the association between stress and inflammatory breast diseases. Psychometric data, cytokine levels in breast milk and blood samples were analysed postpartum (T1). Psychometric data and course of breast feeding were evaluated twelve weeks later (T2). Patients were divided into case- and control-groups (according to the presence of breast diseases). Results, Mothers of the case group (n = 23) were significantly older and showed significantly increased stress levels between T1 and T2 compared with the control group (n = 43). Leucocytes in the postpartum blood count were significantly decreased in the case group. There were no significant differences between groups in the concentrations of Th-1- and Th-2-cytokines in breast milk postpartum. Conclusion, Higher maternal age, postpartum increase in stress perception and low number of leucocytes are associated with a higher incidence of inflammatory breast diseases. Further studies must examine the causality of this effect. [source] Meeting a Binational Research Challenge: Substance Abuse Among Transnational Mexican Farmworkers in the United StatesTHE JOURNAL OF RURAL HEALTH, Issue 2007Victor Garcia PhD ABSTRACT:,To help in understanding the manner in which community, individual, and other factors in the United States and Mexico contribute to drug use among transnational migrants, this paper introduces a binational social ecology model of substance abuse in this population. We draw on our 2 NIH-funded ethnographic studies,1 on problem drinking and the other on drug abuse,among transnational Mexican workers in the mushroom industry of southeastern Pennsylvania. Our model demonstrates that major reasons for substance abuse among transnational migrants include nontraditional living arrangements in labor camps and overcrowded apartments, the absence of kin and community deterrents to drug use, social isolation, the presence of drug use and binge drinking subcultures, the availability of drugs, family history of drugs, previous drug use or witnessing of drug use in Mexico, and drug use norms and drug availability in Mexico. It suggests the need for US and Mexican researchers to collaborate in binational teams and address factors on both sides of the border. Our binational social ecology model, together with our research recommendations, will assist alcohol and drug researchers to discover how community and individual factors in both the United States and abroad fit and interact beyond mere association and provide a more comprehensive research approach to substance abuse research among transnational migrants. [source] | |||||||||||||||||||||||||