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Major Producers (major + producers)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

Trefoil factor family 3 expression in the oral cavity

EUROPEAN JOURNAL OF ORAL SCIENCES, Issue 6 2009
T. Storesund
This study examined the expression, in oral keratinocytes and in the major and minor salivary glands, of Trefoil factor family 3 (TFF3) peptide. Trefoil factor family 3 messenger RNA (mRNA) and peptide were detected in cultures of normal oral keratinocytes by quantitative real-time polymerase chain reaction (PCR) and western blotting, respectively. Trefoil factor family 3 was found, by immunohistochemical analyses, to be expressed in the basal layers of the oral mucosal epithelium. In salivary glands, immunohistochemical staining showed that TFF3 peptide expression was strongest in the mucous acini of the submandibular and the small salivary glands. Serous cells in the same glands showed weak staining. In the parotid gland, many serous acini showed weak positive staining, while other areas did not. In all glands examined, the intercalated, striated, and collecting ducts were moderately TFF3-positive. Double immunostaining confirmed that mucous (MUC5B positive) cells were moderately or strongly positive for TFF3 and that some serous (MUC7 positive) cells showed restricted TFF3 expression, mostly in a granular pattern. The prevalence of the TFF3 peptide in the salivary secretions of healthy volunteers was detected by western blotting of saliva from minor salivary glands (four of five) and the parotid gland (one of five) and of mixed submandibular/sublingual saliva (five of five). In conclusion, the submandibular and small salivary glands appear to be the major producers of oral TFF3, but duct cells of all glands and keratinocytes of the oral mucosa may also contribute as sources of TFF3 in the oral cavity. [source]

The CD8+ dendritic cell subset

IMMUNOLOGICAL REVIEWS, Issue 1 2010
Ken Shortman
Summary:, Mouse lymphoid tissues contain a subset of dendritic cells (DCs) expressing CD8, together with a pattern of other surface molecules that distinguishes them from other DCs. These molecules include particular Toll-like receptor and C-type lectin pattern recognition receptors. A similar DC subset, although lacking CD8 expression, exists in humans. The mouse CD8+ DCs are non-migrating resident DCs derived from a precursor, distinct from monocytes, that continuously seeds the lymphoid organs from bone marrow. They differ in several key functions from their CD8, DC neighbors. They efficiently cross-present exogenous cell-bound and soluble antigens on major histocompatibility complex class I. On activation, they are major producers of interleukin-12 and stimulate inflammatory responses. In steady state, they have immune regulatory properties and help maintain tolerance to self-tissues. During infection with intracellular pathogens, they become major presenters of pathogen antigens, promoting CD8+ T-cell responses to the invading pathogens. Targeting vaccine antigens to the CD8+ DCs has proved an effective way to induce cytotoxic T lymphocytes and antibody responses. [source]

Organic facies and geochemical aspects in Neogene neritic sediments of the Takafu syncline area of central Japan: Paleoenvironmental and sedimentological reconstructions

ISLAND ARC, Issue 4 2006
Ken Sawada
Abstract Organic petrological observations of kerogen macerals and organic geochemical analyses of carbon isotopes of kerogen macerals and biomarkers were conducted on Neogene neritic sediments of the Takafu syncline area of central Japan. The Senmi, Sakainomiya and Lower Shigarami Formations in that area were deposited at the neritic provinces on the southern edge of the paleo-Japan Sea during the Late Miocene to Early Pliocene. Sedimentary organic matter in these formations was almost terrigenous in origin. Changes in kerogen maceral compositions reflect sedimentological and tectonic histories evaluated in previous studies from sedimentary facies and paleontology. It was found that carbon isotope ratios (,13C) of kerogen macerals increased from ,28, to ,25, from the Sakainomiya to the lower part of the Lower Shigarami Formations. The cause of that increase was presumably the expansion of C4 plants into southwest Japan. The timing was concordant with that of the expansion of C4 plant grasslands in East Asia. The oxicity (oxic to anoxic) conditions of sea bottoms evaluated from pristane/phytane ratios varied. Particularly, in the lower part of the Senmi Formation, layers in which no steroid biomarkers could be detected were found, and had presumably formed under oxic conditions when strong biodegradation had occurred. Concentrations of regular (C27,C29) steranes and dinosteranes were higher in the Sakainomiya and Lower Shigarami Formations. This indicates that dinoflagellates-dominant primary productions were higher at those stages. In addition, concentrations of diatomaceous biomarkers such as C26 norsterane increased from the Lower Shigarami Formation, thus adding diatoms to the major producers. Furthermore, similar associations between the increases of ,13C values of kerogen macerals and concentrations of diatomaceous biomarkers were observed in the Takafu syncline area. Thus, the expansion of C4 plants was possibly associated with the high production of diatom in the shallow-marine areas of the paleo-Japan Sea during the Neogene Period. [source]

Proximity Services in Belgium: An Analysis of Public and Nonprofit Relations

ANNALS OF PUBLIC AND COOPERATIVE ECONOMICS, Issue 1 2001
Francesca Petrella
In this paper, we analyze the interaction between nonprofit organizations (NPOs) and government with regard to the provision of proximity services. Given the characteristics of these services and the organizational features specific to each sector, we argue that the relationship between the public and the nonprofit sectors is necessary but rather complex. We illustrate our analysis with some empirical evidence collected by the CERISIS-UCL in 1996 for the city of Charleroi (Belgium). This survey shows that NPOs are the major producers of proximity services but are, on average, largely subsidized by government. Public intervention is also significant in the production of these services but is the most striking in their financing. These results evoke the existence of a multifaceted interaction between the public and nonprofit sectors, that we try to understand in this paper. Our analysis highlights that the tension between the current focus of public policies on job creation for the low-skilled unemployed and the service-based mission of most NPOs might generate inappropriate responses to the needs of the community. It also suggests that this conflict of objectives, given the current organization of proximity services, is likely to threaten the autonomy and originality of the nonprofit sector. [source]

POST-MEDIEVAL CRUCIBLE PRODUCTION AND DISTRIBUTION: A STUDY OF MATERIALS AND MATERIALITIES,

ARCHAEOMETRY, Issue 1 2009
M. MARTINÓN-TORRES
This paper is concerned with the manufacture and trade of post-medieval crucibles (14th,19th centuries). The analytical study of crucibles from different contexts in Europe and America employed optical microscopy and SEM,EDS, coupled with archaeological and historical data. We identified two major producers of crucibles, both of them in Central Europe, whose products appear widely distributed internationally. The analytical data allow an explanation of the technical reasons behind their superior reputation, as both crucible types shared comparable material properties, such as thermal, chemical and mechanical stability. Conversely, the two crucible types were radically different in their manufacture and appearance. We argue that, besides technical considerations, sensorial aspects such as texture and colour may have played an important role in the perception and choice of materials. [source]