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Major Deficiencies (major + deficiency)
Selected AbstractsThe psychological contract: A critical reviewINTERNATIONAL JOURNAL OF MANAGEMENT REVIEWS, Issue 2 2006Niall Cullinane Literature on the psychological contract has blossomed progressively over the last ten years to the extent that it is now firmly located within the lexicon of the Human Resource Management (HRM) discipline. Yet as this review indicates, the theoretical assumptions that seem to pervade the psychological contract literature are not without major deficiencies, which in turn pose serious questions around the continued sustainability of the construct as currently constituted. This paper addresses some of the central problems presently confronting the theoretical side of the psychological contract literature. In seeking to advance knowledge and understanding, this review calls for an alternative approach to studying the psychological contract on the basis of a more critical and discursive literature analysis. From this, the authors unpick the construct of the psychological contract as portrayed in much of the extant literature and argue that, in its present form, it symbolizes an ideologically biased formula designed for a particular managerialist interpretation of contemporary work and employment. [source] Organizational failure: a critique of recent research and a proposed integrative frameworkINTERNATIONAL JOURNAL OF MANAGEMENT REVIEWS, Issue 1 2004Kamel Mellahi There is a long-running debate in the business literature on the causes of organizational failure. On the one hand, classical industrial organization (IO) and organization ecology (OE) scholars have typically assumed a deterministic role of the environment and argued that managers are constrained by exogenous industrial and environmental constraints leaving them with little real strategic choice, and hence managers' role should be ignored. On the other hand, the organization studies (OS) and organizational psychology (OP) literature takes a more voluntaristic perspective and argues that managers are the principal decision makers of the firm and, consequently, their actions and perceptions are the fundamental cause of organizational failure. This paper addresses the major deficiencies observed in the diverse body of literature covering this field, suggests an integrative framework and identifies the specific theoretical and methodological challenges ahead for researchers seeking to advance knowledge in the field of organizational failure. [source] Pitfalls in the design and analysis of paediatric clinical trials: a case of a ,failed' multi-centre study, and potential solutionsACTA PAEDIATRICA, Issue 2 2009Johanna H Van Der Lee Abstract Aim: To increase awareness of possible pitfalls in the design and analysis of a multi-centre randomized clinical trial and to give an overview of alternative study designs and their consequences for power analyses in case of limited availability of trial participants. Methods: Investigation of the assumptions in the power calculation and re-analysis of the original data of a ,failed' trial on the effect of dexamethasone on the duration of mechanical ventilation in young children with respiratory syncytial virus infection. Use of ,boundaries approach' is explored using the data from this trial. A comprehensive overview of the various modern solutions for the design of a subsequent trial in this field is given. Results: Two frequent major deficiencies of trial design and data analysis are reviewed in depth, i.e. too optimistic assumptions for the sample size calculation and failure to adjust for centre effects. Conclusion: Critical review of trial assumptions and if necessary sample size recalculation based on an internal pilot by a data monitoring committee is recommended to maximize the probability of obtaining conclusive results. [source] Balancing needs and means: the dilemma of the ,-cell in the modern worldDIABETES OBESITY & METABOLISM, Issue 2009G. Leibowitz The insulin resistance of type 2 diabetes mellitus (T2DM), although important for its pathophysiology, is not sufficient to establish the disease unless major deficiency of ,-cell function coexists. This is demonstrated by the fact that near-physiological administration of insulin (CSII) achieved excellent blood glucose control with doses similar to those used in insulin-deficient type 1 diabetics. The normal ,-cell adapts well to the demands of insulin resistance. Also in hyperglycaemic states some degree of adaptation does exist and helps limit the severity of disease. We demonstrate here that the mammalian target of rapamycin (mTOR) system might play an important role in this adaptation, because blocking mTORC1 (complex 1) by rapamycin in the nutritional diabetes model Psammomys obesus caused severe impairment of ,-cell function, increased ,-cell apoptosis and progression of diabetes. On the other hand, under exposure to high glucose and FFA (gluco-lipotoxicity), blocking mTORC1 in vitro reduced endoplasmic reticulum (ER) stress and ,-cell death. Thus, according to the conditions of stress, mTOR may have beneficial or deleterious effects on the ,-cell. ,-Cell function in man can be reduced without T2DM/impaired glucose tolerance (IGT). Prospective studies have shown subjects with reduced insulin response to present, several decades later, an increased incidence of IGT/T2DM. From these and other studies we conclude that T2DM develops on the grounds of ,-cells whose adaptation capacity to increased nutrient intake and/or insulin resistance is in the lower end of the normal variation. Inborn and acquired factors that limit ,-cell function are diabetogenic only in a nutritional/metabolic environment that requires high functional capabilities from the ,-cell. [source] A critique of Emanuel's hurricane model and potential intensity theoryTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 632 2008Roger K. Smith Abstract We present a critique of Emanuel's steady-state hurricane model, which is a precursor to his theory for hurricane potential intensity (PI). We show that a major deficiency of the theory is the tacit assumption of gradient wind balance in the boundary layer, a layer that owes its existence to gradient wind imbalance in the radial momentum equation. If a more complete boundary-layer formulation is included using the gradient wind profiles obtained from Emanuel's theory, the tangential wind speed in the boundary layer becomes supergradient, invalidating the assumption of gradient wind balance. We show that the degree to which the tangential wind is supergradient depends on the assumed boundary-layer depth. The full boundary-layer solutions require a knowledge of the tangential wind profile above the boundary layer in the outer region where there is subsidence into the layer and they depend on the breadth of this profile. This effect is not considered in Emanuel's theory. We argue that a more complete theory for the steady-state hurricane would require the radial pressure gradient above the boundary layer to be prescribed or determined independently of the boundary layer. The issues raised herein highlight a fundamental problem with Emanuel's theory for PI, since that theory makes the same assumptions as in the steady-state hurricane model. Our current findings together with recent studies examining intense hurricanes suggest a way forward towards a more consistent theory for hurricane PI. Copyright © 2008 Royal Meteorological Society [source] | ||||||||||