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Selected AbstractsCONTEXTUALIZING LEARNING OBJECTS USING ONTOLOGIESCOMPUTATIONAL INTELLIGENCE, Issue 3 2007Phaedra Mohammed Educational research over the past three years has intensified such that the context of learning resources needs to be properly modeled. Many researchers have described and even mandated the use of ontologies in the research being conducted, yet the process of actually connecting one or more ontologies to a learning object has not been extensively discussed. This paper describes a practical model for associating multiple ontologies with learning objects while making full use of the IEEE LOM specification. The model categorizes these ontologies according to five major categories of context based on the most popular fields of study actively being pursued by the educational research community: Thematic context, Pedagogical context, Learner context, Organizational context, and Historical/Statistical context. [source] Calibrating conservation: new tools for measuring successCONSERVATION LETTERS, Issue 4 2008Valerie Kapos Abstract Conservation practitioners, policy makers, and donors agree that there is an urgent need to identify which conservation approaches are most likely to succeed in order to use more effectively the limited resources available for conservation. While recently developed standards of good practice in conservation are helpful, a framework for evaluation is needed that supports systematic analysis of conservation effectiveness. A conceptual framework and scorecard developed by the Cambridge Conservation Forum help to address common constraints to evaluating conservation success: unclear objectives, ineffective information management, the long time frames of conservation outcomes, scarcity of resources for evaluation, and lack of incentives for such evaluation. For seven major categories of conservation activity, the CCF tools help clarify conservation objectives and provide a standardized framework that is a useful basis for managing information about project outcomes and existing conservation experience. By identifying key outcomes that can predict conservation success and can be assessed in relatively short time frames, they help to make more efficient use of scarce monitoring and evaluation resources. With wide application, the CCF framework and evaluation tool can provide a powerful platform for drawing on the experience of past and ongoing conservation projects to identify quantitatively factors that contribute to conservation success. [source] Pulmonary neuroendocrine neoplasms: A review of clinicopathologic and cytologic featuresDIAGNOSTIC CYTOPATHOLOGY, Issue 8 2010F.I.A.C., Momin T. Siddiqui M.D. Abstract Neuroendocrine tumors form a distinct group of lung neoplasms sharing characteristic cytohistologic, immunohistochemical, ultrastructural, and molecular features. The objective of this review article is to discuss the diagnostic classifications and the morphologic cytologic,histologic features for the different categories of neuroendocrine tumors of the lung. An accurate characterization of the neuroendocrine tumors of the lung requires knowledge of specific criteria separating the major categories, which is highly essential for determining prognosis and treatment options for these patients. Diagn. Cytopathol. 2010;38:607,617. 2009 Wiley-Liss, Inc. [source] Cover Picture: Electrophoresis 7'2010ELECTROPHORESIS, Issue 7 2010Article first published online: 26 MAR 2010 Issue no. 7 is a special issue on CE-MS consisting of "19 manuscripts subdivided into three major categories: one devoted to instrumental and methodical advances, two providing an insight into up-to-date applications from the fields of technical and natural products, food and environmental analysis on the one hand and biomedical and pharmaceutical analysis on the other hand. Diverse approaches how CE-MS can be employed for the solution of various analytical problems can be found in these papers. Different modes of electroseparation techniques in the capillary format such as CZE, CEC or MEEKC are coupled to various MS instruments ranging from simple quadrupole MS instruments to state of the art QTOF's, using a range of interfaces such as ESI, ICP or APPI. So this special issue will again try to present an overview of current trends and developments in the fields of CE-MS" [source] Prevalence of Childhood Epilepsy and Distribution of Epileptic Syndromes: A Population-based Survey in Okayama, JapanEPILEPSIA, Issue 3 2006Eiji Oka Summary:,Methods: Information on patients younger than 13 years with active epilepsy was collected from medical records. Patients diagnosed with epilepsy according to clinical and EEG findings were put on the list even if those patients had had a single seizure or seizures occurring during febrile episodes. Results: In total, 2,220 cases were identified from a background population of 250,997. The prevalence rate was 8.8 per 1,000. If we exclude patients who had experienced a single seizure or seizures occurring during febrile episodes to compare our results with previous reports, the prevalence rate was 5.3 per 1,000. Of the 2,220 cases, 2,030 (91.4%) were classified into three major categories by ILAE classification. They consisted of 1,556 (76.7%) with localization-related epilepsy, 453 (22.3%) with generalized epilepsy, and 21 (1.0%) with undetermined epilepsy. Of the 2,030 cases, 309 (15.2%) were classified into epileptic syndrome categories, and 84.8% of the total were nonspecific types of epilepsy. Conclusions: The prevalence rate of childhood epilepsy was distributed from 5.3 to 8.8 per 1,000. The appearance rate of various types of epileptic syndromes was low. Most cases could not be classified into the detailed categories of the International Classification (ILAE, 1989). [source] FAMILY DISPUTE RESOLUTION: CHARTING A COURSE FOR THE FUTUREFAMILY COURT REVIEW, Issue 3 2009Amy Holtzworth-Munroe This article summarizes ideas for future directions in the field of family dispute resolution, as discussed by legal experts, social scientists, and other participants at the Indiana University,Bloomington conference on family dispute resolution. Five major categories of future directions were discussed: (1) clarifying differing goals for work in this field; (2) recognizing, understanding, and assessing for heterogeneity among couples and families facing divorces, break ups in adult relationships, and reconfigurations of adult relationships with the children ("relationship dissolution"); (3) testing our assumptions and commonly held beliefs about relationship dissolution; (4) empirically testing the efficacy of interventions for families experiencing relationship dissolution; and (5) disseminating research findings to those on the frontline. [source] Evaluating bias due to population stratification in case-control association studies of admixed populations,GENETIC EPIDEMIOLOGY, Issue 1 2004Yiting Wang Abstract The potential for bias from population stratification (PS) has raised concerns about case-control studies involving admixed ethnicities. We evaluated the potential bias due to PS in relating a binary outcome with a candidate gene under simulated settings where study populations consist of multiple ethnicities. Disease risks were assigned within the range of prostate cancer rates of African Americans reported in SEER registries assuming k=2, 5, or 10 admixed ethnicities. Genotype frequencies were considered in the range of 5,95%. Under a model assuming no genotype effect on disease (odds ratio (OR)=1), the range of observed OR estimates ignoring ethnicity was 0.64,1.55 for k=2, 0.72,1.33 for k=5, and 0.81,1.22 for k=10. When genotype effect on disease was modeled to be OR=2, the ranges of observed OR estimates were 1.28,3.09, 1.43,2.65, and 1.62,2.42 for k=2, 5, and 10 ethnicities, respectively. Our results indicate that the magnitude of bias is small unless extreme differences exist in genotype frequency. Bias due to PS decreases as the number of admixed ethnicities increases. The biases are bounded by the minimum and maximum of all pairwise baseline disease odds ratios across ethnicities. Therefore, bias due to PS alone may be small when baseline risk differences are small within major categories of admixed ethnicity, such as African Americans. © 2004 Wiley-Liss, Inc. [source] Model,data synthesis in terrestrial carbon observation: methods, data requirements and data uncertainty specificationsGLOBAL CHANGE BIOLOGY, Issue 3 2005M. R. Raupach Systematic, operational, long-term observations of the terrestrial carbon cycle (including its interactions with water, energy and nutrient cycles and ecosystem dynamics) are important for the prediction and management of climate, water resources, food resources, biodiversity and desertification. To contribute to these goals, a terrestrial carbon observing system requires the synthesis of several kinds of observation into terrestrial biosphere models encompassing the coupled cycles of carbon, water, energy and nutrients. Relevant observations include atmospheric composition (concentrations of CO2 and other gases); remote sensing; flux and process measurements from intensive study sites; in situ vegetation and soil monitoring; weather, climate and hydrological data; and contemporary and historical data on land use, land use change and disturbance (grazing, harvest, clearing, fire). A review of model,data synthesis tools for terrestrial carbon observation identifies ,nonsequential' and ,sequential' approaches as major categories, differing according to whether data are treated all at once or sequentially. The structure underlying both approaches is reviewed, highlighting several basic commonalities in formalism and data requirements. An essential commonality is that for all model,data synthesis problems, both nonsequential and sequential, data uncertainties are as important as data values themselves and have a comparable role in determining the outcome. Given the importance of data uncertainties, there is an urgent need for soundly based uncertainty characterizations for the main kinds of data used in terrestrial carbon observation. The first requirement is a specification of the main properties of the error covariance matrix. As a step towards this goal, semi-quantitative estimates are made of the main properties of the error covariance matrix for four kinds of data essential for terrestrial carbon observation: remote sensing of land surface properties, atmospheric composition measurements, direct flux measurements, and measurements of carbon stores. [source] Rheological, textural and melting properties of commercial samples of some of the different types of pasteurized processed cheeseINTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, Issue 2 2007YANJIE LU The detailed rheological and textural properties of commercially available samples of the three major categories of pasteurized processed cheese in the USA, that is, pasteurized process American cheese (PPA), pasteurized process cheese product (PPP) and pasteurized process cheese food (PPF), were analysed. All samples had similar pH values, ranging from 5.65 to 5.87, but most were ,5.7. Even within each of the categories considerable differences were observed in textural and melting behaviour. The samples with the lowest melt and the lowest loss tangent parameter from the rheological tests were two PPF and one PPA samples. These two PPF samples also had the highest hardness and adhesiveness force. Significant correlations were observed between several textural, rheological and melting properties. [source] Victims of Domestic Violence: A Proposal for a Community Diagnosis Based on One of Two Domains of NANDA Taxonomy IIINTERNATIONAL JOURNAL OF NURSING TERMINOLOGIES AND CLASSIFICATION, Issue 2003Patricia Serpa de Souza Batista PURPOSE To explore and identify diagnostic components to amplify NANDA nursing diagnoses by modifying the root violence. Whereas violence is nondebatable as a diagnostic concept in nursing, other alternatives have not been identified in the two existing diagnoses. METHODS Using the case study method, this qualitative study sought to identify commonalties in a population of women who were "donnas da casa" (homemakers) in a small rural community of approximately 100 families, typical of the Brazilian northeast. The sample of 7 women was identified through a larger study that had been based on health needs of the community. Data were obtained through observation during a home visit and a semistructured interview based on NANDA Taxonomy II. Observations were focused on hygiene, manner of dress, home environment, and physical and emotional state. Data were analyzed by content and clustered into major categories. From these a profile of the women and another of the partners emerged. FINDINGS Subjects ranged in age from 33 to 43 years, and number of children between 3 and 7. One of the 7 women was literate; 5 were underweight; all were slovenly attired. They appeared sad and older than their age. The majority seemed relieved to unburden themselves to the interviewers as they went through a gamut of emotions such as sadness, anguish, and irritability expressed through crying, restlessness, changes in body language, and tone of voice. The shortage of beds was supplemented by hammocks and mats or cardboard. The women spoke of being confined to their home and of male partners who drank on weekends, thus leaving them with little money for necessities of life. There were accounts of beatings when the partner returned home after drinking, overt nonacceptance of children from previous marriages, and general destruction of the family environment. New children were regarded as just another mouth to feed. DISCUSSION The profiles pointed to the necessity of identifying a new nursing diagnosis that would be linked, only tangentially, by the root violence to the two diagnoses in NANDA Taxonomies I and II. This insight led us to consider that a new method of listing NANDA diagnoses, by root only, is imperative in the evolution of Taxonomy II. Proposed descriptors, Victims of (Axis 3) and Domestic (Axis 6) would be identified by Axes, thereby facilitating the process of classifying in the Domains and Classes. The two existing NANDA diagnoses, risk for other-directed violence and risk for self-directed violence, are proposed for classification in Class 3, Violence, in Domain 11 of Taxonomy II. Safety/Protection could, by virtue of their modification power, find anchor in another domain such as Domain 6, Self-Perception. CONCLUSIONS Although Safety/Protection seems the most logical domain for classification by root, the axes, dimensions of human responses, could pull the diagnosis in another direction, thereby dictating other nursing interventions and nursing outcomes [source] Barriers to Optimal Hypertension ControlJOURNAL OF CLINICAL HYPERTENSION, Issue 8 2008Gbenga Ogedegbe MD There is an obvious gap in the translation of clinical trial evidence into practice with regards to optimal hypertension control. The three major categories of barriers to BP control are patient-related, physician-related, and medical environment/health care system factors. Patient-related barriers include poor medication adherence, beliefs about hypertension and its treatment, depression, health literacy, comorbidity, and patient motivation. The most pertinent is medication adherence, given its centrality to the other factors. The most salient physician-related barrier is clinical inertia,defined, as the failure of health care providers to initiate or intensify drug therapy in a patient with uncontrolled BP. The major reasons for clinical inertia are: 1) overestimation of the amount of care that physicians provide; 2) lack of training on how to attain target BP levels; and 3) clinicians' use of soft reasons to avoid treatment intensification by adopting a "wait until next visit" approach in response to patients' excuses. [source] Metasynthesis: withdrawing life-sustaining treatments: the experience of family decision-makersJOURNAL OF CLINICAL NURSING, Issue 2 2009Mary Ann Meeker Aim., The present study was undertaken to synthesise findings from qualitative investigations of family participation in decisions to withdraw and/or withhold life-sustaining treatment from a seriously ill family member. Background., As a consequence of increasing effectiveness and sophistication of available medical interventions, death is commonly preceded by a decision to withdraw or withhold potentially life-sustaining treatments. These decisions take place in a bioethical context characterised by the preeminence of self-determination, but patients are typically too ill to make their own decisions. Thus, family members are called upon to participate in these morally consequential decisions on the patient's behalf. Design., Metasynthesis Method., Metasynthesis is a form of inquiry that provides for integration of qualitative studies' findings to strengthen knowledge for practice and advance theoretical development. This metasynthesis was conducted using the constant comparative methods of grounded theory. Results., Family members engage in a process of participation in decision-making that is comprised of three major categories: reframing reality, relating and integrating. Surrogates used both cues and information as they reframed their understanding of the patient's status. Relationships with providers and with other family members powerfully influenced the decision-making process. Integrating was characterised by reconciling and going forward. This part of the process has both intrapersonal and interpersonal aspects and describes how family decision-makers find meaning in their experience and move forward in their lives. Conclusions., This synthesis provides a more comprehensive and empirically supported understanding of family members' experiences as they participate in treatment decisions for dying family members. Relevance to clinical practice., This metasynthesis provides evidence to improve family care during treatment withdrawal/withholding decision-making and a theoretical model that can be used to guide creation of clinical practice guidelines. Through increased understanding of family members' experiences, clinicians can more effectively support family decision-making processes. [source] ICD: a qualitative study of patient experience the first year after implantationJOURNAL OF CLINICAL NURSING, Issue 8 2004Helen CM Kamphuis MSc Background., The experiences of how patients live with an implantable cardioverter defibrillator are still poorly understood. Only a few qualitative studies have investigated this phenomenon. This paper was undertaken as part of a larger project to evaluate quality of life and psychological well-being in those survivors of cardiac arrest who have received an implantable cardioverter defibrillator. Aims and objectives., The aim of this qualitative study was to explore how implantable cardioverter defibrillator recipients perceive their lives during the first year after implantation of the device. Methods., A sample of 21 patients who received an implantable cardioverter defibrillator was interviewed during three consecutive periods: one, six and 12 months postdischarge from the hospital. The semi-structured interviews were based on insights gained from a literature review. The transcripts were subjected to content analysis. Results., Analysis of the data revealed seven major categories: physical deterioration, cognitive changes, perceived social support, dependency, contact with the doctor, confrontation with mortality and uncertainty surrounding having a shock. Anxiety, uncertainty, disappointment, frustration, unexpected barriers, acceptance of and dependency on the implantable cardioverter defibrillator played a major role in the lives of implantable cardioverter defibrillator recipients. Well-being improved throughout the year. During the first months after discharge from the hospital the focus was on regaining physical health. During the early postimplantation period both the implantable cardioverter defibrillator recipient and family members had adapted to the situation. Reflection on the impact and consequences of the cardiac arrest was reported more often in the late postimplantation period. Conclusions., Content analysis is a resourceful approach giving answers to questions that have hardly been addressed within the domain of cardiology. Implantable cardioverter defibrillator recipients face a complex first year, especially the first 6 months. Cognitive deterioration and confrontation with mortality are problems that need to be researched further. Relevance to clinical practice., Caregivers are able to explain to future patients what they can expect in the first year after implantation. Caregivers may become more receptive to physical, psychological and social limitations and to emotional and social problems that occur in implantable cardioverter defibrillator recipients, enabling them to act upon them. [source] Systemic medications: clinical significance in periodonticsJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 2002Sebastian G. Ciancio Abstract Systemic medications are of value as adjuncts to periodontal therapy. These medications can be divided into two major categories: antibiotics and agents for host modulation. Antibiotics have been shown to be valuable adjuncts in specialized types of periodontal disease, such as localized and generalized aggressive periodontitis, and of possible value in severe chronic periodontitis. Antibiotics have been studied individually, in combination and in sequential therapy. Host modulators include Periostat, non-steroidal anti-inflammatory agents, alendronate (Fosamax), hormone replacement therapy and anti-arthritic medications. These agents produce their beneficial effects by a variety of mechanisms of action, including inhibition of matrix metalloproteinases, inhibition of prostaglandin production, stimulation of osteoblasts, inhibition of osteoclasts, and other anti-inflammatory mechanisms of action. [source] Home Care Nurses' Descriptions of Important Agency AttributesJOURNAL OF NURSING SCHOLARSHIP, Issue 4 2003Linda Flynn Purpose: To identify attributes of home care agencies described by nurses as important to their professional practice and job satisfaction. Design: Seven focus groups with home health care staff nurses were conducted at 6 home care agencies located in three states in the Mid-Atlantic region of the United States. A total of 58 home care nurses participated in the study. Methods: Transcriptions of tape-recorded focus groups were subjected to open and axial coding techniques. Results: Six major categories and eight subcategories of organizational attributes described by home care nurses as important to the support of their practice and job satisfaction were identified. Conclusions: Attributes described by home health nurses were not only similar to those described by hospital-based nurses as reported in the ,magnet hospital' literature, but they also were consistent with key concepts described in theories of professional workforce organization. Findings provide insight into developing workplace environments to support home care nurses. [source] Ascertainment of birth defects: The effect on completeness of adding a new source of dataJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 6 2000C Bower Background: The Western Australian (WA) Birth Defects Registry aims for complete ascertainment of birth defects in WA, but the proportions of birth defects in rural areas and in Aboriginal children are lower than in metropolitan and non-Aboriginal children. The effect on ascertainment of adding data from the Rural Paediatric Service (RPS) was investigated. Method: A file of all cases of birth defects for children born 1980,1997 and recorded on the RPS database was linked to the Registry. Results: The addition of this new data source had little effect on the overall prevalence of birth defects (an increase from 5.38 to 5.41%). There was a slightly greater effect on the prevalence of birth defects in rural residents (4.67%,4.76%) and Aboriginal children (4.55,4.78%), although the prevalence for each of these groups is still less than for metropolitan residents and non-Aboriginal infants, respectively. All major categories of birth defects were represented in the new cases and, in general, their addition made little difference to the prevalence of each category. The exception was fetal alcohol syndrome, which increased from 0.13 per 1000 to 0.18 per 1000 once the 21 new cases from the RPS were added. Conclusion: Complete ascertainment of birth defects is important in developing and evaluating preventive programs, and in investigating clusters of birth defects. [source] The Final Ends of Higher Education in Light of an African Moral TheoryJOURNAL OF PHILOSOPHY OF EDUCATION, Issue 2 2009THADDEUS METZ From the perspective of an African ethic, analytically interpreted as a philosophical principle of right action, what are the proper final ends of a publicly funded university and how should they be ranked? To answer this question, I first provide a brief but inclusive review of the literature on Africanising higher education from the past 50 years, and contend that the prominent final ends suggested in it can be reduced to five major categories. Then, I spell out an intuitively attractive African moral theory and apply it to these five final ends, arguing that three of them are appropriate but that two of them are not. After that, I maintain that the African moral theory prescribes two additional final ends for a public university that are not salient in the literature. Next, I argue that employing the African moral theory as I do enables one to rebut several criticisms of Africanising higher education that have recently been made from a liberal perspective. I conclude by posing questions suitable for future research. [source] Constant or special observations of inpatients presenting a risk of aggression or violence: nurses' perceptions of the rules of engagementJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 4 2005I. MACKAY bsc (hons) rmn In acute psychiatric settings the practice of ,observation' is commonly employed. Increased levels of observation, ,constant' or ,special' are used for those perceived as presenting a ,higher' risk. As an intervention it is used most frequently for those at risk of self-harm or suicide, the practice is also however, used for those thought to present a risk of violent behaviour. In this descriptive study the perceptions of 1st level registered mental nurses (RMNs) gave an account of observation for those perceived to be at risk of violence or aggression and insight into what was considered important and desirable in practice. Unstructured qualitative interviews were conducted with a purposive sample of six RMNs from a psychiatric intensive care unit. Three major categories, Procedure, Role, and Skills emerged which revealed a complex practice far removed from its literal description as merely ,watching'. Six subcategories emerged from the Role. (1) intervening; (2) maintaining the safety of the patient and others; (3) prevention de-escalation and the management of aggression and violence; (4) assessing; (5) communication; and (6) therapy. Skills in these and, experience were thought to IMPACT on the success of the practice. The description of this and the skills involved offer a definition of the ,rules of engagement' which give insight to the practice and the training needs of staff advocated for ,observation'. The acronym IMPACT may be useful in this. [source] Hepatitis C and Alcohol: Fundamental and Translational Research DirectionsALCOHOLISM, Issue 4 2003Timothy R. Morgan The scientific knowledge base that would inform and direct the development of more effective treatment and intervention strategies for these linked pandemics is inadequate. Therefore, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) organized a workshop in which a multidisciplinary group of experts was asked to review the state-of-the-science specific to alcohol in the context of hepatitis C infection. The panel was charged with identifying newly emerging areas likely to lead to advances in fundamental research and to identify those with the greatest potential for accelerating the development of more effective treatment options. The workshop panel made recommendations for research in four major categories: clinical studies of alcohol and HCV; virology and immunology; liver fibrosis and mechanisms of liver injury; and the development of model systems. This article summarizes the panel's deliberations and their recommendations for future research on alcohol and hepatitis C. [source] Chinese Nationalism and Sino,Japanese RelationsPACIFIC FOCUS, Issue 2 2008Jing-Dong Yuan Contemporary Chinese nationalism has its roots in the country's nation-building and identity-forming movements in the late 19th and early 20th centuries that sought to establish China's place in the community of nations. Today, nationalism in China can be characterized as falling into two major categories. On the one hand, there is nationalism embedded in patriotism with great pride in China's civilization, major achievements, and confidence in the country's future in embracing and meeting the challenges of globalization. On the other hand, there is the sentimental nationalism that reacts to what is perceived as injustice and insult done to China and has a strong victim mentality. The domestic discourse of nationalism can be influenced by government propaganda, intellectual debates, populous display of emotion and repulsion, or a mixture of all three. As China continues to grow in economic power and political influence, how nationalism is handled can have a significant impact on relations with its neighbors and beyond. [source] E-BUSINESS AND SUPPLY CHAIN MANAGEMENT: AN OVERVIEW AND FRAMEWORK,PRODUCTION AND OPERATIONS MANAGEMENT, Issue 4 2002M. ERIC JOHNSON The web is having a significant impact on how firms interact with each other and their customers. Past stumbling blocks for supply chain integration such as high transaction costs between partners, poor information availability, and the challenges of managing complex interfaces between functional organizations are all dissolving on the web. In this paper, we examine how the web is changing supply chain management. We present a survey of emerging research on the impact of e-business on supply chain management including descriptive frameworks, analytical models, empirical analysis, and case studies. We classify the work into three major categories: e-commerce, e-procurement, and e-col-laboration. [source] Use of Transgenic Animals to Improve Human Health and Animal ProductionREPRODUCTION IN DOMESTIC ANIMALS, Issue 4 2005L-M Houdebine Contents Transgenic animals are more widely used for various purposes. Applications of animal transgenesis may be divided into three major categories: (i) to obtain information on gene function and regulation as well as on human diseases, (ii) to obtain high value products (recombinant pharmaceutical proteins and xeno-organs for humans) to be used for human therapy, and (iii) to improve animal products for human consumption. All these applications are directly or not related to human health. Animal transgenesis started in 1980. Important improvement of the methods has been made and are still being achieved to reduce cost as well as killing of animals and to improve the relevance of the models. This includes gene transfer and design of reliable vectors for transgene expression. This review describes the state of the art of animal transgenesis from a technical point of view. It also reports some of the applications in the medical field based on the use of transgenic animal models. The advance in the generation of pigs to be used as the source of organs for patients and in the preparation of pharmaceutical proteins from milk and other possible biological fluids from transgenic animals is described. The projects in course aiming at improving animal production by transgenesis are also depicted. Some the specific biosafety and bioethical problems raised by the different applications of transgenesis, including consumption of transgenic animal products are discussed. [source] Local axon collaterals of lamina I projection neurons in the spinal cord of young ratsTHE JOURNAL OF COMPARATIVE NEUROLOGY, Issue 14 2010Peter Szucs Abstract Large, mediolaterally oriented neurons in lamina I of the spinal cord, frequently referred to as marginal cells of Waldeyer, are known to project to supraspinal targets via the anterolateral tract (ALT). Although dendritic organization of lamina I neurons has been extensively studied, little is known about their local axonal morphology and branching. With the help of oblique illumination, we visually identified large lamina I neurons in the isolated lumbar enlargement (L1,L6) of the spinal cord of P14,P20 rats. By using intracellular and cell-attached biocytin injections, we achieved extensive axonal and dendritic labeling in 77 lamina I cells, 40 of which were identified as ALT projection neurons. In the majority of the cases (n = 28), the main axon of these projection neurons gave rise to one or more thin collaterals on the ipsilateral side. Based on their trajectory and location, these collaterals could be divided into three major categories: dorsal, lateral, and ventral. Lamina I projection neurons had dorsal (n = 5), lateral (n = 8), or ventral (n = 6) collaterals only or a combination of these collateral types (n = 9). Our results suggest that lamina I ALT projection neurons can additionally function as local-circuit and propriospinal neurons participating in intra- and intersegmental spinal cord processing. J. Comp. Neurol. 518:2645,2665, 2010. © 2010 Wiley-Liss, Inc. [source] Pediatric Laryngotracheal Obstruction: Current Perspectives on StridorTHE LARYNGOSCOPE, Issue 7 2006John Bent MD Abstract Objectives/Hypothesis: To assess how medical advances have impacted the diagnosis, management, and outcomes of pediatric laryngotracheal obstruction, and to describe the advantages of audio-video documentation of stridorous children. Study Design and Methods: Retrospective. Methods and Materials: 268 patients were referred for suspected laryngotracheal obstruction during the 30 months between September 1, 1995 and March 1, 1998: 173 had 206 flexible fiberoptic laryngoscopies, and 160 had 273 direct laryngoscopies. One hundred and forty-one children were identified with laryngotracheal obstruction, yielding 40 different diagnoses that could be classified into 9 major categories. Thirty-six children (25.5%) had multiple sites of upper airway obstruction. Results: 138 children had follow-up >1 month. Twelve children died (8.7%), leaving 126 survivors (mean follow-up = 21.1 months). Outcomes were classified as resolved (44.2%), improved (37.0%), stable (9.4%), failed (0.7%), or death (8.7%). Better outcomes were seen in more readily treated diagnostic categories, such as tracheobronchial foreign body, chronic laryngitis, and suprastomal granulation tissue; laryngeal stenosis, tracheomalacia, and recurrent respiratory papillomatosis, had less favorable outcomes (P <.001). The former group also showed superior outcome compared to laryngomalacia (P <.001) and vocal cord mobility disorders (P = .004). Ninety-four patients (68.1%) had comorbidities complicating their management. Comorbid conditions were universal among deceased patients and least common in the resolved outcomes category (56.7%), supporting the premise that patients with poor outcomes are more likely to have comorbidities than patients with resolution of laryngotracheal symptoms (P = .034). Conclusions: Audio-video recording of pediatric laryngotracheal obstruction offers numerous advantages. Children classified into an array of diagnostic categories usually have favorable outcomes, but opportunities for continued advances exist, particularly regarding management of comorbidity and chronic obstruction. [source] SOURCES OF PRODUCTIVITY GROWTH IN AUSTRALIAN TEXTILE AND CLOTHING FIRMS,AUSTRALIAN ECONOMIC PAPERS, Issue 3 2007I.K.M. MOKHTARUL WADUD This paper estimates the sources of productivity growth in Australian textile and clothing firms based on the Business Longitudinal Survey (BLS) from 1995 to 1998. Productivity growth estimates have been obtained for each sub-category of textile and clothing firms. Sources of growth in multifactor productivity (MFP) are examined with growth in technical efficiency and scale effects based on estimates of stochastic frontier production functions. Separate estimates of output growth have been compared with the productivity growth estimates for each of the product categories. MFP improved in all clothing firms and declined in textile firms over 1997,1998 by four-digit level of Australia New Zealand Standard Industrial classification Scheme (ANZSIC). MFP declined in most major categories of both textile and clothing firms in 1995,1997. Changes in technical efficiency mostly dominated scale effects in the overall direction of MFPG in both textile and clothing firms. The findings of the study provide evidence for policies for improving the firms' operative performance in the ongoing liberalised regime. [source] Sex differences in the prevalence of human birth defects: A population-based study,BIRTH DEFECTS RESEARCH, Issue 5 2001Joseph M. Lary Background Sex differences in the prevalence of several human birth defects have often been reported in the literature, but the extent of sex differences for most birth defects is unknown. To determine the full extent of sex differences in birth defects in a population, we examined population-based data from the Metropolitan Atlanta Congenital Defects Program (MACDP). Methods MACDP records were analyzed for 1968 through 1995. We determined the sex-specific prevalence of all major birth defects, using the total number of live births by sex during these years as the denominator. For each specific defect, we calculated a relative risk with regard to sex on the basis of the ratio of prevalence among males to prevalence among females. Male,female relative risks were also determined for total major birth defects and for several broad categories of defects. Results The overall prevalence of major defects at birth was 3.9% among males and 2.8% among females. All but two of the major categories of birth defects (nervous system defects and endocrine system defects) had a higher prevalence among males. Defects of the sex organs were eight and one-half times more prevalent among males and accounted for about half of the increased risk of birth defects among males relative to females. Urinary tract defects were 62% more prevalent among males, and gastrointestinal tract defects were 55% more prevalent among males. Among specific defect types, twofold or greater differences in prevalence by sex were common. Conclusions Our data indicate that sex differences in the prevalence of specific human birth defects are common, and male infants are at greater risk for birth defects than female infants. Several mechanisms have been proposed to account for these differences. Teratology 64:237,251, 2001. Published 2001 Wiley-Liss, Inc. [source] Selective apoptosis of natural killer-cell tumours by l -asparaginaseBRITISH JOURNAL OF HAEMATOLOGY, Issue 6 2005Miki Ando Summary We examined the effectiveness of various anti-tumour agents to natural killer (NK)-cell tumour cell lines and samples, which are generally resistant to chemotherapy, using flow cytometric terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labelling (TUNEL) assay. Although NK-YS and NK-92 were highly resistant to various anti-tumour agents, l -asparaginase induced apoptosis in these two NK-cell lines. NK-cell leukaemia/lymphoma and acute lymphoblastic leukaemia (ALL) samples were selectively sensitive to l -asparaginase and to doxorubicin (DXR) respectively. Samples of chronic NK lymphocytosis, an NK-cell disorder with an indolent clinical course, were resistant to both drugs. Our study clearly separated two major categories of NK-cell disorders and ALL according to the sensitivity to DXR and l -asparaginase. We examined asparagine synthetase levels by real-time quantitative polymerase chain reaction (RQ-PCR) and immunostaining in these samples. At least in nasal-type NK-cell lymphoma, there was a good correlation among asparagine synthetase expression, in vitro sensitivity and clinical response to l -asparaginase. In aggressive NK-cell leukaemia, although asparagine synthetase expression was high at both mRNA and protein levels, l -asparaginase induced considerable apoptosis. Furthermore, samples of each disease entity occupied a distinct area in two-dimensional plotting with asparagine synthetase mRNA level (RQ-PCR) and in vitrol -asparaginase sensitivity (TUNEL assay). We confirmed rather specific anti-tumour activity of l -asparaginase against NK-cell tumours in vitro, which provides an experimental background to the clinical use of l -asparaginase for NK-cell tumours. [source] The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysisBRITISH JOURNAL OF PHARMACOLOGY, Issue 1 2010Amy B Cadwallader Diuretics are drugs that increase the rate of urine flow and sodium excretion to adjust the volume and composition of body fluids. There are several major categories of this drug class and the compounds vary greatly in structure, physicochemical properties, effects on urinary composition and renal haemodynamics, and site and mechanism of action. Diuretics are often abused by athletes to excrete water for rapid weight loss and to mask the presence of other banned substances. Because of their abuse by athletes, diuretics have been included on The World Anti-Doping Agency's (WADA) list of prohibited substances; the use of diuretics is banned both in competition and out of competition and diuretics are routinely screened for by anti-doping laboratories. This review provides an overview of the pharmacology and toxicology of diuretics and discusses their application in sports. The most common analytical strategies currently followed by the anti-doping laboratories accredited by the WADA are discussed along with the challenges laboratories face for the analysis of this diverse class of drugs. [source] Recent trends in the treatment of advanced lung cancerCANCER SCIENCE, Issue 6 2006Nagahiro Saijo Lung cancer is one of the major causes of death in many countries because of high rates of smoking, especially in Asian countries. Lung cancer is divided into two major categories based on their biological characteristics and the selection of treatment methods: non-small cell lung cancer (NSCLC; 85%) and small cell lung cancer (15%). Early detection and complete resection are very important in NSCLC, but the cure rate is not very high, except in stage 1A disease. It is extremely important to understand the biology of lung cancer and to introduce more effective treatments in order to improve the survival of NSCLC patients. Numerous clinical trials involving lung cancer patients have led to ,state-of-the-art' treatments for each stage of the disease. Progress in chemotherapy and molecular target based therapy have altered the standard therapy for NSCLC. (Cancer sci 2006; 97) [source] The Discursive Malleability of an IdentityJOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 1 2006Chaise LaDousa This article employs a dialogic approach, in the parlance of Bakhtin, to explore the ways in which a school smedium,its primary language of instruction, has become a major category of identity in North India. Many people describe themselves and others by invoking attendance at either a Hindi- or English-medium school. The first task of this article is to account for what Bakhtin callscentripetal forcesthat enable people at different positions in terms of class or school experience to use a common duality of Hindiversus English-medium and its attendant social resonances. The second task is to account for the abilities of a teacher to question the inevitability of the medium divide and to radically reframe what is important about schooling. Her abilities derive, in part, from her experiences with schools, attesting to Bakhtin s insight that centripetal forces in language are never total, and that centrifugal forces arise from complex engagements with institutions. [source] | |||||||||||||||||||