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Major

Distribution by Scientific Domains
Medical Sciences40%
Life Sciences23%
Chemistry8%
Earth and Environmental Science7%
Humanities and Social Sciences7%
Business, Economics, Finance and Accounting4%
7 Other Domains11%
Distribution within Medical Sciences
Hematology7%
Dermatology5%
59 Other Subdomains63%

Kinds of Major

  • great tit parus major
  • l. major
  • leishmania major
    		•
  • other major
  • p. major
  • pagrus major
    		•
  • parus major
  • plantago major
  • thalassaemia major
    		•
  • thalassemia major
  • tit parus major

    • Terms modified by Major

  • major abdominal surgery
  • major achievement
  • major activity
  • major advance
  • major advantage
  • major adverse cardiac
  • major adverse cardiac event
  • major adverse cardiovascular event
  • major adverse effects
  • major adverse event
  • major aetiological factor
  • major affective disorders
  • major aim
  • major alkaloid
  • major allele
  • major allergen
  • major alteration
  • major amputation
  • major anomaly
  • major application
  • major approach
  • major area
  • major argument
  • major aspect
  • major autoantigen
  • major bacterial pathogen
  • major bands
  • major barrier
  • major basic protein
  • major benefit
  • major bioactive constituent
  • major biome
  • major birch pollen allergen
  • major birth defects
  • major bleeding
  • major bleeding complications
  • major blood vessel
  • major bottleneck
  • major branch
  • major breakthrough
  • major burden
  • major capsid protein
  • major cardiac event
  • major cardiovascular event
  • major cardiovascular risk factor
  • major carotenoid
  • major carp
  • major category
  • major causative factor
  • major cause
  • major cell type
  • major centre
  • major challenge
  • major change
  • major channel
  • major characteristic
  • major city
  • major clade
  • major class
  • major clinical
  • major clinical challenge
  • major clinical problem
  • major clinical trials
  • major cluster
  • major colorectal surgery
  • major company
  • major complication
  • major complication rate
  • major complications
  • major component
  • major compound
  • major concern
  • major conclusion
  • major condition
  • major conformational change
  • major congenital anomalies
  • major congenital malformation
  • major connector
  • major consequence
  • major consideration
  • major constituent
  • major constraint
  • major contaminant
  • major contributing factor
  • major contribution
  • major contributor
  • major contributory factor
  • major control
  • major coronary artery
  • major coronary event
  • major corporation
  • major criterioN
  • major criticism
  • major crop
  • major cytogenetic response
    		•
  • major databases
  • major decision
  • major decline
  • major decrease
  • major defect
  • major deficiency
  • major depression
  • major depressive
  • major depressive disorder
  • major depressive episode
  • major determinant
  • major development
  • major diagnosis
  • major diastereomer
  • major difference
  • major difficulty
  • major dimension
  • major discontinuity
  • major discrepancy
  • major disease
  • major disruption
  • major disturbance
  • major drawback
  • major driver
  • major drivers
  • major driving force
  • major drought
  • major earthquake
  • major economic
  • major economy
  • major effect
  • major effects
  • major effort
  • major element
  • major emphasis
  • major endpoint
  • major enzyme
  • major episode
  • major epitope
  • major ethnic groups
  • major event
  • major evolutionary transition
  • major exception
  • major excitatory neurotransmitter
  • major expansion
  • major exporter
  • major facilitator superfamily
  • major factor
  • major factor contributing
  • major family
  • major fault
  • major feature
  • major finding
  • major flavonoid
  • major focus
  • major food source
  • major force
  • major form
  • major fraction
  • major fragment
  • major function
  • major fungal pathogen
  • major gap
  • major gene
  • major global health problem
  • major goal
  • major group
  • major groups
  • major habitat
  • major habitat type
  • major haemorrhage
  • major haplotype
  • major health
  • major health problem
  • major hemorrhage
  • major hepatectomy
  • major hepatic resection
  • major histocompatibility complex
  • major histocompatibility complex class i
  • major histocompatibility complex class ii
  • major histocompatibility complex molecule
  • major hospital
  • major human pathogen
  • major hurdle
  • major hypothesis
  • major illness
  • major impact
  • major impediment
  • major implication
  • major importance
  • major improvement
  • major incident
  • major increase
  • major indication
  • major indicator
    		•
  • major infection
  • major infections
  • major influence
  • major ingredient
  • major inhibitor
  • major inhibitory neurotransmitter
  • major injury
  • major innovation
  • major input
  • major insect pest
  • major interaction
  • major interest
  • major involvement
  • major ion
  • major island
  • major isoform
  • major isomer
  • major issue
  • major issues
  • major journal
  • major life event
  • major ligand
  • major limitation
  • major limiting factor
  • major lineage
  • major liver resection
  • major locus
  • major malformation
  • major manifestation
  • major market
  • major mean
  • major mechanism
  • major mediator
  • major mental disorders
  • major merger
  • major metabolic pathway
  • major metabolite
  • major milestone
  • major modification
  • major modifications
  • major molecular response
  • major morbidity
  • major morphological change
  • major mortality factor
  • major muscle
  • major myelin protein
  • major nutrient
  • major objective
  • major obstacle
  • major ones
  • major organ
  • major orthopaedic surgery
  • major outbreak
  • major outcome
  • major outer membrane protein
  • major parameter
  • major part
  • major party
  • major pathogen
  • major pathogenic factor
  • major pathway
  • major patient
  • major pattern
  • major peak
  • major pest
  • major phase
  • major phenotype
  • major phosphorylation site
  • major player
  • major point
  • major policy
  • major policy change
  • major population
  • major port
  • major portion
  • major postoperative complications
  • major power
  • major predictor
  • major predisposing factor
  • major preoccupation
  • major prey
  • major priority
  • major problem
  • major procedure
  • major process
  • major producers
  • major product
  • major product ion
  • major products
  • major prognostic factor
  • major progress
  • major project
  • major proportion
  • major protein
  • major protein component
    		•
  • major psychiatric disorders
  • major public health concern
  • major public health implication
  • major public health issue
  • major public health problem
  • major qtl
  • major quantitative trait locus
  • major question
  • major reason
  • major receptor
  • major reduction
  • major regions
  • major regulator
  • major relevance
  • major requirement
  • major resection
  • major reservoir
  • major response
  • major result
  • major review
  • major revision
  • major risk
  • major risk factor
  • major river
  • major river basin
  • major river system
  • major role
  • major route
  • major safety concern
  • major salivary gland
  • major saponin
  • major shift
  • major shortcoming
  • major side effects
  • major side-effect
  • major signaling pathway
  • major sink
  • major site
  • major social
  • major solute
  • major source
  • major species
  • major step
  • major storm
  • major strategy
  • major strength
  • major stressor
  • major stroke
  • major structural change
  • major structural component
  • major structure
  • major studies
  • major subdivision
  • major subgroup
  • major subset
  • major substrate
  • major subtype
  • major subunit
  • major sugar
  • major surgery
  • major surgical procedure
  • major symptom
  • major target
  • major task
  • major taxa
  • major teaching hospital
  • major technical challenge
  • major theme
  • major themes
  • major theory
  • major threat
  • major trading partner
  • major transcription factor
  • major transformation
  • major transition
  • major trauma
  • major trend
  • major tributary
  • major trigger
  • major type
  • major use
  • major variable
  • major variation
  • major vascular complications
  • major vascular surgery
  • major vector
  • major vegetation type
  • major vessel
  • major virulence factor
  • major volatile compound
  • major way
  • major work

    • Selected Abstracts

    IS AGE A RISK FACTOR FOR WARFARIN-RELATED MAJOR BLEEDS IN ELDERLY PATIENTS WITH ATRIAL FIBRILLATION?

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 7 2006
    Huai Yong Cheng MD
    No abstract is available for this article. [source]

    INDIVIDUAL AND COMBINED CYTOTOXIC EFFECTS OF THE MAJOR FOUR AFLATOXINS IN DIFFERENT IN VITRO STABILIZED SYSTEMS

    JOURNAL OF FOOD BIOCHEMISTRY, Issue 5 2010
    CORNELIA BRAICU
    ABSTRACT The present study aims to investigate the cytotoxic effect of the major aflatoxins (B1, B2, G2 and G2) and also aflatoxin combination, using a simple, rapid and cheap cytotoxicity test like MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay in three in vitro models (human umbilical vein endothelial cells [HUVEC], human lung fibroblasts [HFL] and A2780 cell line) and to extrapolate the data to in vivo situation using a prediction model. A difference in cell sensitivity has been observed for B1 and B1 + B2, in the following order A2789 > HFL > HUVEC, while for B2, G1, G2, Mix (B1 + B2 + G1 + G2) the order was HFL > A2789 > HUVEC when comparing the IC50 (half maximal inhibitory concentration) values. We confirm that in vitro cytotoxicity test MTT assay is able to predict in vivo toxicity, at least for aflatoxins using the prediction model. The values of LD50 (lethal dose 50%) calculated from experiments are different for each cell line. This fact may indicate that some species are more resistant than other and target organs are not necessarily those predicted, because the A2780 ovarian cancer cells seem to be more sensitive to B1 than cells of endothelial or fibroblasts origin. PRACTICAL APPLICATIONS This study is in concordance with the international tendency that refined the current techniques to lessen pain or distress, to reduce the number of animals necessary for a particular test or to replace animals with non-whole-animal models, such as in vitro cell cultures. The practical application of such methodologies may help solve the economic problem related to very expensive in vivo toxicology studies and implement preventive methods based on the calculated data and known mechanism of action of individual or combined toxins easily studied in vitro. The nature of coexistence of many types of mycotoxins in complex environmental samples, such as food and water, has been reported worldwide. How these mycotoxins might affect human health in combination is largely unknown. This study had, as a goal, to test the toxicity of the four aflatoxins and aflatoxin combination on human cells. Due to the lack of aflatoxins mixture data regarding the human cytotoxicity, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures. [source]

    Effect of Normal Saline Infusion on the Diagnostic Utility of Base Deficit in Identifying Major Injury in Trauma Patients

    ACADEMIC EMERGENCY MEDICINE, Issue 12 2006
    Richard Sinert DO
    Abstract Background Base deficit (BD) is a reliable marker of metabolic acidosis and is useful in gauging hemorrhage after trauma. Resuscitation with chloride-rich solutions such as normal saline (NS) can cause a dilutional acidosis, possibly confounding the interpretation of BD. Objectives To test the diagnostic utility of BD in distinguishing minor from major injury after administration of NS. Methods This was a prospective observational study at a Level 1 trauma center. The authors enrolled patients with significant mechanism of injury and measured BD at triage (BD-0) and at four hours after triage (BD-4). Major injury was defined by any of the following: injury severity score of ,15, drop in hematocrit of ,10 points, or the patient requiring a blood transfusion. Patients were divided into a low-volume (NS < 2L) and a high-volume (NS , 2L) group. Data were reported as mean (±SD). Student's t- and Wilcoxon tests were used to compare data. Receiver operating characteristic (ROC) curves tested the utility of BD-4 in differentiating minor from major injury in the study groups. Results Four hundred eighty-nine trauma patients (mean age, 36 [± 18] yr) were enrolled; 82% were male, and 34% had penetrating injury. Major-(20%) compared with minor-(80%) injury patients were significantly (p = 0.0001) more acidotic (BD-0 mean difference: ,3.3 mmol/L; 95% confidence interval [CI] =,2.5 to ,4.2). The high-volume group (n = 174) received 3,342 (±1,821) mL, and the low-volume group (n = 315) received 621 (±509) mL of NS. Areas under the ROC curves for the high-volume (0.63; 95% CI = 0.52 to 0.74) and low-volume (0.73; 95% CI = 0.60 to 0.86) groups were not significantly different from each other. Conclusions Base deficit was able to distinguish minor from major injury after four hours of resuscitation, irrespective of the volume of NS infused. [source]

    Why Don't More Students Major in IS?

    DECISION SCIENCES JOURNAL OF INNOVATIVE EDUCATION, Issue 2 2009
    William L. Kuechler
    ABSTRACT The large increases in the number of information systems (IS) majors about 10 years ago have been matched by equally large decreases in IS enrollments over the last few years. This article addresses the question of why students choose any major in general, and why students no longer choose to become an IS major in particular. We used a validated survey instrument and the responses from 163 students to examine this question in detail. Not surprisingly, we found that "genuine interest" in the subject was the most salient factor affecting the decision to major in IS. More surprising were what factors did not appear to influence this decision,for example, the promise of good job salaries, job security, the advice of others, or even the image of those who become IS professionals. Students seem aware that information technology employment opportunities exist; if job and salary issues contribute to choosing majors,other than IS, it is due to the perception of an unfavorable work/salary ratio for our field rather than one of job security or availability. That is, the amount of work to get an IS degree (the perception of harder-than-average courses) combined with (for many students) the perception of an undesirable amount of continuous training to keep an IS career just do not seem to balance with salary levels. These findings have important implications for the recruiting efforts of IS faculty seeking to attract more IS majors. [source]

    Major and minor depression in Parkinson's disease: a neuropsychological investigation

    EUROPEAN JOURNAL OF NEUROLOGY, Issue 9 2006
    A. Costa
    Previous studies have failed to distinguish the differential contribution of major and minor depression to cognitive impairment in patients with idiopathic Parkinson's disease (PD). This study was aimed at investigating the relationships among major depression (MD), minor depression (MiD) and neuropsychological deficits in PD. Eighty-three patients suffering from PD participated in the study. MD and MiD were diagnosed by means of a structured interview (SCID-I) based on the DSM-IV criteria, and severity of depression was evaluated by the Beck Depression Inventory. For the neuropsychological assessment, we used standardized scales that measure verbal and visual episodic memory, working memory, executive functions, abstract reasoning and visual-spatial and language abilities. MD patients performed worse than PD patients without depression on two long-term verbal episodic memory tasks, on an abstract reasoning task and on three measures of executive functioning. The MiD patients' performances on the same tests fell between those of the other two groups of PD patients but did not show significant differences. Our results indicate that MD in PD is associated with a qualitatively specific neuropsychological profile that may be related to an alteration of prefrontal and limbic cortical areas. Moreover, the same data suggest that in these patients MiD and MD may represent a gradual continuum associated with increasing cognitive deficits. [source]

    ENVIRONMENTAL CONDITIONS AFFECT THE MAGNITUDE OF INBREEDING DEPRESSION IN SURVIVAL OF DARWIN'S FINCHES

    EVOLUTION, Issue 6 2002
    Lukas F. Keller
    Abstract Understanding the fitness consequences of inbreeding (inbreeding depression) is of importance to evolutionary and conservation biology. There is ample evidence for inbreeding depression in captivity, and data from wild populations are accumulating. However, we still lack a good quantitative understanding of inbreeding depression and what influences its magnitude in natural populations. Specifically, the relationship between the magnitude of inbreeding depression and environmental severity is unclear. We quantified inbreeding depression in survival and reproduction in populations of cactus finches (Geospiza scandens) and medium ground finches (Geospiza fortis) living on Isla Daphne Major in the Galapagos Archipelago. Our analyses showed that inbreeding strongly reduced the recruitment probability (probability of breeding given that an adult is alive) in both species. Additionally, in G. scandens, first-year survival of an offspring withf= 0.25 was reduced by 21% and adults withf= 0.25 experienced a 45% reduction in their annual probability of survival. The magnitude of inbreeding depression in both adult and juvenile survival of this species was strongly modified by two environmental conditions, food availability and number of competitors. In juveniles, inbreeding depression was only present in years with low food availability, and in adults inbreeding depression was five times more severe in years with low food availability and large population sizes. The combination of relatively severe inbreeding depression in survival and the reduced recruitment probability led to the fact that very few inbred G. scandens ever succeeded in breeding. Other than recruitment probability, no other trait showed evidence of inbreeding depression in G. fortis, probably for two reasons: a relatively high rate of extrapair paternity (20%), which may lead to an underestimate of the apparent inbreeding depression, and low sample sizes of highly inbred G. fortis, which leads to low statistical power. Using data from juvenile survival, we estimated the number of lethal equivalents carried by G. scandens, G. fortis, and another congener, G. magnirostris. These results suggest that substantial inbreeding depression can exist in insular populations of birds, and that the magnitude of the inbreeding depression is a function of environmental conditions. [source]

    Experimental and numerical studies on dynamic crack growth in layered slate rock under wedge impact loads: part II , non-plane strain problem

    FATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 10 2007
    M. R. ALAM
    ABSTRACT Dynamic crack propagation in non-plane strain (or 3D) slate blocks under wedge impact loads was investigated numerically in this part of the paper. A parabolic-shaped crack trajectory was taken into consideration to model the crack propagation in slate blocks for analyzing the impact splitting of layered slate rock. Major and minor axes of the parabola were determined from the condition of equal mode I stress intensity factors (SIFs) along the crack front. Mode I SIFs were determined for experimental breaking loads for each increment of crack growth in a manner similar to that mentioned in part I of this paper. These values were compared with the plane strain material fracture toughness value obtained from experimental studies and very good agreement was obtained between them, for the case of actual load applied on the specimen. Numerical analysis of a field problem, i.e., separation of a large-sized slate slab from the rock strata in a slate quarry using wedge impacting, was also carried out in this paper. It can be observed that a large magnitude of load is required to break large-sized slate blocks; but this load is applied through a number of smaller load-capacity actuators-in-parallel, requiring large power capacity for the hydraulic pumps. However, this required power could be reduced considerably if the load applied on the line of hydraulic actuators is cascaded across the (line of) actuators (starting from centrally placed actuators) with a small time delay (equal to the initial crushing time in slate rock). [source]

    K-Ar age determination, whole-rock and oxygen isotope geochemistry of the post-collisional Bizmi,en and Çalt, plutons, SW Erzincan, eastern Central Anatolia, Turkey

    GEOLOGICAL JOURNAL, Issue 4 2005
    Ayten Önal
    Abstract Post-collisional granitoid plutons intrude obducted Neo-Tethyan ophiolitic rocks in central and eastern Central Anatolia. The Bizmi,en and Çalt, plutons and the ophiolitic rocks that they intrude are overlain by fossiliferous and flyschoidal sedimentary rocks of the early Miocene Kemah Formation. These sedimentary rocks were deposited in basins that developed at the same time as tectonic unroofing of the plutons along E,W and NW,SE trending faults in Oligo-Miocene time. Mineral separates from the Bizmi,en and Çalt, plutons yield K-Ar ages ranging from 42 to 46,Ma, and from 40 to 49,Ma, respectively. Major, trace, and rare-earth element geochemistry as well as mineralogical and textural evidence reveals that the Bizmi,en pluton crystallized first, followed at shallower depth by the Çalt, pluton from a medium-K calcalkaline, I-type hybrid magma which was generated by magma mixing of coeval mafic and felsic magmas. Delta 18O values of both plutons fall in the field of I-type granitoids, although those of the Çalt, pluton are consistently higher than those of the Bizmi,en pluton. This is in agreement with field observations, petrographic and whole-rock geochemical data, which indicate that the Bizmi,en pluton represents relatively uncontaminated mantle material, whereas the Çalt, pluton has a significant crustal component. Structural data indicating the middle Eocene emplacement age and intrusion into already obducted ophiolitic rocks, suggest a post-collisional extensional origin. However, the pure geochemical discrimination diagrams indicate an arc origin which can be inherited either from the source material or from an upper mantle material modified by an early subduction process during the evolution of the Neo-Tethyan ocean. Copyright © 2005 John Wiley & Sons, Ltd. [source]

    Pre-Variscan metagabbro from NW Sardinia, Italy: evidence of an enriched asthenospheric mantle source for continental alkali basalts

    GEOLOGICAL JOURNAL, Issue 2 2003
    Marcello Franceschelli
    Abstract Small metagabbro bodies are enclosed in the metasedimentary sequence of NW Sardinia. The metagabbros represent the last magmatic episode before the continent,continent collision that built up the Variscan chain of north Sardinia. The metagabbros are composed of variable proportions of plagioclase and pyroxene igneous relics and metamorphic minerals. Major and trace element data, specifically high TiO2 and P2O5 and low K and Rb contents, as well as light rare-earth elements, Nb and Ta enrichment, suggest an alkaline affinity for the gabbro and emplacement in a within-plate tectonic setting. The gabbro was derived from an ocean island alkali basalt-like asthenospheric mantle source enriched with incompatible elements and uncontaminated by crustal or subducted materials. Non-modal modelling indicates a 5,7% partial melting of the asthenospheric mantle. Copyright © 2003 John Wiley & Sons, Ltd. [source]

    Direct Current Plasma Emission Spectrometric Determination of Major, Minor and Trace Elements in Microwave Oven Acid Leachates of Powdered Whole Coal Samples

    GEOSTANDARDS & GEOANALYTICAL RESEARCH, Issue 1 2005
    Sandro Fadda
    DCP-AES; échantillons de charbon; four à micro-ondes; éléments facilement ionisables; effets de matrice. Major concentrations of Al2O3, Fe2O3, MgO, CaO, Na2O and K2O, minor levels of TiO2, P2O5 and thirty petrologically, geochemically and environmentally significant trace elements have been determined in microwave oven acid leachates of whole powdered coal samples by direct current plasma-atomic emission spectrometry (DCP-AES). A single sample preparation procedure was suitable for all the determinations with no additional dilution step for major elements solution. Dried samples (0.5 g) were treated in low-pressure PFA digestion vessels with HF/HCl/HNO3/HClO4 acids to quantitatively extract the analytes from the bulk material, while leaving the major part of organic matrix as a residue. The major constituents of geological samples, in particular the easily ionised elements (EIEs) such as alkali and alkaline earths, may complicate the instrumental determinations in DCP-AES because of differential enhancements of elemental emission intensities and stray light interferences. Taking account of these factors, the coal matrix is considered to have very low major oxide totals as compared to many other common geo-environmental and related materials (rocks, sediments, soil, ashes etc.). The sample size employed here, while yielding a relatively concentrated solution to cover a wide range of elemental determinations, provided a sample matrix that significantly diminished interferences for DCP measurements. The need for closely matching the unknowns and calibrators was eliminated except for overall acidity and an excess quantity of caesium for EIE buffering. Calibration of the spectrometer was accomplished by simple aqueous single element solutions as high concentration calibrators in addition to a reagent blank as a low concentration calibrator. Two point working curves were established to allow for the maximum concentrations of each element expected in the unknowns. The precision of determinations under routine conditions as well as the reproducibility of the leaching and precision of instrumental measurements have been evaluated. Relative standard deviations (RSD) were of 1,2% for those elements whose concentrations in solid samples were well above the limits of quantification. Method detection limits in the buffered solutions were also evaluated. To evaluate the accuracy of the microwave oven-DCP method a suite of eight certified coal reference materials of differing rank, were analysed with good agreement with the certified and/or available published data. Results are presented for the uncertified major oxides in the AR series reference materials. Les concentrations en éléments majeurs: Al2O3, Fe2O3, MgO, CaO, Na2O et K2O, en éléments mineurs TiO2, P2O5 et en 30 éléments en trace dont le comportement est important en Pétrologie, en Géochimie et en Environnement, ont été analysées par spectrométrie d'émission atomique à plasma à courant direct (DCP-AES), dans des lessivages acides effectués dans un four à micro-ondes sur des échantillons de charbon mis en poudre. Ce mode préparatoire unique est adaptéà toutes les déterminations sans qu'il soit nécessaire d'effectuer une dilution supplémentaire pour l'analyse des éléments majeurs. Les échantillons préalablement desséchés (0.5 g) sont traités dans les pots de PFA de basse pression, avec un mélange d'acides HF/HCl/HNO3/HClO4, afin d'extraire quantitativement les analytes du matériel géologique, tout en laissant la plus grande part de la matrice organique sous forme résiduelle. Les constituants majeurs de ces échantillons géologiques, en particulier les éléments facilement ionisables (EIEs) tels que les alcalins et les alcalino-terreux, peuvent compliquer l'analyse en DCP-AES à cause des rendements variables des intensités d'émission élémentaires et des interférences de raies de lumière. Mais là dessus, la matrice de charbon se révèle être bien plus pauvre en oxydes majeurs que les autres matériaux géologiques, environnementaux ou de type proche (roches, sédiments, sols, cendres). La taille d'échantillon retenue ici, tout en fournissant une solution relativement concentrée qui permet la détermination de beaucoup d'éléments, fournit une matrice qui diminue significativement les interférences lors de la mesure par DCP-AES. Le besoin d'avoir les solutions d'échantillons et les solutions de calibration avec des matrices très proches est donc éliminé, mis à part pour l'acidité totale et la quantité excessive de Césium pour tamponner les EIE. La calibration du spectromètre est faite avec des solutions mono- élémentaires aqueuses, pour déterminer les points de concentrations élevées et avec le blanc de réactifs pour le point de concentration basse. Les courbes de calibrations sont déterminées avec 2 points, pour autoriser l'analyse de concentrations maximales pour chaque élément dans les échantillons inconnus. La précision des déterminations en conditions de routine ainsi que la reproductibilité de l'opération de lessivage et la précision instrumentale des analyses ont étéévaluées. Les déviations standards relatives (RSD) sont de 1,2% pour tout élément dont les concentrations dans le solide sont au dessus des limites de quantification. Les limites de détection de la méthode dans les solutions tamponnées ont aussi étéévaluées. Enfin, pour évaluer la justesse de cette méthode "micro-ondes - DCP" huit charbons certifiés matériaux de référence de différents types ont été analysés, et sont en bon accord avec les données certifiées ou seulement disponibles publiées. Les données sur un certain nombre d'oxydes d'éléments majeurs actuellement non certifiés sont présentées pour les matériaux de référence AR. [source]

    Monoterpene emissions from rubber trees (Hevea brasiliensis) in a changing landscape and climate: chemical speciation and environmental control

    GLOBAL CHANGE BIOLOGY, Issue 11 2007
    YONG-FENG WANG
    Abstract Emissions of biogenic volatile organic compounds (VOCs) have important roles in ecophysiology and atmospheric chemistry at a wide range of spatial and temporal scales. Tropical regions are a major global source of VOC emissions and magnitude and chemical speciation of VOC emissions are highly plant-species specific. Therefore it is important to study emissions from dominant species in tropical regions undergoing large-scale land-use change, for example, rubber plantations in South East Asia. Rubber trees (Hevea brasiliensis) are strong emitters of light-dependent monoterpenes. Measurements of emissions from leaves were made in the dry season in February 2003 and at the beginning of the wet season in May 2005. Major emitted compounds were sabinene, , -pinene and , -pinene, but , -ocimene and linalool also contributed significantly at low temperature and light. Cis -ocimene was emitted with a circadian course independent of photosynthetic active radiation (PAR) and temperature changes with a maximum in the middle of the day. Total isoprenoid VOC emission potential at the beginning of the wet season (94 ,g gdw,1 h,1) was almost two orders of magnitude higher than measured in the dry season (2 ,g g dw,1 h,1). Composition of total emissions changed with increasing temperature or PAR ramps imposed throughout a day. As well as light and temperature, there was evidence that assimilation rate was also a factor contributing to seasonal regulating emission potential of monoterpenes from rubber trees. Results presented here contribute to a better understanding of an important source of biogenic VOC associated with land-use change in tropical South East Asia. [source]

    Response Evaluation Criteria in Cancer of the Liver (RECICL) proposed by the Liver Cancer Study Group of Japan (2009 Revised Version)

    HEPATOLOGY RESEARCH, Issue 7 2010
    Masatoshi Kudo
    The World Health Organization (WHO) criteria and Response Evaluation Criteria in Solid Tumors (RECIST) are inappropriate to assess the direct effects of treatment on the hepatocellular carcinoma (HCC) by locoreginal therapies such as radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE). Therefore, establishment of response evaluation criteria solely devoted for HCC is needed urgently in the clinical practice as well as in the clinical trials of HCC treatment, such as molecular targeted therapies, which cause necrosis of the tumor. Response Evaluation Criteria in Cancer of the Liver (RECICL) was revised in 2009 by Liver Cancer Study Group of Japan based on the 2004 version of RECICL, which was commonly used in Japan. Major revised points of the RECICL 2009 is to provide TE4a (Complete response with enough ablative margin) and TE4b (complete response without enough ablative margin) for local ablation therapy. Second revised point is that setting the timing at which the overall treatment effects are assessed. Third point is that emergence of new lesion in the liver is regarded as progressive disease, different from 2004 version. Finally, 3 tumor markers including alpha-fetoprotein (AFP) and AFP-L3 and des-gamma-carboxy protein (DCP) were also added for the overall treatment response. We hope this new treatment response criteria, RECICL, proposed by Liver Cancer Study Group of Japan will benefit the HCC treatment response evaluation in the setting of the daily clinical practice and clinical trials as well not only in Japan, but also internationally. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 5 2010
    Article first published online: 29 JUN 2010
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Reviews; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 1 2010
    Article first published online: 29 DEC 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Reviews; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 4 2008
    Article first published online: 22 MAY 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Reviews; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 3 2008
    Article first published online: 31 MAR 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Reviews; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 6 2007
    Article first published online: 2 AUG 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Reviews; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 8 2006
    Article first published online: 29 NOV 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 7 2006
    Article first published online: 9 OCT 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current awareness in human psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 3 2005
    Article first published online: 30 MAR 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current Awareness in Human Psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 4 2003
    Article first published online: 19 MAY 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current Awareness in Human Psychopharmacology

    HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 7 2002
    Article first published online: 24 SEP 200
    In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs - General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted. [source]

    Current epidemiology of atopic dermatitis in south-eastern Nigeria

    INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 10 2004
    Edith N. Nnoruka MB
    Background, Atopic dermatitis (AD) is a common pruritic, eczematous skin disorder that runs a chronic and relapsing course. In Nigeria, it is currently on the increase, particularly amongst infants, and has created cost burdens for families. It occurs in association with a personal or family history of asthma, allergic rhinitis and conjunctivitis. Major and minor criteria exist as guidelines for arriving at a diagnosis of AD, and surveys from Western countries have shown that these features, in particular the minor features, vary with ethnicity and genetic background and can be used to aid diagnosis. African dermatologists have also voiced concern that the much used Hanifin criteria for diagnosis of AD may need some adaptation for use in Africa. Objective, To document the features and disease outcomes of AD seen amongst dermatology hospital patients in Enugu, south-eastern Nigeria, with a view to reflecting current features amongst Nigerian Blacks. Methods, A prospective study of AD patients seen over a 2-year period at a tertiary referral dermatology clinic (University of Nigeria Teaching Hospital, Enugu, Nigeria) was carried out. A total of 1019 patients aged between 4 weeks and 57 years were included in the study. Results, The prevalence of AD was 8.5%, which is much higher than the prevalence of AD reported in various parts of Nigeria 15 years ago. AD occurred before the age of 10 years in 523 (51.3%) patients, whilst 250 (24.5%) had onset after 21 years. The earliest age of onset in infants was in the first 6 weeks of life, and this was found in 129 patients (12.7%). Education and occupation of household heads were the most significant (P < 0.001) factors associated with seeking proper health care for the child's AD. Four hundred and forty-one (43.3%) patients presented with subacute atopic eczema and 326 (32%) patients with severe impeteginized eczema. Four hundred and twenty-five patients (41.7%) had at least one first-degree family member with AD (16.7%), allergic rhinitis (10.3%), asthma (14.6%) and allergic conjunctivitis (2.1%), while 55 (13.3%) of controls had a positive family history (P < 0.01) of allergy. A personal history of AD only, without concomitant respiratory allergies, was seen in 486 (47.7%) patients. The face was affected in 431 (42.3%) patients. Inverse distribution of a flexural rash was observed over the extensor aspect of the joints: the elbow in 502 patients (49.3%), the wrist joint in 183 patients (17.9%) and the knee joints in 354 patients (34.7). The commonly observed minor features included xerosis in 719 patients (71%), papular lichenoid lesions in 547 patients (54.1%), infraorbital folds in 498 patients (49.2%), palmar hyper linearity in 524 patients (51.8%) and raised peripheral blood eosinophils in 519 patients (51%), particularly for those with severe AD. Fissured heels, forehead lichenification, orbital darkening, nail pitting, sand paper-like skin lesions on the elbows/knees/lateral malleolli, knuckle dermatitis of the hands, palmar erythema and pitted keratolysis occurred more uncommonly as minor features. Infective complications were very common and included bacterial infections (folliculitis, impetiginized dermatitis and pyodermas) in 425 (41.7%) patients, fungal infections in 377 (37%) patients, parasitic infections (scabies) in 90 (8.8%) patients and viral infection (herpes simplex and molluscum contagiosum) in 29 (2.9%) patients. Thirteen of these atopics were also HIV positive. Aggravating factors most commonly reported included heat intolerance, excessive sweating, humidity, grass intolerance, thick woollen clothing and drug reactions. Only three patients had food intolerance. Three hundred and ten patients (30.4%) recalled their AD being worse in the hot humid periods and 383 (37.6%) could not recall any periods of relief or remission. Conclusions, The prevalence of AD amongst south-eastern Nigerian Blacks is on the increase, as in other areas, although it is still lower here than in other parts of the world. Many conventional minor features were found, but some occurred less frequently than in other countries, which may be attributed to ethnicity. Further studies will be required to confirm the ethnic differences in these features of AD amongst Nigerians and other Africans, to clarify the features of AD that are peculiar to Africans. [source]

    Major and trace element provenance signatures in stream sediments from the Kando River, San'in district, southwest Japan

    ISLAND ARC, Issue 2 2006
    Edwin Ortiz
    Abstract Basement rocks in the catchment of the Kando River in southwest Japan can be divided into two main groups. Paleogene to Cretaceous felsic granitoids and volcanic rocks dominate in the upstream section, and more mafic, mostly Miocene volcanic and volcaniclastic rocks occur in the downstream reaches. Geochemically distinctive Mount Sambe adakitic volcanic products also crop out in the west. X-ray fluorescence analyses of major elements and 14 trace elements were made of two size fractions (<180 and 180,2000 µm) from 86 stream sediments collected within the catchment, to examine contrasts in composition between the fractions as a result of sorting and varying source lithotype. The <180 µm fractions are depleted in SiO2 and enriched in most other major and trace elements relative to the 180,2000 µm fractions. Na2O, K2O, Ba, Rb and Sr are either depleted relative to the 180,2000 µm fractions, or show little contrast in abundance. Sediments from granitoid-dominated catchments are distinguished by greater K2O, Th, Rb, Ba and Nb than those derived from the Miocene volcanic rocks. Granitoid-derived <180 µm fractions are also enriched in Zr, Ce and Y. Sediments derived from the Miocene volcanic rocks generally contain greater TiO2, Fe2O3*, Sc, V, MgO and P2O5, reflecting their more mafic source. Sediments containing Sambe volcanic rocks in their source are marked by higher Sr, CaO, Na2O and lower Y, reflecting an adakitic signature that persists into the lower main channel, where compositions become less variable as the bedload is homogenized. Normalization against source averages shows that compositions of the 180,2000 µm fractions are less fractionated from their parents than are the <180 µm fractions, which are enriched for some elements. Contrast between the size fractions is greatest for the granitoid-derived sediments. Weathering indices of the sediments are relatively low, indicating source weathering is moderate, and typical of temperate climates. Some zircon concentration has occurred in granitoid-derived <180 µm fractions relative to 180,2000 µm counterparts, but Th/Sc and Zr/Sc ratios overall closely reflect both provenance and homogenization in the lower reaches. [source]

    Provenance of sandstones from the Wakino Subgroup of the Lower Cretaceous Kanmon Group, northern Kyushu, Japan

    ISLAND ARC, Issue 1 2000
    Daniel K. Asiedu
    Abstract The Wakino Subgroup is a lower stratigraphic unit of the Lower Cretaceous Kanmon Group. Previous studies on provenance of Wakino sediments have mainly concentrated on either petrography of major framework grains or bulk rock geochemistry of shales. This study addresses the provenance of the Wakino sandstones by integrating the petrographic, bulk rock geochemistry, and mineral chemistry approaches. The proportions of framework grains of the Wakino sandstones suggest derivation from either a single geologically heterogeneous source terrane or multiple source areas. Major source lithologies are granitic rocks and high-grade metamorphic rocks but notable amounts of detritus were also derived from felsic, intermediate and mafic volcanic rocks, older sedimentary rocks, and ophiolitic rocks. The heavy mineral assemblage include, in order of decreasing abundance: opaque minerals (ilmenite and magnetite with minor rutile), zircon, garnet, chromian spinel, aluminum silicate mineral (probably andalusite), rutile, epidote, tourmaline and pyroxene. Zircon morphology suggests its derivation from granitic rocks. Chemistry of chromian spinel indicates that the chromian spinel grains were derived from the ultramafic cumulate member of an ophiolite suite. Garnet and ilmenite chemistry suggests their derivation from metamorphic rocks of the epidote-amphibolite to upper amphibolite facies though other source rocks cannot be discounted entirely. Major and trace element data for the Wakino sediments suggest their derivation from igneous and/or metamorphic rocks of felsic composition. The major element compositions suggest that the type of tectonic environment was of an active continental margin. The trace element data indicate that the sediments were derived from crustal rocks with a minor contribution from mantle-derived rocks. The trace element data further suggest that recycled sedimentary rocks are not major contributors of detritus. It appears that the granitic and metamorphic rocks of the Precambrian Ryongnam Massif in South Korea were the major contributors of detritus to the Wakino basin. A minor but significant amount of detritus was derived from the basement rocks of the Akiyoshi and Sangun Terrane. The chromian spinel appears to have been derived from a missing terrane though the ultramafic rocks in the Ogcheon Belt cannot be discounted. [source]

    Lived Experiences of Mothers Caring for Children With Thalassemia Major in Thailand

    JOURNAL FOR SPECIALISTS IN PEDIATRIC NURSING, Issue 1 2007
    Suksiri Prasomsuk
    ISSUES AND PURPOSE.,Thalassemic patients must be given continuous treatment throughout their lives due to the physical and psychological effects of their disorder; their families also are impacted. This qualitative study explored the lived experiences of 15 mothers of children with thalassemia major by conducting semistructured interviews; the data were analyzed utilizing content analysis. CONCLUSION.,Six themes were identified: lack of knowledge about thalassemia, psychosocial problems, concerns for the future, social support systems, financial difficulty, and the effectiveness of healthcare services. PRACTICE IMPLICATIONS.,These findings suggest that a holistic, culturally sensitive nursing approach should be considered when caring for children with thalassemia. [source]

    Effects of natural disturbance and selective logging on Nothofagus forests in south-central Chile

    JOURNAL OF BIOGEOGRAPHY, Issue 7 2002
    William Pollmann
    Aim Changes in stand structure, floristic composition and tree population dynamics during the last four centuries were described in southern temperate rain forests. The impacts of natural and anthropogenic disturbance since the late 1560s were examined for old-growth and logged forests. Location The study was conducted in montane Nothofagus alpina forests in the Andean Range of south-central Chile. Study sites were located at a range of altitudes between 1000 and 1250 m a.s.l. Methods Temporal variation in species recruitment and annual dendroecological data were used to determine the historical development and disturbance history of three old-growth forests, and three stands after selective logging in the late 1880s to early 1900s. Considering the spatial structure of evergreen vs. deciduous elements, the forests are a mixture of deciduous and evergreen tree species. Results Stem density, maximum stem diameter and basal area differed between the old-growth and logged stands, but species composition did not. At lower altitudes, N. alpina was the dominant canopy species in both old-growth and logged stands, but regeneration of N. alpina was significantly different in these stands. At higher altitudes, N. alpina and N. dombeyi were the dominant canopy species in both old-growth and logged stands, and here regeneration patterns of these Nothofagus species were similar. After selective logging, in mixed forests of shade-intolerant Nothofagus and more shade-tolerant trees (such as Laurelia philippiana) there has been a shift in regeneration from more shade-tolerant resprouting species towards Nothofagus. Major and moderate releases in radial growth, indicative of disturbance, occurred in most of the older trees during the last four centuries, and especially during the last 100 years. Growth rates of N. alpina are higher than those of associated shade-tolerant trees, and apparently increase after disturbances. Main conclusions Results suggest that under disturbance regimes dominated by treefall gaps, and additionally canopy openings by selective logging, maintenance of Nothofagus species appears to be associated with complementary differences in growth rate, sprouting capacity, canopy residence time, and longevity. Such small-scale canopy openings may help explain the relative abundance of N. alpina in montane mixed rain forests in the Andean Range, where the maintenance of Nothofagus species in many stands has been attributed to a high frequency of coarse-scale disturbance. My results serve to emphasize that understanding the species coexistence and forest dynamics in Nothofagus forests may require attention to interspecific differences in life-history characteristics. [source]

    Participatory land-use planning and conservation in northern Tanzania rangelands

    AFRICAN JOURNAL OF ECOLOGY, Issue 2009
    Abiud L. Kaswamila
    Abstract In developing countries, participatory land-use planning is seen as a panacea to mitigate land-use conflicts and enhance land productivity. This assumption has not been thoroughly tested in wildlife corridors. Three villages were selected for this study. Several methods were used to provide indication of the performance of the plans against their stated objectives of mitigating conflicts and conserving wildlife corridors. Three hundred and fifty-eight households and eight park and extension workers were interviewed. In addition, focus group discussion with the nomadic Barabeig, field assessment and review of land-use plan/general management plan reports were carried out. Results reveal that land-use plans failed to achieve their set objectives. For example, 75% of the households held this view. Major causes of failure were insufficient participation by stakeholders in the planning process, lack of robust, transparent and accountable implementation strategies, inadequacy of qualified staff and lack of ,holistic approach' to the planning process. Taking these findings into account, an improved buffer zone land-use planning framework is suggested. For the framework to enhance both conservation and development and to enable policies and legislation, equitable benefit sharing and conservation education, initiation of compensation schemes for depredation caused by wild animals and intensification of patrols are required. [source]

    Cellulose structure and biosynthesis: What is in store for the 21st century?

    JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 3 2004
    R. Malcolm Brown Jr.
    Abstract This article briefly summarizes historical developments in fundamental research related to the structure and biosynthesis of cellulose. Major advances concerning the structure of cellulose include the discovery of a new suballomorph of cellulose I, the lattice imaging of glucan chains showing no fringe micelle structure, parallel chain orientation in cellulose I, and the discovery of nematic ordered cellulose. Major advances in biosynthesis include the discovery of the terminal synthesizing complex, the isolation and purification of cellulose synthase, the in vitro synthesis of cellulose I, and synthetic cellulose assembly. This article focuses on recent advances in molecular biology with cellulose, including the cloning and sequencing of cellulose synthase genes from bacteria, cyanobacteria, and vascular plants; proof of the terminal synthesizing complex as the site of the catalytic subunit of cellulose synthase; cellulose and callose synthase expression during growth and development; and phylogenetic aspects of cellulose synthase evolution. This article concludes with thoughts about future uses for the accumulating genetic information on cellulose biosynthesis for textiles and forest products and discusses possibilities of new global resources for cellulose production. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 487,495, 2004 [source]

    A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS),

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 5 2005
    G. FINAZZI
    Summary.,Background:,The optimal intensity of oral anticoagulation for the prevention of recurrent thrombosis in patients with antiphospholipid antibody syndrome is uncertain. Retrospective studies show that only high-intensity oral anticoagulation [target international normalized ratio (INR) >3.0] is effective but a recent randomized clinical trial comparing high (INR range 3.0,4.0) vs. moderate (INR 2.0,3.0) intensities of anticoagulation failed to confirm this assumption. Methods:,We conducted a randomized trial in which 109 patients with antiphospholipid syndrome (APS) and previous thrombosis were given either high-intensity warfarin (INR range 3.0,4.5, 54 patients) or standard antithrombotic therapy (warfarin, INR range 2.0,3.0 in 52 patients or aspirin alone, 100 mg day,1 in three patients) to determine whether intensive anticoagulation is superior to standard treatment in preventing symptomatic thromboembolism without increasing the bleeding risk. Results:,The 109 patients enrolled in the trial were followed up for a median time of 3.6 years. Mean INR during follow-up was 3.2 (SD 0.6) in the high-intensity warfarin group and 2.5 (SD 0.3) (P < 0.0001) in the conventional treatment patients given warfarin. Recurrent thrombosis was observed in six of 54 patients (11.1%) assigned to receive high-intensity warfarin and in three of 55 patients (5.5%) assigned to receive conventional treatment [hazard ratio for the high intensity group, 1.97; 95% confidence interval (CI) 0.49,7.89]. Major and minor bleeding occurred in 15 patients (two major) (27.8%) assigned to receive high-intensity warfarin and eight (three major) (14.6%) assigned to receive conventional treatment (hazard ratio 2.18; 95% CI 0.92,5.15). Conclusions:,High-intensity warfarin was not superior to standard treatment in preventing recurrent thrombosis in patients with APS and was associated with an increased rate of minor hemorrhagic complications. [source]