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Macromolecular Therapeutics (macromolecular + therapeutics)

Distribution by Scientific Domains

Polymers and Materials Science	75%

Selected Abstracts

Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface,

ANGEWANDTE CHEMIE, Issue 8 2010
Kuangshi Wu
Peptide verbinden: Die Bildung von Heterodimeren mit Doppelwendelstrukturen aus komplementären Zufallsknäuel-Peptiden, von denen eines an ein Antikörper-Fragment (grau; rotes Peptid) und das andere an ein Copolymer (schwarz; grünes Peptid) gekuppelt ist, vernetzt CD20-Zielantigene (orange) auf Raji-B-Zellen und löst dadurch eine Apoptose aus (siehe Schema). [source]

Design of Multiresponsive Hydrogel Particles and Assemblies

ADVANCED FUNCTIONAL MATERIALS, Issue 11 2010
Grant R. Hendrickson
Abstract In the realm of soft nanotechnology, hydrogel micro- and nanoparticles represent a versatile class of responsive materials. Over the last decade, our group has investigated the synthesis and physicochemical properties of a variety of synthetic hydrogel particles. From these efforts, several particle types have emerged with potentially enabling features for biological applications, including nanogels for targeted drug delivery, microlenses for biosensing, and coatings for biomedical devices. For example, core/shell nanogels have been used to encapsulate and deliver small interfering RNA to ovarian cancer cells; nanogels used in this fashion may improve therapeutic outcomes for a variety of macromolecular therapeutics. Microgels arranged as multilayers on implantable biomaterials greatly minimize the host inflammatory response to the material. Furthermore, the triggered release of drugs (i.e., insulin) has been demonstrated from similar assemblies. The goal of this feature article is to highlight developments in the design of responsive microgels and nanogels in the context of our recent efforts and in relation to the community that has grown up around this fascinating class of materials. [source]

Biomedical Materials: Nanoporous Biodegradable Elastomers (Adv. Mater.

ADVANCED MATERIALS, Issue 2 2009
2/2009)
The mechanical properties and degradation rate of elastomers can be tailored with nanoporosity. The elastomers described in this study by Guillermo Ameer and co-workers (p. 188) are based on citric acid and are biocompatible. The nanopores also facilitate the entrapment and slow release of macromolecular therapeutics. The inside cover depicts the nano- and microarchitecture of the elastomer prior to pore collapse. [source]

Peeling Back the Layers: Controlled Erosion and Triggered Disassembly of Multilayered Polyelectrolyte Thin Films,

ADVANCED MATERIALS, Issue 23 2007
M. Lynn
Abstract Methods for the layer-by-layer deposition of oppositely charged polymers on surfaces can be used to assemble thin multilayered films using a broad range of natural, synthetic, and biologically relevant materials. These methods also permit precise, nanometer-scale control over the compositions and internal structures of multicomponent assemblies. Provided that the individual components of these materials are selected or designed appropriately, these methods provide tantalizing new opportunities to design thin films and coatings that provide spatial, temporal, or active control over the release of one or several different agents from surfaces. The last two years have seen a significant increase in reports describing the development of new chemical, physical, and biomolecular approaches to the controlled erosion, triggered disassembly, or general deconstruction of multilayered polymer films. In this Progress Report, we highlight recent work from our laboratory and several other groups toward the design of ultrathin multilayered assemblies that i),permit broad, tunable, and sophisticated control over film erosion, and ii),provide new opportunities for the localized release of macromolecular therapeutics, such as DNA and proteins, from surfaces. [source]