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Lower Mortality (lower + mortality)
Terms modified by Lower Mortality Selected AbstractsLOWER MORTALITY FROM H1N1 INFLUENZA IN OLDER ARGENTINEANS: MEN MORE AFFECTEDJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9 2010Matheus Roriz-Cruz MD First page of article [source] Protective immunity of sevenband grouper, Epinephelus septemfasciatus Thunberg, against experimental viral nervous necrosisJOURNAL OF FISH DISEASES, Issue 1 2001S Tanaka This paper describes the protective immune responses of sevenband grouper, Epinephelus septemfasciatus Thunberg, immunized with live piscine nodavirus, the causative agent of viral nervous necrosis (VNN), or the Escherichia coli, expressed recombinant coat protein. Nodavirus-neutralizing antibodies were detected at titres ranging from 1:158 to 1:1257 in serum of sevenband grouper which survived intramuscular injection with the virus, by a cell culture assay system. The virus-neutralizing ability of immune serum was also confirmed by injecting virus previously treated with serum into fish. This indicates establishment of acquired immunity in survivors and thus explains why survivors from natural infection are resistant to recurrence of the disease. Young sevenband grouper were immunized twice by intramuscular injections with the recombinant coat protein. Immunized fish produced neutralizing antibodies at high titres for at least 110 days and showed significantly lower mortalities in virus challenge tests. These results suggest the potential for vaccination against VNN in sevenband grouper, which is susceptible to piscine nodavirus at all life-stages. [source] Escape from natural enemies during climate-driven range expansion: a case studyECOLOGICAL ENTOMOLOGY, Issue 3 2008ROSA MENÉNDEZ Abstract 1.,A major, and largely unexplored, uncertainty in projecting the impact of climate change on biodiversity is the consequence of altered interspecific interactions, for example between parasitoids and their hosts. The present study investigated parasitism in the Brown Argus butterfly, Aricia agestis; a species that has expanded northward in Britain during the last 30 years in association with climate warming. 2.,Aricia agestis larvae suffered lower mortality from parasitoids in newly colonised areas compared with long-established populations. This result was consistent over four consecutive generations (2 years) when comparing one population of each type, and also when several populations within the historical and recently colonised range of the species were compared within a single year. Thus, A. agestis appears to be partially escaping from parasitism as it expands northwards. 3.,Reduced parasitism occurred despite the fact that several of the parasitoid species associated with A. agestis were already present in the newly colonised areas, supported predominantly by an alternative host species, the Common Blue butterfly, Polyommatus icarus. 4.,As the species expand their distributions into areas of increased climatic suitability, invasion fronts may escape from natural enemies, enhancing rates of range expansion. The results suggest that the decoupling of interspecific interactions may allow some species to exploit a wider range of environments and to do so more rapidly than previously thought possible. [source] Top-down and bottom-up regulation of herbivores: Spodoptera frugiperda turns tables on endophyte-mediated plant defence and virulence of an entomopathogenic nematodeECOLOGICAL ENTOMOLOGY, Issue 3 2004Douglas S. Richmond Abstract., 1. The fungus Neotyphodium lolii forms a symbiotic relationship with its grass host Lolium perenne (perennial ryegrass). The fungus benefits from access to plant nutrients and photosynthate, whereas the plant benefits from acquired chemical defence against herbivory. 2. This study examined the potential for endophyte-mediated plant defences to influence interactions between fall armyworm Spodoptera frugiperda, and the entomopathogenic nematode Steinernema carpocapsae and clarified biological mechanisms underlying the observations made. 3. In laboratory and greenhouse experiments, S. frugiperda larvae were fed endophytic or non-endophytic L. perenne then exposed to S. carpocapsae or injected with the nematodes' symbiotic bacteria Xenorhabdus nematophila. 4. In all instances, S. frugiperda larvae fed endophyte-infected grass suffered significantly lower mortality than those fed non-endophytic plants. Although larvae fed endophyte-infected grass often had significantly lower biomass than those fed uninfected grass, these differences did not account for altered susceptibility to S. carpocapsae. 5. Endophyte-mediated reductions in herbivore susceptibility to the nematode pathogen represent a herbivore adaptation that effectively turns the tables on both plant and natural enemy by reducing the virulence of the nematodes' symbiotic bacteria while expanding the temporal window of herbivory. [source] Mortality risk up to 25 years after initiation of treatment among 420 Swedish women with alcohol addictionADDICTION, Issue 3 2009Brit Haver ABSTRACT Aims Women treated for alcohol addiction have mortality rates three to five times those of women from the general population (GP). However, these figures may be inflated because socially disadvantaged women with advanced drinking careers are over-represented in previous studies. Our aim was to study the long-term mortality of socially relatively well-functioning patients coming to their first treatment, compared to matched GP controls. Design The mortality rates and causes of death were compared between patients and their matched GP controls, using data from the Causes of Death Register throughout the follow-up period (0,25 years). Setting A specialized treatment programme for women only, called ,Early treatment for Women with Alcohol Addiction' (EWA) at the Karolinska Hospital, Stockholm, Sweden. Participants Subjects (n = 420) receiving their first treatment at the EWA programme, compared to a group of matched GP women (n = 2037). Findings The women patients had significantly higher mortality than matched GP controls throughout the whole follow-up period, with a relative risk of 2.4. However, the younger women had four times higher mortality than their matched controls. The peak of deaths occurred during the first 5 years, and alcohol-related causes of death were highly over-represented, as were uncertain suicides and accidents. Conclusions First-time-treated women with alcohol addiction have a substantially lower mortality than reported previously from clinical samples, except for the youngest group. Our figures were corrected for confounding factors such as socio-demographic status. We believe our results could apply to broader groups of heavy drinking women, inside or outside specialized treatment settings. [source] Factors influencing the partitioning and toxicity of nanotubes in the aquatic environment,,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 9 2008Alan J. Kennedy Abstract Carbon nanotubes (NTs) may be among the most useful engineered nanomaterials for structural applications but could be difficult to study in ecotoxicological evaluations using existing tools relative to nanomaterials with a lower aspect ratio. Whereas the hydrophobicity and van der Waals interactions of NTs may suggest aggregation and sedimentation in aquatic systems, consideration regarding how engineered surface modifications influence their environmental fate and toxicology is needed. Surface modifications (e.g., functional groups and coatings) are intended to create conditions to make NTs dispersible in aqueous suspension, as required for some applications. In the present study, column stability and settling experiments indicated that raw, multiwalled NTs (MWNTs) settled more rapidly than carbon black and activated carbon particles, suggesting sediment as the ultimate repository. The presence of functional groups, however, slowed the settling of MWNTs (increasing order of stability: hydroxyl > carboxyl > raw), especially in combination with natural organic matter (NOM). Stabilized MWNTs in high concentrations of NOM provided relevance for water transport and toxicity studies. Aqueous exposures to raw MWNTs decreased Ceriodaphnia dubia viability, but such effects were not observed during exposure to functionalized MWNTs (>80 mg/L). Sediment exposures of the amphipods Leptocheirus plumulosus and Hyalella azteca to different sizes of sediment-borne carbon particles at high concentration indicated mortality increased as particle size decreased, although raw MWNTs induced lower mortality (median lethal concentration [LC50], 50 to >264 g/kg) than carbon black (LC50, 18,40 g/kg) and activated carbon (LC50, 12,29 g/kg). Our findings stress that it may be inappropriate to classify all NTs into one category in terms of their environmental regulation. [source] Effect of varying pesticide exposure duration and concentration on the toxicity of carbaryl to two field-collected stream invertebrates, Calineuria californica (Plecoptera: Perlidae) and Cinygma sp. (Ephemeroptera: Heptageniidae)ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2001Jennifer L. Peterson Abstract The effect of exposure duration on the toxicity of a forest insecticide (carbaryl) was assessed under environmentally realistic exposure regimes against two stream invertebrates indigenous to the United States Pacific Northwest, Calineuria californica (Plecoptera: Perlidae) and Cinygma sp. (Ephemeroptera: Heptageniidae). Laboratory bioassays were conducted to evaluate the relationship between pulsed exposures of 15, 30, and 60 min and toxicity for a range of chemical concentrations (10.2,1,730 ,g/L). For Cinygma sp., the 50% lethal concentration (LC50) values were calculated as 848 ,g/L (15 min), 220 ,g/L (30 min), and 165 ,g/L (60 min). The C. californica consistently had lower mortality at a given concentration compared with Cinygma sp. Fifteen- and 30-min exposures did not elicit 50% mortality with C. californica, and it had a 60-min LC50 of 1,139 ,g/L. Time to 50% mortality over 96 h after a 15-, 30-, or 60-min exposure, with the rest of the test period in freshwater (PLT50), was a function of exposure duration and concentration. Analysis of symptomology throughout the test period for C. californica gave evidence of recovery from the knockdown and moribund states, but this was not the case for Cinygma sp. The pulse duration resulting in 50% mortality was calculated as 43 min for Cinygma sp. exposed at 204 ,g/L and 16 min at 408 ,g/L. A three-dimensional probit plane model [Y = , 10.86 + 4.83(In C) + 3.0(In T)], where Y is probit mortality, C is concentration in ,g/L and T is time in hours, was used to explain the interaction between concentration (,g/L) and duration of exposure (hours) for Cinygma sp. [source] Mimicking Natural Nursing Conditions Promotes Early Pup Survival in Domestic RabbitsETHOLOGY, Issue 3 2000Gérard Coureaud In the wild rabbit, Oryctolagus cuniculus, mother,young relationships are based on restricted, once-per-day nursing interactions. Correspondingly, pups have evolved an efficient strategy of energy saving. Here we investigate under breeding conditions, whether matching or not, the once-daily nursing visit by the rabbit females has an effect on pup survival and growth. Two nursing regimen were applied to 89 primiparous (P) and to 78 multiparous (M) does: (a) one that matched the once daily nursing pattern (closed nest-box during the whole day except for a few minutes devoted to nursing) and (b) one that did not match it (24 h free nest access). In P females, the controlled nest access resulted in lower mortality between birth and weaning (8.1%) as compared to the free nest-access (18%). This effect was recorded from postnatal d 3,4 onwards. Both treatments induced different death causes (starvation (63%) in controlled-access regimen, and wounds and nest-soiling (29%) in free-access regimen). While both experimental nest-access regimens differentially affected pup survival in P or M females, they were without influence on pup growth rate in does of either parity. It is concluded that repeated nest visits by the female increase risks of injury to pups, and of out-of-time pup activation or sucking, and that, more generally, it plays against the ethophysiologigal strategy of biomass conservation evolved by rabbit newborns. The fact that the nest-access regimen no longer affected pup survival from the second parity suggests that the behaviour of multiparous does more adequately models the offspring demands. [source] Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNAFEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 2 2008Petya Dimitrova Abstract In this study, double-stranded Candida albicans DNA was administered in systemic C. albicans infection in at dose of 20 ,g per mouse at 4, 5 and 6 weeks of age. The level of IL-12 in serum was elevated as a result of yeast DNA treatment and correlated with lower mortality and decreased kidney and liver injury. Macrophage activation was demonstrated by an increase of nitric oxide (NO) and IL-12 production. These effects were Janus activation kinases (JAK)/signal transducer and activator of transcription (STAT) dependent as they were inhibited by selective JAK inhibitor tyrphostin AG-490. DNA influenced adaptive immune response through elevation of anti- Candida IgG antibody production in systemic C. albicans infection. Thus, C. albicans DNA augmented innate and adaptive immune responses against the pathogen. [source] Natural variability of fisheries and lunar illumination: a hypothesisFISH AND FISHERIES, Issue 2 2008Santiago Hernández-León Abstract Long-term synchronous trends in small pelagic fisheries catches around the world suggest that fish populations are governed by the same global climate forcings. Recent findings regarding the population dynamics of zooplankton during the lunar cycle in sub-tropical waters may shed light on the influence of the lunar cycle on fish spawning and mortality. Here I hypothesize that, in the short-term, observed changes in zooplankton abundance during the lunar cycle promote periods of enhanced feeding by adult fish and lower mortality (and increased growth) in their early planktonic stages. Furthermore, a striking 9-year periodicity in sardine and anchovy mortality was inferred in four major upwelling areas, coinciding with the long-term variability in lunar illumination. It is suggested that both short- and long-term changes in lunar illumination should be considered when modelling the effect of climate on the natural variability of fisheries. [source] Impact of treating facilities' volume on survival for early-stage laryngeal cancer,HEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 9 2009Amy Y. Chen MD Abstract Background Treatment at a high-volume facility has been associated with better outcomes in a variety of conditions. The relationship between volume and survival from laryngeal cancer has not been examined previously. Methods A total of 11,446 early-stage laryngeal cancer patients (1996,1998) who reported to the National Cancer Database (NCDB) were analyzed. Proportional hazards regression was used to assess the relationship between survival and treatment volume controlling for other factors associated with survival. Results Treatment at low-volume facilities was associated with a significantly increased likelihood of death (hazard ratio 1.20, 95% CI 1.04,1.38). Surgical resection, as compared with radiation treatment, was associated with lower mortality (HR 0.74, 95% CI 0.69,0.80). Conclusion This study is the first to assess the relationship between survival and treatment volume in laryngeal cancer. Treatment at a high-volume facility is associated with better survival. Surgical treatment rather than radiation was also associated with better survival, although we could not control for confounders that may bias treatment selection. © 2009 Wiley Periodicals, Inc. Head Neck, 2009 [source] An efficient therapeutic approach to patients with acute promyelocytic leukemia using a combination of arsenic trioxide with low-dose all-trans retinoic acidHEMATOLOGICAL ONCOLOGY, Issue 2 2004Guanjun Wang Abstract The use of arsenic trioxide (As2O3, ATO) combined with all-trans retinoic acid (ATRA) has recently been reported to induce remission in patients with acute promyelocytic leukemia (APL). However, its efficiency remains inconclusive mainly due to the small number of the available cases. In this study, therefore, we present a clinical study using a combination of ATO with low-dose ATRA (LD-ATRA) to treat 108 APL patients (80 newly diagnosed patients, 28 relapsed patients). Therapeutic outcomes using the ATO/LD-ATRA approach were compared with those of APL patients treated either with ATO alone (65 patients) or ATRA alone (51 patients). The results showed that the ATO/LD-ATRA approach provided significantly better therapeutic outcomes as compared to either ATO or ATRA alone, as evidenced by lower mortality, a higher CR rate and a reduced period to CR. In addition, the toxic side-effects have been no worse with the combined ATO/LD-ATRA treatment than with either ATO or ATRO alone and in some cases have been reduced. These data suggest that the ATO/LD-ATRA regimen is superior to either regimen given alone to patients with APL. Copyright © 2004 John Wiley & Sons, Ltd. [source] The regulation of brood reduction in Booted Eagles Hieraaetus pennatus through habitat heterogeneityIBIS, Issue 4 2008EVA CASADO Brood reduction, the death of one or more chicks through siblicide or starvation, can occur through density-dependence in fecundity. Brood reduction may arise in territorial breeding systems either as a response to a high level of territorial interference in a situation of high density or as a result of habitat heterogeneity. To test the predictions of the two main hypotheses that attempt to explain how density-dependent fecundity is generated, the Habitat Heterogeneity Hypothesis (HHH) and the Individual Adjustment Hypothesis (IAH), we analysed the relationship between density and fecundity in an expanding population of Booted Eagles in Doñana National Park, Spain, using an 18-year data series. We also studied the occurrence and frequency of brood reduction in the same Booted Eagle population to appreciate further its effects and the factors that influence its occurrence and frequency. Our results support the HHH in the present situation of high density, as fecundity in the better territories (older and more frequently occupied) was higher than in low quality territories and was not affected by population density in high density periods. Nevertheless, the fecundity of high quality territories was affected (although not significantly) by population density in periods of low density, suggesting that the IAH was supported when only high quality territories were occupied. Older territories were used more frequently and chicks in these areas hatched earlier and suffered lower mortality than in new territories. We found a significant negative relationship between mean fecundity and its skewness, a finding that also supports HHH. During years of food shortage, less frequently occupied territories suffered higher rates of brood reduction. Brood reduction in this Booted Eagle population was a consequence of the heterogeneous structure of the habitat, with some territories having a higher probability of brood reduction than others. Parental nutritional condition did not affect brood reduction. The effect of brood reduction on nestling quality and population dynamics is also discussed. [source] Establishment of a stroke unit in a district hospital: review of experienceINTERNAL MEDICINE JOURNAL, Issue 2 2007A. Chiu Abstract Background: The experience and outcomes of co-locating acute stroke and stroke rehabilitation care in a district hospital were reviewed. Method: Information for patients admitted to Blacktown and Mt Druitt Hospitals before and after setting up an acute stroke unit (SU) (12 months data for each period), including mortality and length of stay (LOS) at the hospital were obtained from various sources, including the diagnosis-related group and subacute and non-acute casemix databases. Results: There was a significant reduction of mortality (18 vs 10%; P = 0.01) and reduced total LOS (46 vs 39 days; P = 0.01) with similar functional outcomes in the post-SU period. Fifty per cent of patients were unable to access the acute SU. Patients admitted into the SU had lower mortality (5 vs 14%; P = 0.01) and were also discharged from hospital earlier (35 vs 54 days; P = 0.01) than patients admitted into general wards during the post-SU period. Thirty-four per cent of patients received rehabilitation within the rehabilitation facility in the post-SU period compared with 19% in the pre-SU period. Conclusion: The Blacktown experience showed the feasibility of establishing a co-located SU within rehabilitation facility with good outcomes as illustrated by the significant reduction in the stroke mortality, a reduction in the total LOS and an increase in the number of patients receiving rehabilitation post-stroke. [source] Time course of bleomycin-induced lung fibrosisINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 3 2002G. Izbicki Summary. Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time-course of bleomycin-induced lung fibrosis in mice using computer-assisted morphometry. C57Bl/6J mice were treated with a single IT dose of bleomycin or control saline. Animals were killed 3, 6, 14 and 21 days post-IT. Lung injury was evaluated by analysis of bronchoalveolar lavage (BAL) fluid, hydroxyproline concentration in the lung, routine light microscopic examination resulting in a semiquantitative morphological index (SMI) of lung injury, and quantitative morphological measurements (fibrosis fraction and alveolar wall area fraction) aided by optimas image analysis software. Changes in BAL fluid attributed to bleomycin treatment include increased total cell count (days 14 and 21), and increased percentage of neutrophils (days 3 and 6) followed by a sustained increase in lymphocytes (days 6, 14 and 21). Hydroxyproline levels increased in bleomycin-treated mice on days 14 and 21. Median SMI grades were significantly elevated on days 3, 14 and 21. Computer-assisted morphometry demonstrated a 3-fold increase in fibrosis fraction and a 1.3-fold increase in wall area fraction in bleomycin-treated mice on day 14, with no further increase on day 21. These data also demonstrate that the most suitable time point for assessing lung fibrosis in this model is 14 days after IT instillation of bleomycin, based on the observation that at 14 days the animals developed extensive fibrosis, but had less variability in the fibrotic response and lower mortality than later at 21 days. Computer-assisted morphometry provides objective and quantitative measurements that are a useful tool for the evaluation of bleomycin-induced lung injury. [source] Being well and doing well: on the importance of income for healthINTERNATIONAL JOURNAL OF SOCIAL WELFARE, Issue 2006S.V. Subramanian Income is robustly associated with health status. Higher income is associated with lower mortality and morbidity, both cross-nationally and within societies. This relationship is not just confined to low levels of income, but extends well beyond median levels of income in society with diminishing marginal returns to health status with additional increments in income. Drawing upon the absolute and relative interpretations of income and conceptualising them simul-taneously at the individual and community level, we develop a typology of income,health relationships and discuss the distinctiveness of, and connections between, each type. We conclude that a multilevel conceptual and methodological framework is most appropriate to understand the income,health relationship. [source] Relative Fitness and Frailty of Elderly Men and Women in Developed Countries and Their Relationship with MortalityJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2005Arnold Mitnitski PhD Objectives: To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples. Design: Cross-sectional and cohort studies. Setting: Seven population-based and four clinical/institutional surveys in four developed countries. Participants: Thirty-six thousand four hundred twenty-four people (58.5% women) aged 65 and older. Measurements: A frailty index was constructed as a proportion of all potential deficits (symptoms, signs, laboratory abnormalities, disabilities) expressed in a given individual. Relative frailty is defined as a proportion of deficits greater than average for age. Measures of deficits differed across the countries but included common elements. Results: In each country, community-dwelling elderly people accumulated deficits at about 3% per year. By contrast, people from clinical/institutional samples showed no relationship between frailty and age. Relative fitness/frailty in both sexes was highly correlated (correlation coefficient >0.95, P<.001) with mortality, although women, at any given age, were frailer and had lower mortality. On average, each unit increase in deficits increased by 4% the hazard rate for mortality (95% confidence interval=0.02,0.06). Conclusion: Relative fitness and frailty can be defined in relation to deficit accumulation. In population studies from developed countries, deficit accumulation is robustly associated with mortality and with age. In samples (e.g., clinical/institutional) in which most people are frail, there is no relationship with age, suggesting that there are maximal values of deficit accumulation beyond which survival is unlikely. [source] Pneumonia Versus Aspiration Pneumonitis in Nursing Home Residents: Prospective Application of a Clinical AlgorithmJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2005Joseph M. Mylotte MD Objectives: To prospectively evaluate a clinical algorithm for the diagnosis of pneumonitis and pneumonia in nursing home residents. Design: Prospective cohort study. Setting: Inpatient geriatrics unit. Participants: Nursing home residents admitted to the hospital with suspected pneumonia. Measurements: Identification of pneumonitis and pneumonia using the algorithm; medical record review and abstraction of clinical data; hospital outcome and length of stay. Results: One hundred seventy episodes of suspected pneumonia were screened with the algorithm and classified into four groups: 25% pneumonia, 28% aspiration pneumonitis of 24 hours or less duration, 12% aspiration pneumonitis of more than 24 hours' duration, and 35% an aspiration event without pneumonitis. Presenting symptoms and signs, laboratory tests, severity of illness measures, or serum C-reactive protein levels did not distinguish between the four groups. Those with an aspiration event without pneumonitis tended to be treated less often with antibiotic therapy after admission (P=.004) and after discharge (P=.01). Of those who survived, there was no significant difference in mean hospital length of stay between the four groups. There was no significant difference in the percentage of case fatality between the four groups, but those with aspiration pneumonitis of 24 hours or less duration and with an aspiration event without pneumonitis had a lower mortality than the other two groups. Conclusion: Distribution of episodes of suspected pneumonia by clinical category as determined using the algorithm was similar to that of the derivation study, as were case fatality rates in each category. These findings suggest that the algorithm may be useful for making the distinction between pneumonitis and pneumonia in nursing home residents; further studies are warranted. [source] Ecological play in the coevolutionary theatre: genetic and environmental determinants of attack by a specialist weevil on milkweedJOURNAL OF ECOLOGY, Issue 6 2003Anurag A. Agrawal Summary 1We studied the genetic and environmental determinants of attack by the specialist stem-attacking weevil, Rhyssomatus lineaticollis on Asclepias syriaca. 2In natural populations, the extent of stem damage and oviposition were positively correlated with stem width, but not stem height. We hypothesized that both genotypic and environmental factors influencing stem morphology would affect attack by weevils. 3In a common garden study with 21 full-sib families of milkweed, both phenotypic and genetic correlations indicated that weevils impose more damage and lay more eggs on thicker stemmed plants. 4Of three other putative resistance traits, only latex production showed a negative genetic correlation with weevil attack. 5When neighbouring grasses were clipped to reduce light competition, focal milkweed plants received up to 2.6 times the photosynthetically active radiation and 1.6 times the red to far red ratio of light compared with plants with intact grass neighbours. Focal milkweed plants were therefore released from the classic neighbour avoidance response and had 20% shorter internode lengths, were 30% shorter, and had 90% thicker stems compared with controls. 6Clipping of grass neighbours resulted in nearly 2.7 times the damage and oviposition by stem weevils, thus supporting the hypothesis of an environmental or trait-mediated indirect influence on resistance. 7Although attack of plants by weevils strongly increases the probability of stem mortality, thicker stems experience lower mortality, thus counteracting the selective impact of weevil-induced plant mortality. 8The determinants of attack on milkweeds include both genetic variation for stem thickness and an indirect environmental influence of plant neighbours. If milkweeds and weevils are coevolving, the interaction is diffuse because the ecological neighbourhood is likely to modify the patterns of reciprocal natural selection. [source] Contrasts in the hypo-osmoregulatory abilities of a freshwater and an anadromous population of inconnuJOURNAL OF FISH BIOLOGY, Issue 4 2001K. L. Howland Juvenile freshwater and anadromous inconnu Stenodus leucichthys regulated plasma ions following a direct transfer from fresh to brackish water (10,15,), but suffered osmoregulatory collapse with 100% mortality in 48 h when directly transferred to 25, salinity. Acclimation to brackish water for 2 weeks improved hypo-osmoregulatory capacity in both populations, with acclimated fish showing smaller increases in blood plasma ion concentrations, higher Na+ -K+ ATPase activity, and lower mortality than non-acclimated fish following transfer to 25, sea water. Anadromous inconnu maintained pre-treatment plasma ion levels during acclimation, whereas these levels increased during acclimation in freshwater inconnu. Juvenile anadromous inconnu are therefore able to adapt physiologically to sea water of at least 25,, if brackish-water acclimation is available, but freshwater inconnu have diminished saltwater tolerance, relative to the anadromous form. [source] A long-term study of neighbour-regulated demography during a decline in forest species diversityJOURNAL OF VEGETATION SCIENCE, Issue 1 2006Lin Yi-ching Abstract Question: Did disturbance, no density-dependence of the dominant species, and negative neighbourhood interactions on rare species affect tree demography during a decline in species diversity associated with the increase of Acer saccharum from 1939,2001? Hypotheses: 1. The rise in dominance of A. saccharum was because of its advantage in disturbances and lack of density-dependence of its demography. 2. Rare species were not favoured by disturbances, including those from Dutch elm disease, and demonstrated negative neighbourhood interactions with A. saccharum. Location: Brownfield Woods in Illinois, USA. Methods: Historical maps of trees (, 7.6 cm DBH) from 1939, 1951, 1988, and 2001 in 16 quadrats (48 m × 68 m) were used to compare demography of eight tree species. Effects of disturbances, density-dependence, and neighbourhood interactions on mortality and recruitment of tree species within a 6-m radius of individual target trees were studied. Results: A. saccharum demonstrated a demographic advantage over rare species. It had lower mortality and higher recruitment rates. Disturbances facilitated recruitment of A. saccharum, but did not enhance rare species. Density-dependence of both mortality and recruitment of A. saccharum occurred, but population projection models indicated that ecological conditions became more favourable for A. saccharum in the past 62 years. Furthermore, negative neighbourhood interactions were detected between rare species and A. saccharum. The increase in neighbouring A. saccharum significantly increased mortality and reduced recruitment of the rare species. Conclusions: The general disturbance regime, enhanced by Dutch elm disease, in Brownfield Woods facilitated the rise of dominance of A. saccharum. Meanwhile, rare species declined as a result of their disadvantage in disturbance and negative neighbourhood interactions with A. saccharum. [source] Effect of hospital volume and teaching status on outcomes of acute liver failureLIVER TRANSPLANTATION, Issue 9 2008Ashwin N. Ananthakrishnan Acute liver failure (ALF) often requires multidisciplinary support. Higher hospital volumes have been associated with better outcomes for surgical procedures, but whether such a relationship exists for ALF has not been explored previously. In this study, our aim was to examine if hospital volume affects mortality from ALF. Using data from the Nationwide Inpatient Sample for the years 2001 to 2004, we identified cases by the presence of a primary discharge diagnosis of ALF (International Classification of Diseases, 9th revision, Clinical Modification code 570.x). Hospitals were divided into low-, medium-, and high-volume hospitals on the basis of 1 to 5, 6 to 20, and more than 20 annual ALF discharges. There were 17,361, 6756, and 1790 discharges with ALF from low-, medium-, and high-volume hospitals, respectively. There was no difference in adjusted mortality between low- and high-volume hospitals (odds ratio 0.94, 95% confidence interval 0.68-1.28). Teaching hospitals had a trend toward lower mortality among patients with hepatic encephalopathy (odds ratio 0.69, 95% confidence interval 0.47-1.01). High-volume centers had a higher rate of orthotopic liver transplantation (OLT) primarily because they were transplant centers, had better in-hospital post-OLT survival, and showed a trend toward a shorter time to OLT. In conclusion, patients with ALF receiving care at teaching hospitals and high-volume centers tend to be sicker. However, teaching hospitals and high-volume centers have equivalent in-hospital survival despite caring for this more severely ill cohort. Liver Transpl 14:1347,1356, 2008. © 2008 AASLD. [source] Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicityPHYTOTHERAPY RESEARCH, Issue 11 2007Yan-Fei Xin Abstract The objective of this work was to explore the hypothesis that Lycium barbarum (LB) may be protective against doxorubicin (DOX)-induced cardiotoxicity through antioxidant-mediated mechanisms. Male SD rats were treated with distilled water or a water extract of LB (25 mg/kg, p.o.) daily and saline or DOX (5 mg/kg, i.v.) weekly for 3 weeks. Mortality, general condition and body weight were observed during the experiment. DOX-induced cardiotoxicity was assessed by electrocardiograph, heart antioxidant activity, serum levels of creatine kinase (CK) and aspartate aminotransferase (AST) and histopathological change. The DOX group showed higher mortality (38%) and worse physical characterization. Moreover, DOX caused myocardial injury manifested by arrhythmias and conduction abnormalities in ECG (increased QT and ST intervals and ST elevation), a decrease of heart antioxidant activity, an increase of serum CK and AST, as well as myocardial lesions. Pretreatment with LB significantly prevented the loss of myofibrils and improved the heart function of the DOX-treated rats as evidenced from lower mortality (13%), normalization of antioxidative activity and serum AST and CK, as well as improving arrhythmias and conduction abnormalities. These results suggested that LB elicited a typical cardioprotective effect on DOX-related oxidative stress. Furthermore, in vitro cytotoxic study showed the antitumor activity of DOX was not compromised by LB. It is possible that LB could be used as a useful adjunct in combination with DOX chemotherapy. Copyright © 2007 John Wiley & Sons, Ltd. [source] Correlates of mortality in elderly COPD patients: Focus on health-related quality of lifeRESPIROLOGY, Issue 1 2009Raffaele ANTONELLI-INCALZI ABSTRACT Background and objective: The Saint George Respiratory Questionnaire (SGRQ) is widely used as a measure of health-related quality of life (HRQL) in patients with COPD. This study tested whether the SGRQ predicts the survival of patients with COPD. Methods: The study recruited 238 patients with COPD who were participants in the multicentre Salute Respiratoria nell'Anziano (Sa.R.A.) study. Patients' sociodemographic, clinical and functional characteristics were assessed and the association between the SGRQ and mortality, corrected for potential confounders, was estimated. Results: The mean age of study participants was 72.6 years. Over the 5-year observation period there were 88 deaths. After adjustment for potential confounders, the SGRQ score was associated with an increased risk of dying (hazard ratio (HR): 1.22 for four-point increments; 95% confidence interval (CI): 1.02,1.45). There was no association between mortality and the Symptoms subscale (corrected HR: 1.13; 95% CI: 0.96,1.32), whereas each four-point increment of the Activity (HR: 1.20; 95% CI: 1.00,1.43) and Impact (HR: 1.38; 95% CI: 1.03,1.83) subscale scores were associated with increased mortality. Higher FEV1 relative to predicted (HR: 0.73 for each 5% increment; 95% CI: 0.58,0.91) and better performance at the 6-min walking test relative to predicted (HR: 0.93 for each 5% increment; 95% CI: 0.89,0.97) were associated with lower mortality. Conclusions: In elderly COPD patients, the SGRQ can improve prognostic models based on classical indicators of disease severity. [source] Impact of Rural Residence on Survival of Male Veterans Affairs Patients After Age 65THE JOURNAL OF RURAL HEALTH, Issue 4 2010Todd A. MacKenzie PhD Abstract Objectives: More than 1 in 5 Veterans Affairs (VA) users lives in a rural setting. Rural veterans face different barriers to health care than their urban counterparts, but their risk of death relative to their urban counterparts is unknown. The objective of our study was to compare survival between rural and urban VA users. Methods: We linked the Large Health Survey of Veteran Enrollees conducted in 1999 to the Veterans Administration vital status registry. We used time-to-event regression models controlling for patient race, education, ZIP-code median income, and marital and smoking status. Findings: Of the 372,463 male veterans of age 65 or greater, 80,931 lived in rural settings. Age-adjusted mortality was 5.9% higher (95% CI, 4.5%-7.2%) in rural residents compared to urban residents. After adjusting for age, education, and ZIP-code median income, rural residents had 3.0% lower mortality (95% CI, 1.5%-4.4%). Compared to urban and suburban VA users, rural VA users' mortality at age 65 was 12% lower, but this advantage gradually diminished by age 75. Conclusion: Mortality after the age of 65 for male VA users is higher in rural dwellers than in urban dwellers. However, among veterans of the same socioeconomic characteristics, rural-dwelling veterans have up to 15% better mortality than urban-dwelling veterans until the age of 75. [source] Surgical Excision of Acoustic Neuroma: Patient Outcome and Provider CaseloadTHE LARYNGOSCOPE, Issue 8 2003Fred G. Barker II Abstract Objectives/Hypothesis For many complex surgical procedures, larger hospital or surgeon caseload is associated with better patient outcome. We examined the volume,outcome relationship for surgical excision of acoustic neuromas. Study Design Retrospective cohort study. Methods The Nationwide Inpatient Sample (1996 to 2000) was used. Multivariate regression analyses were adjusted for age, sex, race, payer, geographic region, procedure timing, admission type and source, medical comorbidities, and neurofibromatosis status. Results At 265 hospitals, 2643 operations were performed by 352 identified primary surgeons. Outcome was measured on a four-level scale at hospital discharge: death (0.5%) and discharge to long-term care (1.2%), to short-term rehabilitation (4.4%), and directly to home (94%). Outcomes were significantly better after surgery at higher-volume hospitals (OR 0.47 for fivefold-larger caseload, P <.001) or by higher-volume surgeons (OR 0.46, P <.001). Of patients who had surgery at lowest-volume-quartile hospitals, 12.3% were not discharged directly home, compared with 4.1% at highest-volume-quartile hospitals. There was a trend toward lower mortality for higher-volume hospitals (P = .1) and surgeons (P = .06). Of patients who had surgery at lowest-caseload-quartile hospitals, 1.1% died, compared with 0.6% at highest-volume-quartile hospitals. Postoperative complications (including neurological complications, mechanical ventilation, facial palsy, and transfusion) were less likely with high-volume hospitals and surgeons. Length of stay was significantly shorter with high-volume hospitals (P = .01) and surgeons (P = .009). Hospital charges were lower for high-volume hospitals (by 6% [P = .006]) and surgeons (by 6% [P = .09]). Conclusion For acoustic neuroma excision, higher-volume hospitals and surgeons provided superior short-term outcomes with shorter lengths of stay and lower charges. [source] The Relationship Between the Emergent Primary Percutaneous Coronary Intervention Quality Measure and Inpatient Myocardial Infarction MortalityACADEMIC EMERGENCY MEDICINE, Issue 8 2010Rahul K. Khare MD ACADEMIC EMERGENCY MEDICINE 2010; 17:793,800 © 2010 by the Society for Academic Emergency Medicine Abstract Background:, In the setting of acute ST-segment elevation myocardial infarction (STEMI), reperfusion therapy with emergent primary percutaneous coronary intervention (PCI) significantly reduces mortality. It is unknown whether a hospital's performance on the Centers for Medicare & Medicaid Services (CMS) quality metric for time from patient arrival to angioplasty is associated with its overall hospital acute myocardial infarction (AMI) mortality rate. Objectives:, The objective of this study was to evaluate if hospitals with higher performance on the time-to-PCI quality measure are more likely to achieve lower mortality for patients admitted for any type of AMI. Methods:, Using merged 2006 data from the Nationwide Inpatient Sample (NIS), the American Hospital Association (AHA) annual survey, and CMS Hospital Compare quality indicator data, we examined 69,101 admissions with an International Classification of Diseases, Ninth Revision (ICD-9)-coded principal diagnosis of AMI in the 116 hospitals that reported more than 24 emergent primary PCI admissions in that year. Hospitals were categorized into quartiles according to percentage of admissions in 2006 that achieved the primary PCI timeliness threshold (time-to-PCI quality measure). Using a random effects logistic regression model of inpatient mortality, we examined the significance of the hospital time-to-PCI quality measure after adjustment for other hospital and individual patient sociodemographic and clinical characteristics. Results:, The unadjusted inpatient AMI mortality rate at the 27 top quartile hospitals was 4.3%, compared to 5.1% at the 32 bottom quartile (worst performing) hospitals. The risk-adjusted odds ratio (OR) of inpatient death was 0.83 (95% confidence interval [CI] = 0.72 to 0.95), or 17% lower odds of inpatient death, among patients admitted to hospitals in the top quartile for the time-to-PCI quality measure compared to the case if the hospitals were in the bottom 25th percentile. Conclusions:, Hospitals with the highest and second highest quartiles of time-to-PCI quality measure had a significantly lower overall AMI mortality rate than the lowest quartile hospitals. Despite the fact that a minority of all patients with AMI get an emergent primary PCI, hospitals that perform this more efficiently also had a significantly lower mortality rate for all their patients admitted with AMI. The time-to-PCI quality measure in 2006 was a potentially important proxy measure for overall AMI quality of care. [source] A comparison of severely injured trauma patients admitted to level 1 trauma centres in Queensland and GermanyANZ JOURNAL OF SURGERY, Issue 3 2010Johanna M. M. Nijboer Abstract Background:, The allocation of a trauma network in Queensland is still in the developmental phase. In a search for indicators to improve trauma care both locally as state-wide, a study was carried out comparing trauma patients in Queensland to trauma patients in Germany, a country with 82.4 million inhabitants and a well-established trauma system. Methods:, Trauma patients ,15 years of age, with an Injury Severity Score (ISS) , 16 admitted to the Princess Alexandra Hospital (PAH) and to the 59 German hospitals participating in the Trauma Registry of the German Society for Trauma Surgery (DGU-G) during the year 2005 were retrospectively identified and analysed. Results:, Both cohorts are comparable when it comes to demographics and injury mechanism, but differ significantly in other important aspects. Striking is the low number of primary admitted patients in the PAH cohort: 58% versus 83% in the DGU-G cohort. PAH patients were less physiologically deranged and less severely injured: ISS 25.2 ± 9.9 versus 29.9 ± 13.1 (P < 0.001). Subsequently, they less often needed surgery (61% versus 79%), ICU admission (49% versus 92%) and had a lower mortality: 9.8% versus 17.9% of the DGU-G cohort. Conclusions:, Relevant differences were the low number of primary admissions, the lesser severity of injuries, and the low mortality of the patients treated at the PAH. These differences are likely to be interrelated and Queensland's size and suboptimal organization of trauma care may have played an important role. [source] Dietary intake of probiotics and maslinic acid in juvenile dentex (Dentex dentex L.): effects on growth performance, survival and liver proteolytic activitiesAQUACULTURE NUTRITION, Issue 4 2006M.C. HIDALGO Abstract Two feeding trials were carried out to evaluate the efficiency of probiotics and maslinic acid, on growth and survival of juvenile dentex; liver proteolytic activities were also investigated in the second trial. For experiment 1, triplicate groups were fed six diets with two probiotics (Bacillus toyoi, T, and B. cereus, E) at increasing levels (0.5, 1 and 2 g kg,1 diet) and a control diet. Growth and feed conversion were not significantly influenced by the probiotics. The diet T1 produced the lower mortality, whereas diet E1 rendered the higher mortality. It was concluded that no significant effects on growth and survival were found following the addition of two kinds of probiotics to dentex diets. However, the diet E0.5 showed a tendency to ameliorate the growth and feed utilization of the diet. In a second trial, triplicate groups were fed four diets with increasing levels of maslinic acid (0, 20, 40 and 80 mg kg,1 diet). Growth of fish given diets with the highest level of maslinic acid (D80) was slightly but not significantly lower than those from the other groups. Furthemore, mortality of fish fed diet D40 was the lowest. Changes in liver proteasome and endoprotease activities measured on sodium dodecyl sulphate (SDS)/gelatin gels were also detected in a dose-dependent manner. It was concluded that a dietary maslinic acid at a level of 80 mg kg,1 diet seems to be too high for juvenile dentex to maintain a maximal growth and survival rate. [source] Impact of a native predatory whelk on cultivated oysters (Crassostrea gigas) crops in San Quintin Bay, MexicoAQUACULTURE RESEARCH, Issue 4 2009Laura F Rodriguez Abstract San Quintin Bay (Baja, California, Mexico) is extensively utilized by artisanal farmers to cultivate Pacific oysters (Crassostrea gigas) using a rope/rack system. A large juvenile oyster mortality event was significantly correlated with the presence of native predatory whelks, Macron trochlea. Surveys, field and lab experiments were performed to identify the predatory behaviour of the whelk, determine factors affecting oyster mortality, and quantify the impact on oyster farmers. Macron trochlea was found to be a voracious, active predator, which can consume ,4 juvenile oysters day,1. Juvenile oysters suffer significantly higher mortality in the presence of whelks. Macron trochlea has the largest impact on small oysters. Once oysters grow to >30 mm they reach a size refuge above which there is much lower mortality. At average growth rates, an oyster can escape predation after ,3 months. But, in areas of highest whelk densities, at average predation rates, whelks could consume the standing crop of juvenile oysters in approximately 43 days. For the artisanal oyster farmers of San Quintin this represents a substantial economic loss, which was unaccounted for previously. Farmers can reduce loss to whelk predation by seeding juvenile oysters in low whelk density areas until oysters reach the size refuge. [source] | ||||||||||||||||