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Long-term Evaluation (long-term + evaluation)
Selected AbstractsAn Opioid Screening Instrument: Long-Term Evaluation of the Utility of the Pain Medication Questionnaire by Holmes et al.PAIN PRACTICE, Issue 2 2006Steven D. Passik PhD No abstract is available for this article. [source] Long-Term Evaluation of Myoblast Seeded Patches Implanted on Infarcted Rat HeartsARTIFICIAL ORGANS, Issue 6 2010Marie-Noëlle Giraud Abstract Cell transplantation presents great potential for treatment of patients with severe heart failure. However, its clinical application was revealed to be more challenging than initially expected in experimental studies. Further investigations need to be undertaken to define the optimal treatment conditions. We previously reported on the epicardial implantation of a bio-engineered construct of skeletal myoblast-seeded polyurethane and its preventive effect on progression toward heart failure. In the present study, we present a long-term evaluation of this functional outcome. Left anterior descending coronary ligation was performed in female Lewis rats. Two weeks later, animals were treated with either epicardial implantation of biograft, acellular scaffold, sham operation, or direct intramyocardial skeletal myoblast injection. Functional assessments were performed with serial echocardiographies every 3 months and end point left ventricle pressure was assessed. Hearts were then harvested for histological examinations. Myocardial infarction induced a slow and progressive reduction in fractional shortening after 3 months. Progression toward heart failure was significantly prevented for up to 6 months after injection of myoblasts and for up to 9 months following biograft implantation. Nevertheless, this effect vanished after 12 months, with immunohistological examinations revealing an absence of the transplanted myoblasts within the scaffold. We demonstrated that tissue therapy is superior to cell therapy for stabilization of heart function. However, beneficial effects are transient. [source] Long-term evaluation of animal-assisted therapy for institutionalized elderly people: a preliminary resultPSYCHOGERIATRICS, Issue 1 2007Namiko KAWAMURA Abstract Background:, Many researchers theorize that animal-assisted therapy (AAT) will have an effect on people suffering from the symptoms of dementia by evaluating short-term-effects. The purpose of this research was to evaluate the psychological and behavioral effects of AAT on elderly residents of a nursing home on a long-term basis. Methods:, The subjects consisted of 10 residents of a residential nursing home. Researchers first created each participant's goal in an agreement with the nursing home staff. Visits were made twice a month, and on each occasion three or four dogs were taken. The residents were able to freely feed, hold and play with the dogs, with each dog placed on a separate table. Data collection methods included GBS Scale Japanese Version (GBSS-J) and Mental Function Impairment Scale (MENFIS). Data was collected four times during the period 2003,05. The scores were analyzed using SPSS11.5J. Results:, According to GBSS-J, the scores for intellectual function, spontaneity, emotional function and other mental functions decreased during the first 6 months of the study and then increased until the twelfth month. The score for Motor function increased over the 12 months. When comparisons were made item by item, there were significant decreases in impaired orientation in space, and emotional liability during the first 6 months. According to MENFIS, the overall score tended to decrease during the first 6-month period but increased from 6 months to 12 months. There was a tendency for scores to decrease in impaired emotional function, especially impaired suitability of emotional expression and impaired stability of emotional expression over the 12-month period. Conclusions:, After 6 months of participation in AAT, there were improvements in mental functions, though physical functions decreased. It is suggested that after a 6 month period each subject's needs and goals should be re-examined. [source] Reducing racism in Aboriginal health care in Australia: where does cultural education fit?AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 2010Angela Durey Abstract Objective: This paper discusses whether educating health professionals and undergraduate students in culturally respectful health service delivery is effective in reducing racism, improving practice and lessening the disparities in health care between Aboriginal and non-Aboriginal Australians. Approach: The paper supports the concept of race as a social construction that is discursively produced and reproduced. Studies on the effectiveness of cross-cultural education for undergraduate students and health professionals to reduce racism and deliver culturally respectful health care to indigenous or minority populations are examined for evidence of sustained improvements to practice. Conclusion: Programs in culturally respectful health care delivery can lead to short-term improvements to practice. Sustained change is more elusive as few programs conducted long-term evaluations. Long-term evaluation of programs in culturally respectful health care delivery is necessary to identify whether early changes to behavior and practices are sustained. Strategies linking policies to practice to reduce health disparities between Aboriginal and non-Aboriginal Australians are also needed. Implications: Confronting the effects of racism in health services towards Aboriginal Australians is a priority requiring a multi-tiered commitment to strategies linking policy to practice to reduce health disparities between Aboriginal and non-Aboriginal Australians. Part of this strategy includes preparing undergraduates and health professionals for culturally respectful health care with education programs that are evaluated for long-term improvements to practice. [source] In-Situ ozonation of contaminated groundwaterENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 3 2000Michael A. Nimmer This paper presents case studies in the application of insitu ozone sparging to remediate petroleum contaminated groundwater. This technology was developed and installed due to shortcomings with other conventional remedial technologies evaluated for groundwater remediation. The main objective of this study was to develop a system to supply ozone to the groundwater aquifer and to evaluate the system performance in the field. Three different applications were evaluated for this study, all containing petroleum-contaminated groundwater. The ozone sparging system consists of an air compressor, ozone generator, a programmable logic controller, and associated gauges and controls. The mixture of air and ozone is injected into the groundwater aquifer through microporous sparge points contained in various sparge well designs. The initial results from the three applications demonstrated that ozone sparging is a viable alternative to remediate petroleum -contaminated groundwater. Significant reductions in petroleum constituents we re observed shortly after system start-up at all sites. During the one to two years operation at the three sites, a number of maintenance items we re identified; these items we re addressed by modifications to the system design and operation. A long-term evaluation of the system operation has not yet been performed. [source] Medium-term results of oral tacrolimus treatment in refractory inflammatory bowel diseaseINFLAMMATORY BOWEL DISEASES, Issue 2 2007Siew C. Ng MRCP Abstract Background: This study aimed to evaluate the efficacy of oral tacrolimus in patients with inflammatory bowel disease (IBD) refractory to conventional therapy, including azathioprine, 6-mercaptopurine, and infliximab. Methods: Retrospective review of all patients with IBD treated with oral tacrolimus was undertaken. Tacrolimus was administered at an initial dose of 0.05 mg/kg twice daily, aiming for serum trough levels of 5,10 ng/mL. We evaluated clinical response, a retrospective estimated Crohn's disease activity index (CDAI) for Crohn's disease (CD), modified Truelove-Witts index for ulcerative colitis (UC), and modified pouch disease activity index (mPDAI) for pouchitis. Patients had been monitored clinically for benefit and side effects and by whole blood tacrolimus level approximately every 4 weeks for the duration of treatment. Clinical remission was defined as an estimated CDAI <150 (CD), an inactive disease score on the Truelove-Witts index (UC), and mPDAI <5 (pouchitis). Results: Twelve patients with CD, six with UC, and one with pouchitis, all resistant to previous therapies, were treated for a median of 5 months. After 4 weeks 10 CD (83%), four UC (67%) patients, and one pouchitis patient had a clinical response. There was a median reduction of the estimated CDAI of 108 points (range 35,203; P = 0.002) and stool frequency of three per day at week 4. Remission was achieved in 42% (5/12) of CD and 50% (3/6) of UC patients at the end of follow-up. Side effects included temporary elevated creatinine (n = 1), tremor (n = 3), arthralgia (n = 1), insomnia (n = 1), and malaise (n = 1). Four patients discontinued treatment due to side effects. Conclusion: Oral tacrolimus is well tolerated and effective in patients with refractory IBD in the short- to medium-term. Further controlled, long-term evaluation is warranted. (Inflamm Bowel Dis 2007) [source] Sailing the Bremen CogINTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 2 2009Gabriele Hoffmann The 14th-century Bremen Cog is the only near-complete representative of a type of large ship with a single square-sail which dominated North European waters for c.200 years. The evaluation of sailing properties, seaworthiness, potential and characteristics of two replicas is made by professional seamen who have taken them to their limits. Their judgements need to be recorded now, or they will be forgotten especially as systematic tests and sea-trials have been limited and documentation lost. The replicas' captains' expert opinion on the Bremen Cog as a sea-going vessel is a rare case of long-term evaluation of a large-scale experimental-archaeology project. © 2009 The Authors [source] Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's diseaseMOVEMENT DISORDERS, Issue 6 2006Andrew Siderowf MD, MSCE Abstract We evaluated the long-term effects of subthalamic nucleus (STN) stimulation on health-related quality of life (HRQL) in patients with advanced Parkinson's disease (PD). STN stimulation improves motor function and decreases medication requirements in patients with advanced PD. The impact of STN stimulation on HRQL is less well established, especially beyond 1 year after surgery. We report HRQL outcomes for 18 patients with advanced PD. Patients were evaluated with the Parkinson's Disease Questionnaire-39 (PDQ-39), the Medical Outcome Study Short Form (SF-36), and the EuroQol visual analogue scale (VAS) before surgery, 6 months postoperatively, and at a long-term follow-up visit (mean, 35.9 months; range, 18,57 months after surgery). Preoperative scores on HRQL measures were compared to results obtained at short- and long-term follow-up evaluations. The VAS and all domains of the PDQ-39 except for cognition, communication, and social support showed marked improvements at 6 months after surgery. At the long-term follow-up, there were sustained improvements in the VAS (63% improvement; P = 0.0009) and in several domains of the PDQ-39 [mobility: 20%, P = 0.01; activities of daily living (ADL): 29%, P = 0.005; emotional well-being: 26%, P = 0.02; stigma: 43%, P = 0.003; and bodily discomfort: 35%, P = 0.007]. At the long-term evaluation, only the vitality domain of the SF-36 was significantly improved from baseline (16%; P = 0.01). In this selected group of patients, many of the short-term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable. © 2006 Movement Disorder Society [source] Evaluating for long-term impact of an environmental education program at the Kalinzu Forest Reserve, UgandaAMERICAN JOURNAL OF PRIMATOLOGY, Issue 5 2010C.W. Kuhar Abstract Although the importance of evaluating the effectiveness of conservation education programs cannot be underestimated, few evaluations of these programs and their resulting impact on the environment have been conducted. A partnership between scientists, educators, and local administrators on an evaluation program has been developed to evaluate a model of education program evaluation that includes short- and long-term evaluation of (1) knowledge and attitude change, (2) behavior change, and (3) positive biological impact. Previous work has shown short-term knowledge retention from this education program. In the current study follow-up evaluations were collected from students at 14 schools outside the Kalinzu Forest Reserve, Uganda. By comparing performance 30 days, 1 year and 2 years after the initial program we demonstrate that knowledge gain from this program is not transient. However, although knowledge is a prerequisite for appropriate conservation actions it does not guarantee appropriate behaviors will be performed. Anecdotal evidence of behavior change and positive biological impact is discussed within the context of the challenges with changing behavior and evaluating the true biological impacts of those behaviors. Ultimately, conservation professionals will need to partner with educators and social scientists to effectively measure the impact of conservation education and human-based conservation programs on primate populations and their habitat. Am. J. Primatol. 72:407,413, 2010. © 2009 Wiley-Liss, Inc. [source] Long-Term Evaluation of Myoblast Seeded Patches Implanted on Infarcted Rat HeartsARTIFICIAL ORGANS, Issue 6 2010Marie-Noëlle Giraud Abstract Cell transplantation presents great potential for treatment of patients with severe heart failure. However, its clinical application was revealed to be more challenging than initially expected in experimental studies. Further investigations need to be undertaken to define the optimal treatment conditions. We previously reported on the epicardial implantation of a bio-engineered construct of skeletal myoblast-seeded polyurethane and its preventive effect on progression toward heart failure. In the present study, we present a long-term evaluation of this functional outcome. Left anterior descending coronary ligation was performed in female Lewis rats. Two weeks later, animals were treated with either epicardial implantation of biograft, acellular scaffold, sham operation, or direct intramyocardial skeletal myoblast injection. Functional assessments were performed with serial echocardiographies every 3 months and end point left ventricle pressure was assessed. Hearts were then harvested for histological examinations. Myocardial infarction induced a slow and progressive reduction in fractional shortening after 3 months. Progression toward heart failure was significantly prevented for up to 6 months after injection of myoblasts and for up to 9 months following biograft implantation. Nevertheless, this effect vanished after 12 months, with immunohistological examinations revealing an absence of the transplanted myoblasts within the scaffold. We demonstrated that tissue therapy is superior to cell therapy for stabilization of heart function. However, beneficial effects are transient. [source] Serum Neopterin Monitoring and Vitamin E-Modified, Regenerated Hemodialyzer Membrane Influence on BiocompatibilityARTIFICIAL ORGANS, Issue 1 2002Katsunori Yoshida Abstract: The exposure of blood to hemodialysis membranes results in numerous phenomena and/or complications in hemodialyzed patients, which have an influence on the quality of life (QOL) of those patients. A vitamin E-modified regenerated cellulose membrane (E-membrane) was developed to act as a scavenger for reactive oxygen species causing complications in hemodialysis patients. Neopterin (NEOP) is a metabolite derived from guanosine triphosphate with the production and release of NEOP being induced in monocytes and macrophages by cytokines such as interferon-, (IFN-,). Serum neopterin levels are shown to be a reactive marker of bioincompatibility of dialysis membranes in hemodialysis patients. The following report evaluates the usefulness of serum NEOP as a marker for the biocompatibility of the E-membrane hemodialyzer in a clinical study. In the clinical study, where extracorporeal ultrafiltration strategies with E-membranes were employed, the serum levels of NEOP were lower than those in patients using cellulose triacetate membranes (C-membranes). In the long-term evaluation of the biocompatibility of E- and C-membranes, the increase of serum neopterin levels in the C-membrane was higher than those in the E-membrane. In conclusion, the evaluation of serum neopterin levels during hemodialysis shows that the E-membrane has a good biocompatibility in hemodialyzed patients. [source] Multicentre retrospective analysis of the outcome of artificial anal sphincter implantation for severe faecal incontinenceBRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 11 2001Dr D. F. Altomare Background: A new prosthetic device, the ActiconTM artificial anal sphincter, has recently been introduced for treating severe faecal incontinence. The results of this procedure in 28 patients are presented. Methods: The patients underwent operation for severe faecal incontinence in four Italian university hospitals and patients were reviewed after a median follow-up of 19 (range 7,41) months. Results: Early infections occurred in four patients, requiring removal of the device in three. Dehiscence of the perineal wound occurred in nine patients. After activation of the device, the cuff had to be removed in a further four patients (for rectal erosion in two, anal pain in one and late infection in one). The cuff was accidentally broken in one patient. A new anal cuff was repositioned successfully in two patients. Overall, five patients had complete removal of the device and two removal of the cuff only. Twenty-one patients available for long-term evaluation had a major improvement in faecal continence. Median resting anal pressure increased from 27 mmHg before surgery to 32 mmHg after operation. Preoperative squeeze pressure was 42 mmHg while maximum postoperative anal pressure with the activated device was 67 mmHg. The median American Medical System incontinence score decreased significantly from 98·5 to 5·5 (P < 0·001). Similar figures were observed using the Continence Grading Scale (from 14·9 to 2·6; P < 0·001). Twelve patients developed symptoms of obstructed defaecation while two patients complained of anal pain. Conclusion: Improved continence was achieved after neosphincter implantation in three-quarters of the patients. Early infection and rectal erosion, together with difficulty in evacuating, are still major concerns with this technique. © 2001 British Journal of Surgery Society Ltd [source] Reconstruction of maxillary and mandibular defects using prefabricated microvascular fibular grafts and osseointegrated dental implants , a prospective studyCLINICAL ORAL IMPLANTS RESEARCH, Issue 5 2004Claude Jaquiéry Abstract: The fibular flap can be used for a variety of indications. Recently, the treatment of four patients with severely atrophied upper jaws using a method to prefabricate the vascularized fibular graft has been published. This technique consists of a two-stage operation procedure that allows simultaneous prosthodontic rehabilitation and immediate placement of dental implants. In this paper eight patients with 29 ITI implants (Straumann AG, Waldenburg, Switzerland) who had reconstruction of either the upper or lower jaw are presented. The aim of the study was (i) to evaluate the behavior of the newly formed soft tissue around implants inserted in the fibula by applying periodontal parameters, (ii) to monitor prospectively the integration of the implants in the fibular graft, and (iii) to assess the osseous integration of the fibular graft used for reconstruction of the upper or lower jaw. Two implants failed during the observation time because of avascular bone at the distal end of the fibular graft. Stabilization of the graft, however, was never compromised. Due to the prefabrication firmly attached gingiva-like soft tissue could be provided preventing periimplant soft tissue inflammation and facilitating oral hygiene. After 1 year of observation the mean attachment level was similar to implants placed in original bone whereas vertical bone loss measured radiographically was lower in the present study. This may indicate that the remodeling of a bicortical bone requires a longer period of time compared with the bone of the alveolar crest. The prospective 1-year results are promising but long-term evaluation of periodontal and radiological parameters are required. Résumé Le lambeau péroné peut être utilisé pour une variété d'indications. Récemment le traitement de quatre patients avec une atrophie sévère des mâchoires supérieures et utilisant une méthode pour préfabriquer un greffon péroné vascularisé a été publié. Cette technique consiste en une opération en deux étapes qui permet la réhabilitation prothétique simultanée et le placement immédiat des implants dentaires. Dans ce rapport huit patients avec 29 implants ITI (Straumann AG, Waldenburg, Switzerland) ont eu une reconstruction de la mâchoire supérieure ou inférieure. Le but de cette étude a été 1) d'évaluer le comportement des tissus mous nouvellement formés autour des implants insérés dans le péroné en appliquant les paramètres parodontaux, 2) de suivre d'une manière prospective l'intégration des implants dans le greffon péroné et 3) d'examiner l'intégration osseuse de l'implant péroné utilisé pour la reconstruction de ces mâchoires. Deux implants ont échoué durant la période d'observation parce que l'os alvéolaire n'était pas vasculariséà la partie distale du greffon. La stabilisation du greffon n'a cependant jamais été compromise. La préfabrication d'un tissu ressemblant à de la gencive préfabriquée a permit d'éviter l'inflammation gingivale et de faciliter l'hygiène buccale. Après une année d'observation le niveau d'attache moyen était semblable au niveau des implants placés dans l'os original tandis que la perte osseuse verticale mesurée radiographiquement était inférieure dans l'étude présente. Ceci peut indiquer que le remodelage de l'os bicortical requiert une période plus importante comparée à l'os du rebord alvéolaire. Ces résultats prospectifs à une année sont encourageants mais l'évaluation à long terme des paramètres parodontaux et radiologiques reste encore nécessaire. Zusammenfassung Der Fibula-Lappen kann bei einer Vielzahl von Indikationen angewendet werden. Kürzlich wurde eine Publikation über die Behandlung von vier Patienten mit stark atrophierten Oberkiefern mittels vorfabrizierten vaskularisierten Fibula transplantaten veröffentlicht. Diese Technik besteht aus einer Operation in zwei Phasen, welche die Sofortimplantation von dentalen Implantaten und gleichzeitige prothetische Rekonstruction erlaubt. In diesem Artikel werden acht Patienten mit 29 Implantaten (Straumann AG, Waldenburg, Switzerland), bei welchen entweder eine OK- oder UK-Rekonstruktion durchgeführt wurde, präsentiert. Das Ziel der Studie war (i) das Verhalten des neu gebildeten Gewebes um die Implantate, welche in die Fibula eingesetzt worden waren mittels parodontalen Parametern zu untersuchen, (ii) die Integration der Implantate in das Fibula-Transplantat prospektiv aufzuzeichnen und (iii) die ossäre Integration des für die Rekonstruktion des OK oder UK verwendeten Fibula-Transplantats zu ermitteln. Zwei Implantate zeigten während der Beobachtungsperiode Misserfolge wegen avaskulärem Knochen an den distalen Enden des Fibula-Transplantats. Die Stabilisierung des Transplantats war jedoch niemals beeinträchtigt. Durch die Vorfabrizierung konnten gut angewachsene gingiva-ähnliche Weichgewebe geschaffen werden, welche eine periimplantäre Entzündung der Weichgewebe verhinderten und die Mundhygiene erleichterten. Nach einer Beobachtungszeit von einem Jahr war das mittlere Attachmentniveau ähnlich dem von Implantaten, welche in alveolären Knochen inseriert worden waren, während der radiologisch gemessene Knochenverlust in der vorliegenden Studie geringer war. Dies könnte ein Indiz dafür sein, dass die Remodellierung eines bikortikalen Knochens im Vergleich zum Alveolarknochen längere Zeit benötigt. Die prospektiven Resultate nach einem Jahr sehen vielversprechend aus, aber es muss eine Auswertung der parodontalen und radiologischen Parameter über einen längeren Zeitraum durchgeführt werden. Resumen El colgajo peroneal puede ser usado para una variedad de indicaciones. Recientemente se ha publicado el tratamiento de cuatro pacientes con maxilares superiores severamente atróficos usando un método para prefabricar el injerto peroneal vascularizado. Esta técnica consiste en un procedimiento de operación de dos fases que permite la rehabilitación prostodóntica y la colocación inmediata de implantes dentales simultáneamente. En este artículo se presentan ocho pacientes con 29 implantes ITI (Strauman AG, Waldenburg) teniendo una reconstrucción de tanto el maxilar superior como del inferior. La intención del presente estudio fue (i) evaluar el comportamiento de del tejido blando neoformado alrededor de los implantes insertados en la tibia aplicando parámetros periodontales, (ii) monitorizar prospectivamente la integración de los implantes en el injerto perineal y (iii) valorar la integración ósea del injerto perineal usado para la reconstrucción del maxilar superior o inferior. Dos implantes fracasaron durante el periodo de observación debido a hueso sin vascularización en el final distal del injerto perineal. De todos modos, la estabilización del injerto no se vio nunca comprometida. Debido a la prefabricación se pudo suministrar un tejido blando tipo encía adherida previniendo inflamación del tejido blando periimplantario y facilitando la higiene oral. Tras un año de observación el nivel de inserción medio fue similar a los implantes insertados en las áreas de hueso original mientras que la pérdida de hueso vertical medida radiograficamente fue menor en el presente estudio. Esto puede indicar que el remodelado de un hueso bicortical requiere un periodo mas largo de tiempo comparado con el hueso de la cresta alveolar. Los resultados prospectivos de un año son prometedores pero se requieren evaluaciones de los parámetros periodontales y radiológicos a largo plazo. [source] Histomorphological evaluation of loaded plate-form and root-form implants in Macaca mulatta monkeysCLINICAL ORAL IMPLANTS RESEARCH, Issue 2 2002Michael McCracken Abstract: As part of a long-term evaluation of endosteal dental implants in primates, this paper describes the histological response to plate-form and root-form implants. Thirty-six primates received 48 mandibular distal abutment implants. After healing, the implants were restored with fixed partial dentures, which remained in function for two years. A subset of the group was ligated at the gingival sulcus to biologically stress tissues supporting the implants. Crestal bone height around implants was quantified using digital subtraction radiographic techniques. The ligated implants lost more crestal bone than non-ligated implants, as shown by ANOVA (P < 0.05). After retrieval, implants were embedded and sectioned for histomorphometric analysis including measurement of per cent osseointegration. Both plate-form and root-form non-ligated implants demonstrated about 60% osseointegration. When ligated, plate-form implants dropped to an average integration of only 34%, while root-form implants maintained 62% integration, a significant difference. These data show that in this primate model, plate-form and root-form implants maintained integration while in function for two years. When stressed with ligation, root-form implants maintained relative amounts of osseointegration, while per cent osseointegration of plate-form implants decreased. Résumé Ce manuscript décrit la réponse histologique à long terme au niveau des implants-plateau ou racine. Trente-six primates ont reçu 48 implants comme pilier distal au niveau de la mandibule. Après guérison, les implants ont été chargés avec des prothèses partielles fixées qui sont restées en fonction durant deux années. Un sous-groupe a été ligaturé au niveau des sulci gingivaux afin d'augmenter l'accumulation de plaque dentaire au niveau de ces implants. La hauteur osseuse crestale autour des implants a été quantifée en utilisant des techniques de soustraction radiologique. Les implants ligaturés ont perdu davantage d'os crestal que les non-ligaturés (ANOVA: P<0.05). Après leur avulsion les implants ont été enfouis dans des blocs et découpés pour une analyse histomorphométrique évaluant la mesure de l'ostéointégration. Les deux types d'implant avaient une ostéintégration d'environ 60%. Lorsqu'il y avait une ligature, les implants-plateau avaient une diminution de l'intégration allant jusqu'à 34% tandis que ceux en forme racine maintenaient une intégration de 62%. Ces données ont montré que dans ce modèle de primate, les implants-plateau et -racine maintenaient une intégration durant leur mise en fonction de deux années. Lorsqu'une ligature était placée les implants-racine maintenaient une bonne quantité d'ostéo?ntégration tandis que cette dernière était significativement inférieure lorsque les implants-plateau étaient utilisés. Zusammenfassung Diese Arbeit ist Teil einer Langzeitstudie über enossale Zahnimplantaten an Primaten und beschreibt die histologische Antwort auf scheiben- und wurzelförmige ?mplantate. 36 Primaten erhielten 48 seitliche Unterkieferimplantate. Nach der Heilphase wurden die ?mplantate mit festsitzenden Teilprothesen versorgt, die während zwei Jahren in Funktion verblieben. Ein Teil der Gruppe erhielt im den Sulcus eine Ligatur, um die dem ?mplantat angrenzendenden Gewebe einer biologischen Stressituation auszusetzen. Die Höhe des Alveolarknochens um die ?mplantate wurde mit Hilfe der digitalen Subtraktionsradiographie quantitativ erfasst. Die ?mplantate mit einer Ligatur verloren mehr Alveolarknochen als die nichtligierten ?mplantate (ANOVA; P<0.05). Nach der Entnahme wurden die ?mplantate eingebettet und histologische Schnitte angefertigt. Diese dienten der histomorphometrischen Analyse und der Bestimmung des Osseointegrationsgrades in Prozenten. Sowohl die scheiben-, wie auch die wurzelförmigen ?mplantate zeigten ohne Ligaturen eine 60%-ige Osseointegration. Wurden aber Ligaturen angelegt, so reduzierte sich der Grad der Osseointegration bei den scheibenförmigen ?mplantaten auf 34%, bei den wurzelförmigen ?mplantate auf 62%, es handelte sich um einen signifikanten Unterschied. Die Resultate dieses Primatenmodells zeigen, dass die scheiben- und wurzelförmigen ?mplantate während einer Funktionszeit von zwei Jahren ihre Osseointegration beibehalten. Werden die Gewebe aber mit Ligaturen zur experimentellen Entzündung gebracht, können die wurzelförmigen ?mplantate ihren Osseontegrationsgrad beibehalten, bei den scheibenförmigen ?mplantaten nahm er ab. Resumen Como parte de una evaluación a largo plazo de implantes dentales endoóseos en primates, este trabajo describe la respuesta histológica a implantes con forma de placa y con forma de raíz. Treinta y seis primates recibieron 48 implantes distales mandibulares con pilar. Tras la cicatrización, los implates se restauraron con dentaduras parciales fijas, que permanecieron en functión durante 2 años. A un subconjunto del grupo se les colocó una ligadura en el surco gingival para estresar los tejidos que soportan los implantes. Se cuantificó la altura de la cresta ósea alrededor de los implantes usando técnicas radiográficas de sustracción digital. Los implantes ligados perdieron mas hueso crestal que los implantes no ligados, como se muestra en ANOVA (P<0.05). Tras la retirada, los implantes se embebieron y seccionaron para análisis histomorfométrico incluyendo mediciones del porcentaje de osteointegración. Tanto los implantes con forma de placa como los de forma de raíz no ligados mostraron un 60 por ciento de osteointegración. Cuando se ligaron, los implantes con forma de placa bajaron a una media de integración de solo el 34 por ciento, mientras que los implantes con forma de raíz mantuvieron el 62 por ciento de integración, una diferencia significativa. Estos datos muestran que en este modelo de primates, lo implantes con forma de placa y forma de raíz mantuvieron la integración en función durante 2 años. Al estresarse con ligaduras, los implantes con forma de raíz mantuvieron unas cantidades relativas de osteointegración, mientras que el porcentaje de integración de los implantes con forma de placa disminuyó. [source] Captive and wild orangutan (Pongo sp.) survivorship: a comparison and the influence of managementAMERICAN JOURNAL OF PRIMATOLOGY, Issue 8 2009S.A. Wich Abstract For managers of captive populations it is important to know whether their management provides a species with the physical and social environment that maximizes its survivorship. To determine this, survivorship comparisons with wild populations and long-term evaluations of captive populations are important. Here we provide both for orangutans. We show that survivorship has increased during the past 60 years for captive orangutan populations in zoos. In addition, we show that survivorship of captive orangutans in the past used to be lower than for wild orangutans, but that for recently born (1986,2005) orangutans survivorship is not significantly different from the wild. This indicates that captive management in the past was suboptimal for orangutan survivorship, but that modern management of captive orangutans has increased their survivorship. We discuss the possible factors of modern management that could have influenced this. Am. J. Primatol. 71:680,686, 2009. © 2009 Wiley-Liss, Inc. [source] Reducing racism in Aboriginal health care in Australia: where does cultural education fit?AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 2010Angela Durey Abstract Objective: This paper discusses whether educating health professionals and undergraduate students in culturally respectful health service delivery is effective in reducing racism, improving practice and lessening the disparities in health care between Aboriginal and non-Aboriginal Australians. Approach: The paper supports the concept of race as a social construction that is discursively produced and reproduced. Studies on the effectiveness of cross-cultural education for undergraduate students and health professionals to reduce racism and deliver culturally respectful health care to indigenous or minority populations are examined for evidence of sustained improvements to practice. Conclusion: Programs in culturally respectful health care delivery can lead to short-term improvements to practice. Sustained change is more elusive as few programs conducted long-term evaluations. Long-term evaluation of programs in culturally respectful health care delivery is necessary to identify whether early changes to behavior and practices are sustained. Strategies linking policies to practice to reduce health disparities between Aboriginal and non-Aboriginal Australians are also needed. Implications: Confronting the effects of racism in health services towards Aboriginal Australians is a priority requiring a multi-tiered commitment to strategies linking policy to practice to reduce health disparities between Aboriginal and non-Aboriginal Australians. Part of this strategy includes preparing undergraduates and health professionals for culturally respectful health care with education programs that are evaluated for long-term improvements to practice. [source] Retrospective Clinical Evaluation of 86 Procera AllCeramÔ Anterior Single Crowns on Natural and Implant-Supported AbutmentsCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 2005Fernando Zarone MD ABSTRACT Background: The Procera AllCeramÔ (Nobel Biocare AB, Göteborg, Sweden, and Procera Sandvik AB, Stockholm, Sweden) technique is one alternative to metal-ceramic restorations. However, few long-term evaluations of its use for single crowns on natural and implant-supported abutments are available. Purpose: The aim of the present study was to assess the clinical performance of Procera AllCeram single crowns when placed in aesthetic sites supported by either natural teeth or implants over a period of 48 months. Materials and Methods: Eighty-six single crowns were fabricated and used in 51 patients. The restorations were examined according to the California Dental Association's quality assessment system. Results: One crown was lost after 20 months of follow-up. Of the 85 restorations that completed the 48-month follow-up, only one crown (1.2%) showed a veneering porcelain chip. All crowns were ranked as either excellent or acceptable. The success rates of single crowns supported by natural tooth and implant-supported abutments were 100% and 98.3%, respectively; the total crown success rate was 98.8%. Conclusion: Within the limitations of the present study, Procera AllCeram crowns proved to be a reliable therapeutic choice for the restoration of anterior teeth on both natural and implant-supported abutments. The hybrid glass-ionomer cement used in the present study appeared to be a reliable luting agent. [source] | ||||||||||