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Long-term Effects (long-term + effects)
Kinds of Long-term Effects Selected AbstractsLONG-TERM EFFECTS OF ALCOHOL POLICIES: AN ECONOMIC PERSPECTIVEADDICTION, Issue 3 2010PIETER VAN BAAL No abstract is available for this article. [source] SHORT-TERM AND LONG-TERM EFFECTS OF TEMPERATURE ON PHOTOSYNTHESIS IN THE DIATOM THALASSIOSIRA PSEUDONANA UNDER UVR EXPOSURES,JOURNAL OF PHYCOLOGY, Issue 3 2007Cristina Sobrino Temperature is expected to modify the effects of ultraviolet radiation (UVR) on photosynthesis by affecting the rate of repair. We studied the effect of short-term (1 h) and long-term (days) acclimation to temperature on UVR photoinhibition in the diatom Thalassiosira pseudonana Hasle et Heimdal. Photosynthesis was measured during 1 h exposures to varying irradiances of PAR and UVR + PAR at 15, 20, and 25°C, the latter corresponding to the upper temperature limit for optimal growth in T. pseudonana. The exposures allowed the estimation of photosynthesis,irradiance (P,E) curves and biological weighting functions (BWFs) for photoinhibition. For the growth conditions used, temperature did not affect photosynthesis under PAR. However, photoinhibition by UVR was highly affected by temperature. For cultures preacclimated to 20°C, the extent of UVR photoinhibition increased with decreasing temperature, from 63% inhibition of PAR-only photosynthesis at 25°C to 71% at 20°C and 85% at 15°C. These effects were slightly modified after several days of acclimation: UVR photoinhibition increased from 63% to 75% at 25°C and decreased from 85% to 80% at 15°C. Time courses of photochemical efficiency (,PSII) under UVR + PAR were also fitted to a model of UVR photoinhibition, allowing the estimation of the rates of damage (k) and repair (r). The r/k values obtained for each temperature treatment verified the responses observed with the BWF (R2 = 0.94). The results demonstrated the relevance of temperature in determining primary productivity under UVR exposures. However, the results suggested that temperature and UVR interact mainly over short (hours) rather than long (days) timescales. [source] An Echocardiographic Analysis of the Long-Term Effects of Carvedilol on Left Ventricular Remodeling, Systolic Performance, and Ventricular Filling Patterns in Dilated CardiomyopathyECHOCARDIOGRAPHY, Issue 7 2005Peter S. Rahko M.D. Background: The long-term clinical benefit of beta blockade is well recognized, but data quantifying long-term effects of beta blockade on remodeling of the left ventricle (LV) is limited. Methods: This consecutive series evaluates the long-term response of the LV to the addition of carvedilol to conventional therapy for dilated cardiomyopathy. There were 33 patients who had a LV ejection fraction <45%, LV enlargement and symptomatic heart failure. Quantitative Doppler echocardiography was performed at baseline 6, 12, 24, and 36 months after initiation of carvedilol to evaluate LV ejection fraction, LV volume, wall stress, mass, regional function, and diastolic performance. Results: Compared to baseline there was a significant and sustained reduction in end-systolic volume and end-systolic wall stress with a corresponding improvement in LV ejection fraction. The LV mass did not decline but relative wall thickness increased toward normal. An analysis of regional wall motion responses showed an improvement in all areas, particularly the apical, septal, and lateral walls that was significantly more frequent in patients with a nonischemic etiology. Filling patterns of the LV remained abnormal throughout the study but changed with therapy suggesting a decline in filling pressures. These changes were sustained for 3 years. Conclusion: (1) The addition of carvedilol to conventional therapy for a dilated cardiomyopathy significantly improves LV ejection fraction and reduces LV end-systolic volume and wall stress for at least 3 years, (2) the response to 6 months of treatment predicts the long-term response, (3) the typical response is partial improvement of the LV, complete return to normal size, and function is uncommon, and (4) abnormalities of LV filling persist in virtually all patients throughout the course of treatment. [source] Long-Term Effects of Stressors on Relationship Well-Being and Parenting Among Rural African American Women,FAMILY RELATIONS, Issue 2 2008Velma M. Murry Abstract: This investigation of the effects of stressful life events on rural African American women's relationship well-being, psychological functioning, and parenting included 361 married or long-term cohabiting women. Associations among stressful events, socioeconomic status, perceived racial discrimination, coping strategies, psychological functioning, relationship well-being, and parenting were tested. Stressful events were related directly to diminished relationship well-being and heightened psychological distress and indirectly to compromised parenting. The results can inform research and intervention with African American women. [source] Long-Term Effects of Fiscal Policy on the Size and Distribution of the Pie in the UK,FISCAL STUDIES, Issue 3 2008Xavier Ramos C5; E6; H3 Abstract. This paper provides a joint analysis of the output and distributional long-term effects of various fiscal policies in the UK, using a vector autoregression (VAR) approach. Our findings suggest that the long-term impact on GDP of increasing public spending and taxes is negative, and especially strong in the case of current expenditure. We also find significant distributional effects associated with fiscal policies, indicating that an increase in public spending reduces inequality while a rise in indirect taxes increases income inequality. [source] Testing the Long-Term Effects of the Go Sun Smart Worksite Health Communication Campaign: A Group-Randomized Experimental StudyJOURNAL OF COMMUNICATION, Issue 3 2008Peter A. Andersen This study examined the long-term effects of the Go Sun Smart (GSS) campaign, a large-scale health communication intervention designed to promote sun safety to employees at 26 ski areas in western North America. Employees were enrolled in a pair-matched group-randomized pretest,posttest controlled design with 2 follow-up surveys. Half of the ski areas were randomly assigned to implement GSS in the winter. This article reports analyses of a hierarchical linear design with responses from 1,463 employees who completed the second follow-up survey at the end of the following summer (69% of those who completed the first posttest). GSS continued to have positive effects on employees who worked at intervention ski areas into the summer. Employees exposed to GSS reported less sunburning, engaged in more sun safety behaviors, were more aware of the program, and had more discussions of sun safety at home than employees at matched control group resorts. The long-term effects of GSS support recommending that sun protection programs be implemented at workplaces, but such programs should be implemented with high fidelity to achieve maximum benefits. Despite limitations due to nonresponse, geography, measurement, and ethnicity, the hierarchical clustered design improved the internal validity and generalizability of the findings. [source] Long-Term Effects of Minimum Drinking Age Laws on Past-Year Alcohol and Drug Use DisordersALCOHOLISM, Issue 12 2009Karen E. Norberg Background:, Many studies have found that earlier drinking initiation predicts higher risk of later alcohol and substance use problems, but the causal relationship between age of initiation and later risk of substance use disorder remains unknown. Method:, We use a "natural experiment" study design to compare the 12-month prevalence of Diagnostic and Statistical Manual, Fourth Edition, alcohol and substance use disorders among adult subjects exposed to different minimum legal drinking age laws minimum legal drinking age in the 1970s and 1980s. The sample pools 33,869 respondents born in the United States 1948 to 1970, drawn from 2 nationally representative cross-sectional surveys: the 1991 National Longitudinal Alcohol Epidemiological Survey (NLAES) and the 2001 National Epidemiological Study of Alcohol and Related Conditions. Analyses control for state and birth year fixed effects, age at assessment, alcohol taxes, and other demographic and social background factors. Results:, Adults who had been legally allowed to purchase alcohol before age 21 were more likely to meet criteria for an alcohol use disorder [odds ratio (OR) 1.31, 95% confidence intervals (95% CI) 1.15 to 1.46, p < 0.0001] or another drug use disorder (OR 1.70, 95% CI 1.19 to 2.44, p = 0.003) within the past-year, even among subjects in their 40s and 50s. There were no significant differences in effect estimates by respondent gender, black or Hispanic ethnicity, age, birth cohort, or self-reported age of initiation of regular drinking; furthermore, the effect estimates were little changed by inclusion of age of initiation as a potential mediating variable in the multiple regression models. Conclusion:, Exposure to a lower minimum legal purchase age was associated with a significantly higher risk of a past-year alcohol or other substance use disorder, even among respondents in their 40s or 50s. However, this association does not seem to be explained by age of initiation of drinking, per se. Instead, it seems plausible that frequency or intensity of drinking in late adolescence may have long-term effects on adult substance use patterns. [source] Critical review of the World Health Organization's (WHO) 2007 report on ,evidence of the long-term effects of breastfeeding: systematic reviews and meta-analysis' with respect to obesityOBESITY REVIEWS, Issue 6 2008M. B. Cope Summary Obesity among children and adults has become a highly recognized public health concern and there is an increasing need to discover causes and evaluate preventative measures. One putatively causal influence on obesity is breastfeeding (BF). The World Health Organization (WHO) recently published a report (WR) on ,Evidence of the Long-Term Effects of Breastfeeding: Systematic Reviews and Meta-Analysis' and concluded ,that the evidence suggests that breastfeeding may have a small protective effect[emphasis added] on the prevalence of obesity . . . [and] the effect of breastfeeding was not likely to be due to publication bias or confounding.' Here we provide a critical overview of the WR's section on BF and obesity by addressing eight questions: Q1: Is there sufficient evidence to conclude that BF is associated with lower rates of obesity in children? Q2: Is there sufficient evidence to conclude that BF is associated with lower rates of obesity among breastfed offspring once they reach adulthood? Q3: If there are such associations, what are their magnitudes in comparison with other putatively causal factors and with respect to the potential impact on individual or population levels of obesity? Q4: Is there sufficient evidence to conclude that BF causes a reduction in risk of obesity during childhood? Q5: Is there sufficient evidence to conclude that BF does not cause a reduction in risk of obesity during childhood? Q6: Is there sufficient evidence to conclude that BF causes a long-term reduction in risk of obesity that persists into adulthood? Q7: Is there sufficient evidence to conclude that BF does not cause a long-term reduction in risk of obesity that persists into adulthood? Q8: What further research might be done to address these questions? We conclude that, while BF may have benefits beyond any putative protection against obesity, and benefits of BF most likely outweigh any harms, any statement that a strong, clear or consistent body of evidence shows that BF causally reduces the risk of overweight or obesity is unwarranted at this time. [source] Long-Term Effects of Upgrading to Biventricular Pacing: Differences with Cardiac Resynchronization Therapy as Primary IndicationPACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 7 2010GAETANO PAPARELLA M.D. Background: Few studies have assessed the long-term effects of cardiac resynchronization therapy (CRT) in patients with advanced heart failure (HF) and previously right ventricular apical pacing (RVAP). Aims: To assess the clinical and hemodynamic impact of upgrading to biventricular pacing in patients with severe HF and permanent RVAP in comparison with patients who had CRT implantation as initial therapy. Methods and Results: Thirty-nine patients with RVAP, advanced HF (New York Heart Association [NYHA] III,IV), and severe depression of left ventricular ejection fraction (LVEF) were upgraded to biventricular pacing (group A). Mean duration of RVAP before upgrading was 41.8 ± 13.3 months. Clinical and echocardiographic results were compared to those obtained in a group of 43 patients with left bundle branch block and similar clinical characteristics undergoing "primary" CRT (group B). Mean follow-up was 35 ± 10 months in patients of group A and 38 ± 12 months in group B. NYHA class significantly improved in groups A and B. LVEF increased from 0.23 ± 0.07 to 0.36 ± 0.09 (P < 0.001) and from 0.26 ± 0.02 to 0.34 ± 0.10 (P < 0.001), respectively. Hospitalizations were reduced by 81% and 77% (P < 0.001). Similar improvements in echocardiographic signs of ventricular desynchronization were also observed. Conclusion: Patients upgraded to CRT exhibit long-term clinical and hemodynamic benefits that are similar to those observed in patients treated with CRT as initial strategy. (PACE 2010; 841,849) [source] Short-Term and Long-Term Effects of Soil Ripping, Seeding, and Fertilization on the Restoration of a Tropical RangelandRESTORATION ECOLOGY, Issue 2010David Kinyua Rangeland degradation is a serious problem in semiarid Africa. Extensive areas of bare, compacted, nutrient-poor soils limit the productivity and biodiversity of many areas. We conducted a set of restoration experiments in which all eight combinations of soil tilling, fertilization, and seeding with native perennial grasses were carried out in replicated plots. After 6 months, little aboveground biomass was produced in plots without tilling, regardless of seeding or fertilization. Tilling alone tripled plant biomass, mostly of herbaceous forbs and annual grasses. Perennial grasses were essentially limited to plots that were both tilled and seeded. The addition of fertilizer had no significant additional effects. After 7 years, vegetation had declined, but there were still large differences among treatments. After 10 years, one tilled (and seeded) plot had reverted to bare ground, but the other tilled plots still had substantial vegetation. Only one seeded grass (Cenchrus ciliaris) was still a contributor to total cover after 10 years. We suggest that restoration efforts on these soils be directed first to breaking up the surface crust, and second to the addition of desirable seed. A simple ripping trial inspired by this experiment showed considerable promise as a low-cost restoration technique. [source] Seizures in the Developing Brain Cause Adverse Long-term Effects on Spatial Learning and AnxietyEPILEPSIA, Issue 12 2004Umit Sayin Summary:,Purpose: Seizures in the developing brain cause less macroscopic structural damage than do seizures in adulthood, but accumulating evidence shows that seizures early in life can be associated with persistent behavioral and cognitive impairments. We previously showed that long-term spatial memory in the eight-arm radial-arm maze was impaired in rats that experienced a single episode of kainic acid (KA)-induced status epilepticus during early development (postnatal days (P) 1,14). Here we extend those findings by using a set of behavioral paradigms that are sensitive to additional aspects of learning and behavior. Methods: On P1, P7, P14, or P24, rats underwent status epilepticus induced by intraperitoneal injections of age-specific doses of KA. In adulthood (P90,P100), the behavioral performance of these rats was compared with that of control rats that did not receive KA. A modified version of the radial-arm maze was used to assess short-term spatial memory; the Morris water maze was used to evaluate long-term spatial memory and retrieval; and the elevated plus maze was used to determine anxiety. Results: Compared with controls, rats with KA seizures at each tested age had impaired short-term spatial memory in the radial-arm maze (longer latency to criterion and more reference errors), deficient long-term spatial learning and retrieval in the water maze (longer escape latencies and memory for platform location), and a greater degree of anxiety in the elevated plus maze (greater time spent in open arms). Conclusions: These findings provide additional support for the concept that seizures early in life may be followed by life-long impairment of certain cognitive and behavioral functions. These results may have clinical implications, favoring early and aggressive control of seizures during development. [source] Pentylenetetrazol-induced Recurrent Seizures in Rat Pups: Time Course on Spatial Learning and Long-term EffectsEPILEPSIA, Issue 6 2002Li-Tung Huang Summary: ,Purpose: Recurrent seizures in infants are associated with a high incidence of neurocognitive deficits. Animal models have suggested that the immature brain is less vulnerable to seizure-induced injury than is that in adult animals. We studied the effects of recurrent neonatal seizures on cognitive tasks performed when the animals were in adolescence and adulthood. Methods: Seizures were induced by intraperitoneal injection of pentylenetetrazol (PTZ) for 5 consecutive days, starting from postnatal day 10 (P10). At P35 and P60, rats were tested for spatial memory by using the Morris water maze task. In adulthood, motor performance was examined by the Rotarod test, and activity level was assessed by the open field test. Seizure threshold was examined by inhalant flurothyl. To assess presence or absence of spontaneous seizures, rats were video recorded for 4 h/day for 10 consecutive days for the detection of spontaneous seizures. Finally, brains were examined for histologic evidence of injury with cresyl violet stain and Timm staining in the supragranular zone and CA3 pyramidal cell layers of the hippocampus. Results: PTZ-treated rats showed significant spatial deficits in the Morris water maze at both P35 and P60. There were no differences in seizure threshold, motor balance, or activity level during the open field test. Spontaneous seizures were not recorded in any rat. The cresyl violet stain showed no cell loss in either the control or experimental rats. PTZ-treated rats exhibited more Timm staining in the CA3 subfield. However, the control and experimental rats showed similar Timm staining within the supragranular zone. Conclusions: Our findings indicate that recurrent PTZ-induced seizures result in long-term cognitive deficits and morphologic changes in the developing brain. Furthermore, these cognitive deficits could be detected during pubescence. [source] Long-term Effects of Labor AnalgesiaJOURNAL OF OBSTETRIC, GYNECOLOGIC & NEONATAL NURSING, Issue 3 2000Karin Nyberg CNM No abstract is available for this article. [source] Long-term Effects of the Efficiency Wage Hypothesis in Goodwin-type EconomiesMETROECONOMICA, Issue 4 2000Piero Manfredi The existence of an efficiency wage mechanism in Goodwin-type models may lead to the unexpected appearance of an economically meaningful equilibrium with zero labour share, which is globally stable for some parameter constellation and allows the system to attain its ,maximal growth'. A subsequent ,normative' comparison between the possible long-term regimes of the economy shows that (1) the zero labour share equilibrium can be the ,preferred' equilibrium in terms of welfare; (2) in all the long-term regimes the welfare is higher than in the original Goodwin model; (3) a point of maximal welfare exists. Moreover, the effects of rational behaviour of firms are compared with the ,traditional' situation in which rationality is not explicitly assumed. A striking result appears: myopic rationality can have deleterious effects on the profit of firms and on the overall welfare of the economy. [source] Long-term effects of botulinum toxin A in children with cerebral palsyDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 2 2009KRISTINA TEDROFF MD The long-term effects of botulinum toxin A (BoNT-A) treatment in children with cerebral palsy (CP) are still elusive. We studied a prospective clinical cohort of 94 children with different subtypes (50% spastic diplegic CP, 22% hemiplegic CP, 25% tetraplegic CP, 3% dyskinetic CP), sex (55% male, 45% female), severity according to Gross Motor Function Classification System (29% Level I, 15% Level II, 16% Level III, 17% Level IV, 23% Level V), and age (median 5y 4mo, range 11mo,17y 8mo). The longest follow-up time was 3 years 7 months (median 1y 6mo) and included a maximum of eight injections per muscle (median two injections to a specific muscle). Outcome measurements were muscle tone (Modified Ashworth Scale) and joint range of motion (ROM). Assessments were made at a minimum before and 3 months after each injection. Ninety-five per cent confidence intervals for differences from baseline were used to identify significant changes. BoNT-A injections induced reduction of long-term spasticity in all muscle-groups examined: the gastrocnemius, hamstring, and adductor muscles. The reduction in tone was most distinct in the gastrocnemius muscle, and each repeated injection produced an immediate reduction in muscle tone. However, improvement in ROM was brief and measured only after the first injections, whereupon the ROM declined. Thus, the results suggest that BoNT-A can be effective in reducing muscle tone over a longer period, but not in preventing development of contractures in spastic muscles. The dissociation between the effects on muscle tone and ROM indicates that development of contractures is not coupled to increased muscle tone only, but might be caused by other mechanisms. [source] Long-term effects of leisure time physical activity on risk of insulin resistance and impaired glucose tolerance, allowing for body weight history, in Danish menDIABETIC MEDICINE, Issue 1 2007T. Berentzen Abstract Aims To determine if the level of leisure time physical activity (LTPA) in young adulthood in obese and non-obese men reduces the risk of insulin resistance (IR) and impaired glucose tolerance (IGT) in middle age, and if such an effect is explained by the current level of LTPA, or by the body mass index (BMI) history preceding and subsequent to the assessment of LTPA. Methods Longitudinal study of groups of obese and randomly selected non-obese men identified at around age 19, and re-examined at mean ages of 32, 44 and 51. BMI was measured at all four examinations. LTPA was assessed by self-administrated questionnaires at the last three examinations. IR and the presence of IGT was determined by an oral glucose tolerance test at the last examination. Results LTPA in young adulthood reduced the risk of IR and IGT in middle age throughout the range of BMI. Adjustment for the BMI history preceding and subsequent to the assessment of LTPA attenuated the association with IR and IGT, but active men remained at low risk of IR and IGT. Adjustment for subsequent and current levels of LTPA, smoking habits, alcohol intake, educational level and family history of diabetes had no notable influence on the results. Conclusion LTPA appears to reduce the risk of IR and IGT, an effect which is not explained by the current level of physical activity, and only partially explained by the BMI history preceding and subsequent to the assessment of LTPA. [source] Long-term effects of ungulates on phytophagous insectsECOLOGICAL ENTOMOLOGY, Issue 2 2007JOSÉ M. GÓMEZ Abstract 1.,Most plants interact with a diverse suite of herbivores, allowing the opportunity for the existence of positive and negative interactions between highly dissimilar organisms. However, most studies on herbivorous interactions have been performed under the assumption that they occur mainly between similar species. Consequently, ecologists are still far from a full understanding of the ecological factors that determine insect population dynamics. 2.,In this study, a 7-year field experiment was conducted that manipulated the presence of ungulates to evaluate their effects on the abundance, attack rate, and survival of four guilds of co-occurring herbivorous insects living on the same host plant: seed predators, stem borers, gall makers and sap suckers. These four guilds differed in habits and behaviour, the first three being sessile and endophytic and the last being free-living. 3.,This study shows that the abundance of all four guilds was negatively affected by ungulates. However, the effect on attack rate differed among guilds, as mammals do not affect the seed predator attack rate. Ungulates also differentially affected insect survival, ingesting only seed predators and gall makers. 4.,In summary, this study suggests that diverse mechanisms may affect different insect guilds in different ways. Therefore, competition between disparate herbivores appears to be complex and can be provoked by multiple mechanisms. [source] Effect of habitat fragmentation on spawning migration of brown trout (Salmo trutta L.)ECOLOGY OF FRESHWATER FISH, Issue 3 2006C. Gosset Abstract , Human-induced habitat alteration is one of the main causes of the decline of freshwater fish populations. The watershed of the River Bidasoa (Spain) is an example of heavily fragmented habitat. The local brown trout (Salmo trutta L.) population is disturbed, with evidence of poor recruitment as well as low adult densities in the main stem. Forty male and female adult migratory trout were tagged with external or internal radio transmitters and released. Fixed stations with data loggers and mobile antennae were used with daily surveys to track fish movements during the migration and spawning period (3 months). Migration distances did not exceed 10 km, and half of the fish never entered a tributary in the study area. Fragmentation because of weirs on the main stem apparently prevented fish from reaching their spawning destination. Fish that entered the tributaries were first confronted with an accessibility problem because of low discharge. However, each fish chose one tributary, without making attempts to run up in other tributaries. Once in the tributary, fish were restrained in their upstream movements by dams. The study area appeared to be isolated from the vast upper part of the watershed. Within the study area, upper parts of tributaries also seemed strongly disconnected from the main stem. This study illustrates the negative impact of river fragmentation on S. trutta migration pattern. Population sustainability can be directly affected through the low availability of spawning grounds for migratory fish. Long-term effects of fragmentation may cause reproductive isolation within watersheds, which in the case of trout also means isolated phenotypic population units. [source] Long-term effects of idiotype vaccination on the specific T-cell response in peripheral blood and bone marrow of multiple myeloma patientsEUROPEAN JOURNAL OF HAEMATOLOGY, Issue 5 2007Amir Osman Abdalla Abstract Objectives:, To elucidate long-term effects of idiotype (Id) vaccination on Id-specific T cells of multiple myeloma (MM) patients and compare Id-specific T-cell responses of peripheral blood with those of bone marrow (BM). Materials and methods:, Id-specific T-cell responses of peripheral blood mononuclear cells (PBMC) were compared with those of BM mononuclear cells (BMMC) in 10 MM patients vaccinated with the Id protein at a median time of 41 months since the last immunization. The PBMC responses at late follow-up were also compared with those during active immunization. The responses were assessed by a proliferation assay, enzyme-linked immunospot (ELISPOT) (,-interferon), cytometric bead array (CBA) for secreted cytokines and quantitative real-time polymerase chain reaction (QRT-PCR) for cytokine gene expression. Results:, At the late testing time, an Id-specific response was detected in PBMC of five patients (ELISPOT, CBA, QRT-PCR) and in BMMC of four patients (CBA, QRT-PCR). A response in both compartments was noted only in three patients. The cytokines gene profile was consistent with a predominance of Th2 cells [interleukin (IL)-4, IL-5, IL-10]. Comparison of the Id-specific responses of PBMC during active immunization with those at the late follow-up showed that the frequency and magnitude of the responses had decreased significantly by time (proliferation/ELISPOT) (P < 0.02) and shifted at the gene level from a Th1 to a Th2 profile (P < 0.05). Conclusion:, Id-specific T cells may decline overtime and shift toward a Th2 response and may be found at a similar frequency of patients in blood and BM. [source] Long-term effects of intravenous high dose methylprednisolone pulses on bone mineral density in patients with multiple sclerosisEUROPEAN JOURNAL OF NEUROLOGY, Issue 7 2005M. Zorzon To determine the effects of high dose methylprednisolone (HDMP) pulses on bone mineral density (BMD) in patients with multiple sclerosis (MS), we studied 25 MS patients who received regular pulses of HDMP as well as pulses of HDMP for relapses, 18 MS patients who received HDMP at the same dose schedule only for relapses, and 61 healthy controls. We measured BMDs at lumbar spine and femoral neck and we assessed biochemical markers of bone metabolism and turnover. The average lifetime dosage of MP was 75.4 (SD 11.9) g in the pulsed HDMP group and 28.6 (SD 18.3) g in the HDMP for relapses group (P < 0.0001). Two MS patients (4.7%) and four controls (6.6%) had osteoporosis (P = NS), whereas 25 patients with MS (58.1%) and 21 controls (34.4%) had osteopenia (P = 0.016). BMDs measured at lumbar spine and femoral neck and biochemical indices of bone metabolism did not differ in MS patients and controls. BMD measures were not associated with lifetime methylprednisolone dosage. In partial correlation analysis, controlling for age, gender and menopausal status there was a significant inverse correlation between BMD at femoral neck and Expanded Disability Status Scale (EDSS) score (r = ,0.31, P =0.05). In conclusion, treatment with repeated HDMP pulses was not associated with osteoporosis in patients with MS who participated in a trial of methylprednisolone. However, osteopenia was observed more frequently in MS patients than healthy controls. Our data are reassuring, as them suggest that repeated pulses of methylprednisolone do not result in substantially increased risk of osteoporosis in MS patients. Moreover, osteopenia was found only in patients treated for relapses, who had a significantly higher EDSS score than patients in the HDMP group, suggesting that decreased mobility may contribute to bone loss more than corticosteroid use. BMD should be monitored in patients with MS, regardless of the use of methylprednisolone. [source] Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin's lymphomaEUROPEAN JOURNAL OF ORAL SCIENCES, Issue 1 2004Aynur O The aim of this study was to investigate the late effects of treatment for childhood non-Hodgkin's lymphomas (NHL) on oral health and dental development. Thirty-six long-term survivors that had been treated with chemotherapy of childhood NHL were included in this study and 36 volunteers with similar age and sex distribution served as controls. Both groups underwent a complete orodental examination for decayed, missing and filled teeth and surfaces, gingival and periodontal health according to the Loe,Silness Gingival Index and Sillnes,Loe Plaque Index, enamel defects and discolorations, root malformations, eruption status, agenesis, premature apexifications and microdontia. The severity of these disturbances related to age at the time of NHL diagnosis were also evaluated by creating two groups as <,5 yr and >,5 yr. Although none of the parameters altered with age, patients had significantly higher plaque index, more enamel discolorations and root malformations than did the controls. The results show that long-term survivors of NHL patients exhibit some orodental disturbances that may be attributed to the chemotherapy regimens. [source] Long-term effects of crop rotation and fertilization on soil organic matter compositionEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 6 2007M. Kaiser Summary Long-term effects of crop rotation and fertilization are mostly observed with respect to the amount of soil organic matter (SOM) and measured in terms of soil organic carbon (SOC). In this paper, we analyze the SOM composition of samples from long-term agricultural field experiments at sandy and clayey sites that include complex crop rotations and farm-yard manure applications. The organic matter (OM) composition of the soil samples, OM(Soil), and that of sequentially extracted water, OM(W), and sodium pyrophosphate, OM(PY), soluble fractions was analyzed using Fourier Transform Infrared Spectroscopy (FTIR). The fraction OM(PY) represented between 13 and 34% of SOC, about 10 times that of OM(W). Site specific differences in OM(Soil) composition were larger than those between crop rotations and fertilizer applications. The smaller C=O group content in FTIR spectra of OM(W) compared with OM(PY) suggests that analysis of the more stable OM(PY) fraction is preferable over OM(W) or OM(Soil) for identifying long-term effects, the OM(Soil) and OM(W) fractions and the content of CH groups being less indicative. Farm-yard manure application leads to a more similar content of C=O groups in OM(PY) between crop rotations and fertilizer plots at both sites. Short-term effects from soil tillage or potato harvesting on composition of OM require further studies. [source] Reproductive function in male rats after brief in utero exposure to diethylstilboestrolINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 6 2000G. H. G. Behrens Long-term effects of brief in utero exposure to diethylstilboestrol (DES) during a foetal period known to be critical for gonadal development were evaluated. Rats were exposed to DES (100 ,g/kg body-weight) from day 17 to 19 of pregnancy. All of the DES-treated pregnant rats (11/11) ate parts or whole of their offspring during the first day after birth (p=0.03). Surviving male offspring were examined on day 63 post-partum. DES induced a reduction in weight of the testis (p=0.06) and ventral prostate (p=0.07), even after this short exposure. DES tended to reduce the number of Sertoli cells (p=0.13). Our findings indicate that even a short in utero exposure of rats to DES during a critical period for gonadal development results in cannibalism and reduced testis and ventral prostate weight. [source] Sensitivity of Crops to Increased Ultraviolet Radiation in Northern Growing ConditionsJOURNAL OF AGRONOMY AND CROP SCIENCE, Issue 1 2002K. Hakala Crops growing at high latitudes are adapted to low intensities of solar ultraviolet B radiation (UV-B). As a result of destruction of stratospheric ozone layer especially at the Polar Regions of the globe, the intensity of UV-B is projected to increase at high latitudes. In order to find out the consequences of increased UV-B on crops, the sensitivity of different varieties of barley, wheat, oats, clover, timothy, meadow fescue, tall fescue and potato was tested in Jokioinen, Finland. The experiment was conducted in the field, under natural light, with a continuous 30 % increase in UV-B. Both increased UV-B and the control with slightly increased UV-A radiation affected the number of lateral shoots in cereals, and the specific leaf area and the content of phenolic substances in grasses. The effects varied according to plant variety and time of growing season. However, no visible damage, nor changes in biomass and yield production were found in any of the crops. Long-term effects on, e.g. genetic stability and germination of crop seed remain to be studied. Empfindlichkeit von Kulturpflanzenbeständen gegenüber einer Erhöhung der ultravioletten Einstrahlung unter nördlichen Wachstumsbedingungen Kulturpflanzenbestände, die unter hohen Breitengraden wachsen, sind an geringe Intensitäten der solaren ultravioletten B Einstrahlung (UV-B) angepasst. Aufgrund der Destruktion der Stratosphäre, insbesondere der Ozonschicht, im Bereich der polaren Gebiete der Erde, ist eine zunehmende Intensität der UV-B Strahlung in hohen Breitengraden festzustellen. Um die Konsequenzen einer Erhöhung von UV-B auf Kulturpflanzenbestände zu bestimmen, wurde die Empfindlichkeit unterschiedlicher Arten wie Gerste, Weizen, Hafer, Klee, Wiesenlieschgras, Wiesenschwingel, Rohrschwingel und Kartoffel in Jokioinen, Finnland, untersucht. Das Experiment wurde im Felde durchgeführt unter natürlichen Lichtbedingungen mit einer kontinuierlichen Zunahme von 30 % für UV-B. Sowohl eine Erhöhung der UV-B als auch die Kontrolle mit leicht erhöhten UV-B Strahlungen beeinflussten die Anzahl der Nebenwurzeln bei den Getreidepflanzen und die spezifische Blattfläche sowie den Gehalt an phenolischen Substanzen bei den Gräsern. Die Wirkungen variierten entsprechend der Pflanzenvarietät und der Anbauzeit. Allerdings wurden keine erkennbare Schädigungen noch Änderungen in der Biomasse und in der Ertragsproduktion bei einer der untersuchten Pflanzenbestände gefunden. Langzeitwirkungen auf die genetische bedingte Stabilität und Keimung der Kulturpflanzen sollte weiterhin untersucht werden. [source] Lake restoration: successes, failures and long-term effectsJOURNAL OF APPLIED ECOLOGY, Issue 6 2007MARTIN SØNDERGAARD Summary 1Eutrophication constitutes a serious threat to many European lakes and many approaches have been used during the past 20,30 years to improve lake water quality. Results from the various lake restoration initiatives are diverse and the long-term effects are not well described. 2In this study we evaluated data from more than 70 restoration projects conducted mainly in shallow, eutrophic lakes in Denmark and the Netherlands. Special focus was given to the removal of zooplanktivorous and benthivorous fish, by far the most common internal lake measure. 3In more than half of the biomanipulation projects, Secchi depth increased and chlorophyll a decreased to less than 50% within the first few years. In some of the shallow lakes, total phosphorus and total nitrogen levels decreased considerably, indicating an increased retention or loss by denitrification. The strongest effects seemed to be obtained 4,6 years after the start of fish removal. 4The long-term effect of restoration initiatives can only be described for a few lakes, but data from biomanipulated lakes indicate a return to a turbid state within 10 years or less in most cases. One of reasons for the lack of long-term effects may be internal phosphorus loading from a mobile pool accumulated in the sediment. 5Synthesis and applications. Lake restoration, and in particular fish removal in shallow eutrophic lakes, has been widely used in Denmark and the Netherlands, where it has had marked effects on lake water quality in many lakes. Long-term effects (> 8,10 years) are less obvious and a return to turbid conditions is often seen unless fish removal is repeated. Insufficient external loading reduction, internal phosphorus loading and absence of stable submerged macrophyte communities to stabilize the clear-water state are the most probable causes for this relapse to earlier conditions. [source] Bone Material Properties in Trabecular Bone From Human Iliac Crest Biopsies After 3- and 5-Year Treatment With Risedronate,,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 10 2006Erich Durchschlag Abstract Long-term effects of risedronate on bone mineral maturity/crystallinity and collagen cross-link ratio in triple iliac crest biopsies of osteoporotic women were evaluated. In this double-blinded study, 3- and 5-year treatment with risedronate arrested the tissue aging encountered in untreated osteoporosis and in osteoporosis treated with other antiresorptives. This effect may be contributing to risedronate's antifracture efficacy. Introduction: Risedronate is widely used in the treatment of osteoporosis. It reduces bone turnover, increases BMD, and decreases fracture risk. To date, there are no data available on the long-term effects of risedronate on bone material properties in humans. Materials and Methods: Osteoporotic women enrolled in the VERT-NA trial received either risedronate (5 mg/day, orally) or placebo for up to 5 years. All subjects received calcium. They also received vitamin D supplementation if deficient at baseline. Triple iliac crest biopsies were collected from a subset of these subjects at baseline, 3 years, and 5 years. Mineral maturity/crystallinity and collagen cross-link ratio was measured in these biopsies using Fourier transform infrared imaging. Results: Patients that received placebo exhibited increased mineral maturity/crystallinity and collagen cross-link ratio after 3 and 5 years compared with baseline values. On the contrary, patients that received risedronate retained baseline values in both bone material indices throughout. A more spatially detailed analysis revealed that this was achieved mainly through beneficial effects on active bone-forming areas. Surprisingly, patients that received risedronate achieved premenopausal values at bone-forming areas in both indices after 5 years of treatment. Conclusion: Long-term treatment with risedronate affects bone material properties (mineral maturity/crystallinity and collagen cross-link ratio) and arrests the tissue aging apparent in untreated osteoporosis. These changes at the material level of the bone matrix may contribute to risedronate's rapid and sustained antifracture efficacy in osteoporotic patients. [source] Long-Term Dosing of Arzoxifene Lowers Cholesterol, Reduces Bone Turnover, and Preserves Bone Quality in Ovariectomized Rats,,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 12 2002Yanfei L. Ma M.D. Abstract Long-term effects of a new selective estrogen receptor modulator (SERM) arzoxifene were examined in ovariectomized (OVX) rats. Arzoxifene was administered postoperatively (po) at 0.1 mg/kg per day or 0.5 mg/kg per day to 4-month-old rats, starting 1 week after OVX for 12 months. At study termination, body weights for arzoxifene groups were 16,17% lower than OVX control, which was caused by mainly reduced gain of fat mass. Longitudinal analysis of the proximal tibial metaphysis (PTM) by computed tomography (CT) at 0, 2, 4, 6, 9, and 12 months showed that OVX induced a 22% reduction in bone mineral density (BMD) at 2 months, which narrowed to a 12% difference between sham-operated (sham) and OVX rats by 12 months. Both doses of arzoxifene prevented the OVX-induced decline in BMD. Histomorphometry of the PTM showed that arzoxifene prevented bone loss by reducing osteoclast number in OVX rats. Arzoxifene maintained bone formation indices at sham levels and preserved trabecular number above OVX controls. Micro-CT analysis of lumbar vertebrae showed similar preservation of BMD compared with OVX, which were not different from sham. Compression testing of the vertebra and three-point bending testing of femoral shaft showed that strength and toughness were higher for arzoxifene-treated animals compared with OVX animals. Arzoxifene reduced serum cholesterol by 44,59% compared with OVX. Uteri wet weight from arzoxifene animals was 38,40% of sham compared with OVX rats, which were 29% of sham. Histology of the uterine endometrium showed that cell heights from both doses of arzoxifene were not significantly different from OVX controls. In summary, treatment of OVX rats with arzoxifene for nearly one-half of a lifetime maintained beneficial effects on cholesterol and the skeleton. These data suggest that arzoxifene may be a useful therapeutic agent for osteoporosis in postmenopausal women. [source] Long-term effects of prescribed early fire, grazing and selective tree cutting on seedling populations in the Sudanian savanna of Burkina FasoAFRICAN JOURNAL OF ECOLOGY, Issue 1 2009Didier Zida Abstract Annual early fire, selective tree cutting and exclusion of grazing are currently used as management tools in the Sudanian savanna of Burkina Faso although their long-term effects on seedling recruitment are poorly documented. A factorial experiment involving fire, grazing and cutting, each with two levels, was established in 1992 to study the effects of these management regimes and their interactions on the regeneration of woody species, and examine whether their effects varied temporally. Species richness, density and the morphology of seedlings were assessed in 1997 and 2002, and their relative changes were determined. The change in species richness of multi-stemmed individuals was significantly higher (P = 0.018) on plots that received fire × cutting treatment than the control plots. Significantly more species with single-stem were found on unburnt than on burnt plots (P < 0.001). Grazing tended to reduce the change in total density while fire (P < 0.001) and grazing (P = 0.029) significantly reduced the change in density of single-stemmed individuals. Selective cutting did not affect the total seedling density, but tended to reduce the change in single-stemmed seedling density. Principal component analysis revealed species-specific responses to treatments, particularly the relatively high abundance of lianas compared with other species. Résumé Les feux annuels précoces, la coupe sélective d'arbres et l'exclusion du pâturage sont des moyens actuellement utilisés dans la gestion de la savane soudanienne du Burkina Faso, mais leurs effets à long terme sur le recrutement de jeunes plants sont encore mal documentés. Une expérience factorielle impliquant le feu, le pâturage et la coupe, chacun à deux niveaux, a été mis en place en 1992 pour étudier les effets de ces régimes de gestion et leurs interactions sur la régénération d'espèces ligneuses et pour voir si ces effets variaient de façon temporelle. La richesse spécifique, la densité et la morphologie des jeunes plants furent évaluées en 1997 et en 2002, et l'on a leurs changements relatifs déterminés. Le changement de la richesse spécifique des individus multicoles était significativement plus important (P = 0.018) dans les parcelles qui avaient subi le traitement feu × coupe que dans les parcelles témoins. On a trouvé significativement plus d'espèces à tige unique dans les parcelles non brûlées que dans les parcelles brûlées (P < 0.001). Le pâturage avait tendance à réduire le changement de densité totale alors que le feu (P < 0.001) et le pâturage (P = 0.029) réduisaient significativement le changement de densité des individus à tige unique. La coupe sélective n'affectait pas la densité totale des jeunes plants mais avait tendance à réduire le changement de la densité des plants à tige unique. L'analyse en composantes principales a révélé que les réponses aux différents traitements étaient spécifiques aux espèces, particulièrement l'abondance de lianes, relativement grande par rapport aux autres espèces. [source] Long-term effects of computer training of phonological awareness in kindergartenJOURNAL OF COMPUTER ASSISTED LEARNING, Issue 1 2005Eliane Segers Abstract The present study examined the long-term effects of a computer intervention for the development of phonological awareness in Dutch kindergartners. Native Dutch and immigrant children worked with the software 15 min/week during one school year. Following a pretest , interim test , post-test , retention test design, the effects on rhyming, phonemic segmentation, auditory blending, and grapheme knowledge were assessed. The intervention showed significant immediate effects on rhyming and grapheme knowledge. The time spent on the computer games also correlated with the learning gains for the experimental group. In the first grade, retention effects were demonstrated after 4 months of formal reading education. [source] Long-term effects of calorie restriction on serum sex-hormone concentrations in menAGING CELL, Issue 2 2010Roberto Cangemi Summary Calorie restriction (CR) slows aging and consistently reduces circulating sex hormones in laboratory animals. However, nothing is known regarding the long-term effects of CR with adequate nutrition on serum sex-hormone concentration in lean healthy humans. In this study, we measured body composition, and serum total testosterone, total 17-,-estradiol, sex hormone,binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEA-S) concentrations in 24 men (mean age 51.5 ± 13 years), who had been practicing CR with adequate nutrition for an average of 7.4 ± 4.5 years, in 24 age- and body fat,matched endurance runners (EX), and 24 age-matched sedentary controls eating Western diets (WD). We found that both the CR and EX volunteers had significantly lower body fat than the WD volunteers (total body fat, 8.7 ± 4.2%; 10.5 ± 4.4%; 23.2 ± 6.1%, respectively; P = 0.0001). Serum total testosterone and the free androgen index were significantly lower, and SHBG was higher in the CR group than in the EX and WD groups (P , 0.001). Serum 17,-estradiol and the estradiol:SHBG ratio were both significantly lower in the CR and EX groups than in the WD group (P , 0.005). Serum DHEA-S concentrations were not different between the three groups. These findings demonstrate that, as in long-lived CR rodents, long-term severe CR reduces serum total and free testosterone and increases SHBG concentrations in humans, independently of adiposity. More studies are needed to understand the role of this CR-mediated reduction in sex hormones in modulating the pathogenesis of age-associated chronic diseases such as cancer and the aging process itself. 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