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Apolipoprotein E Polymorphism (apolipoprotein + e_polymorphism)

Distribution by Scientific Domains
Medical Sciences80%

Selected Abstracts

Survival in Finnish Centenarians in Relation to Apolipoprotein E Polymorphism

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 7 2001
J. Louhija MD
No abstract is available for this article. [source]

Apolipoprotein E Polymorphism and the Characteristics of Diseased Vessels in Male Chinese Patients With Angiographic Coronary Artery Disease: A Case-Case Study

CLINICAL CARDIOLOGY, Issue 6 2010
Shao-Sheng Li MD
Background Variations in the apolipoprotein E (apo E) gene may predict the incidence of coronary artery disease (CAD). However, the correlation between apo E polymorphism and the severity of CAD is still unclear. Hypothesis Apolipoprotein E polymorphism can predict CAD. Methods Used a case-case study of 213 Chinese angiographically-defined CAD patients who were screened for apo E genotypes. The characteristics of their diseased vessels were recorded. Results Apolipoprotein E4 carriers had > 75% stenosis, more wide-ranging and longer vessel disease, a greater number of diseased vessels, and a higher Gensini score than apo E2 carriers or individuals with the apo E3/3 genotype. Apolipoprotein E2 carriers had ,75% stenosis and a shorter length of vessel disease than individuals with the apo E3/3 genotype or apo E4 carriers. The severity of stenosis, length of vessel disease, and number of diseased vessels were affected by the interaction between genotype and body mass index, family history of CAD, total plasma cholesterol level, smoking history, and hypertension history. Conclusion The apo E4 allele may serve as an independent genetic marker predicting severity of CAD. Other CAD risk factors may accelerate the process of pathogenesis. The apo E2 allele may play a protective role. Copyright © 2010 Wiley Periodicals, Inc. [source]

Apolipoprotein E polymorphism interacts with cigarette smoking in progression of multiple sclerosis

EUROPEAN JOURNAL OF NEUROLOGY, Issue 7 2009
A. Sena
Background and purpose:, The influence of apolipoprotein E (ApoE) polymorphism on clinical severity of multiple sclerosis (MS) is still controversial. Cigarette smoking has been suggested to influence the progression of disability in these patients. In this study, we aimed to investigate whether an interaction of smoking with the ApoE polymorphism influences the progression of disability in MS patients. Methods:, Smoking history from 205 female patients with MS was obtained. Clinical data collected include age at onset, disease duration, annual relapse rate, the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score (MSSS). ApoE polymorphism was examined in all patients and stratified according to smoking status and associations with the clinical data investigated. Results:, There were no significant associations between cigarette smoking and any of the clinical characteristics in the whole group of patients. In women carrying the ApoE E4 isoform, smokers had a lower EDSS (P = 0.033) and MSSS (P = 0.023) in comparison with non-smokers. Conclusion:, Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability. These findings need to be confirmed by future large longitudinal studies. [source]

Apolipoprotein E polymorphism and neuronal plasticity

AMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 4 2006
Enric Bufill
No abstract is available for this article. [source]

Apolipoprotein E Polymorphism and the Characteristics of Diseased Vessels in Male Chinese Patients With Angiographic Coronary Artery Disease: A Case-Case Study

CLINICAL CARDIOLOGY, Issue 6 2010
Shao-Sheng Li MD
Background Variations in the apolipoprotein E (apo E) gene may predict the incidence of coronary artery disease (CAD). However, the correlation between apo E polymorphism and the severity of CAD is still unclear. Hypothesis Apolipoprotein E polymorphism can predict CAD. Methods Used a case-case study of 213 Chinese angiographically-defined CAD patients who were screened for apo E genotypes. The characteristics of their diseased vessels were recorded. Results Apolipoprotein E4 carriers had > 75% stenosis, more wide-ranging and longer vessel disease, a greater number of diseased vessels, and a higher Gensini score than apo E2 carriers or individuals with the apo E3/3 genotype. Apolipoprotein E2 carriers had ,75% stenosis and a shorter length of vessel disease than individuals with the apo E3/3 genotype or apo E4 carriers. The severity of stenosis, length of vessel disease, and number of diseased vessels were affected by the interaction between genotype and body mass index, family history of CAD, total plasma cholesterol level, smoking history, and hypertension history. Conclusion The apo E4 allele may serve as an independent genetic marker predicting severity of CAD. Other CAD risk factors may accelerate the process of pathogenesis. The apo E2 allele may play a protective role. Copyright © 2010 Wiley Periodicals, Inc. [source]