Link

Distribution by Scientific Domains

Kinds of Link

  • article link
  • causal link
  • clear link
  • close link
  • closer link
  • common link
  • communication link
  • critical link
  • crucial link
  • direct link
  • economic link
  • empirical link
  • evolutionary link
  • first link
  • functional link
  • fundamental link
  • genetic link
  • global link
  • historical link
  • important link
  • indirect link
  • key link
  • mechanistic link
  • miss link
  • molecular link
  • negative link
  • network link
  • new link
  • novel link
  • pathophysiologic link
  • physiological link
  • positive link
  • possible link
  • potential link
  • satellite link
  • significant link
  • social link
  • specific link
  • strong link
  • stronger link
  • structural link
  • theoretical link
  • tight link
  • trophic link
  • weak link
  • wireless link

  • Terms modified by Link

  • link failure
  • link function
  • link layer
  • link protein
  • link resource

  • Selected Abstracts


    MEMORY ORGANIZATION AS THE MISSING LINK BETWEEN CASE-BASED REASONING AND INFORMATION RETRIEVAL IN BIOMEDICINE

    COMPUTATIONAL INTELLIGENCE, Issue 3-4 2006
    Isabelle Bichindaritz
    Mémoire proposes a general framework for reasoning from cases in biology and medicine. Part of this project is to propose a memory organization capable of handling large cases and case bases as occur in biomedical domains. This article presents the essential principles for an efficient memory organization based on pertinent work in information retrieval (IR). IR systems have been able to scale up to terabytes of data taking advantage of large databases research to build Internet search engines. They search for pertinent documents to answer a query using term-based ranking and/or global ranking schemes. Similarly, case-based reasoning (CBR) systems search for pertinent cases using a scoring function for ranking the cases. Mémoire proposes a memory organization based on inverted indexes which may be powered by databases to search and rank efficiently through large case bases. It can be seen as a first step toward large-scale CBR systems, and in addition provides a framework for tight cooperation between CBR and IR. [source]


    THE TIMING AND MECHANISMS OF THE OFFENDING-DEPRESSION LINK,

    CRIMINOLOGY, Issue 3 2007
    SONJA E. SIENNICK
    Why is juvenile delinquency associated with depression in young adulthood? One possibility is that delinquency interferes with socioeco-nomic attainment and disrupts entry into adult roles, perhaps because of official labeling processes or adolescent socialization into deviance, and these repercussions of delinquency lead to depression. Another possibility is that grown delinquents may show high levels of depression because they tend to offend in adulthood, and adult offenders tend to be depressed. I use data from the National Longitudinal Study of Adolescent Health to examine the timing and mechanisms of the offending-depression relationship. The results suggest that delinquency is negatively associated with later status attainment and that the status attainment deficits of grown delinquents are not fully explained by justice system contacts or by adolescent delinquent peer influence. A portion of the longitudinal delinquency-depression link is explained by the low levels of education of grown delinquents and by their involvement with the justice system. Still, young adult depression is more closely tied to recent offending than it is to juvenile delinquency, official labeling, or the status attainment consequences of delinquency. [source]


    THE MISSING LINK IN GENERAL DETERRENCE RESEARCH,

    CRIMINOLOGY, Issue 3 2005
    GARY KLECK
    Research on the deterrent effects of punishment falls into two categories: macro-level studies of the impact of aggregate punishment levels on crime rates, and individual-level studies of the impact of perceived punishment levels on self-reported criminal behavior. For policy purposes, however, the missing link,ignored in previous research,is that between aggregate punishment levels and individual perceptions of punishment. This paper addresses whether higher actual punishment levels increase the perceived certainty, severity, or swiftness of punishment. Telephone interviews with 1,500 residents of fifty-four large urban counties were used to measure perceptions of punishment levels, which were then linked to actual punishment levels as measured in official statistics. Hierarchical linear model estimates of multivariate models generally found no detectable impact of actual punishment levels on perceptions of punishment. The findings raise serious questions about deterrence-based rationales for more punitive crime control policies. [source]


    A CROSS-CULTURAL EXAMINATION OF THE LINK BETWEEN CORPORAL PUNISHMENT AND ADOLESCENT ANTISOCIAL BEHAVIOR,

    CRIMINOLOGY, Issue 1 2000
    RONALD L. SIMONS
    Several studies with older children have reported a positive relationship between parental use of corporal punishment and child conduct problems. This has lead some social scientists to conclude that physical discipline fosters antisocial behavior. In an attempt to avoid the methodological difficulties that have plagued past research on this issue, the present study used a proportional measure of corporal punishment, controlled for earlier behavior problems and other dimensions of parenting, and tested for interaction and curvilinear effects. The analyses were performed using a sample of Iowa families that displayed moderate use of corporal punishment and a Taiwanese sample that demonstrated more frequent and severe use of physical discipline, especially by fathers. For both samples, level of parental warmth/control (i.e., support, monitoring, and inductive reasoning) was the strongest predictor of adolescent conduct problems. There was little evidence of a relationship between corporal punishment and conduct problems for the Iowa sample. For the Taiwanese families, corporal punishment was unrelated to conduct problems when mothers were high on warmth/control, but positively associated with conduct problems when they were low on warmtwcontrol, An interaction between corporal punishment and warmth/Wcontro1 was found for Taiwanese fathers as well. For these fathers, there was also evidence of a curvilinear relationship, with the association between corporal punishment and conduct problems becoming much stronger at extreme levels of corporal punishment. Overall, the results are consistent with the hypothesis that it is when parents engage in severe forms of corporal punishment, or administer physical discipline in the absence of parental warmth and involvement, that children feel angry and unjustly treated, defy parental authority, and engage in antisocial behavior. [source]


    CLIMATE AND DISEASE , NOT MUCH OF A LINK ANYMORE

    ECONOMIC AFFAIRS, Issue 3 2010
    Roger Bate
    No abstract is available for this article. [source]


    DO THE 10 UK SUICIDES AMONG THOSE TAKING THE SMOKING CESSATION DRUG VARENICLINE SUGGEST A CAUSAL LINK?

    ADDICTION, Issue 5 2009
    JOHN STAPLETON
    No abstract is available for this article. [source]


    DIET, CHOLESTEROL METABOLISM, AND ALZHEIMER'S DISEASE: APOLIPOPROTEIN E AS A POSSIBLE LINK?

    JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2006
    Francesco Panza MD
    No abstract is available for this article. [source]


    LINK BETWEEN DOMESTIC R&D AND INFLOW OF FDI: A GAME-THEORETIC ANALYSIS

    PACIFIC ECONOMIC REVIEW, Issue 2 2008
    Hamid Beladi
    Further, the existing theoretical explanations of such empirical results appear to be inadequate. This study presents an alternative game-theoretic explanation for the observed correlations. The results show that the seemingly contradictory observed mixed correlations can be explained in an encompassing model in terms of the multinationals' competitive and interactive assessment of the efficiency and expenditure consequences that domestic R&D could generate for the undertaking domestic competitors. [source]


    PILL-STROKE LINK: CASE NOT CLOSED

    PERSPECTIVES ON SEXUAL AND REPRODUCTIVE HEALTH, Issue 3 2004
    Dore Hollander
    No abstract is available for this article. [source]


    PLENARY SESSION: ,THE LINK AND THE OTHER'

    THE INTERNATIONAL JOURNAL OF PSYCHOANALYSIS, Issue 3 2002
    Jane Milton
    No abstract is available for this article. [source]


    A FAMILY WITH AUTOSOMAL DOMINANT MUTILATING NEUROPATHY NOT LINKED TO EITHER 3q13-q22 OR 9q22 LOCI

    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Issue 1 2000
    E. Bellone
    The clinical separation of CMT2 from HSAN I may be difficult in some kindreds in which the sensory and motor symptoms and deficits are approximately alike. The genetic studies of CMT2 families are also controversial: one form of CMT2 was shown to map on chromosome 3q13-q22 and named CMT2B; the HSAN I locus was mapped to 9q22.1. We describe a family with an autosomal dominant inheritance in which at least three members, belonging to three generations, developed a progressive neuropathy that combined limb weakness, wasting, and severe distal sensory loss leading to prominent mutilating changes. The onset was in late childhood, with progressive weakness in the lower limbs and later in the hands, resulting in a severe paralysis in the feet in one patient. Sensory disturbances were pronounced in 2 patients, and led to poorly healing ulcerations with osteomyelitis and amputations in one foot and mutilating lesions of both hands. Electrophysiological investigation revealed an axonopaty with consistent motor damage. Sural nerve biopsy showed a reduction in the density of both myelinated and unmyelinated fibers, with regenerating clusters. Linkage analysis using 5 microsatellite markers within to the critical 9q22 region was performed. Lod scores of this family calculated by LINKAGE package excluded association to this locus. We also performed linkage studies with chr. 3q13-q22 markers associated to the CMT2b locus. Lod scores excluded this locus as well as responsiblity of the familial phenotype. The severity of motor involvement would suggest classifying the disorder of this family as a form of HSMN II rather than HSAN, indicating that a new locus is involved in the pathogenesis of this disorder. [source]


    THEORETICAL LINKS BETWEEN KANT AND CONFUCIANISM: PRELIMINARY REMARKS

    JOURNAL OF CHINESE PHILOSOPHY, Issue 1 2006
    Article first published online: 21 FEB 200, CHUNG-YING CHENG
    [source]


    Craniorachischisis and Heterotaxia with Heart Disease in Twins: Link or Change Nature?

    CONGENITAL HEART DISEASE, Issue 5 2010
    Sebastiano Bianca MD
    ABSTRACT Craniorachischisis is a rare neural tube defect in which both acrania and a complete schisis of the vertebral column are present. Heterotaxy results from failure to establish normal left,right asymmetry during embryonic development and is characterized by a variable group of congenital anomalies that include complex cardiac malformations and situs inversus or situs ambiguous. We report a diamniotic twin pregnancy with two malformed fetuses affected one by craniorachischisis and the other by heterotaxya with paired right-sided viscera, asplenia, and complex congenital heart disease. The occurrence of severe congenital anomalies in both members of the twin pair implies a strong influence of genetic factors. At present, the genetic basis determining the different phenotypes observed in our twins is unknown. Our case with the simultaneous presence of both midline and laterality defects in twins supports the hypothesis that the midline plays a critical role in establishing left,right asymmetry in the body and that a mutation in a gene responsible for both heterotaxy and midline defects may be strongly supposed. [source]


    Exploring the Link between Dominant Logic and Company Performance

    CREATIVITY AND INNOVATION MANAGEMENT, Issue 2 2000
    Georg Von Krogh
    To revitalize the discussion on dominant logic our paper aims to establish the forgotten link between dominant logic and firm performance. To do so, the concept is enhanced conceptually and operationalized by developing a framework including firms' conceptualization of the business (external environment) and of themselves (internal environment) and performance. The framework is applied to a longitudinal study of two consumer electronics firms. The empirical evidence shows that differences in dominant logic lead to different strategic reactions to developments in the industry, and thus result in performance differences. [source]


    Grazing and community structure as determinants of invasion success by Scotch broom in a New Zealand montane shrubland

    DIVERSITY AND DISTRIBUTIONS, Issue 1 2003
    P. J. Bellingham
    Abstract. Scotch broom (Cytisus scoparius (L.) Link; Fabaceae) is a problematic invasive plant in many countries, and while attention has been paid to traits that make it a successful invader, there has been less focus on the properties of ecosystems that it invades. We conducted an experiment in a New Zealand montane shrubland with tussock grasses that has been invaded by Scotch broom to determine features that rendered it susceptible to invasion. We planted broom seedlings into the shrubland (control) and into three treatments: (1) resident shrubs removed, (2) tussocks removed and (3) shrubs and tussocks removed. We measured broom seedling mortality and growth over two growing seasons. The site was grazed by sheep in the first season, and scarcely grazed in the second, wetter season. Survivorship across all treatments after 19 months was 42%, and was lowest where shrubs were retained but tussocks removed. Broom seedlings grew taller and had greater leaf areas in treatments that retained shrubs. Neighbouring (within 49 cm) shrubs had no effects on survivorship or growth of broom seedlings. Neighbouring tussocks increased survivorship of broom seedlings but depressed their growth. Grazing by sheep was the most important determinant of survivorship and growth of broom seedlings, and effects were uniform regardless of experimental treatments. Initial high mortality of seedlings (48% in the first 3 months) was due to grazing, and height growth was often negative during periods of grazing. In the second growing season when the site was less grazed and there was greater rainfall, there was a rapid increase in height across all treatments. Continued grazing of the site by sheep is likely to be the chief means of retarding the invasion. [source]


    Population Growth and the Environment in Africa: Local Informal Institutions, the Missing Link,

    ECONOMIC GEOGRAPHY, Issue 2 2002
    Valentina Mazzucato
    Abstract: Population and environment debates regarding Africa, whether Malthusian or Boserupian in nature, focus on population levels as the driving force behind the relationship between environment and society. This article argues, instead, that how people adjust to their rise in numbers is more important than are population levels. It focuses on the role of local informal institutions, such as land tenure systems, but also on customs, norms, and networks, and their change over time in mediating the relationship between people and the environment. The article is based on fieldwork conducted between 1995 and 1998 in the Sahelian and Sudano-Sahelian zones of Africa, as well as on a review of colonial documents pertaining to the area written in the first half of the twentieth century. The article concludes that adaptations made to local, informal institutions within the past century have enabled an environmentally sustainable land use within the context of a rising population and growing scarcity of natural resources. [source]


    Copper toxicity thresholds for important restoration grass species of the western United States,

    ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 12 2002
    Mark W.
    Abstract Copper toxicity thresholds for plant species that are used in restoration activities in western North America have not been established. As a result, ecological risk assessments must rely on toxicity thresholds established for agronomic species, which usually differ from those of species used in restoration. Thus, risk assessors have the potential for classifying sites as phytotoxic to perennial, nonagronomic species and calling for intensive remediation activities that may not be necessary. The objective of this study was to provide a better estimate of Cu toxicity thresholds for five grass species that are commonly used in restoration efforts in the western United States. We used a greenhouse screening study where seedlings of introduced redtop (Agrostis gigantea Roth.), the native species slender wheatgrass (Elymus trachycaulus [Link] Gould ex Shinners var. Pryor), tufted hairgrass (Deschampsia caespitosa [L.] Beauvois), big bluegrass (Poa secunda J. Presl var. Sherman), and basin wildrye (Leymus cinereus [Scribner&Merrill] A. Löve var. Magnar) and the agricultural species common wheat (Triticum aestivum L.) were grown in sand culture and exposed to supplemental concentrations of soluble Cu of 0 (control), 50, 100, 150, 200, 250, and 300 mg/L. We determined six measures of toxicity: the 60-d mean lethal concentration (LC50), 60-d mean effective concentration (EC50)-plant, 60-d EC50-shoot, 60-d EC50-root, phytotoxicity threshold (PT50)-shoot, and the PT50-root. Results suggest that these restoration grass species generally have higher Cu tolerance than agronomic species reported in the past. Of the species tested, redtop appeared to be especially tolerant of high levels of substrate and tissue Cu. Values of EC50-plant for restoration grasses were between 283 and 710 mg Cu/L compared to 120 mg Cu/L for common wheat. Measured PT50-shoot values were between 737 and 10,792 mg Cu/ L. These reported thresholds should be more useful for risk assessors than those currently used, which are based largely on agronomic crops. [source]


    The Missing Link in Cognition.

    EUROPEAN JOURNAL OF NEUROLOGY, Issue 7 2009
    Origins of self-reflective consciousness
    No abstract is available for this article. [source]


    Advances in Multiple Sclerosis Clinical Research and Therapy edited by Sten Fredrikson and Hans Link.

    EUROPEAN JOURNAL OF NEUROLOGY, Issue 3 2000
    Published in Assciation with the European Committee for Treatment, Research in Multiple Sclerosis.
    No abstract is available for this article. [source]


    2,3-Di- n -undecylanthracene and 2,3-Di- n -decyloxyanthracene (DDOA) , on the Connecting Link between the Aromatic Substrate and the Aliphatic Chain in Self-Assembling Systems

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 12 2009
    Henning Hopf
    Abstract In contrast to its bis(oxa) analog 1 (DDOA), the hydrocarbon 11 was not found to form organogels with linear alcohols, alkanes, toluene, acetonitrile and other solvents. Whereas the photoreactivity of 1 did not follow the usual behaviour of anthracene derivatives, compound 11, irradiated in cyclohexane, produced the two expected [4+4]cycloadducts 12 and 13 (anti and syn photodimers, respectively). These facts point to the role of the connecting link between the rigid core and the flexible chain for some self-assembled systems.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]


    THE HISTORY OF A NEARCTIC COLONIZATION: MOLECULAR PHYLOGENETICS AND BIOGEOGRAPHY OF THE NEARCTIC TOADS (BUFO)

    EVOLUTION, Issue 11 2004
    Gregory B. Pauly
    Abstract Previous hypotheses of phylogenetic relationships among Nearctic toads (Bufonidae) and their congeners suggest contradictory biogeographic histories. These hypotheses argue that the Nearctic Bufo are: (1) a polyphyletic assemblage resulting from multiple colonizations from Africa; (2) a paraphyletic assemblage resulting from a single colonization event from South America with subsequent dispersal into Eurasia; or (3) a monophyletic group derived from the Neotropics. We obtained approximately 2.5 kb of mitochondrial DNA sequence data for the 12S, 16S, and intervening valine tRNA gene from 82 individuals representing 56 species and used parametric bootstrapping to test hypotheses of the biogeographic history of the Nearctic Bufo. We find that the Nearctic species of Bufo are monophyletic and nested within a large clade of New World Bufo to the exclusion of Eurasian and African taxa. This suggests that Nearctic Bufo result from a single colonization from the Neotropics. More generally, we demonstrate the utility of parametric bootstrapping for testing alternative biogeographic hypotheses. Through parametric bootstrapping, we refute several previously published biogeographic hypotheses regarding Bufo. These previous studies may have been influenced by homoplasy in osteological characters. Given the Neotropical origin for Nearctic Bufo, we examine current distributional patterns to assess whether the Nearctic-Neotropical boundary is a broad transition zone or a narrow boundary. We also survey fossil and paleogeographic evidence to examine potential Tertiary and Cretaceous dispersal routes, including the Paleocene Isthmian Link, the Antillean and Aves Ridges, and the current Central American Land Bridge, that may have allowed colonization of the Nearctic. [source]


    Volatile needle and wood extracts of oriental spruce Picea orientalis (L.) Link

    FLAVOUR AND FRAGRANCE JOURNAL, Issue 5 2003
    Günes Uçar
    Abstract Volatile needle and wood extracts of oriental spruce obtained from trees grown naturally in eastern Black Sea regions and in an cultivated stand near Istanbul were analysed by GC,MS. Despite considerable differences in both tree-to-tree and natural-to-cultivated aspects, the needle and wood extracts exhibit characteristic compounds, which might be of chemotaxonomic interest. The monoterpenes , -3-carene, limonene and bornyl acetate dominate in the needles, whereas the appreciable amounts of labdadienol isomers and high content of diterpenoids characterize the wood extracts. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    Learner Accuracy and Learner Performance: The Quest for a Link

    FOREIGN LANGUAGE ANNALS, Issue 2 2000
    Janet M. Renou
    Specifically, we examined learner performance in carrying out three steps of a written and oral grammatically judgment test. First, subjects' ability to identify and correct an error, and to provide the rule, which the correction entailed, was examined according to group membership (communicative or grammar), types of errors, and mode of presentation. In a second phase of the analysis, judgment ability was compared with specific aspects of L2 proficiency. Results show significant differences between the groups in their ability to provide the rule that the correction entailed. Furthermore, significant differences in judgment ability were found depending on whether the item was presented in the written or oral mode. Generally, little difference was found in levels of L2 proficiency between subjects who could correct the error and provide the rule in comparison with those who were only able to correct the error. [source]


    Nanocomposite Synthesis: Embryonic States of Fluorapatite,Gelatine Nanocomposites and Their Intrinsic Electric-Field-Driven Morphogenesis: The Missing Link on the Way from Atomistic Simulations to Pattern Formation on the Mesoscale (Adv. Funct.

    ADVANCED FUNCTIONAL MATERIALS, Issue 22 2009
    Mater.
    Fractal aggregates of fluorapatite,gelatine nanocomposites (SEM image taken by Yigit Öztan, MPI CPfS),which bears a strong resemblance to the biosystem hydroxyapatite,collagen, a key material in human bones and teeth,are formed from bundles of calcified protein molecules representing the first (embryonic) states of shape development and leading to extended processes of self-organisation. This process has been studied in detail by P. Simon et al., and is reported on page 3596. [source]


    Embryonic States of Fluorapatite,Gelatine Nanocomposites and Their Intrinsic Electric-Field-Driven Morphogenesis: The Missing Link on the Way from Atomistic Simulations to Pattern Formation on the Mesoscale

    ADVANCED FUNCTIONAL MATERIALS, Issue 22 2009
    Paul Simon
    Abstract The shape development of fluorapatite (FAP),gelatine nanocomposites is revealed by means of HRTEM investigations starting from molecular dimensions up to the formation of mesoscaled (elongated) hexagonal prisms. The composite nature of the aggregates is proved by IR spectroscopy and by chemical analyses on all states of shape development. The initial states are characterized by triple-helical fiber protein bundles, which are mineralized step-by-step forming and fixing nanoplatelets of FAP in a mosaic arrangement. After being fully mineralized the bundles form elongated composite nanoboards. In the next step of the growth process the boards aggregate to bundles of boards which are in a more or less parallel alignment with respect to each other. By adding up more and more composite nanoboards a critical size is reached and an electric field is developed, which takes over control and directs the further development of the aggregates. This kind of electric-field-directed growth of the elongated polar nanoboards additionally leads to the formation and inclusion of protein nanofibrils into the growing composite aggregate. By this method, cone-like nanofibril structures develop along the long axis of the aggregates accompanied by more perfect parallel alignment of the composite boards within the aggregates. Further shape development is characterized by adding up composite nanoboards, in particular to increase the third dimension in volume. This thickening process preferably takes place in the middle part of the elongated aggregates and finally proceeds to their basal ends until a perfect hexagonal prismatic seed is formed, which then is ready for further shape development on the micrometer scale. [source]


    The Care,tech Link: An Examination of Gender, Care and Technical Work in Healthcare Labour

    GENDER, WORK & ORGANISATION, Issue 4 2008
    Sally Lindsay
    Despite the dramatic increase of technology in the healthcare field, little is known of how care work and technical work are related. Examining substitute healthcare providers offers a useful illustration of the care,tech link because nursing (care) and medical (technical) models often merge. Forty-two interviews with men and women (nurse practitioners, nurse anaesthetists and physician assistants) were conducted in the USA. The results showed that the gendered nature of care,tech boundaries has shifted in small but important ways and that the gendering of work influenced the shape of these boundaries. Men often encountered barriers when moving too far into the care realm and attempted to overcome this by ,caring cautiously' and emphasizing problem-solving care. Women faced similar barriers from the ,old boys network' when they entered highly technical areas. There is also evidence that men and women challenged existing care,tech boundaries and moved beyond their traditional roles. [source]


    Helicobacter pylori Infection and Gastric Autoimmune Diseases: Is There a Link?

    HELICOBACTER, Issue 6 2003
    Fabio Presotto
    ABSTRACT Background.,Helicobacter pylori is thought to be involved in atrophic body gastritis. We explored the prevalence of H. pylori infection in asymptomatic subjects with gastric parietal cell antibodies, as well as in patients with pernicious anemia, to evaluate a possible role of H. pylori gastric infection in gastric autoimmunity. Patients and Methods., We studied 79 consecutive asymptomatic subjects with parietal cell antibodies, 24 patients with pernicious anemia, and 66 parietal cell antibody-negative controls. All patients underwent gastric biopsies for histology and detection of H. pylori. Red blood cell count and volume, serum levels of gastrin, pepsinogen I, iron, folic acid, vitamin B12, and circulating antibodies to H. pylori and to intrinsic factor were also determined. Results., We found an atrophic body gastritis in 14 of the 79 asymptomatic subjects with parietal cell antibodies (18%) and in 2 of the 66 controls (3%) (p = .01). Mean levels of gastrin were increased (p < .0001), while those of pepsinogen were reduced (p < .001) compared with controls. H. pylori was identified at the gastric level and/or circulating anti- H. pylori antibodies were detected in 46 parietal cell antibody-positive subjects (58%) compared with 26 controls (39%) (p = .03). In patients with pernicious anemia we found an atrophic body gastritis in 18 of 24 cases (75%) (p < .001 vs. controls). Mean levels of gastrin were markedly increased (p < .0001) and those of pepsinogen I decreased (p < .0001) relative to controls. Only five of these patients (21%) had evidence of H. pylori infection compared with 46 of the parietal cell antibody-positive subjects (58%) (p = .003) and 26 of the controls (39%). Considering all patients with gastric autoimmunity (i.e. with parietal cell antibodies and/or with pernicious anemia), H. pylori was found in 44 of 72 of those without atrophy (61%) but in 6 of 31 with gastric body atrophy (19%) (p < .001), indicating that H. pylori infection is greatly reduced when gastric acid secretion decreases. Conclusions., The frequent detection of H. pylori infection in subjects with early gastric autoimmunity, indicated by the presence of parietal cell antibodies, suggests that H. pylori could have a crucial role in the induction and/or the maintenance of autoimmunity at the gastric level. [source]


    Theta rhythm of navigation: Link between path integration and landmark navigation, episodic and semantic memory

    HIPPOCAMPUS, Issue 7 2005
    György Buzsáki
    Abstract Five key topics have been reverberating in hippocampal-entorhinal cortex (EC) research over the past five decades: episodic and semantic memory, path integration ("dead reckoning") and landmark ("map") navigation, and theta oscillation. We suggest that the systematic relations between single cell discharge and the activity of neuronal ensembles reflected in local field theta oscillations provide a useful insight into the relationship among these terms. In rats trained to run in direction-guided (1-dimensional) tasks, hippocampal cell assemblies discharge sequentially, with different assemblies active on opposite runs, i.e., place cells are unidirectional. Such tasks do not require map representation and are formally identical with learning sequentially occurring items in an episode. Hebbian plasticity, acting within the temporal window of the theta cycle, converts the travel distances into synaptic strengths between the sequentially activated and unidirectionally connected assemblies. In contrast, place representations by hippocampal neurons in 2-dimensional environments are typically omnidirectional, characteristic of a map. Generation of a map requires exploration, essentially a dead reckoning behavior. We suggest that omnidirectional navigation through the same places (junctions) during exploration gives rise to omnidirectional place cells and, consequently, maps free of temporal context. Analogously, multiple crossings of common junction(s) of episodes convert the common junction(s) into context-free or semantic memory. Theta oscillation can hence be conceived as the navigation rhythm through both physical and mnemonic space, facilitating the formation of maps and episodic/semantic memories. © 2005 Wiley-Liss, Inc. [source]


    Clues, Margins, and Monads: The Micro,Macro Link in Historical Research

    HISTORY AND THEORY, Issue 3 2001
    Matti Peltonen
    This article discusses the new microhistory of the 1970s and 1980s in terms of the concept of exceptional typical, and contrasts the new microhistory to old microhistory, in which the relationship between micro and macro levels of phenomena was defined by means of the concepts of exceptionality and typicality. The focus of the essay is on Carlo Ginzburg's method of clues, Walter Benjamin's idea of monads, and Michel de Certeau's concept of margins. The new microhistory is also compared with methodological discussions in the social sciences. In the mid-1970s concepts like the micro,macro link or the microfoundations of macrotheory were introduced in sociology and economics. But these largely worked in terms of the concepts of typicality or exceptionality, and this has proved to be problematic. Only historians have developed concepts that escape these and the older definitions of the micro,macro relationship; indeed, the "new microhistory" can best be described in terms of the notion of "exceptional typical." The essay explores the meaning of this notion. [source]


    The Use of Person,Group Fit for Employment Selection: A Missing Link in Person,Environment Fit

    HUMAN RESOURCE MANAGEMENT, Issue 3 2001
    James D. Werbel
    Given an increased emphasis on work teams in organizations, it is important to select applicants based on their ability to make contributions to a given work team. This paper proposes that person,group fit should be useful to select applicants for work teams and suggests that effective use of person,group fit will create both more cohesive work units and more effectively functioning work units. It proposes ways to make valid and reliable assessments of person,group fit that could be used to minimize bias in the selection process. Finally, it addresses several implications of using the person,group fit paradigm for human resource management practice. © 2001 John Wiley & Sons, Inc. [source]