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Antimycotic Drugs (antimycotic + drug)

Distribution by Scientific Domains

Medical Sciences	80%

Selected Abstracts

Effect of infection with Trichophyton mentagrophytes varietas interdigitale on phagocytosis in humans

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 2 2004
T Gregurek-Novak
ABSTRACT Background and aim, Phagocytosis by polymorphonuclear leucocytes (PMNLs) and macrophages is important in the defence of human organisms, especially in mycotic infections of the skin. The aim of this study was to examine the relationship between phagocytosis and a chronic type of infection with Trichophyton mentagrophytes varietas interdigitale (T. m. var. interdig.). Materials and methods, A group of 256 patients was investigated from 1990 to 2000. They were all treated with terbinafine. The parameters for phagocytosis were analysed by the Hersy method. Results, The immunological status of all of the patients was altered. Ingestion, digestion and random mobility decreased significantly (P < 0.001). Out of 256 patients treated with terbinafine, 196 (76%) were cured completely and the values for phagocytosis became normal. Conclusion, This investigation confirms the defect in the function of phagocytes of patients chronically infected by T. m. var. interdig. Terbinafine was shown to be an effective antimycotic drug, both fungicidal and immunostimulative. [source]

In vitro and in vivo antifungal activity of cetrimide (cetyltrimethyl ammonium bromide) against fungal keratitis caused by Fusarium solani

MYCOSES, Issue 1 2007
Yehia A.-G.
Summary Mycotic keratitis is a devastating eye infection acquired after eye injury. Cetrimide at 15 and 20 mg ml,1 produced no surviving Fusarium solani growth with minimal inhibitory concentration value of 0.10 mg ml,1. Topical administration of three drops (0.3 ml) of cetrimide aqueous solution of 10 mg ml,1 at pH 6.4 three times daily succeeded to cure human severe resistant F. solani keratitis in a time course of <3 weeks, and with complete healing after 6 weeks. Cetrimide-treated rabbit corneas section appeared with normal compact epithelium and endothelium with no vacuolation in Descemet's endothelial complex: an indication that cetrimide has no significant toxic effects. So, cetrimide at 10 mg ml,1 may be effective and safe topical therapy in patients with mycotic keratitis, especially F. solani ulcers. Currently, there is no antimycotic drug with a good corneal penetration, which is safe and has a fungicidal activity. [source]

Complement and fungal pathogens: an update

MYCOSES, Issue 6 2008
Cornelia Speth
Summary Fungal infections are a serious complication in immunocompromised patients such as human immunodeficiency virus-infected individuals, patients with organ transplantations or with haematological neoplasia. The lethality of opportunistic fungal infection is high despite a growing arsenal of antimycotic drugs, implying the urgent need for supportive immunological therapies to strengthen the current inefficient antimicrobial defences of the immunocompromised host. Therefore, increasing effort has been directed to investigating the interplay between fungi and the host immunity and thus to find starting points for additional therapeutic approaches. In this article, we review the actual state of the art concerning the role of complement in the pathogenesis of fungal infections. Important aspects include the activation of the complement system by the fungal pathogen, the efficiency of the complement-associated antimicrobial functions and the arsenal of immune evasion strategies applied by the fungi. The twin functions of complement as an interactive player of the innate immunity and at the same time as a modulator of the adaptive immunity make this defence weapon a particularly interesting therapeutic candidate to mobilise a more effective immune response and to strengthen in one fell swoop a broad spectrum of different immune reactions. However, we also mention the ,Yin-Yang' nature of the complement system in fungal infections, as growing evidence assigns to complement a contributory part in the pathogenesis of fungus-induced allergic manifestations. [source]

Agar sublimation test for the in vitro determination of the antifungal activity of morpholine derivatives

MYCOSES, Issue 5-6 2004
A. Polak
Antimykotische Aktivität; Morpholine; Sublimation Summary We studied the in vitro antifungal activities of a wide range of antimycotic agents, including amorolfine, terbinafine, naftifine, five morpholine derivatives, ciclopiroxolamine, bifonazole, clotrimazole, ketoconazole, itraconazole, fluconazole, voriconazole, flucytosine, amphotericin B, nystatin, and caspofungin, against Candida albicans and Trichophyton rubrum by conventional agar diffusion tests and by a novel sublimation method. For the sublimation method, 6 mm filter paper disks were soaked with defined amounts of antimycotic drugs, air dried, placed in the center of the lids of 9 cm Petri dishes, and incubated upside down with inoculated agar plates 10 mm above the disks. The conventional disk diffusion tests produced inhibition zones as previously described. The disk sublimation tests produced large inhibition zones with amorolfine, five amorolfine derivatives, and terbinafine, but with none of the other antifungal agents. Possible therapeutic advantages of agents, which are able to overcome air cavities in mycotic lesions, e.g. in onychomycosis, are discussed. Zusammenfassung Wir untersuchten in vitro die antimykotische Aktivität eines breiten Spektrums von Antimykotika, einschließlich Amorolfin, Terbinafin, Naftifin, fünf Morpholin-Derivaten, Ciclopiroxolamin, Bifonazol, Clotrimazol, Ketoconazol, Itraconazol, Fluconazol, Voriconazol, 5-Fluorcytosin, Amphotericin B, Nystatin und Caspofungin, gegenüber Candida albicans und Trichophyton rubrum mit konventionellen Agardiffusionstesten und mit einer neuartigen Sublimationsmethode. Für die Sublimationsmethode wurden 6 mm-Filterpapier-Blättchen mit definierten Mengen von Antimykotika getränkt, luftgetrocknet, in die Mitte der Deckel von 9 cm-Petrischalen gelegt und mit der inokulierten Agarplatte 10 mm über den Blättchen umgedreht inkubiert. Die konventionellen Agardiffusionsteste produzierten Hemmhöfe wie früher beschrieben. Die Blättchen-Sublimationsteste produzierten große Hemmhöfe mit Amorolfin, fünf Morpholin-Derivaten und Terbinafin, nicht jedoch mit den anderen Antimykotika. Mögliche therapeutische Vorteile von Agentien, die luftgefüllte Hohlräume in mykotischen Läsionen überbrücken können, z. B. im Nagel bei Onychomykose, werden diskutiert. [source]

Recent Approaches to Antifungal Therapy for Invasive Mycoses

CHEMMEDCHEM, Issue 3 2009
Bijoy
Abstract Antimycotic agents: Diverse classes of antimycotic drugs have been developed over the past decades with the goal of improving selectivity and efficacy. This review discusses both conventional and novel targets for antifungal agents and the possibility of vaccination in the treatment of invasive fungal infections. Invasive fungal infections with primary and opportunistic mycoses have become increasingly common in recent years and pose a major diagnostic and therapeutic challenge. They represent a major area of concern in today's medical fraternity. The occurrence of invasive fungal diseases, particularly in AIDS and other immunocompromised patients, is life-threatening and increases the economic burden. Apart from the previously known polyenes and imidazole-based azoles, newly discovered triazoles and echinocandins are more effective in terms of specificity, yet some immunosuppressed hosts are difficult to treat. The main reasons for this include antifungal resistance, toxicity, lack of rapid and microbe-specific diagnoses, poor penetration of drugs into sanctuary sites, and lack of oral or intravenous preparations. In addition to combination antifungal therapy, other novel antimycotic treatments such as calcineurin signaling pathway blockers and vaccines have recently emerged. This review briefly summarizes recent developments in the pharmacotherapeutic treatment of invasive fungal infections. [source]