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Anterior Uveitis (anterior + uveitis)
Kinds of Anterior Uveitis Selected AbstractsBilateral Anterior Uveitis after Intense Pulsed Light Therapy for Pigmented Eyelid LesionsDERMATOLOGIC SURGERY, Issue 9 2008ANNA L. Y. PANG MBBS/BA First page of article [source] 4151: Epidemiology of uveitis in the Middle East and North AfricaACTA OPHTHALMOLOGICA, Issue 2010M KHAIRALLAH Purpose Numerous studies have examined the pattern of uveitis around the world. Most of them are from western countries, including the USA and countries in Europe, and Eastern Asia. The aim of this presentation is to review the epidemiological characteristics of uveitis in the the Middle East and North Africa. Methods The epidemiologic data on uveitis available from the Middle East and North Africa were reviewed. Results Several recent studies addressed the pattern of uveitis in different countries, including Iran, Saudi Arabia, Turkey, and Tunisia. Uveitis was most often seen in adults with a peak age at presentation in the third and fourth decades. There was no dramatic difference in gender distribution. Anterior uveitis was the most common anatomic form of uveitis, but a high rate of posterior uveitis and panuveitis was reported. A definitive or presumed specific diagnosis could be established for 57-87% of patients. The most common infectious entities were herpetic anterior uveitis, toxoplasmosis, and tuberculosis (Saudi Arabia). The most common identifiable non-infectious entities included Behçet's disease and Vogt-Koyanagi-Harada disease. Conclusion Herpetic infection, toxoplasmosis, and tuberculosis are the most common infectious causes of uveitis in the Middle East and North Africa. Behçet's diease and Vogt-Koyanagi-Harada disease are the most common non-infectious uveitic entities.HLA-B27 acute anterior uveitis, ocular sarcoidosis, and juvenile idiopathic arthritis associated uveitis are less common than in western countries. [source] 2251: Anterior uveitis caused by Herpes virusesACTA OPHTHALMOLOGICA, Issue 2010N MARKOMICHELAKIS [source] A new technique of anterior TAP enhances the positivity of CMV by PCR in hypertensives anterior uveitisACTA OPHTHALMOLOGICA, Issue 2009P KOCH Purpose Anterior uveitis can be severely disabling. Especially, hypertensives anterior uveitis can lead to a decrease in visual acuity, posterior synechiaes, cataract, glaucoma, etc. Diagnosis is frequently complex. Two main aetiologies are retained: non infectious (auto-immunes) and infectious forms. Amongst the lasts, various aetiologies are possible. Viral anterior uveitis remained difficult to diagnose for a long time. However, since the emergence of the polymerase chain reaction (PCR), the diagnosis is definitely easier. Nevertheless, anterior TAP result is determined by different limitations including the puncture technique, the PCR primers used, and of course the investigated virus. Methods We hereby propose a new technique of anterior TAP that allowed us to increase our PCR results in CMV anterior uveitis. Two samples were obtained: firstly, a conventional anterior TAP was realised; followed by a rinsing of the anterior chamber with saline solution. A Goldman-Witmer index for rubeola was performed in the first sample. Both samples were examined for viral PCR (HSV1, 2, VZV, CMV, EBV, Rubeola) Results We did not found any side effect of the technique used by comparison with normal anterior TAP. Diagnosis was obtained in 20 of the 35 eyes tested. Rubeola diagnosis was obtained in 11/20 eyes, VZV in 1/20, HSV1 in 4/20, and CMV in 4/20. Intriguingly, CMV diagnosis was obtained in three cases only in the second syringe and not in the first Conclusion We have, to date, detected 4 cases of CMV anterior uveitis in a cohort of 35 patients with anterior uveitis. We did not meet any complication but obtained interesting results concerning CMV diagnosis, using a rinsing of the anterior chamber (second syringe). [source] Macular oedema with associated uveitis and cataract following presentation of Type 1 diabetes mellitus in severe ketoacidosisDIABETIC MEDICINE, Issue 4 2000D. Gordon Abstract We present a case of cystoid macular oedema presenting in a newly diagnosed diabetic teenager. She had developed anterior uveitis prior to diabetes and whether this contributed to the subsequent ocular complications remains speculative. The macular changes resolved spontaneously over 6 months without the use of grid laser photocoagulation. [source] Clinical significance of granuloma in Crohn's diseaseINFLAMMATORY BOWEL DISEASES, Issue 3 2002Dr. Nizar N. Ramzan Abstract Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6%) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum. [source] Enthesis inflammation in recurrent acute anterior uveitis without spondylarthritisARTHRITIS & RHEUMATISM, Issue 7 2009Santiago Muñoz-Fernández Objective To investigate whether patients with idiopathic recurrent acute anterior uveitis (AAU) have enthesis alterations comparable with those in patients with spondylarthritis (SpA). Methods A blinded, controlled study of enthesis evident on ultrasound (US) examination was performed in 100 patients and controls classified into 5 groups, as follows: patients with confirmed SpA (group 1), patients with recurrent AAU who were positive for HLA,B27 and did not have SpA (group 2), patients with recurrent AAU who were negative for HLA,B27 and did not have SpA (group 3), patients with forms of uveitis other than those related to SpA (group 4), and healthy controls (group 5). In total, 12 enthesis locations were explored in each patient and control subject by 2 ultrasonographers who were blinded with regard to the diagnosis. A newly developed US method, the Madrid Sonography Enthesitis Index (MASEI), in which the diagnosis of SpA is determined as a cutoff score of 18 points, was used. Results A total of 1,200 entheses were explored by US in 100 patients and controls. The MASEI cutoff limit was met or exceeded by 81%, 55.6%, 40%, 10%, and 19% of the subjects in the 5 groups, respectively. The MASEI score was significantly higher in groups 1 and 2 than in groups 4 and 5. The differences between groups 1 and 3 were also found to be significant. Conclusion Our findings indicate that a high percentage of HLA,B27,positive patients with idiopathic recurrent AAU without features of SpA have enthesis lesions comparable with those seen in patients with SpA. These data suggest that patients with recurrent AAU, especially those who are HLA,B27 positive, have an abortive or incomplete form of SpA. [source] Serious complications of cosmetic NewColorIris implantationACTA OPHTHALMOLOGICA, Issue 6 2010Justin E. Anderson Acta Ophthalmol. 2010: 88: 700,704 Abstract. Purpose:, This case report describes serious postoperative complications and markedly elevated intraocular pressure (IOP) associated with the NewColorIris cosmetic implant. Methods:, We report an interventional case series of two patients who suffered multiple complications after NewColorIris implantation carried out in Panama. Assessment included visual acuity, photography, endothelial cell count and anterior segment optical coherence tomography (OCT) when possible. Results:, Both patients presented with endothelial cell loss, uveitis, pigment dispersion and elevated IOP. Anterior segment OCT demonstrated irregularities in the position and configuration of the implants within the anterior chamber with resultant areas of implant,iris and implant,endothelial contact. One patient had acute postoperative hyphaema that resolved with anterior chamber tissue plasminogen activator injection. Both patients required explantation OU, one eye has required trabeculectomy, and one eye with bullous keratopathy is being evaluated for Descemet's stripping endothelial keratoplasty. Conclusions:, Implantation of the NewColorIris cosmetic implant can lead to serious complications including hyphaema, uncontrolled IOP, severe endothelial cell loss, bullous keratopathy and anterior uveitis. Explantation may lead to improvement, but permanent damage to the trabecular meshwork and corneal endothelium persists. [source] 1262: Symptoms and signs of anterior uveitisACTA OPHTHALMOLOGICA, Issue 2010I TUGAL-TUTKUN Purpose Based on the anatomic classification of uveitis, iritis and iridocyclitis are classified as anterior uveitis. Methods Symptoms and signs of anterior uveitis will be presented Results Patients with acute anterior uveitis typically present with red eyes, photophobia, ocular pain, and sometimes visual blurring. In chronic anterior uveitis, onset is usually insidious and patients may be asymptomatic until the development of complications. Ciliary injection, endothelial dusting or fine keratic precipitates (KPs), cells and flare in the anterior chamber with or without hypopyon formation or fibrinous exudate are the typical findings of alternating unilateral acute nongranulomatous anterior uveitis which is most commonly seen in association with HLA-B27 antigen and spondyloarthropaties. Medium-size KPs or large mutton-fat KPs, chronic flare, Koeppe and Busacca nodules of the iris, peripheral anterior synechiae and broad-based posterior synechiae are the typical findings of granulomatous anterior uveitis which is often chronic. Viral anterior uveitis is characterized by unilateral recurrent episodes of anterior uveitis characterized by endotheliitis, elevated intraocular pressure, and patchy or sectoral iris atrophy. JIA-associated anterior uveitis is typically a bilateral nongranulomatous chronic anterior uveitis often complicated by band keratopathy, seclusion of the pupil, and cataract. Conclusion Symptoms and signs in anterior uveitis vary depending on the acute or chronic, ganulomatous or nongranulomatous nature of the disease. Specific anterior uveitic entities are characterized by a distinct constellation of ocular signs. [source] 1266: Main anterior entities 1: non-granulomatousACTA OPHTHALMOLOGICA, Issue 2010P NERI Purpose To describe the clinical course, the laboratory work-up and the treatment of different types of anterior non-granulomatous uveitis. Methods The current literature is reviewed and the experience of a tertiary referral centre is reported. Results The lecture describes the most typical subsets of non-granulomatous uveitis. Most part of the talk is dedicated to the most common form of non-granulomatous anterior uveitis: the acute anterior uveitis (AAU), which is very often associated with the HLA-B27 allele. This antigen is also typically associated with the spondyloarthropathies, which are inflammatory joint diseases of the vertebral column. The correct interpretation of the clinical pattern can drive the decision towards the right therapeutic strategy. Other uveitis entities are described also. Conclusion Non-granulomatous uveitis is one of the most important ocular inflammations. It is mandatory to pay attention to the clinical findings and to the laboratory work-up, in order to achieve a good therapeutic approach. [source] 2215: Animal models of herpetic retinitisACTA OPHTHALMOLOGICA, Issue 2010M LABETOULLE The Herpes simplex virus (HSV) is characterized its ability to replicate in the nervous system, before inducing a latent infection with potential reactivation. Most frequent ocular complications of recurrent HSV infection are keratitis and conjunctivitis. Less frequently, the iris and the ciliary body may also be involved (anterior uveitis). The most severe HSV ocular infection is retinitis, a rare but potentially blinding disease, due to frequent bilateral involvement. Studies on human post-mortem tissues showed that HSV is widely distributed in the population, with a preferential location within the trigeminal ganglions (innervating the cornea), but also in the superior cervical ganglions (innervating the iris) or in brain/medullar tissues (innervating the retina). Animal models have been developed to understand the pathogenic processes that lead to this rare but devastating retinal disease. Since human is the only natural host of HSV, it is difficult to obtain a perfect animal model that perfectly mimics the disease. Several animal models, based on different inoculation procedures, are thus necessary to circumscribe the anatomical, cellular and molecular aspects that lead to retinal infection. Finally, HSV retinitis appears as a clinical condition that is highly constrained by the relationships between the strain of the virus and the immune response of the host. [source] 3143: Management of iris melanomas with 125 iodine plaque radiotherapyACTA OPHTHALMOLOGICA, Issue 2010BF FERNANDES Purpose The experience with 125Iodine (I125) plaque brachytherapy in the treatment of IM at the Princess Margaret Hospital/University Health Network is the subject of the report to follow. Methods All cases of IM submitted to I125 plaque radiotherapy were included. Patients' demographic, clinical, management, and follow-up data were reviewed. Outcome measures included rates of tumor control, eye preservation, systemic metastases, and brachytherapy-related complications. Results Fourteen IMs were included in the study. All patients had blue/green irises. Mean largest basal dimension and thickness were 7.1 +/- 2.1 mm (range, 4.0 to 11.5 mm) and 2.2 +/- 0.8 mm (range, 1.0 to 3.5 mm), respectively. Ten patients (71%) had seeding and 2 (14%) had glaucoma at presentation. Median follow-up was 26.6 +/- 19.5 months (range, 6 to 72 months). Tumor control was achieved in 100% of the cases and no eye was enucleated because of radiation-induced complications. At last visit, all patients were alive and free of metastasis. Final visual acuity was the same as or better than before treatment in 9 patients (75%). Cataract was the most common complication (8; 75%), followed by persistent glaucoma (2; 17%) and anterior uveitis (1; 8%). No other significant complication was seen during the follow-up period. Conclusion Plaque radiotherapy is a safe and effective conservative treatment option for IM, although cataract is a common, yet treatable, complication. This treatment scheme circumvents an intraocular procedure and may avoid the dissemination of malignant cells, and provides a margin of safety in the treatment of clinically undetectable disease. [source] 4151: Epidemiology of uveitis in the Middle East and North AfricaACTA OPHTHALMOLOGICA, Issue 2010M KHAIRALLAH Purpose Numerous studies have examined the pattern of uveitis around the world. Most of them are from western countries, including the USA and countries in Europe, and Eastern Asia. The aim of this presentation is to review the epidemiological characteristics of uveitis in the the Middle East and North Africa. Methods The epidemiologic data on uveitis available from the Middle East and North Africa were reviewed. Results Several recent studies addressed the pattern of uveitis in different countries, including Iran, Saudi Arabia, Turkey, and Tunisia. Uveitis was most often seen in adults with a peak age at presentation in the third and fourth decades. There was no dramatic difference in gender distribution. Anterior uveitis was the most common anatomic form of uveitis, but a high rate of posterior uveitis and panuveitis was reported. A definitive or presumed specific diagnosis could be established for 57-87% of patients. The most common infectious entities were herpetic anterior uveitis, toxoplasmosis, and tuberculosis (Saudi Arabia). The most common identifiable non-infectious entities included Behçet's disease and Vogt-Koyanagi-Harada disease. Conclusion Herpetic infection, toxoplasmosis, and tuberculosis are the most common infectious causes of uveitis in the Middle East and North Africa. Behçet's diease and Vogt-Koyanagi-Harada disease are the most common non-infectious uveitic entities.HLA-B27 acute anterior uveitis, ocular sarcoidosis, and juvenile idiopathic arthritis associated uveitis are less common than in western countries. [source] Severe anterior uveitis as a complication of high-dose cytosine,arabinosideACTA OPHTHALMOLOGICA, Issue 8 2009Johan Moberg No abstract is available for this article. [source] Emerging and poorly known viral inflammatory eye diseasesACTA OPHTHALMOLOGICA, Issue 2009M KHAIRALLAH Arthropod vector borne diseases are among the most important emergent infections. They include a wide variety of bacterial, viral, and parasitic diseases that are transmitted to humans by the bite of mosquito, tick, or other arthropod. Most of them are prevalent in tropical and subtropical areas, but they tend to spread into new regions mainly due to increasing temperatures worldwide, movement of people, increasing human population densities, wider dispersal of competent vectors, and transportation of goods and animals. Numerous arthropod vector borne diseases have been associated with uveitis. Among them, specific viral diseases recently emerged as important causes of uveitis in the developing and developed world. They include West Nile virus (WNV) infection, Rift Valley fever (RVF) , dengue fever (DF), and Chikungunya. These viral diseases have been recently associated with an array of ocular manifestations, including anterior uveitis, retinitis, chorioretinitis, retinal vaculitis, and optic nerve involvement. Proper clinical diagnosis of any of these infectious diseases is based on epidemiological data, history, systemic symptoms and signs, and the pattern of uveitis. The diagnosis is usually confirmed by detection of specific antibody in serum. A systematic ocular examination, showing fairly typical findings, can help establish an early clinical diagnosis of a specific systemic viral infection while serologic testing is pending. Prevention remains the mainstay for control of arthropod vector borne viral diseases. [source] Progress in monitoring inflammation in JIAACTA OPHTHALMOLOGICA, Issue 2009B BODAGHI Purpose To analyze the most appropriate strategy to monitor ocular inflammation in children with juvenile idiopathic arthritis - associated uveitis. Methods Slit lamp biomicroscopy is widely used to evaluate the importance of anterior segment flare and cells in children with anterior uveitis. However, different studies have clearly shown that other tools such as laser flare photometry and OCT may improve the monitoring during the follow-up. Therefore, both tests are performed in all children referred to our Department for the management of JIA-associated uveitis. Results Laser flare photometry showed for the first time that active ocular inflammation may be associated with a significant level of flare even in the absence of detectable cells. This is a major finding to start a therapeutic approach or change it for a more aggressive strategy and monitor the decrease of flare. Moreover, the level of flare decrease under therapy may predict further serious complications such as secondary glaucoma or cataract. OCT features are important to identify macular alterations in nearly 85% of children with anterior uveitis associated with JIA. Conclusion Both laser flare photometry and OCT are non invasive and quantitative methods that may significantly improve the visual outcome of JIA-associated uveitis. [source] The present role of corticosteroids in uveitisACTA OPHTHALMOLOGICA, Issue 2009M KHAIRALLAH Corticosteroids are the most widely used anti-inflammatory and immunosuppressant drugs in ophthalmology in general, and remain the mainstay of therapy for patients with uveitis. An infectious etiology for intraocular inflammation should be adequately excluded or appropriately covered with anti-infectious therapy before administration of corticosteroid therapy. Topical corticosteroids alone are usually effective in the management of anterior uveitis and have little activity against intermediate or posterior uveitis. Ocular adverse effects of topical steroid therapy mainly include ocular hypertension and cataract. The use of periocular steroid injections (subconjunctival, anterior or posterior subtenon, orbital floor) are important modalities in the management of anterior uveitis refractory to topical treatment and intermediate or posterior uveitis, particularly unilateral cases. Systemic corticosteroids remain the initial drug of choice for most patients with severe bilateral intermediate or posterior uveitis. Therapy is initiated with 1.0 to 2.0 mg/Kg of oral prednisone or prednisolone as a single morning dose, followed by a slow taper. Use of intravenous pulse steroid therapy is an important option in acute, severe, bilateral posterior segment inflammation. In several cases, the level of systemic steroid required to control the inflammation is too high and unacceptable. Immunosuppressive drugs as steroid-sparing agents are indicated is such cases. Intravitreal injection of triamcinolone acetonide and slow-release intraocular devices are therapeutic options that can be used in selected uveitis cases refractory to conventional therapy and biologic agents. [source] A new technique of anterior TAP enhances the positivity of CMV by PCR in hypertensives anterior uveitisACTA OPHTHALMOLOGICA, Issue 2009P KOCH Purpose Anterior uveitis can be severely disabling. Especially, hypertensives anterior uveitis can lead to a decrease in visual acuity, posterior synechiaes, cataract, glaucoma, etc. Diagnosis is frequently complex. Two main aetiologies are retained: non infectious (auto-immunes) and infectious forms. Amongst the lasts, various aetiologies are possible. Viral anterior uveitis remained difficult to diagnose for a long time. However, since the emergence of the polymerase chain reaction (PCR), the diagnosis is definitely easier. Nevertheless, anterior TAP result is determined by different limitations including the puncture technique, the PCR primers used, and of course the investigated virus. Methods We hereby propose a new technique of anterior TAP that allowed us to increase our PCR results in CMV anterior uveitis. Two samples were obtained: firstly, a conventional anterior TAP was realised; followed by a rinsing of the anterior chamber with saline solution. A Goldman-Witmer index for rubeola was performed in the first sample. Both samples were examined for viral PCR (HSV1, 2, VZV, CMV, EBV, Rubeola) Results We did not found any side effect of the technique used by comparison with normal anterior TAP. Diagnosis was obtained in 20 of the 35 eyes tested. Rubeola diagnosis was obtained in 11/20 eyes, VZV in 1/20, HSV1 in 4/20, and CMV in 4/20. Intriguingly, CMV diagnosis was obtained in three cases only in the second syringe and not in the first Conclusion We have, to date, detected 4 cases of CMV anterior uveitis in a cohort of 35 patients with anterior uveitis. We did not meet any complication but obtained interesting results concerning CMV diagnosis, using a rinsing of the anterior chamber (second syringe). [source] Efficacy of systemic ganciclovir as a therapeutic strategy for cytomegalovirus-associated anterior uveitis in immunocompetent patientsACTA OPHTHALMOLOGICA, Issue 2009M ANGI Purpose Cytomegalovirus (CMV)-associated anterior uveitis is a newly recognized entity that accounts for half of patients with Posner-Schlossman syndrome. To date, the therapeutic management of these patients remains controversial. The aim of this study was to assess the efficacy of systemic Ganciclovir as a treatment for PCR-proven CMV-associated hypertensive anterior uveitis. Methods Retrospective interventional study of 27 consecutive patients treated in a single centre between 2002 and 2008. Main outcome measures included intraocular pressure (IOP) and anterior chamber inflammation. Results All patients responded to systemic Ganciclovir, with mean IOP dropping from 32 to 14 mmHg (p<0,05). Relapses occurred in 50% of cases within one year from the first antiviral course. Repeated treatment allowed control of the disease in 75% of cases (follow-up range: 12-78 months). Conclusion Ganciclovir is effective but remains a suspensive therapeutic strategy. [source] Foveal serous detachment in juvenile idiopathic arthritis(JIA)-associated uveitisACTA OPHTHALMOLOGICA, Issue 2009F LIANG Purpose To characterize the foveal serous detachment(FSD) in JIA-associated uveitis. To investigate the correlation with visual acuity (VA) and ocular inflammation. Methods 9 children having FSD with JIA-associated uveitis were identified between 2005-2007. All were treated with periocular steroid injection and systemic anti-TNF , antibody.Outcome measures included VA,ocular inflammation quantified by laser flare photometry and the macular profile analyzed by OCT. Results All patients(8 female,1 male) had bilateral uveitis and 6 had bilateral SRD. All patients had risk factors to develop severe anterior uveitis. The mean age at the onset of uveitis and at the onset of FSD was 4.1±1.1years and 7.6±2.2years. At the onset of FSD 6 children were refractory to methotrexate and systemic corticosteroids. It had a high frequency of ocular complications:87% posterior synechiae, 80% cataract, 60% band keratopathy and 20% glaucoma.FSD appeared isolated in 21% of eyes,it was associated with diffuse macular edema in 46% and with cystoid macular edema in 12% of cases. Before therapeutic intensification,the mean VA was 0.46logMAR,the mean foveal thickness(FT) was 261,m. At 6 months follow-up:VA increased to 0.22logMAR(p=0.017),the reduction of flare was 41%(p=0.003),the mean FT was 229,m(p=0.59). At 12 months follow-up,the mean VA was 0.19logMAR(p=0.0029),the mean FT was 196,m(p=0.009),only 1 eye showed persistant SRD. Conclusion FSD is a late-stage complication of sustained and insufficiently treated anterior uveitis in JIA-associated uveitis and must be considered for the long-term visual outcome. An agressive immunomodulatory strategy is mandatory in order to achieve strict control of ocular inflammation and improve the visual function. [source] Longitudinal study of anterior segment inflammation by ultrasound biomicroscopy in patients with acute anterior uveitisACTA OPHTHALMOLOGICA, Issue 2 2009Yang Peizeng Abstract. Purpose:, This study aimed to investigate dynamic changes in the anterior segment in patients with acute anterior uveitis (AAU) using ultrasound biomicroscopy (UBM). Methods:, Acute anterior uveitis was diagnosed in 18 patients according to history and ocular examinations. Ultrasound biomicroscopy was performed and the results at three time-points (within 2 weeks of the uveitis attack, and at 2,4 weeks and 6 weeks after it) were analysed. The relationships between clinical manifestations and UBM findings were also evaluated. Results:, All investigated AAU patients showed severe ciliary injection, numerous dust keratic precipitates (KPs), aqueous flare and inflammatory cells, and were treated predominantly with corticosteroid and cycloplegic eyedrops. Ultrasound biomicroscopy showed a large number of cells in the anterior and posterior chamber, marked oedema and exudates in and around the iris and ciliary body within 2 weeks of AAU onset. These abnormalities were dramatically improved at 2,4 weeks and almost resolved at 6 weeks and thereafter. Conclusions:, Ultrasound biomicroscopy reveals severe inflammatory changes in and around the ciliary body in patients with AAU. These signs rapidly resolve upon treatment. [source] Increased CD40 ligand in patients with acute anterior uveitisACTA OPHTHALMOLOGICA, Issue 3 2005Carsten Øgard Abstract. Purpose:,The inflammatory response in acute anterior uveitis (AU) is believed to be primarily mediated by autoreactive T-cells. We wanted to evaluate whether the T-cell activation marker CD40 ligand is involved in the AU immunopathogenesis. Methods:,We evaluated the expression of the CD40 ligand on CD4+ T-cells, CD8+ T-cells and CD19+ B-cells on peripheral blood mononuclear cells using flow cytometry in six patients with unilateral AU, six patients with monosymptomatic optic neuritis (ON) as inflammatory controls, and in six healthy controls. The ex vivo induction of the CD40 ligand on T-cells in patients and controls was also studied. Results:,A significantly higher expression of the CD40 ligand on both CD4+ (p < 0.05) and CD8+ (p < 0.05) T-cells in patients with AU compared to ON patients and healthy controls was found. There was a significantly higher induction of the CD40 ligand on CD8+ T-cells in AU patients compared to ON patients and healthy controls (p < 0.01). No differences in the B-cell population were observed between the three groups. Conclusion:,Patients with AU had increased expression of the CD40 ligand on T-cells in the blood and expressed higher levels of the CD40 ligand when stimulated, compared to ophthalmological inflammatory controls and healthy controls. The data suggest that the CD40 ligand is involved in the development of AU. [source] Q fever-associated HLAB27 anterior uveitisCLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 8 2008Lia Rossiter-Thornton BMedSci MBBS(Hons) No abstract is available for this article. [source] Acute anterior uveitis in primary careCLINICAL AND EXPERIMENTAL OPTOMETRY, Issue 2 2007Ian F Gutteridge MScOptom FAAO Acute anterior uveitis is an important ocular disease of considerable interest to therapeutically and non-therapeutically qualified optometrists. This review examines the role of optometrists in the primary care setting and gives guidelines for appropriate care of patients with anterior uveitis. Diagnosis and differentiation from other forms of anterior segment inflammation are the initial requirement. In parallel, possible medical conditions associated with acute anterior uveitis must be considered, with appropriate referral to medical practitioners. In uncomplicated cases of recurrent acute anterior uveitis, optometrists can initiate topical treatment and monitor resolution of inflammation, while being aware of possible complications of both the disease and its treatment. It is especially important in new attacks of anterior uveitis to liaise with the patient's general practitioner about medical investigation for underlying disease. Atypical, complicated or severe anterior uveitis should be promptly referred for specialist care. [source] | ||||||||||