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Anterior Ischaemic Optic Neuropathy (anterior + ischaemic_optic_neuropathy)

Distribution by Scientific Domains
Medical Sciences100%

Kinds of Anterior Ischaemic Optic Neuropathy

  • non-arteritic anterior ischaemic optic neuropathy
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    Selected Abstracts

    4121: Combined OCT retinal nerve fibre layer analysis and VEP in neuro-ophthalmic disease

    ACTA OPHTHALMOLOGICA, Issue 2010
    P GOOD
    Purpose Ocular Coherence Tomography (OCT) has become a valuable tool in assessing retinal nerve fibre layer thickness (RNFL) in Patients with optic nerve disease. This study is designed to compare RNFL thickness n with Visual Evoked Cortical Potentials (VECP)in patients with known optic nerve disease and comparing these to a group of patients with primary open angle glaucoma (POAG). Methods Twenty Patients (37 eyes) with clinically determined optic nerve disease underwent pattern reversal VECP and also OCT using a Spectralis OCT system. Assessment of global and segmental RNFL was made. Six Patients were diagnosed as Dominant Optic atrophy, 3 with Lebers Optic Neuropathy (LHON), 6 with Nutritional amblyopia, 3 with Anterior Ischaemic Optic Neuropathy (AION), and 2 with Demyelinating disease. These Patients were also compared to a group of 10 patients (20 eyes) with Primary Open Angle Glaucoma POAG. Results Pattern reversal VECP were abnormal in 32/37 eyes (86%): 26/32 (81%) of these being of reduced amplitude, and 20/32 (62%) being delayed. Amongst the patients with POAG only 4/20 eyes (20%) had abnormal VECP, and none were delayed. Thinning of the RNFL occurred in 36/37 eyes (97%) with optic nerve disease; 24 (65%) had global thinning, and the remainder segmental thinning only. All of the eyes with POAG had RNFL thinning but only 6/20 eyes (30%) had global thinning. Bipolar cell thinning of the central retina was noted in 6 eyes with optic nerve disease. Conclusion OCT is a valuable tool in the assessment of patients with optic nerve disease. Thinning of the RNFL was a more consistent finding than delay of the VECP in optic nerve disease, and a combination of VECP and OCT is helpful in the differential diagnosis of low tension glaucoma and optic nerve disease. [source]

    CASE REPORT: Clinical application of mfERG/VEP in assessing superior altitudinal hemifield loss

    CLINICAL AND EXPERIMENTAL OPTOMETRY, Issue 4 2005
    Dr Henry Ho-lung Chan PhD FAAO
    Multifocal ERG (mfERG) and multifocal VEP (mfVEP) have been used widely in the investigation of pathological changes or functional variations in the visual system. Altitudinal hemifield loss is a visual field defect that is usually found in patients with ischaemic optic neuropathy (ION). Anterior ischaemic optic neuropathy (AION) is a complex multi-factorial disease and it is difficult to diagnose according to clinical symptoms and signs alone. AION is believed to be caused by an infarction of the optic nerve due to the occlusion of the posterior ciliary arteries. The current report presents a patient diagnosed with non-arteritic AION. In this report, the mfERG findings did not match the results of the visual field test but those of the mfVEP did. After consideration of the visual electrophysiological and visual field results, the defect arises from neither the retina nor the visual pathway behind the optic chiasma. Hence, the optic nerve is the most likely location of the lesion, causing the superior altitudinal hemi-field loss. This report shows that the mfERG and mfVEP techniques can be used for objective visual field assessment to supplement the conventional visual field testing. [source]

    Current safety and tolerability issues in men with erectile dysfunction receiving PDE5 inhibitors

    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 9 2007
    W. J. G. Hellstrom
    Summary Aims:, Treatment of erectile dysfunction (ED) has been greatly advanced by the advent of phosphodiesterase type-5 (PDE5) inhibitors. Upon the introduction of these agents, their cardiovascular (CV) safety was a major concern, mainly due to their vasodilatory effects. We conducted an electronic literature review of data concerning the safety and tolerability issues of men with ED receiving PDE5 inhibitors. Results:, Although safety concerns have been raised, evaluation of CV safety and related adverse events in clinical trials has not revealed any atypical safety issues. Discussion:, No causal association has been established to date between non-arteritic anterior ischaemic optic neuropathy (NAION) and PDE5 inhibitors. In addition, there are established guidelines which provide recommendations for the safe and effective use of these agents in treating men with ED and associated comorbidities. Conclusions:, Clinical trial and postmarketing surveillance data confirm the safety and tolerability profile of the PDE5 inhibitors, even in patients with endothelial dysfunction-associated comorbidities. [source]

    Nonarteritic ischaemic optic neuropathy (NAION) after 36 h of intake of sildenafil citrate: first Egyptian case

    ANDROLOGIA, Issue 5 2009
    M. M. El-Domyati
    Summary Sildenafil citrate is a selective phosphodiesterase 5 (PDE-5) inhibitor and partial phosphodiesterase 6 inhibitor prescribed for erectile dysfunction. Post-marketing case reports of nonarteritic anterior ischaemic optic neuropathy (NAION) over the past few years suggest a potential link with PDE-5 inhibitors. We report a case of a 48-year-old male patient who had acute vision loss 36 h after the intake of 50 mg sildenafil citrate. NAION occurred at a period of minimal blood level of sildenafil citrate. So, erectile dysfunction drugs must be strongly considered with NAION even though their users may have neither predisposing nor precipitating factors for NAION and even if occurring at a time of minimal blood level of these drugs. [source]

    Reaction time during semi-automated kinetic perimetry (SKP) in patients with advanced visual field loss

    ACTA OPHTHALMOLOGICA, Issue 1 2010
    Katarzyna Nowomiejska
    Abstract. Purpose:, This study aimed to evaluate reaction time (RT) in patients with advanced visual field (VF) loss using semi-automated kinetic perimetry (SKP). Methods:, Seventy-eight patients with advanced VF loss caused by glaucoma (31) or retinitis pigmentosa (19), homonymous VF loss caused by post-chiasmal lesions (18) and unilateral anterior ischaemic optic neuropathy (AION) (10) were examined with SKP (Octopus 101 perimeter). One eye in each patient was enrolled. Additionally, VFs in the 10 healthy fellow eyes of the patients with AION were compared with those in the 10 affected eyes. Reaction time was assessed during the SKP session by presenting kinetic stimuli (III4e) with constant angular velocities of 3 °/second moving linearly along so-called ,RT vectors' at four different locations inside the III4e isoptre. Each stimulus presentation was repeated four times in randomized order. Results:, The geometric mean RT was 794 ms (95% reference interval [RI] 391,1615 ms) in patients with glaucoma, 702 ms (95% RI 306,1608 ms) in patients with retinitis pigmentosa and 675 ms (95% RI 312,1460 ms) in patients with hemianopia. Increases in RT for every 1 ° of eccentricity were 1%, 0.9% and 0.4%, respectively. The geometric mean RT in the 10 patients with unilateral optic neuropathy was 644 ms in affected eyes and 435 ms in unaffected eyes, reflecting an increase of 51% (95% confidence interval 42,62%). Conclusions:, We found substantial inter-subject variability in RT in patients with advanced VF loss. It is possible to correct the position of the isoptres by assessing individual RT. There were no relevant differences in RT between the disease groups. Reaction time increases with eccentricity. In monocular disease (AION), RT is prolonged, compared with in healthy fellow eyes. However, in clinical routine the RT-related displacement of isoptres is negligible in the vast majority of cases. [source]

    Frequency of non-arteritic anterior ischaemic optic neuropathy in crowded optic discs: the Beijing Eye Study

    ACTA OPHTHALMOLOGICA, Issue 3 2009
    Qi Sheng You
    No abstract is available for this article. [source]

    High-sensitivity C-reactive protein measurements in patients with non-arteritic anterior ischaemic optic neuropathy: a clue to the presence of a microinflammatory response

    ACTA OPHTHALMOLOGICA, Issue 2 2009
    Anat Kesler
    Abstract. Purpose:, To explore the possibility that individuals with non-arteritic anterior ischaemic optic neuropathy (NA-AION) harbour a heightened microinflammatory response compared to carefully matched controls. Methods:, Diagnosis and follow-up were performed by a senior neuro-ophthalmologist (A.K.). The inflammatory biomarkers included white blood cell count, Westergren erythrocyte sedimentation rate (ESR), quantitative fibrinogen as well as high-sensitivity C-reactive protein (hs-CRP). The values of the inflammatory biomarkers of four and five matched controls were compared to patients with NA-AION. Results:, We examined 33 NA-AION patients and 151 controls matched for age, gender, body mass index, oral temperature, smoking status and atherothrombotic risk factors. A significantly elevated concentration was noted for hs-CRP (P = 0.021): 3.3 mg/l for NA-AION patients and 2.1 mg/l for controls. Accelerated ESR (18.8 versus 13.5 mm/hr, P = 0.025) was noted in the NA-AION patients. Conclusion:, Following appropriate matching to apparently healthy controls, patients with NA-AION presented a microinflammatory response, revealed by the presence of increased hs-CRP concentrations and accelerated ESR. The finding, if confirmed in future studies, might shed more light on the eventual pathophysiological processes involved in the disease and pave the way for new therapeutic approaches. [source]

    Intravitreal triamcinolone acetonide injection for acute non-arteritic anterior ischaemic optic neuropathy,

    CLINICAL AND EXPERIMENTAL OPTOMETRY, Issue 6 2008
    Aylin Yaman
    Non-arteritic anterior ischaemic optic neuropathy is the most common optic neuropathy of the elderly, characterised by unilateral, sudden, painless visual loss. No effective treatment has been proven to reverse or limit the course of this disease. We evaluated the role of intravitreal triamcinolone acetonide injection in eyes with non-arteritic anterior ischaemic optic neuropathy (NAION). Four eyes of four patients with acute NAION received a single intravitreal injection of triamcinolone acetonide (4 mg). The time between visual loss and intravitreal injection varied between four and 10 days. Mean age of patients was 57.25 years (range, 44 to 77 years). All patients experienced some visual gain. No complications related to the injection were observed during the following three months. Intravitreal triamcinolone injection may offer help in limiting the damage in this small group of patients with a relatively short history of visual loss due to NAION. [source]