Least

Distribution by Scientific Domains
Distribution within Medical Sciences

Terms modified by Least

  • least 30 days
  • least amount
  • least common
  • least comparable
  • least effective
  • least equivalent
  • least fourfold
  • least half
  • least likely
  • least number
  • least one aspect
  • least one child
  • least one copy
  • least one day
  • least one dose
  • least one drug
  • least one episode
  • least one eye
  • least one gene
  • least one incident
  • least one marker
  • least one member
  • least one occasion
  • least one order
  • least one parent
  • least one prescription
  • least one risk factor
  • least one site
  • least one species
  • least one tooth
  • least one type
  • least one year
  • least part
  • least resistance
  • least sensitive
  • least square
  • least square analysis
  • least square approximation
  • least square estimator
  • least square method
  • least square procedure
  • least square regression
  • least stable
  • least threefold
  • least time
  • least two-thirds
  • least weekly

  • Selected Abstracts


    Long-Term Follow-Up After Autologous Fat Grafting: Analysis of Results from 116 Patients Followed at Least 12 Months After Receiving the Last of a Minimum of Two Treatments

    DERMATOLOGIC SURGERY, Issue 12 2000
    Sorin Eremia MD
    Background. The effectiveness of long-term results for correction of facial rhytides with single or multiple autologous fat transplants remains controversial. Objective. This study is a retrospective review of short- and long-term results for 116 patients who underwent multiple autologous fat grafting sessions into the nasolabial and melolabial (lateral oral commissure) fold, and in some cases additional sites such as lips and glabella. Methods. Criteria for inclusion into the study included at least two treatment sessions and at least a 12-month follow-up evaluation after the last treatment received. A 14-gauge needle cannula was used to aspirate the donor fat and to inject the fat grafts. Results. For the nasolabial and melolabial folds, short-term results at 3,4 months were uniformly excellent. Gradual correction loss was noted between 5 and 8 months, with 25% of patients still rated as excellent and 40% as good. Most patients continued to show correction loss between 9 and 14 months. Only 3,4% of the patients truly maintained long-term correction for more than 14 months. Multiple re-treatments did not significantly increase the percent of patients showing long-term results. For the glabella, the results were very disappointing, with most patients showing complete loss of correction after 3,4 months. For lip augmentation, correction loss was slower than in the glabella, but most patients showed complete loss of correction by 5,8 months. Complications were minimal. Conclusion. Autologous fat grafting is most effective for relatively short-term improvement of facial aging changes in the nasolabial and oral commissures areas. It is less effective for lip augmentation and completely ineffective for the glabella area. [source]


    Fatal Passenger Vehicle Crashes With At Least 1 Driver Younger Than 15 Years: A Fatality Analysis Reporting System Study

    THE JOURNAL OF RURAL HEALTH, Issue 2 2007
    Larry Frisch MD
    ABSTRACT:,Context: A small number of fatalities continue to occur due to motor vehicle crashes on highways in which at least 1 passenger vehicle (automobile, van, or small truck) is driven by a child younger than 15 years. Purpose: The purpose of this study was to extend previous work suggesting that such crashes occur frequently in the Southern states and have relatively high rates in rural areas in the South and Great Plains. Methods: This study utilizes data for the 5-year period 1999-2003 from the National Highway Transportation Safety Administration's online Fatality Analysis Reporting System. All cases were identified in which at least 1 conventional passenger vehicle in a fatal crash was being driven by a child younger than 15 years. Findings: During the 5-year period, 350 fatal crashes occurred with at least 1 driver younger than 15 years involved. Twenty-one of these drivers were licensed (11) or driving with a learner's permit (10). A total of 987 individuals in 419 vehicles were involved in these crashes, and 402 deaths resulted (1.16 deaths/crash). These crashes occurred primarily in Texas, Florida, Arkansas, and Arizona, but the highest rates per 100,000 children were found in North and South Dakota and predominantly in a band of Intermountain and Plains states. There was a strong correlation between crash rates and several measures of rurality. Conclusions: Crashes involving young, largely unlicensed, drivers account for about 70 deaths yearly. [source]


    Emergency Medicine Practitioner Knowledge and Use of Decision Rules for the Evaluation of Patients with Suspected Pulmonary Embolism: Variations by Practice Setting and Training Level

    ACADEMIC EMERGENCY MEDICINE, Issue 1 2007
    Michael S. Runyon MD
    Abstract Background Several clinical decision rules (CDRs) have been validated for pretest probability assessment of pulmonary embolism (PE), but the authors are unaware of any data quantifying and characterizing their use in emergency departments. Objectives To characterize clinicians' knowledge of and attitudes toward two commonly used CDRs for PE. Methods By using a modified Delphi approach, the authors developed a two-page paper survey including 15 multiple-choice questions. The questions were designed to determine the respondents' familiarity, frequency of use, and comprehension of the Canadian and Charlotte rules. The survey also queried the frequency of use of unstructured (gestalt) pretest probability assessment and reasons why physicians choose not to use decision rules. The surveys were sent to physicians, physician assistants, and medical students at 32 academic and community hospitals in the United States and the United Kingdom. Results Respondents included 555 clinicians; 443 (80%) work in academic practice, and 112 (20%) are community based. Significantly more academic practitioners (73%) than community practitioners (49%) indicated familiarity with at least one of the two decision rules. Among all respondents familiar with a rule, 50% reported using it in more than half of applicable cases. A significant number of these respondents could not correctly identify a key component of the rule (23% for the Charlotte rule and 43% for the Canadian rule). Fifty-seven percent of all respondents indicated use of gestalt rather than a decision rule in more than half of cases. Conclusions Academic clinicians were more likely to report familiarity with either of these two specific decision rules. Only one half of all clinicians reporting familiarity with the rules use them in more than 50% of applicable cases. Spontaneous recall of the specific elements of the rules was low to moderate. Future work should consider clinical gestalt in the evaluation of patients with possible PE. [source]


    Introduction of solids and formula to breastfed infants: a longitudinal prospective study in Uppsala, Sweden

    ACTA PAEDIATRICA, Issue 5 2001
    A Hörnell
    The introduction of solids and formula was studied among 506 breastfed infants in Uppsala, Sweden, based on daily recordings during the first year. The mothers had previously breastfed at least 1 infant for at least 4 mo. Thirty-four per cent of the infants were introduced to solids before the age of 4 mo (4,6 mo is recommended in Sweden). Accustoming the infants to solids was a lengthy process. Life-table analyses showed a median duration of 28 d from the first introduction of solids to consumption of >10 ml daily, and 46 d before the infants ate 100 ml of solids in 1 d for the first time. These durations were longer the younger the infant was at the introduction of solids. Thirty-two per cent of infants given formula consumed 100 ml the first time it was given, and 49% did so within 1 wk, regardless of infant age. Conclusion: Parents and healthcare personnel need to be aware that accustoming breastfed infants to solid food is a lengthy process, and that there is a strong age effect on this duration. It is also important to consider what consequences the (usually) more abrupt introduction of formula might have on breastfeeding. [source]


    Early motor development of premature infants with birthweight less than 2000 grams

    ACTA PAEDIATRICA, Issue 12 2000
    SJ Pedersen
    The aim was to assess motor function during infancy in order to predict later function, mainly cerebral palsy. The neuromotor development of a population-based cohort of 209 of 236 (89%) survivors with a birthweight less than 2000 g was assessed using the Infant Neurological International Battery (INFANIB) and detailed neurological assessment. The infants were classified as being normal, dystonic, hypotonic or having suspected cerebral palsy (CP) at 4, 7, 13 and 18 mo corrected age if birthweight was less than 1500 g (n= 119) and at 7 and 13 mo if birthweight was 1500,1999 g (n= 90). Those with dystonia or suspected CP were followed until diagnosed as normal or as having CP after at least 36 mo of age. Fourteen (7%) finally developed CP. Motor function at 4 mo was inaccurate in predicting function at 7 mo and later. All who were normal at 7 mo remained normal in the follow-up period. Eight of 65 who were dystonic at 7 mo developed suspected CP, and three judged as suspected CP were eventually normal. The 14 who developed CP were judged as suspected CP (n= 5) or dystonic (n= 8) and one as hypotonic at 7 mo of age. Conclusions: The specificity of motor evaluation at 7 mo corrected age regarding CP is unsatisfactory, since dystonia at this age is most often transient. A normal neuromotor assessment at 7 mo is highly predictive of subsequent normal motor function. [source]


    Texture Synthesis using Exact Neighborhood Matching

    COMPUTER GRAPHICS FORUM, Issue 2 2007
    M. Sabha
    Abstract In this paper we present an elegant pixel-based texture synthesis technique that is able to generate visually pleasing results from source textures of both stochastic and structured nature. Inspired by the observation that the most common artifacts that occur when synthesizing textures are high-frequency discontinuities, our technique tries to avoid these artifacts by forcing at least one of the direct neighboring pixels in each causal neighborhood to match within a predetermined threshold. This does not only avoid deterioration of the visual quality, but also results in faster synthesis timings. We demonstrate our technique on a variety of stochastic and structured textures. [source]


    Recurrence of kernicterus in term and near-term infants in Denmark

    ACTA PAEDIATRICA, Issue 10 2000
    F Ebbesen
    Classical acute bilirubin encephalopathy (kernicterus) in term and near-term infants had not been seen in Denmark for at least 20 y until 1994. From 1994 to 1998, however, six cases were diagnosed. Aetiology of the hyperbilirubinaemia was known in two infants; spherocytosis and galactosaemia, most likely known in two infants; possible A-O blood type immunization, and unknown in two infants. However, one of these last-mentioned infants had a gestational age of only 36 wk. The maximum plasma total bilirubin concentrations were 531,745 ,mol/L. The increase in the number of cases of kernicterus was considered to have been caused by: (i) a decreased awareness of the pathological signs, (ii) a change in the assessment of the risk of bilirubin encephalopathy, (iii) early discharge of the infants from the maternity ward, (iv) so-called breastfeeding-associated jaundice, (v) demonstration of bilirubin being an antioxidant, and (vi) difficulty in estimating the degree of jaundice in certain groups of immigrants. Accordingly, for prevention: (a) Attempt to change the healthcare workers' understanding of the risk of bilirubin encephalopathy, (b) give further instructions, both orally and in writing, to mothers before discharge from the maternity ward, (c) be more liberal in giving infant formula supplements, (d) conduct home visits by the community nurse at an earlier stage, (e) follow authorized guidelines for phototherapy and exchange transfusion, (f) lower plasma bilirubin concentration limits as an indication for phototherapy and exchange transfusion, (g) screen all term and near-term infants, and (h) measure the skin's yellow colour with a device that corrects for the skin's melanin content. Conclusions: Audit of the six cases presented indicates that measures are necessary in both the primary and secondary healthcare sectors if the risk of kernicterus is to be avoided. Screening may be considered, but in order to identify the problems it would first be reasonable to perform a larger prospective study in which audit is performed on all newborn infants, born at term and near-term, who develop a plasma bilirubin concentration above the exchange transfusion limit. [source]


    Social Infrastructure Planning: A Location Model and Solution Methods

    COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 8 2007
    João F. Bigotte
    Authorities want to determine where to locate the facilities of a social infrastructure network and what should be the capacity of these facilities. Each user must be assigned to its closest facility and, to be economically viable, each facility must serve at least a pre-specified level of demand. The objective is to maximize the accessibility to facilities (i.e., to minimize the distance traveled by users to reach the facilities). A location model that captures the above features is formulated and different solution methods are tested. Among the methods tested, tabu search and a specialized local search heuristic provided the best solutions. The application of the model is illustrated through a case study involving the location of preschools in the municipality of Miranda do Corvo, Portugal. [source]


    Deterministic parallel selection algorithms on coarse-grained multicomputers

    CONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 18 2009
    M. Cafaro
    Abstract We present two deterministic parallel Selection algorithms for distributed memory machines, under the coarse-grained multicomputer model. Both are based on the use of two weighted 3-medians, that allows discarding at least 1/3 of the elements in each iteration. The first algorithm slightly improves the current experimentally fastest algorithm by Saukas and Song where at least 1/4 of the elements are discarded in each iteration, while the second one is a fast, special purpose algorithm working for a particular class of input, namely an input that can be sorted in linear time using RadixSort. Copyright © 2009 John Wiley & Sons, Ltd. [source]


    A test suite for parallel performance analysis tools

    CONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 11 2007
    Michael Gerndt
    Abstract Parallel performance analysis tools must be tested as to whether they perform their task correctly, which comprises at least three aspects. First, it must be ensured that the tools neither alter the semantics nor distort the run-time behavior of the application under investigation. Next, it must be verified that the tools collect the correct performance data as required by their specification. Finally, it must be checked that the tools perform their intended tasks and detect relevant performance problems. Focusing on the latter (correctness) aspect, testing can be done using synthetic test functions with controllable performance properties, possibly complemented by real-world applications with known performance behavior. A systematic test suite can be built from synthetic test functions and other components, possibly with the help of tools to assist the user in putting the pieces together into executable test programs. Clearly, such a test suite can be highly useful to builders of performance analysis tools. It is surprising that, up until now, no systematic effort has been undertaken to provide such a suite. In this paper we describe the APART Test Suite (ATS) for checking the correctness (in the above sense) of parallel performance analysis tools. In particular, we describe a collection of synthetic test functions which allows one to easily construct both simple and more complex test programs with desired performance properties. We briefly report on experience with MPI and OpenMP performance tools when applied to the test cases generated by ATS. Copyright © 2006 John Wiley & Sons, Ltd. [source]


    A set-oriented method definition language for object databases and its semantics

    CONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 14 2003
    Elisa Bertino
    Abstract In this paper we propose a set-oriented rule-based method definition language for object-oriented databases. Most existing object-oriented database systems exploit a general-purpose imperative object-oriented programming language as the method definition language. Because methods are written in a general-purpose imperative language, it is difficult to analyze their properties and to optimize them. Optimization is important when dealing with a large amount of objects as in databases. We therefore believe that the use of an ad hoc, set-oriented language can offer some advantages, at least at the specification level. In particular, such a language can offer an appropriate framework to reason about method properties. In this paper, besides defining a set-oriented rule-based language for method definition, we formally define its semantics, addressing the problems of inconsistency and non-determinism in set-oriented updates. Moreover, we characterize some relevant properties of methods, such as conflicts among method specifications in sibling classes and behavioral refinement in subclasses. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    The use of intuition in mediation

    CONFLICT RESOLUTION QUARTERLY, Issue 2 2007
    Greg Rooney
    How mediators make decisions about what to do in the mediation session is one of the least understood, but most important, issues in the study of mediation. This article explores a number of different approaches, including the use of intuition. It examines the effectiveness of developing premediation strategies and hypotheses and their impact on the mediator's ability to engage with the parties in the here-and-now of the mediation session. [source]


    Differential age-related changes in motor unit properties between elbow flexors and extensors

    ACTA PHYSIOLOGICA, Issue 1 2010
    B. H. Dalton
    Abstract Aim:, Healthy adult ageing of the human neuromuscular system is comprised of changes that include atrophy, weakness and slowed movements with reduced spinal motor neurone output expressed by lower motor unit discharge rates (MUDRs). The latter observation has been obtained mostly from hand and lower limb muscles. The purpose was to determine the extent to which elbow flexor and extensor contractile properties, and MUDRs in six old (83 ± 4 years) and six young (24 ± 1 years) men were affected by age, and whether any adaptations were similar for both muscle groups. Methods:, Maximal isometric voluntary contraction (MVC), voluntary activation, twitch contractile properties, force,frequency relationship and MUDRs from sub-maximal to maximal intensities were assessed in the elbow flexors and extensors. Results:, Both flexor and extensor MVCs were significantly (P < 0.05) less (,42% and ,46% respectively) in the old than in the young. Contractile speeds and the force,frequency relationship did not show any age-related differences (P > 0.05). For the elbow flexors contraction duration was ,139 ms and for the extensors it was ,127 ms for both age groups (P > 0.05). The mean MUDRs from 25% MVC to maximum were lower (,10% to ,36%) in the old than in the young (P < 0.01). These age-related differences were larger for biceps (Cohen's d = 8.25) than triceps (Cohen's d = 4.79) brachii. Conclusion:, Thus, at least for proximal upper limb muscles, mean maximal MUDR reductions with healthy adult ageing are muscle specific and not strongly related to contractile speed. [source]


    Acute Adaptation to Volume Unloading of the Functional Single Ventricle in Children Undergoing Bidirectional Glenn Anastomosis

    CONGENITAL HEART DISEASE, Issue 2 2009
    Catherine Ikemba MD
    ABSTRACT Objective., Volume unloading of the functional single ventricle after a bidirectional Glenn anastomosis (BDG) prior to 1 year of age leads to improved global ventricular function as measured by the myocardial performance index (MPI), a Doppler-derived measurement of combined systolic and diastolic ventricular function. Systolic function remains unchanged after BDG according to previous studies; however, acute changes in global and diastolic function have not been previously investigated in this cohort. Our objective was to assess the short-term effects of the BDG on global ventricular function in patients with a functional single ventricle. Design., Echocardiograms to obtain MPI, isovolumic contraction time, and isovolumic relaxation time were performed at four time periods: in the operating room, in the operating room prior to BDG, shortly after separation from cardiopulmonary bypass, less than 24 hours postoperatively, and either prior to hospital discharge or at the first clinic follow-up visit. Results., Twenty-six patients were enrolled. There was significant ventricular dysfunction noted shortly after separation from cardiopulmonary bypass, median MPI 0.63 (0.39,0.81), that persisted in the short term postoperatively median MPI 0.50 (0.40,0.63). Isovolumic contraction time did not change, however, isovolumic relaxation time was significantly prolonged following BDG. Conclusion., In the postoperative patient after BDG, systolic function is preserved; however, there is evidence of diastolic and global ventricular dysfunction, at least in the short term. [source]


    Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium

    ACTA PHYSIOLOGICA, Issue 4 2010
    O. J. Kemi
    Abstract One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training. Improved maximal oxygen uptake in turn is at least partly achieved because exercise training increases the ability of the myocardium to produce a greater cardiac output. In healthy subjects, this has been demonstrated repeatedly over many decades. It has recently emerged that this scenario may also be true under conditions of an initial myocardial dysfunction. For instance, myocardial improvements may still be observed after exercise training in post-myocardial infarction heart failure. In both health and disease, it is the changes that occur in the individual cardiomyocytes with respect to their ability to contract that by and large drive the exercise training-induced adaptation to the heart. Here, we review the evidence and the mechanisms by which exercise training induces beneficial changes in the mammalian myocardium, as obtained by means of experimental and clinical studies, and argue that these changes ultimately alter the function of the whole heart and contribute to the changes in whole-body function. [source]


    A Risk Adjusted Method for Comparing Adverse Outcomes among Practitioners in Pediatric and Congenital Cardiac Catheterization

    CONGENITAL HEART DISEASE, Issue 4 2008
    Lisa Bergersen MD
    ABSTRACT Objective., We sought to develop a method to adjust for case mix diversity and allow comparison of adverse outcome rates among practitioners in pediatric and congenital cardiac catheterization. Patients and Methods., A single institutional database that captured demographic and procedural data was used to identify patient and procedural characteristics associated with adverse events (AE) and any high severity event classified as preventable or possibly preventable (P/PP). Diagnostic and procedural risk groups were created and indicators of hemodynamic vulnerability were defined. Expected event rates by the practitioners adjusting for case mix were calculated. Standardized adverse event ratios (SAER), defined as the observed rate divided by the expected rate for each practitioner were calculated with 95% confidence intervals. Results., The database included 1727 hemodynamic (30%) and interventional (70%) cases performed by seven practitioners in 18 months. During 147 cases, at least one P/PP AE occurred; among the seven practitioners observed, event rates ranged from 3.2 to 14.2%. In multivariable analysis, risk factors for all P/PP events included highest procedure risk group (odds ratio [OR] 2.1 for group 2, and 2.8 for group 3, relative to group 1, P = .001 and P < .001, respectively) and weight less than 4 kg (OR 2.8, P < .001). High severity P/PP events occurred in 67 cases with rates ranging from 2.0 to 6.6% by the practitioners. For these events, risk factors included: highest procedure risk group (OR 4.5 for group 2, and 4.9 for group 3, both P < .001) and an indicator of hemodynamic vulnerability (OR 1.8, P = .026). For the seven practitioners, the SAER ranged from 0.41 to 1.32 for any P/PP AE and from 0.69 to 1.44 for P/PP high severity events. In this cohort, we did not identify any statistically significant performance differences. Conclusion., Despite wide variations in case mix complexity in pediatric and congenital cardiac catheterization, this study demonstrates a method for risk adjustment which allows equitable comparisons among practitioners at a single institution. [source]


    Lactate kinetics in human tissues at rest and during exercise

    ACTA PHYSIOLOGICA, Issue 4 2010
    Gerrit Van Hall
    Abstract Lactate production in skeletal muscle has now been studied for nearly two centuries and still its production and functional role at rest and during exercise is much debated. In the early days skeletal muscle was mainly seen as the site of lactate production during contraction and lactate production associated with a lack of muscle oxygenation and fatigue. Later it was recognized that skeletal muscle not only played an important role in lactate production but also in lactate clearance and this led to a renewed interest, not the least from the Copenhagen School in the 1930s, in the metabolic role of lactate in skeletal muscle. With the introduction of lactate isotopes muscle lactate kinetics and oxidation could be studied and a simultaneous lactate uptake and release was observed, not only in muscle but also in other tissues. Therefore, this review will discuss in vivo human: (1) skeletal muscle lactate metabolism at rest and during exercise and suggestions are put forward to explain the simultaneous lactate uptake and release; and (2) lactate metabolism in the heart, liver, kidneys, brain, adipose tissue and lungs will be discussed and its potential importance in these tissues. [source]


    Extended Mechanical Circulatory Support With a Continuous-Flow Rotary Left Ventricular Assist Device

    CONGESTIVE HEART FAILURE, Issue 2 2010
    Scott Harris DO
    Background LVAD therapy is an established treatment modality for patients with advanced heart failure. Pulsatile LVADs have limitations in design precluding their use for extended support. Continuous-flow rotary LVADs represent an innovative design with potential for small size and greater reliability by simplification of the pumping mechanism. Methods In a prospective multicenter study, 281 patients urgently listed (United Network for Organ Sharing status 1A or 1B) for heart transplant underwent implant of a continuous-flow LVAD. Survival and transplant rates were assessed at 18 months. Patients were assessed for adverse events throughout the study and for quality of life, functional status, and organ function for 6 months. Results Of 281 patients, 222 (79%) underwent transplant or LVAD removal for cardiac recovery or had ongoing LVAD support at 18-month follow-up. Actuarial survival on support was 72% (95% confidence interval, 65%,79%) at 18 months. At 6 months, there were significant improvements in functional status and 6-minute walk test results (from 0% to 83% of patients in New York Heart Association functional class I or II and from 13% to 89% of patients completing a 6-minute walk test) and in quality of life (mean values improved 41% with Minnesota Living With Heart Failure and 75% with Kansas City Cardiomyopathy questionnaires). Major adverse events included bleeding, stroke, right heart failure, and percutaneous lead infection. Pump thrombosis occurred in 4 patients. Conclusions A continuous-flow LVAD provides effective hemodynamic support for at least 18 months in patients awaiting transplant, with improved functional status and quality of life. [source]


    Validation and Clinical Utility of a Simple In-Home Testing Tool for Sleep-Disordered Breathing and Arrhythmias in Heart Failure: Results of the Sleep Events, Arrhythmias, and Respiratory Analysis in Congestive Heart Failure (SEARCH) Study

    CONGESTIVE HEART FAILURE, Issue 5 2006
    William T. Abraham MD
    Fifty patients with New York Heart Association class III systolic heart failure were enrolled in this prospective multicenter study that compared the diagnostic accuracy of a home-based cardiorespiratory testing system with standard attended polysomnography. Patients underwent at least 2 nights of evaluation and were scored by blinded observers. At diagnostic cutoff points of ,5, ,10, and ,15 events per hour for respiratory disturbance severity, polysomnography demonstrated a sleep-disordered breathing prevalence of 69%, 59%, and 49%, respectively. Compared with polysomnography, the cardiorespiratory testing system demonstrated predictive accuracies of 73%, 73%, and 75%, which improved to 87%, 87%, and 83%, respectively, when analysis of covariance suggested reanalysis omitting one site's data. The system accurately identified both suspected and unsuspected arrhythmias. The device was judged by 80% of patients to be easy or very easy to use, and 74% of patients expressed a preference for the in-home system. Therefore, this system represents a reasonable home testing device in these patients. [source]


    Heart Failure and Diabetes: Collateral Benefit of Chronic Disease Management

    CONGESTIVE HEART FAILURE, Issue 3 2006
    Molly G. Ware MD
    To test the hypothesis that a focus on heart failure (HF) care may be associated with inadequate diabetes care, the authors screened 78 patients (aged 64±11 years; 69% male) with diabetes enrolled in an HF disease management program for diabetes care as recommended by the American Diabetes Association (ADA). Ninety-five percent of patients had hemoglobin A1c levels measured within 12 months, and 71% monitored their glucose at least once daily. Most patients received counseling regarding diabetic diet and exercise, and approximately 80% reported receiving regular eye and foot examinations. Mean hemoglobin A1c level was 7.8±1.9%. There was no relationship between hemoglobin A1c levels and New York Heart Association class or history of HF hospitalizations. Contrary to the authors' hypothesis, patients in an HF disease management program demonstrated levels of diabetic care close to ADA goals. "Collateral benefit" of HF disease management may contribute to improved patient outcomes in diabetic patients with HF. [source]


    Preventing the Spread of Invasive Species: Economic Benefits of Intervention Guided by Ecological Predictions

    CONSERVATION BIOLOGY, Issue 1 2008
    REUBEN P. KELLER
    bioeconomía; economía de las invasiones; invasiones biológicas; Orconectes rusticus; predicciones ecológicas Abstract:,Preventing the invasion of freshwater aquatic species is the surest way to reduce their impacts, but it is also often expensive. Hence, the most efficient prevention programs will rely on accurate predictions of sites most at risk of becoming invaded and concentrate resources at those sites. Using data from Vilas County, Wisconsin (U.S.A.), collected in the 1970s, we constructed a predictive occurrence model for rusty crayfish (Orconectes rusticus) and applied it to an independent data set of 48 Vilas County lakes to predict which of these were most likely to become invaded between 1975 and 2005. We nested this invasion model within an economic framework to determine whether targeted management, derived from our quantitative predictions of likely invasion sites, would increase the economic value of lakes in the independent data set. Although the optimum expenditure on lake protection was high, protecting lakes at this level would have produced net economic benefits of at least $6 million over the last 30 years. We did not attempt to determine the value of nonmarket benefits of protection; thus, our results are likely to underestimate the total benefits from preventing invasions. Our results demonstrate that although few data are available early in an invasion, these data may be sufficient to support targeted, effective, and economically rational management. In addition, our results show that ecological predictions are becoming sufficiently accurate that their application in management can produce net economic benefits. Resumen:,La prevención de la invasión de especies dulceacuícolas es la manera más segura de reducir sus impactos, pero a menudo es costosa. Por lo tanto, los programas de prevención más eficientes dependerán de predicciones precisas de los sitios con mayor riesgo de ser invadidos y concentrarán recursos en esos sitios. Utilizando datos recolectados en los 70s en el Condado Vilas, Wisconsin (E.U.A.), desarrollamos un modelo predictivo de la ocurrencia de Orconectes rusticus y lo aplicamos en un conjunto de datos independientes de 48 lagos en el Condado de Vilas para predecir cuales fueron más susceptibles de ser invadidos entre 1975 y 2005. Anidamos este modelo de invasión en un marco económico para determinar si los objetivos de manejo, derivados de nuestras predicciones cuantitativas de sitios susceptibles a la invasión, incrementarían el valor económico de los lagos del conjunto independiente de datos. Aunque el gasto óptimo para la protección de lagos fue alto, la protección de lagos a este nivel podría haber producido beneficios económicos por un mínimo de $6 millones en los últimos 30 años. No intentamos determinar el valor de los beneficios no comerciables de la protección; por lo tanto, es probable que nuestros resultados subestimen los beneficios totales de la prevención de invasiones. Nuestros resultados demuestran que, aunque se disponga de pocos datos del inicio de una invasión, esos datos pueden ser suficientes para fundamentar acciones de manejo efectivas y económicamente racionales. Adicionalmente, nuestros resultados muestran que las predicciones ecológicas se están volviendo tan precisas que su aplicación en el manejo puede producir beneficios económicos netos. [source]


    Responses of Tuatara (Sphenodon punctatus) to Removal of Introduced Pacific Rats from Islands

    CONSERVATION BIOLOGY, Issue 4 2007
    DAVID R. TOWNS
    erradicación de rata del Pacífico; especie invasora; índice de condición corporal; tuatara Abstract:,Invasive mammalian predators such as rats are now widespread on islands, but hypotheses about their effects have rarely been tested. Circumstantial evidence from New Zealand indicates that, when introduced to islands, Pacific rats (Rattus exulans) have negative effects on endemic plants, invertebrates, birds, and reptiles, including the tuatara (Sphenodon punctatus). We tested the effects of Pacific rats on tuatara by comparing the demographic structure and body condition of tuatara populations on three islands before and after removal of rats and on a fourth island where rats remained. In the presence of rats, juvenile tuatara constituted on average 0,5% of the sample tuatara populations. When Pacific rats were removed after at least 200 years' occupancy, the proportion of juvenile tuatara increased 3.5- to 17-fold and body condition of adult males and females also improved (sometimes dramatically). We predict that, unless Pacific rats are removed from Taranga Island, the tuatara population will collapse because of low population density and the lack of juvenile recruitment. Our results demonstrate that when invasive species exert subtle effects on recruitment and body condition, the effects on populations of long-lived endemic species may only become apparent long after the invasion. Resumen:,Actualmente, los depredadores mamíferos invasores, como las ratas, están ampliamente extendidos en islas, pero las hipótesis sobre sus efectos han sido probadas pocas veces. Evidencia circunstancial de Nueva Zelanda indica que, cuando son introducidas a islas, las ratas del Pacífico (Rattus exulans) tienen un efecto negativo sobre plantas, invertebrados, aves y reptiles endémicos, incluyendo el tuatara (Sphenodon punctatus). Probamos los efectos de ratas del Pacífico sobre tuatara mediante la comparación de la estructura demográfica y la condición corporal de poblaciones de tuatara en tres islas antes y después de la remoción de ratas y en una cuarta isla donde permanecían las ratas. En la presencia de ratas, tuatara juveniles constituían, en promedio, 0,5% de las poblaciones de tuatara. Cuando las ratas eran removidas después de por lo menos 200 años de ocupación, la proporción de tuatara juveniles incremento entre 3.5 y 17 veces y la condición corporal de los machos y hembras adultas también mejoró (algunas veces dramáticamente). Pronosticamos que, a menos que las ratas del Pacífico sean removidas de la Isla Taranga, las poblaciones de tuatara se colapsarán debido a una densidad poblacional baja y por la ausencia de reclutamiento de juveniles. Nuestros resultados demuestran que cuando las especies invasoras ejercen efectos sutiles sobre el reclutamiento y la condición corporal, los efectos sobre las poblaciones de especies endémicas longevas se vuelven aparentes mucho tiempo después de la invasión. [source]


    The Contribution of Long-Term Research at Gombe National Park to Chimpanzee Conservation

    CONSERVATION BIOLOGY, Issue 3 2007
    ANNE E. PUSEY
    chimpancé; conservación de simios mayores; Parque Nacional Gombe; Tanzania Abstract:,Long-term research projects can provide important conservation benefits, not only through research specifically focused on conservation problems, but also from various incidental benefits, such as increased intensity of monitoring and building support for the protection of an area. At Gombe National Park, Tanzania, long-term research has provided at least four distinct benefits to wildlife conservation. (1) Jane Goodall's groundbreaking discoveries of chimpanzee (Pan troglodytes) tool use, hunting, and complex social relationships in what was then a game reserve drew attention to the area and created support for upgrading Gombe to national park status in 1968. (2) The highly publicized findings have earned Gombe and Tanzania the attention of a worldwide public that includes tourists and donors that provide financial support for Gombe, other parks in Tanzania, and chimpanzee conservation in general. (3) Crucial information on social structure and habitat use has been gathered that is essential for effective conservation of chimpanzees at Gombe and elsewhere. (4) A clear picture of Gombe's chimpanzee population over the past 40 years has been determined, and this has helped identify the greatest threats to the viability of this population, namely disease and habita loss outside the park. These threats are severe and because of the small size of the population it is extremely vulnerable. Research at Gombe has led to the establishment of conservation education and development projects around Gombe, which are needed to build local support for the park and its chimpanzees, but saving these famous chimpanzees will take a larger integrated effort on the part of park managers, researchers, and the local community with financial help from international donors. Resumen:,Los proyectos de investigación de largo plazo pueden proporcionar beneficios importantes a la conservación, no solo a través de investigación enfocada específicamente a problemas de conservación, sino también a través de varios beneficios incidentales, como una mayor intensidad de monitoreo y construcción de soporte para la protección de un área. En el Parque Nacional Gombe, Tanzania, la investigación a largo plazo ha proporcionado por lo menos cuatro beneficios a la conservación de vida silvestre. (1) Los descubrimientos innovadores de Jane Goodall sobre el uso de herramientas, la cacería y las complejas relaciones sociales de chimpancés en lo que entonces era una reserva de caza atrajeron la atención al área y crearon el soporte para cambiar a Gombe a estatus de parque nacional en 1968. (2) Los hallazgos muy publicitados han ganado para Gombe y Tanzania la atención del público en todo el mundo incluyendo turistas y donadores que proporcionan soporte financiero a Gombe, otros parques en Tanzania y a la conservación de chimpancés en general. (3) Se ha reunido información crucial sobre la estructura social y el uso del hábitat que ha sido esencial para la conservación efectiva de chimpancés en Gombe y otros sitios. (4) Se ha determinado un panorama claro de la población de chimpancés en Gombe durante los últimos 40 años, y esto a ayudado a identificar las mayores amenazas a la viabilidad de esta población, a saber enfermedades y pérdida de hábitat fuera del parque. Estas amenazas son severas y la población es extremadamente vulnerable por su tamaño pequeño. La investigación en Gombe ha llevado al establecimiento de proyectos de desarrollo y de educación para la conservación en los alrededores del parque, lo cual es necesario para encontrar soporte local para el parque y sus chimpancés, pero el rescate de estos famosos chimpancés requerirá de un esfuerzo más integrado de parte de los manejadores del parque, investigadores y la comunidad local con la ayuda financiera de donadores internacionales. [source]


    Categorizing Urgency of Infant Emergency Department Visits: Agreement between Criteria

    ACADEMIC EMERGENCY MEDICINE, Issue 12 2006
    Rakesh D. Mistry MD
    Abstract Background The lack of valid classification methods for emergency department (ED) visit urgency has resulted in large variation in reported rates of nonurgent ED utilization. Objectives To compare four methods of defining ED visit urgency with the criterion standard, implicit criteria, for infant ED visits. Methods This was a secondary data analysis of a prospective birth cohort of Medicaid-enrolled infants who made at least one ED visit in the first six months of life. Complete ED visit data were reviewed to assess urgency via implicit criteria. The explicit criteria (adherence to prespecified criteria via complete ED charts), ED triage, diagnosis, and resources methods were also used to categorize visit urgency. Concordance and agreement (,) between the implicit criteria and alternative methods were measured. Results A total of 1,213 ED visits were assessed. Mean age was 2.8 (SD ± 1.78) months, and the most common diagnosis was upper respiratory infection (21.0%). Using implicit criteria, 52.3% of ED visits were deemed urgent. Urgent visits using other methods were as follows: explicit criteria, 51.8%; ED triage, 60.6%; diagnosis, 70.3%; and resources, 52.7%. Explicit criteria had the highest concordance (78.3%) and agreement (,= 0.57) with implicit criteria. Of limited data methods, resources demonstrated the best concordance (78.1%) and agreement (,= 0.56), while ED triage (67.9%) and diagnosis (71.6%) exhibited lower concordance and agreement (,= 0.35 and ,= 0.42, respectively). Explicit criteria and resources equally misclassified urgency for 11.1% of visits; ED triage and diagnosis tended to overclassify visits as urgent. Conclusions The explicit criteria and resources methods best approximate implicit criteria in classifying ED visit urgency in infants younger than six months of age. If confirmed in further studies, resources utilized has the potential to be an inexpensive, easily applicable method for urgency classification of infant ED visits when limited data are available. [source]


    A Review of Feral Cat Eradication on Islands

    CONSERVATION BIOLOGY, Issue 2 2004
    MANUEL NOGALES
    efecto de depredación; erradicación; Felis catus; gato asilvestrado; islas Abstract:,Feral cats are directly responsible for a large percentage of global extinctions, particularly on islands. We reviewed feral cat eradication programs with the intent of providing information for future island conservation actions. Most insular cat introductions date from the nineteenth and twentieth centuries, whereas successful eradication programs have been carried out in the last 30 years, most in the last decade. Globally, feral cats have been removed from at least 48 islands: 16 in Baja California (Mexico), 10 in New Zealand, 5 in Australia, 4 in the Pacific Ocean, 4 in Seychelles, 3 in the sub-Antarctic, 3 in Macaronesia (Atlantic Ocean), 2 in Mauritius, and 1 in the Caribbean. The majority of these islands (75%; n= 36) are small (,5 km2). The largest successful eradication campaign took place on Marion Island (290 km2), but cats have been successfully removed from only 10 islands (21%) of ,10 km2. On Cousine Island (Seychelles) cat density reached 243 cats/km2, but on most islands densities did not exceed 79.2 cats/km2 (n= 22; 81%). The most common methods in successful eradication programs were trapping and hunting (often with dogs; 91% from a total of 43 islands). Frequently, these methods were used together. Other methods included poisoning (1080; monofluoracetate in fish baits; n= 13; 31%), secondary poisoning from poisoned rats (n= 4; 10%), and introduction of viral disease (feline panleucopaenia; n= 2; 5%). Impacts from cat predation and, more recently, the benefits of cat eradications have been increasingly documented. These impacts and benefits, combined with the continued success of eradication campaigns on larger islands, show the value and role of feral cat eradications in biodiversity conservation. However, new and more efficient techniques used in combination with current techniques will likely be needed for success on larger islands. Resumen:,Los gatos asilvestrados han sido responsables directos de un gran número de extinciones, particularmente en islas. En este estudio, se revisan los programas de erradicación de este felino con el fin de ofrecer información de utilidad en futuras acciones de conservación en islas. La mayor parte de las introducciones datan de los siglos diecinueve y veinte, mientras que las erradicaciones han sido realizadas básicamente durante los últimos 30 años, y sobre todo en la última década. Los gatos asilvestrados han sido erradicados de al menos 48 islas: 16 de ellas en Baja California (México), 10 en Nueva Zelanda, 5 en Australia, 4 en el Océano Pacífico, 4 en Seychelles, 3 en la Región Subantártica, 3 en Macaronesia (Océano Atlántico), 2 en Mauricio, y una en el Caribe. La mayoría de éstas (75%; n= 36) son de reducidas dimensiones (,5 km2), mientras que la más extensa es Marion Island (290 km2). En tan sólo 10 islas (21%) , 10 km2 se ha podido erradicar este depredador. En Cousine Island (Seychelles) la densidad de gatos alcanzó 243 individuos/km2; sin embargo, en la mayoría de las islas, las densidades no excedieron los 79,2 individuos/km2 (n= 22; 81%). Los métodos más comúnmente empleados fueron el trampeo y la caza, a menudo con perros (91% de un total de 43 islas). Con frecuencia dichas prácticas fueron empleadas conjuntamente. Otros métodos incluyeron venenos (1080, monofluoracetato de sodio en cebos de pescado: n= 13; 31%), envenenamiento secundario con ratas envenenadas (n= 4; 10%) y el virus de la leucemia felina (n= 2; 5%). La información sobre el efecto negativo de los gatos en islas y, más recientemente, el beneficio de su erradicación, se ha ido dando a conocer paulatinamente, poniendo de manifiesto su importancia en la conservación de la biodiversidad insular. No obstante, la combinación de técnicas nuevas y más eficientes junto con las habituales, será necesaria para el éxito de la erradicación de los gatos en islas de grandes dimensiones. [source]


    Studying Biodiversity on Private Lands

    CONSERVATION BIOLOGY, Issue 1 2003
    Jodi Hilty
    Private lands harbor a great amount of biodiversity, including at least some habitat for 95% of the federally listed species in the United States. It is important to conduct conservation biology research on private lands, but our review of the literature indicates that few conservation-oriented field studies are conducted on private property. Based on our success in obtaining permission to conduct research on 43 land parcels in Sonoma County, California, we developed methods to enhance a conservation biologist's chance of obtaining permission to work on private lands. We provide guidelines for researchers to conduct studies successfully on private land with the goal of improving access, data collection, and relationships with private landowners. We also discuss constraints researchers face, such as designing studies appropriate for working on privately owned parcels. In light of the importance of these lands to biodiversity conservation, greater effort should be made to conduct research on private lands. Resumen: Más de la mitad de la tierra en los Estados Unidos es propiedad privada. Las tierras de propiedad privada albergan una gran cantidad de biodiversidad, incluyendo al menos algunos hábitats para el 95% de las especies incluidas en la lista nacional de especies en peligro de extinción en los Estados Unidos. Es importante llevar a cabo investigación sobre biología de la conservación en tierras privadas, pero nuestra revisión de la literatura indica que existen pocos estudios a campo orientados hacia la conservación en propiedades privadas. En base a nuestro éxito en obtener permisos para llevar a cabo estudios de investigación en 43 parcelas de tierra en el condado de Sonoma, California, desarrollamos métodos para mejorar las posibilidades de los biólogos conservacionistas de obtener permisos para trabajar en tierras privadas. Hemos provisto lineamientos para que los investigadores lleven a cabo estudios exilosos en tierras privadas con el objeto de mejorar el acceso, la recolección de datos y las relaciones con los dueños de tierras privadas. También discutimos las limitantes que los investigadores enfrentan, tales como el diseño de estudios adecuados para trabajar en parcelas de propiedad privada. Dada la importancia de estas tierras para la conservación de la biodiversidad, se debería realizar un esfuerzo mayor para llevar a cabo investigaciones en tierras privadas. [source]


    Temporal Extrapolation of PVA Results in Relation to the IUCN Red List Criterion E

    CONSERVATION BIOLOGY, Issue 1 2003
    Oskar Kindvall
    For a population viability analysis ( PVA) to be useful for assessing a species' threat category, the results must have been expressed as the full extinction probability function over time or at least for the three specified time frames. Often this is not the case, and extrapolations from different kinds of PVA results ( e.g., mean time to extinction ) are often necessary. By means of analytic models, we investigated the possibilities of extrapolation. Based on our results, we suggest that extrapolation is not advisable due to the huge errors that can occur. The extinction probability function is the best kind of summary statistic to use when applying criterion E, but even then the threat categorization may be ambiguous. If the extinction risk is low in the near future but increases rapidly later on, a species may be classified as vulnerable even though it is expected to become extinct within 100 years. To avoid this, we suggest that the guidelines to the IUCN Red List criteria include three reference lines that allow for interpretation of the PVA results in the context of the three threat categories within the entire period of 100 years. If the estimated extinction probability function overshoots one of these functions, the species should be classified accordingly. Resumen: Las categorías de amenaza de la lista roja de la IUCN ( críticamente en peligro, en peligro y vulnerable ) están definidos por un juego de criterios ( A-E ). El criterio E se define cuantitativamente por tres límites especificados de riesgo de extinción ( 50%, 20% y 10% ), cada uno de los cuales se asocia a un marco temporal determinado. Para poder usar el análisis de viabilidad poblacional ( PVA ) durante la evaluación de la categoría de amenaza de una especie, los resultados deben ser expresados en función de probabilidad de extinción total sobre un tiempo o al menos para los tres marcos temporales especificados. Frecuentemente este no es el caso y las extrapolaciones de diferente tipo de resultados de PVA ( tiempo promedio de extinción ) son usualmente necesarias. Por medio de modelos analíticos investigamos las posibilidades de extrapolación. En base a nuestros resultados sugerimos que la extrapolación no es recomendable debido a una enorme cantidad de errores que pueden ocurrir. La función de probabilidad de extinción es el mejor tipo de resumen estadístico a usar cuando se aplica el criterio E, pero, aún así, la categorización de amenaza puede ser ambigua. Si el riesgo de extinción es bajo en un futuro inmediato pero incrementa muy rápidamente después, una especie puede ser clasificada como vulnerable aunque se espere que se extinga dentro de los próximos 100 años. Para evitar esto, sugerimos que los lineamientos de los criterios de la Lista Roja de la UICN incluyan tres lineas de referencia que permitan la interpretación de los resultados del PVA en el contexto de las tres categorías dentro de un periodo completo de 100 años. Si la función de probabilidad de extinción estimada se extiende más allá de una de estas funciones, las especies deberán ser clasificadas según sea el caso. [source]


    Possible Environmental Factors Underlying Amphibian Decline in Eastern Puerto Rico: Analysis of U.S. Government Data Archives

    CONSERVATION BIOLOGY, Issue 4 2001
    Robert F. Stallard
    I examined changes in environmental conditions by examining time-series data sets that extend back at least into the 1980s, a period when frog populations were declining. The data include forest cover; annual mean, minimum, and maximum daily temperature; annual rainfall; rain and stream chemistry; and atmospheric-dust transport. I examined satellite imagery and air-chemistry samples from a single National Aeronautics and Space Administration aircraft flight across the Caribbean showing patches of pollutants, described as thin sheets or lenses, in the lower troposphere. The main source of these pollutants appeared to be fires from land clearing and deforestation, primarily in Africa. Some pollutant concentrations were high and, in the case of ozone, approached health limits set for urban air. Urban pollution impinging on Puerto Rico, dust generation from Africa ( potential soil pathogens), and tropical forest burning ( gaseous pollutants) have all increased during the last three decades, overlapping the timing of amphibian declines in eastern Puerto Rico. None of the data sets pointed directly to changes so extreme that they might be considered a direct lethal cause of amphibian declines in Puerto Rico. More experimental research is required to link any of these environmental factors to this problem. Resumen: Las pasadas tres décadas han visto grandes disminuciones poblacionales de especies de anfibios en altas elevaciones de Puerto Rico oriental, una región única en los trópicos húmedos debido al grado de monitoreo ambiental que se ha llevado a cabo mediante los esfuerzos de las agencias de gobierno de los Estados Unidos. Examiné los cambios en condiciones ambientales mediante el análisis de datos de series de tiempo que se extienden hasta los 1980s, un periodo en el que las poblaciones de ranas estaban declinando. Los datos incluyen cobertura forestal; temperatura diaria media, mínima y máxima anual; precipitación anual; química de la lluvia y arroyos; y el transporte atmosférico de polvo. Examiné imágenes de satélite y muestras de química del aire obtenidos de un solo vuelo de una nave de la NASA a lo largo del Caribe que mostraba parches de contaminantes descritas como capas delgadas de lentes en la inferior troposfera. La mayor fuente de contaminantes parece ser los incendios de tierras clareadas y la deforestación, principalmente en África. Algunas concentraciones de contaminantes fueron altas y en el caso del ozono, se aproximó a los límites de salud establecidos para aire urbano. La contaminación urbana afectando a Puerto Rico, la generación de polvo en África ( patógenos del suelo potenciales) y la quema de bosque tropical (contaminantes gaseosos) han incrementado durante las últimas tres décadas, superponiéndose con el periodo en que oturrieron las disminuciones de anfibios en Puerto Rico oriental. Ninguno de estos conjuntos de datos señaló directamente hacia cambios tan extremos que debieran ser considerados como una causa letal directa de las disminuciones en Puerto Rico. Se requiere de más investigación experimental que vincule a estos factores ambientales con este problema. [source]


    Activation of the basal forebrain by the orexin/hypocretin neurones

    ACTA PHYSIOLOGICA, Issue 3 2010
    E. Arrigoni
    Abstract The orexin neurones play an essential role in driving arousal and in maintaining normal wakefulness. Lack of orexin neurotransmission produces a chronic state of hypoarousal characterized by excessive sleepiness, frequent transitions between wake and sleep, and episodes of cataplexy. A growing body of research now suggests that the basal forebrain (BF) may be a key site through which the orexin-producing neurones promote arousal. Here we review anatomical, pharmacological and electrophysiological studies on how the orexin neurones may promote arousal by exciting cortically projecting neurones of the BF. Orexin fibres synapse on BF cholinergic neurones and orexin-A is released in the BF during waking. Local application of orexins excites BF cholinergic neurones, induces cortical release of acetylcholine and promotes wakefulness. The orexin neurones also contain and probably co-release the inhibitory neuropeptide dynorphin. We found that orexin-A and dynorphin have specific effects on different classes of BF neurones that project to the cortex. Cholinergic neurones were directly excited by orexin-A, but did not respond to dynorphin. Non-cholinergic BF neurones that project to the cortex seem to comprise at least two populations with some directly excited by orexin-A that may represent wake-active, GABAergic neurones, whereas others did not respond to orexin-A but were inhibited by dynorphin and may be sleep-active, GABAergic neurones. This evidence suggests that the BF is a key site through which orexins activate the cortex and promote behavioural arousal. In addition, orexins and dynorphin may act synergistically in the BF to promote arousal and improve cognitive performance. [source]


    Global patterns of marine turtle bycatch

    CONSERVATION LETTERS, Issue 3 2010
    Bryan P. Wallace
    Abstract Fisheries bycatch is a primary driver of population declines in several species of marine megafauna (e.g., elasmobranchs, mammals, seabirds, turtles). Characterizing the global bycatch seascape using data on bycatch rates across fisheries is essential for highlighting conservation priorities. We compiled a comprehensive database of reported data on marine turtle bycatch in gillnet, longline, and trawl fisheries worldwide from 1990 to 2008. The total reported global marine turtle bycatch was ,85,000 turtles, but due to the small percentage of fishing effort observed and reported (typically <1% of total fleets), and to a global lack of bycatch information from small-scale fisheries, this likely underestimates the true total by at least two orders of magnitude. Our synthesis also highlights an apparently universal pattern across fishing gears and regions where high bycatch rates were associated with low observed effort, which emphasizes the need for strategic bycatch data collection and reporting. This study provides the first global perspective of fisheries bycatch for marine turtles and highlights region,gear combinations that warrant urgent conservation action (e.g., gillnets, longlines, and trawls in the Mediterranean Sea and eastern Pacific Ocean) and region,gear combinations in need of enhanced observation and reporting efforts (e.g., eastern Indian Ocean gillnets, West African trawls). [source]