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Selected AbstractsSingle-Institution Experience in the Management of Patients with Clinical Stage I and II Cutaneous Melanoma: Results of Sentinel Lymph Node Biopsy in 240 CasesDERMATOLOGIC SURGERY, Issue 11 2005Jordi Rex MD Background. Lymphatic mapping and sentinel lymph node biopsy (SLNB) has been developed as a minimally invasive technique to determine the pathologic status of regional lymph nodes in patients without clinically palpable disease and incorporated in the latest version of the American Joint Committee on Cancer (AJCC) staging system for cutaneous melanoma. Objective. To analyze the results of SLNB and the prognostic value of the micrometastases and the pattern of early recurrences in patients according to sentinel lymph node (SLN) status. Method. Patients with cutaneous melanoma in stages I and II (AJCC 2002) who underwent lymphatic mapping and SLNB from 1997 to 2003 were included in a prospective database for analysis. Results. The rate of identification of the SLN was 100%. Micrometastases to SLN were found in 20.8% of patients. The rate of SLN micrometastases increased according to Breslow thickness and clinical stage. Breslow thickness of 0.99 mm was the optimal cutpoint for predicting the SLNB result. Twenty-four patients (12.3%) developed a locoregional or distant recurrence at a median follow-up of 31 months. Recurrences were more frequent in patients with a positive SLN. Among patients who had a recurrence, those with a positive SLN were more likely to have distant metastases than those with negative SLN. Nodal recurrences were more frequent in patients with a negative SLN compared with those with a positive SLN. Conclusions. The status of the SLN provides accurate staging for identifying patients who may benefit from further therapy and is the most important prognostic factor of relapse-free survival. THIS WORK WAS SUPPORTED BY GRANTS FROM FONDO DE INVESTIGACIONES SANITARIAS (98/0449), BECA DE FORMACIÓ DE PERSONAL INVESTIGADOR (2001/FI0757), AND THE RED ESPÑOLA DE CENTROS DE GENÓMICA DEL CÁNCER (C03/10). [source] Using OXSIM for path planningJOURNAL OF FIELD ROBOTICS (FORMERLY JOURNAL OF ROBOTIC SYSTEMS), Issue 8 2001Stephen Cameron We address the issue of building scalable and reusable path planners for realistic robot manipulators working in three-dimensional space amid complex geometry, by presenting the latest version of our robot manipulator planning toolbox, OxSIM. OxSIM is designed to greatly simplify the building of planners by providing core competence in three-dimensional geometry. This is done by the provision of efficient routines for computing the distance between parts of the robot and its environment. A new version of OXSIM, written in C++, provides an object-oriented interface to the basic system, which increases its ease of use. Here we give an overview of OxSIM and how it works and describe a modified version of the probabilistic road map planner that we have implemented under the framework. © 2001 John Wiley & Sons, Inc. [source] Direct-method SAD phasing of proteins enhanced by the use of intrinsic bimodal phase distributions in the subsequent phase-improvement processACTA CRYSTALLOGRAPHICA SECTION D, Issue 11 2009Li-Jie Wu A modified SAD (single-wavelength anomalous diffraction) phasing algorithm has been introduced in the latest version of the program OASIS. In addition to direct-method phases and figures of merit, Hendrickson,Lattman coefficients that correspond to the original unresolved bimodal phase distributions are also output and used in subsequent phase-improvement procedures in combination with the improved phases. This provides the possibility of rebreaking the SAD phase ambiguity using the ever-improving phases resulting from the phase-improvement process. Tests using experimental SAD data from six known proteins showed that in all cases the new treatment produced significant improved results. [source] Measuring the outcome of occupational therapy: Tools and resourcesAUSTRALIAN OCCUPATIONAL THERAPY JOURNAL, Issue 4 2000Carolyn Unsworth Current pressures to document outcomes and demonstrate the efficacy of occupational therapy intervention arise from fiscal restraints as much as from the humanitarian desire to provide the best quality health care to consumers. However, measuring outcomes is important in facilitating mutual goal setting, increasing the focus of therapy on the client, monitoring client progress, as well as demonstrating that therapy is valuable. The aims of this article are to provide the reader with an overview of what outcomes research is and to provide resources to aid the selection of outcomes assessments in a variety of practice areas. This article adopts the latest version of the World Health Organisation's health classification system (International Classification of Impairments, Activities and Participation), as an organizing framework, and promotes the use of this framework when undertaking outcomes research. [source] Emergency Medicine Clerkship Curriculum: An Update and RevisionACADEMIC EMERGENCY MEDICINE, Issue 6 2010David E. Manthey MD Abstract In 2006, the latest version of a national curriculum for the fourth-year emergency medicine (EM) clerkship was published. Over the past several years, that curriculum has been implemented across multiple clerkships. The previous curriculum was found to be too long and detailed to cover in 4 weeks. As well, updates to the Liaison Committee on Medical Education (LCME)'s form and function document, which guides the structure of a clerkship, have occurred. Combining experience, updated guidelines, and the collective wisdom of members of the national organization of the Clerkship Directors in Emergency Medicine (CDEM), an update and revision of the fourth-year EM clerkship educational syllabi has been developed. ACADEMIC EMERGENCY MEDICINE 2010; 17:638,643 © 2010 by the Society for Academic Emergency Medicine [source] Urban Space and Cyberspace: Urban Environment in the Age of Media and Information TechnologyINTERNATIONAL JOURNAL OF JAPANESE SOCIOLOGY, Issue 1 2002Mikio Wakabayashi Today, the many innovations and the spread of new media and information technologies are bringing new realities to contemporary society. In Japanese sociology, this social transformation is called johoka, or information,oriented transformation. The present study examines two aspects of today's urban environment, concerning this social transformation. One is the phenomenon of "Disneylandization" of the urban environment and the other is the emergence of "cyberspace" or the "cybercity". The former is the proliferation of areas and buildings filled with signs and designs that are quoted from other historical or geographical contexts, and arranged under some "theme" or "concept", such as theme parks. The latter is the emergence of "virtual spaces" and the "virtual city" in computer networks, especially on the Internet. The former is a change in the physical urban environment and the latter is a phenomenon of the non,physical environment, inside computers. However, in spite of this contrast, these phenomena can be considered to result from the same social transformation,that is, the new relationship between space and society. The semantic emptiness, and expectations and desires for a sense of "placeness" in contemporary society are the preconditions of both phenomena. Often these elements are regarded as postmodern phenomena, yet it is of interest to explore Disneylandization and the emergence of the cybercity as the latest versions of the modern urban transformation and the modern urbanism. [source] | ||||||||||