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Late

Distribution by Scientific Domains
Medical Sciences32%
Life Sciences20%
Humanities and Social Sciences17%
Earth and Environmental Science9%
Business, Economics, Finance and Accounting7%
Chemistry3%
Psychology2%
Engineering2%
5 Other Domains8%

Kinds of Late

  • too late
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  • very late
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    Terms modified by Late

  • late 19th century
  • late 20th century
  • late adolescence
  • late adolescent
  • late adulthood
  • late afternoon
  • late age
  • late antigen
  • late antiquity
  • late autumn
  • late blight
  • late bronze age
  • late cambrian
  • late capitalism
  • late carboniferous
  • late childhood
  • late complication
  • late complications
  • late component
  • late cretaceous
  • late death
  • late development
  • late developmental stage
  • late devonian
  • late diagnosis
  • late differentiation
  • late dry season
  • late effects
  • late eighteenth century
  • late embryogenesi
  • late embryonic
  • late endosome
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  • late eocene
  • late evening
  • late event
  • late february
  • late fetal death
  • late flowering
  • late follow-up
  • late g1
  • late g1 phase
  • late gadolinium enhancement
  • late gene
  • late gene expression
  • late gestation
  • late glacial
  • late graft failure
  • late graft loss
  • late group
  • late holocene
  • late holocene environmental change
  • late increase
  • late infection
  • late intermediate period
  • late iron age
  • late january
  • late july
  • late jurassic
  • late lactation
  • late life
  • late loss
  • late lumen loss
  • late manifestation
  • late march
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  • late may
  • late medieval england
  • late mesozoic
  • late middle ages
  • late miocene
  • late modern society
  • late modernity
  • late morbidity
  • late mortality
  • late nasal response
  • late neolithic
  • late nineteenth
  • late nineteenth century
  • late november
  • late oligocene
  • late onset
  • late onset disease
  • late ordovician
  • late outcome
  • late period
  • late permian
  • late phase
  • late pleistocene
  • late pliocene
  • late postoperative complications
  • late postoperative period
  • late potential
  • late pregnancy
  • late presentation
  • late preterm infant
  • late quaternary
  • late reaction
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  • late recurrence
  • late referral
  • late rejection
  • late relapse
  • late response
  • late restenosi
  • late result
  • late season
  • late september
  • late sequelae
  • late slow wave
  • late spring
  • late stage
  • late stent thrombosis
  • late succession
  • late successional stage
  • late summer
  • late teens
  • late tertiary
  • late third
  • late thrombosis
  • late time
  • late time point
  • late toxicity
  • late transition metal
  • late treatment
  • late triassic
  • late twentieth century
  • late winter

    • Selected Abstracts

    Schooling and Labor Market Impacts of a Natural Policy Experiment

    LABOUR, Issue 4 2005
    Harry Patrinos
    These estimates apply to a subgroup of individuals, in the spirit of the local average treatment effect (LATE) literature. Returns to schooling estimates that apply to a subgroup of individuals affected by the policy intervention may be more interesting from a policy perspective than the return to the ,average' individual. We use an instrument based on the 1980 education reform (the Organic Law of Education), which provided for 9 years of compulsory basic education. Alternative estimates derived from interacting the education reform with father's education are also obtained. The estimates are consistent with recent findings suggesting that the effect of education, at least for certain subgroups affected by policy intervention, is as large as or larger than what is suggested by ordinary least squares estimates. [source]

    Sex ratio and maturity indicate the local dispersal and mortality of adult stoneflies

    FRESHWATER BIOLOGY, Issue 8 2006
    I. PETERSEN
    Summary 1.,Despite a recent upsurge in interest, there remains remarkably little information about the dispersal and survival of the adults of most stream-dwelling insects, although this is a basic requirement for understanding their long-term population dynamics. 2.,Using Malaise traps for a whole annual flight period, we captured adult stoneflies (Leuctra nigra) along transects perpendicular to three upland Welsh streams. We assessed spatial and temporal patterns in sex ratio to infer local dispersal and, using maturity as an age marker, estimated the mortality of adult females. 3.,Nearly all adult stoneflies (99%) were taken in the period 26 April,23 July, and the onset of the male and female flight periods was the same. Most males (90%) had been caught by late June. Females were classified as immature (without ripe eggs) or mature, and 90% of immature females had been caught by mid-late June (depending on catchment). As immature females declined in the catch, mature females increased, 10% having been caught by late-May to early June and 90% by early to mid-July. The median catches of immature and mature females were separated by 32 days in all three catchments. 4.,There was a female bias in the sex ratio overall, which increased as time passed and was attributable partially to the greater longevity of females. Late in the flight period, however, female bias was also greater near the stream channel implying a return of mature females (but not males) from the riparian vegetation, presumably to oviposit. 5.,The number of mature females was less than the number of immatures in two of the three channels. Over all three catchments, the overall mortality of females over the 32 days taken to mature was estimated at 29%, equivalent to an exponential daily rate of 1.1% day,1. The apparently negative mortality rate in one catchment (i.e. more matures than immatures being caught) could be due to an influx of adult females from elsewhere along the channel to oviposit. 6.,Natural markers of age and population structure, such as sex ratio and female maturity, thus enabled us to detect a return of females to the stream to oviposit, after prior limited dispersal into the riparian zone, and to infer longitudinal movements in search of suitable sites. We were also able to estimate mortality in the field. Such natural markers seem to have been underexploited in the study of adult aquatic insects. [source]

    How a mega-grazer copes with the dry season: food and nutrient intake rates by white rhinoceros in the wild

    FUNCTIONAL ECOLOGY, Issue 2 2006
    A. M. SHRADER
    Summary 1Few studies have investigated how free-ranging wild herbivores adjust their food intake rate and nutrient gains during the dry season. Our study focused on the largest extant grazer, the white rhinoceros (Ceratotherium simum Burchell 1817). Field measurements were made on changes in bite mass, bite rate and nutrient concentrations of food eaten during the dry season. 2As the dry season progressed, the quality and availability of food resources declined. During this time white rhinos foraged mainly in high-quality short and woodland grasslands. Late in the dry season they also used flushes of green grass in previously burnt Themeda grasslands. 3Bite mass increased linearly with increasing sward height, while bite rate declined. Intake rate was determined primarily by bite mass and thus tended to increase linearly with sward height. Maximum bite mass and intake rate was obtained in swards >20 cm. 4White rhinos did not compensate for seasonal declines in food quality by adjusting their food intake rate or diet breadth. We suggest that white rhinos mobilize fat reserves to help meet their nutritional needs during the dry season. [source]

    Rates Of Postglacial rock weathering on glacially scoured outcrops (Abisko,Riksgränsen area, 68°N)

    GEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 3-4 2002
    Françoise André, Marie
    Ice,polished quartz veins, feldspar phenocrysts and quartzite layers were used as reference surfaces to assess the impact of Postglacial rock weathering in Lapland (68°N). Over 3200 measurements were carried out on roches moutonées and glaciofluvially scoured outcrops distributed within three study areas covering 8 km2. Inferred weathering rates demonstrate that 10,000 years of Holocene weathering did not significantly modify the geometry of Weichselian rock surfaces. However, rates of general surface lowering range from 1 to 25, depending on the rock type, with average values at 0.2 mm ka,1 for homogeneous crystalline rocks (irrespective of their acidity and grain size), 1 mm ka,1 for biotite,rich crystalline rocks, and 5 mm ka,1 for carbonate sedimentary rocks. Accelerated rates were recorded in weathering pits and along joints with values up to ten times higher than on the rest of the rock surface. Comparisons with cold and temperate areas suggest that solution rates of carbonate rocks are highly dependent on climate conditions, whilst granular disintegration of crystalline rocks operates at the same rate whatever the environment. It probably means that microgelivation is not efficient on ice,polished crystalline outcrops even under harsh climate conditions, and that granular disintegration proceeds under various climates from the same ubiquitous combination of biochemical processes. Last, the weathering state of Late,Weichselian roches moutonées can be usefully compared to that of Preglacial tors of the nearby Kiruna area. [source]

    Mass mortality in Northwestern Mediterranean rocky benthic communities: effects of the 2003 heat wave

    GLOBAL CHANGE BIOLOGY, Issue 5 2009
    J. GARRABOU
    Abstract Late in summer 2003, extensive mass mortality of at least 25 rocky benthic macro-invertebrate species (mainly gorgonians and sponges) was observed in the entire Northwestern (NW) Mediterranean region, affecting several thousand kilometers of coastline. We were able to characterize the mortality event by studying six areas covering the main regions of the NW Mediterranean basin. The degree of impact on each study area was quantified at 49 sites by estimating the proportion of colonies affected in populations of several gorgonian species compared with reference data obtained in years without mortality signs. According to these data, the western areas (Catalan coast and Balearic Islands) were the least affected, while the central areas (Provence coast and Corsica-Sardinia) showed a moderate impact. The northernmost and eastern areas (Gulf of Genoa and Gulf of Naples) displayed the highest impact, with almost 80% of gorgonian colonies affected. The heat wave of 2003 in Europe caused an anomalous warming of seawater, which reached the highest temperatures ever recorded in the studied regions, between 1 and 3 °C above the climatic values (mean and maximum). Because this exceptional warming was observed in the depth ranges most affected by the mortality, it seems likely that the 2003 anomalous temperature played a key role in the observed mortality event. A correlation analysis between temperature conditions and degree of impact seems to support this hypothesis. Under the present climate warming trend, new mass mortality events may occur in the near future, possibly driving a major biodiversity crisis in the Mediterranean Sea. [source]

    Time to Send the Preemie Home?

    HEALTH SERVICES RESEARCH, Issue 2p1 2009
    Additional Maturity at Discharge, Outcomes, Subsequent Health Care Costs
    Objective. To determine whether longer stays of premature infants allowing for increased physical maturity result in subsequent postdischarge cost savings that help counterbalance increased inpatient costs. Data Sources. One thousand four hundred and two premature infants born in the Northern California Kaiser Permanente Medical Care Program between 1998 and 2002. Study Design/Methods. Using multivariate matching with a time-dependent propensity score we matched 701 "Early" babies to 701 "Late" babies (developmentally similar at the time the earlier baby was sent home but who were discharged on average 3 days later) and assessed subsequent costs and clinical outcomes. Principal Findings. Late babies accrued inpatient costs after the Early baby was already home, yet costs after discharge through 6 months were virtually identical across groups, as were clinical outcomes. Overall, after the Early baby went home, the Late,Early cost difference was $5,016 (p<.0001). A sensitivity analysis suggests our conclusions would not easily be altered by failure to match on some unmeasured covariate. Conclusions. In a large integrated health care system, if a baby is ready for discharge (as defined by the typical criteria), staying longer increased inpatient costs but did not reduce postdischarge costs nor improve postdischarge clinical outcomes. [source]

    The US Dollar and the Trade Deficit: What Accounts for the Late 1990s?,

    INTERNATIONAL FINANCE, Issue 3 2005
    Benjamin Hunt
    Based on a version of the IMF's global economy model set up to analyse macroeconomic interdependence between the United States and the rest of the world, this paper asks to what extent accelerating productivity growth in the United States may have contributed to the US real exchange rate appreciation and the trade balance deterioration witnessed in the second half of the 1990s. The paper concludes that productivity is only part of this story. A portfolio preference shift in favour of US assets, possibly triggered by faster productivity growth, and some uncertainty and learning about the persistence of both shocks are needed to match the data more satisfactorily. [source]

    Lifestyle, occupation, and whole bone morphology of the pre-Hispanic Maya coastal population from Xcambó, Yucatan, Mexico

    INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 3 2007
    Isabel S. Wanner
    Abstract The present bioarchaeological study examines the external diaphyseal geometric properties of humeri, radii, femora and tibiae of the Classic period skeletal population of Xcambó, Yucatan, Mexico. The diaphysial proportions are evaluated using a biomechanical approach together with data from the material context and other osteological information. Our intent is to provide new answers to questions concerning lifestyle, domestic labour division and subsistence strategies of this coastal Maya settlement that was inhabited from the Late and Terminal Preclassic (300 BC,350 AD) to the Postclassic Period (900,1500 AD). Our results provide evidence for a marked sexual division of labour when compared with values from contemporaneous inland populations. The overall male and female loading patterns differ remarkably in terms of form and in bilateral comparison. A high directional asymmetry in the upper limbs is evident among males, a condition related to maritime transportation and trading activities. On the other hand, female upper limbs are characterized by very low side differences. Forces on the arms of women were probably dominated by food processing, in particular the grinding of grains or seeds. In the lower limbs, males show significantly higher anteroposterior bending strengths, which can be explained by greater engagement in transportation tasks and carrying heavy loads. In the course of the Classic period (350,900 AD), diachronic changes affect the male sample only, which suggests a shift of occupational pattern and physical demands. This shift, in turn, reflects Xcambó's changing role as the centre of a densifying settlement area and its place in the trading activities of northern Yucatan. Other topics of discussion relate to general regional trends and local prehispanic subsistence strategies. Our conclusions emphasize the value of geometric long bone analysis in the reconstruction of activity patterns and lifestyles in ancient coastal settlements. Copyright © 2007 John Wiley & Sons, Ltd. [source]

    Land Commodification: New Land Development and Politics in China since the Late 1990s

    INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 4 2009
    JIANG XU
    Abstract This article examines the development of the land market in China since the late 1990s. It analyses new practices in which urban space is commodified through ad hoc market development, and argues that the structure of the land market is indeed becoming more complicated and that land sales are pervasive and rampant. Under such circumstances, the state has rearticulated its function in land governance in order to apply a more consolidated regulatory power. The politics behind the development of the land market and the rearticulation of the state are explored with reference to the changing role of the state in land commodification. It is argued that, if we understand the market as an emerging institution, the development of the market has been supported by the state. Regulatory land control is becoming a new way for the state to be involved in space commodification. Résumé Cet article porte sur l'évolution du marché foncier en Chine depuis la fin des années 1990. Il analyse de nouvelles pratiques par lesquelles l'espace urbain est marchandiséà travers le développement de marchés spécifiques; de plus, il montre que la structure du marché foncier devient vraiment plus compliquée et que les ventes de terrains se généralisent à grande échelle. Face à cette situation, l'État a réorganisé sa fonction en matière de gouvernance foncière afin d'exercer un pouvoir régulateur plus intégré. La politique à la base de l'essor du marché foncier et la réorganisation étatique sont examinées au regard du nouveau rôle de l'État dans la marchandisation des terrains. Si on considère le marché comme une institution émergente, son développement a donc reçu le soutien de l'État. Ce dernier trouve dans le contrôle régulateur du foncier une nouvelle façon d'être partie prenante dans la marchandisation de l'espace. [source]

    Development of pharyngeal arch arteries in early mouse embryo

    JOURNAL OF ANATOMY, Issue 1 2002
    Tamiko Hiruma
    Abstract The formation and transformation of the pharyngeal arch arteries in the mouse embryo, from 8.5 to 13 days of gestation (DG), was observed using scanning electron microscopy of vascular casts and graphic reconstruction of 1-µm serial epoxy-resin sections. Late in 8.5,9DG (12 somites), the paired ventral aortae were connected to the dorsal aortae via a loop anterior to the foregut which we call the ,primitive aortic arch', as in the chick embryo. The primitive aortic arch extended cranio-caudally to be transformed into the primitive internal carotid artery, which in turn gave rise to the primitive maxillary artery and the arteries supplying the brain. The second pharyngeal arch artery (PAA) appeared late in 9,9.5DG (16,17 somites), and the ventral aorta bent dorsolaterally to form the first PAA anterior to the first pharyngeal pouch by early in 9.5,10DG (21,23 somites). The third PAA appeared early in 9.5,10DG (21,23 somites), the fourth late in 9.5,10DG (27,29 somites), and the sixth at 10DG (31,34 somites). By 10.5DG (35,39 somites), the first and second PAAs had been transformed into other arteries, and the third, fourth and sixth PAAs had developed well, though the PAA system still exhibited bilateral symmetry. By 13DG, the right sixth PAA had disappeared, and the remaining PAAs formed an aortic-arch system that was almost of the adult type. [source]

    ECONOMIC TRENDS: NIGER: Too Little, Too Late?

    AFRICA RESEARCH BULLETIN: ECONOMIC, FINANCIAL AND TECHNICAL SERIES, Issue 7 2010
    Article first published online: 1 SEP 2010
    No abstract is available for this article. [source]

    Atrial Remodeling After Mitral Valve Surgery in Patients with Permanent Atrial Fibrillation

    JOURNAL OF CARDIAC SURGERY, Issue 5 2004
    Fernando Hornero M.D., Ph.D.
    Mitral surgery allows an immediate surgical auricular remodeling and besides in those cases in which sinus rhythm is reached, it is followed by a late remodeling. The aim of this study is to investigate the process of postoperative auricular remodeling in patients with permanent atrial fibrillation undergoing mitral surgery. Methods: In a prospective randomized trial, 50 patients with permanent atrial fibrillation and dilated left atrium, submitted to surgical mitral repair, were divided into two groups: Group I contained 25 patients with left auricular reduction and mitral surgery, and Group II contained 25 patients with isolated valve surgery. Both groups were considered homogeneous in the preoperative assessment. Results: After a mean follow-up of 31 months, 46% of patients included in Group I versus 18% of patients included in Group II restarted sinus rhythm (p = 0.06). An auricular remodeling with size regression occurred in those patients who recovered from sinus rhythm, worthy of remark in Group II (,10.8% of left auricular volume reduction in Group I compared to ,21.5% in Group II; p < 0.05). A new atrial enlargement took place in those patients who remained with atrial fibrillation (+16.8% left auricular volume in Group I vs. +8.4% in Group II; p < 0.05). Conclusions: Mitral surgery produces an atrial postoperative volume that decrease especially when reduction techniques are employed. Late left atrial remodeling depended on the type of atrial rhythm and postoperative surgical volume. [source]

    Too Little, Too Late: Chasing Atrial Fibrillation with Sodium Channel Antagonists

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 6 2006
    Mark E. Anderson M.D., Ph.D.
    [source]

    The Different Mechanisms Between Late and Very Late Recurrences of Atrial Fibrillation in Patients Undergoing a Repeated Catheter Ablation

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 3 2006
    MING-HSIUNG HSIEH M.D.
    Introduction: The mechanisms of late (<1 year after the ablation) and very late (>1 year after the ablation) recurrences of paroxysmal atrial fibrillation (AF) after catheter ablation have not been reported. Methods and Results: Fifty consecutive patients undergoing a repeated electrophysiologic study to investigate the recurrence of paroxysmal AF after the first ablation were included. Group 1 consisted of 12 patients with very late (26 ± 13 months) and group 2 consisted of 38 patients with late (3 ± 3 months) recurrence of paroxysmal AF. In the baseline study, group 1 had a lower incidence of AF foci from the pulmonary veins (PVs) (67% vs 92%, P = 0.048) and a higher incidence of AF foci from the right atrium (50% vs 13%, P = 0.014) than group 2. In the repeated study, group 1 had a higher incidence of AF foci from the right atrium (67% vs 3%, P < 0.001) and a lower incidence of AF foci from the left atrium (50% vs 97%, P < 0.001), including a lower incidence of AF foci from the PVs (50% vs 79%, P = 0.07) and from the left atrial free wall (0% vs 29%, P = 0.046) than group 2. Furthermore, most of these AF foci (64% of group 1, 65% of group 2) were from the previously targeted foci. Conclusion: The right atrial foci played an important role in the very late recurrence of AF, whereas the left atrial foci (the majority were PVs) were the major origin of the late recurrence of AF after the catheter ablation of paroxysmal AF. [source]

    Mechanisms of Right Atrial Tachycardia Occurring Late After Surgical Closure of Atrial Septal Defects

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Issue 7 2005
    ISABELLE MAGNIN-POULL M.D.
    Introduction: In patients without structural heart disease, the most frequently occurring AT is the common atrial flutter. In patients with repaired congenital heart disease other mechanisms of AT may occur, due to the presence of an atriotomy that can provide a substrate for reentry. The aim of the present study was to identify the mechanisms of atrial tachycardia (AT) occurring late after atrial septum defect (ASD) repair, with the help of a three-dimensional electroanatomical mapping system. Methods and Results: Twenty-two consecutive patients presenting with AT underwent complete electroanatomic mapping (CARTO®, Biosense Webster, Diamond Bar, CA) of spontaneously occurring and inducible right ATs. Complete maps of 26 ATs were obtained. Three tachycardia mechanisms were identified: single-loop macroreentrant atrial tachycardia (MAT) (n = 7), double-loop MAT (n = 18), and focal AT (n = 1). In all MATs, protected isthmuses were identified as the electrophysiological substrate of the arrhythmia, most frequently the cavotricuspid isthmus (CTI) (n = 24), and a gap between the inferior vena cava and a line of double potentials (n = 11). A mean number of 13.5 ± 2.1 radiofrequency applications were delivered to transect these critical parts of the circuit. During a follow-up of 25 ± 16 months the RF ablation was acutely successful in all patients. Thirteen patients (59%) had an early recurrence of MAT and needed an additional ablation procedure. One of those patients needed two additional ablation procedures. Conclusions: Three-dimensional electroanatomic mapping is useful to identify postsurgical AT mechanisms; the CTI isthmus is involved in 92% MAT, and if the right atrial free wall (RAFW) abnormal tissue related to surgical scar is present this substrate contributes to the MAT circuit [source]

    Too Much, Too Late: The Advocacy Act in Ontario

    LAW & POLICY, Issue 1 2000
    Ernie Lightman
    This paper examines the concept of government-based social advocacy on behalf of vulnerable people in the community. It uses as a case example the Ontario Advocacy Act, a statute that was surrounded by controversy through its short life. The more general question raised is whether the ideas of government-based advocacy are fundamentally conceptually untenable, or whether the fault lay with the specifics of the act and its implementation. As governments globally cut back on social supports for vulnerable people, the need for advocacy and support are self-evident. This paper explores the broader viability of this one, specific type of response. [source]

    Cholestatic syndrome with bile duct damage and loss in renal transplant recipients with HCV infection

    LIVER INTERNATIONAL, Issue 2 2001
    Johanna K. Delladetsima
    Abstract:Background/Aims: Bile duct cells are known to be susceptible to hepatitis B and C virus, while it has been recently suggested that hepatitis B virus (HBV) and hepatitis C virus (HCV) infection may have a direct role in the pathogenesis of vanishing bile duct syndrome (VBDS) after liver transplantation. We report the development of a cholestatic syndrome associated with bile duct damage and loss in four HCV-infected renal transplant recipients. Methods: All four patients were followed up biochemically, serologically and with consecutive liver biopsies. Serum HCV RNA was quantitatively assessed and genotyping was performed. Results: Three patients were anti-HCV negative and one was anti-HCV/HBsAg positive at the time of transplantation and received the combination of methylprednisolone, azathioprine and cyclosporine A. Two patients became anti-HCV positive 1 year and one patient 3 years post-transplantation. Elevation of the cholestatic enzymes appeared simultaneously with seroconversion, or 2,4 years later, and was related to lesions of the small-sized interlobular bile ducts. Early bile duct lesions were characterized by degenerative changes of the epithelium. Late and more severe bile duct damage was associated with bile duct loss. The progression of the cholestatic syndrome coincided with high HCV RNA serum levels, while HCV genotype was 1a and 1b. Two patients (one with HBV co-infection) developed progressive VBDS and died of liver failure 2 and 3 years after biochemical onset. One patient, despite developing VBDS within a 10-month period, showed marked improvement of liver function after cessation of immunosuppression because of graft loss. The fourth patient, who had mild biochemical and histological bile duct changes, almost normalized liver function tests after withdrawal of azathioprine. Conclusion:Á progressive cholestatic syndrome due to bile duct damage and loss may develop in renal transplant patients with HCV infection. The occurrence of the lesions after the appearance of anti-HCV antibodies and the high HCV RNA levels are indicative of viral involvement in the pathogenesis. Withdrawal of immunosuppressive therapy may have a beneficial effect on the outcome of the disease. [source]

    Three temporal classes of gene expression during the Chlamydia trachomatis developmental cycle

    MOLECULAR MICROBIOLOGY, Issue 4 2000
    E. I. Shaw
    The obligate intracellular bacterium Chlamydia trachomatis has a unique developmental cycle that involves functionally and morphologically distinct cell types adapted for extracellular survival and intracellular multiplication. Infection is initiated by an environmentally resistant cell type called an elementary body (EB). Over the first several hours of infection, EBs differentiate into a larger replicative form, termed the reticulate body (RB). Late in the infectious process, RBs asynchronously begin to differentiate back to EBs, which accumulate within the lumen of the inclusion until released from the host cell for subsequent rounds of infection. In an effort to characterize temporal gene expression in relation to the chlamydial developmental cycle, we have used quantitative,competitive polymerase chain reaction (QC-PCR) and reverse transcription (RT)-PCR techniques. These analyses demonstrate that C. trachomatis double their DNA content every 2,3 h, with synthesis beginning between 2 and 4 h after infection. We determined the onset of transcription of specific temporal classes of developmentally expressed genes. RT-PCR analysis was performed on several genes encoding key enzymes or components of essential biochemical pathways and functions. This comparison encompassed approximately 8% of open reading frames on the C. trachomatis genome. In analysis of total RNA samples harvested at 2, 6, 12 and 20 h after infection, using conditions under which a single chlamydial transcript per infected cell is detected, three major temporal classes of gene expression were resolved. Initiation of transcription appears to occur in three temporal classes which we have operationally defined as: early, which are detected by 2 h after infection during the germination of EBs to RBs; mid-cycle, which appear between 6 and 12 h after infection and represent transcripts expressed during the growth and multiplication of RBs; or late, which appear between 12 and 20 h after infection and represent those genes transcribed during the terminal differentiation of RBs to EBs. Collectively, the data suggest that chlamydial early gene functions are weighted toward initiation of macromolecular synthesis and the establishment of their intracellular niche by modification of the inclusion membrane. Surprisingly, representative enzymes of intermediary metabolism and structural proteins do not appear to be transcribed until 10,12 h after infection; coinciding with the onset of observed binary fission of RBs. Late gene functions appear to be predominately those associated with the terminal differentiation of RBs back to EBs. [source]

    Molecular dynamics of the blood,testis barrier components during murine spermatogenesis

    MOLECULAR REPRODUCTION & DEVELOPMENT, Issue 7 2010
    Masataka Chihara
    The blood,testis barrier (BTB) separates the seminiferous epithelium into the adluminal and basal compartments. During murine spermatogenesis, preleptotene/leptotene spermatocytes migrate from the basal to the adluminal compartment through the BTB during stages VIII,IX. In the present study, we focused on the tight junction (TJ) molecules and analyzed their spatiotemporal expression during the murine seminiferous epithelial cycle. Structural analysis revealed that the principal components of the BTB, for example, claudin-3, claudin-11, occludin, and zonula occludens-1 (ZO-1), were localized at the basal and luminal sides of the preleptotene/leptotene spermatocytes during the migration stages (VIII,IX). Although we detected claudin-11, occludin, and ZO-1 throughout spermatogenesis, claudin-3 was only detected during stages VI,IX. Quantitative PCR using dissected seminiferous tubules from three stages (Early: II,VI, Middle: VII,VIII, Late: IX,I) clarified that the mRNA levels of TJ molecules were not correlated with the histoplanimetrical protein levels during spermatogenesis. Additionally, tubulobulbar complexes, considered to be involved in the internalization of TJ, were observed at the BTB site. Furthermore, a significant reduction in the mRNA levels of genes for the degradation of occludin (Itch) and endocytic recycling (Rab13) were observed during the Late and Middle stages, respectively. Therefore, we hypothesized that the lag between mRNA and protein expression of TJ molecules may be due to posttranslational modulation, for example, tubulobulbar complexes and endocytic recycling processes. In conclusion, these findings indicate that the integrity of the BTB is maintained throughout spermatogenesis, and the stage-specific localization of claudin-3 protein plays an important role in regulating BTB permeability. Mol. Reprod. Dev. 77: 630,639, 2010. © 2010 Wiley-Liss, Inc. [source]

    When Is It Too Late for Cardiac Resynchronization Therapy?

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 5 2008
    BENGT HERWEG M.D.
    First page of article [source]

    Three-Dimensional Mapping of Atypical Right Atrial Flutter Late after Chest Stabbing

    PACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 3 2008
    DANIEL STEVEN M.D.
    We present the case of a female patient who previously underwent cardiac surgery for traumatic anterior right atrial perforation after a stabbing attack. Four years later the patient presented with right atrial common type flutter and isthmus ablation was performed subsequently. However, three years after isthmus ablation the patient was readmitted with atypical right atrial flutter. Electrophysiological study revealed persistent bidirectional isthmus block. Three-dimensional mapping (NavX, St. Jude Medical, St. Paul, MN, USA) demonstrated an incisional tachycardia with the critical isthmus at the border of the anterior area of scar in a close proximity to the superior tricuspid annulus. After ablation of this isthmus the patient was arrhythmia free after a follow-up of 9 months. This case illustrates that three-dimensional scar mapping may help to identify unusual isthmus sites that may be simultaneously responsible for both typical and atypical atrial flutter. [source]

    Late cardiotoxicity after bolus versus infusion anthracycline therapy for childhood cancers

    PEDIATRIC BLOOD & CANCER, Issue 6 2003
    Monesha Gupta MBBS
    Abstract Objective To compare the long-term myocardial function of patients who had been treated with infusion anthracycline therapy (administered continuously over >24 hr, IG) versus bolus therapy (administered over <30 min, BG). Methods We selected 25 patients (BG) and 19 patients (IG) who had three or more years of disease free survival. We evaluated the echocardiograms for left ventricular shortening fraction (SF) obtained at baseline, within one year after the end of therapy (early follow-up), and on long-term follow-up. Results The mean anthracycline dose in the BG was 385 mg/m2 and in the IG was 345 mg/m2 (P,=,0.07). During therapy, one patient in BG and none in IG developed diminished SF. During early follow-up, five of the 22 patients in BG and one of the 17 patients in IG developed diminished SF (P,=,0.2). Of these five patients with diminished SF, three patients in BG and none in IG continued to have abnormally low SF long-term. At mean of 7 years, five of the 25 patients in BG and two of the 19 in IG had diminished SF on (P,=,0.7). Late left ventricular dilatation was seen in 8% in BG and 5% in IG (P,=,1.0). Conclusions At mean of 7 years after end of therapy, diminished cardiac function was seen in 20% of the patient who had received bolus anthracycline compared to 11% of patients who had received it via infusion. This difference did not prove to be statistically significant. Med Pediatr Oncol 2003;40:343,347. © 2003 Wiley-Liss, Inc. [source]

    Maturity-related differences in physical activity among 10- to 12-year-old girls

    AMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 1 2010
    Clemens Drenowatz
    Besides environmental and psycho-social factors explaining the variation in physical activity levels during adolescence, some evidence suggests that biological processes are involved in regulating habitual daily physical activity and energy expenditure. The purpose of this study was to examine the influence of biological maturity status on physical activity. Chronological age, standing height, sitting height, and body mass were measured cross-sectionally in 268 girls, aged 9.5 to 11.5 years. Biological maturity groups (Early, Average, Late) were created according to estimated age at peak-height-velocity (estAPHV). Habitual physical activity was determined with a pedometer (Yamax Digiwalker SW-200) over a 7-day period. Differences in steps/day across maturity groups were examined by ANCOVA, controlling separately for time the pedometer was worn, leg length, and body mass. Mean pedometer steps/day was 10,822 ± 2,639. As expected, body size varied by maturity status (e.g., early > average > late). Significant maturity group differences were found with early maturing girls showing lower activity levels compared to average or late maturers. These differences remained after controlling for time the pedometer was worn and leg length; however, the differences were no longer significant when controlling for body mass. The results suggest that biological maturity status influences physical activity levels in girls between 10 and 12 years of age but the relationship is not independent of body mass. Further research is needed to establish the complex inter-relationships among adiposity, biological maturation, and energy expenditure during puberty. Am. J. Hum. Biol., 2010. © 2009 Wiley-Liss, Inc. [source]

    Dietary variation and stress among prehistoric Jomon foragers from Japan

    AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 4 2007
    Daniel H. Temple
    Abstract Current archaeological evidence indicates that greater dietary reliance on marine resources is recorded among the eastern Jomon, while plant dependence prevailed in western/inland Japan. The hypothesis that the dietary choices of the western/inland Jomon will be associated with greater systemic stress is tested by comparing carious tooth and enamel hypoplasia frequencies between the eastern and western/inland Jomon. Demographic collapse coincides with climate change during the Middle to Late Jomon period, suggesting dwindling resource availability. It is hypothesized that this change was associated with greater systemic stress and/or dietary change among the Middle to Late Jomon. This hypothesis is tested by comparing enamel hypoplasia and carious tooth frequencies between Middle to Late and Late to Final Jomon foragers. Enamel hypoplasia was significantly more prevalent among the western/inland Jomon. Such findings are consistent with archaeological studies that argue for greater plant consumption and stresses associated with seasonal resource depletion among the western/inland Jomon. Approximately equivalent enamel hypoplasia frequencies between Middle to Late and Late to Final Jomon foragers argues against a demographic collapse in association with diminished nutritional returns. Significant differences in carious tooth frequencies are, however, observed between Middle to Late and Late to Final Jomon foragers. These results suggest a subsistence shift during the Middle to Late Jomon period, perhaps in response to a changed climate. The overall patterns of stress documented by this study indicate wide-spread environmentally directed biological variation among the prehistoric Jomon. Am J Phys Anthropol, 2007. © 2007 Wiley-Liss, Inc. [source]

    "Please Call Now, Before It's Too Late": Spectacle Discourse in the Jerry Lewis Muscular Dystrophy Telethon

    THE JOURNAL OF POPULAR CULTURE, Issue 4 2003
    Christopher R. Smit
    First page of article [source]

    Significance of the injection timing of ephedrine to reduce the onset time of rocuronium

    ANAESTHESIA, Issue 8 2008
    D. W. Han
    Summary We postulated that the onset time of rocuronium can be accelerated effectively if it is administered at the time when the effect of ephedrine on cardiac output has reached its maximum. Seventy-five male, anaesthetised, patients were randomly allocated to three groups. Ephedrine 70 ,g.kg,1 was administered at 4 min (Early) or 30 s (Late) before administering rocuronium. The control group received saline at 4 min and at 30 s before rocuronium. The onset time of rocuronium in the Early group was significantly shorter than in the Control group, but there was no difference in the onset time between the Late and Control groups. There were no significant differences in the intubating conditions of the three groups. Ephedrine 70 ,g.kg,1 can reduce the onset time of rocuronium effectively if rocuronium is administered at 4 min following the ephedrine injection, when the effect of ephedrine on cardiac output is expected to reach its maximum. [source]

    The Miocene Saint-Florent Basin in northern Corsica: stratigraphy, sedimentology, and tectonic implications

    BASIN RESEARCH, Issue 4 2007
    William Cavazza
    ABSTRACT Late early,early middle Miocene (Burdigalian,Langhian) time on the island of Corsica (western Mediterranean) was characterized by a combination of (i) postcollisional structural inversion of the main boundary thrust system between the Alpine orogenic wedge and the foreland, (ii) eustatic sealevel rise and (iii) subsidence related to the development of the Ligurian-Provençal basin. These processes created the accommodation for a distinctive continental to shallow-marine sedimentary succession along narrow and elongated basins. Much of these deposits have been eroded and presently only a few scattered outcrop areas remain, most notably at Saint-Florent and Francardo. The Burdigalian,Langhian sedimentary succession at Saint-Florent is composed of three distinguishing detrital components: (i) siliciclastic detritus derived from erosion of the nearby Alpine orogenic wedge, (ii) carbonate intrabasinal detritus (bioclasts of shallow-marine and pelagic organisms), and (iii) siliciclastic detritus derived from Hercynian-age foreland terraines. The basal deposits (Fium Albino Formation) are fluvial and composed of Alpine-derived detritus, with subordinate foreland-derived volcanic detritus. All three detrital components are present in the middle portion of the succession (Torra and Monte Sant'Angelo Formations), which is characterized by thin transitional deposits evolving vertically into fully marine deposits, although the carbonate intrabasinal component is predominant. The Monte Sant'Angelo Formation is characteristically dominated by the deposits of large gravel and sandwaves, possibly the result of current amplification in narrow seaways that developed between the foreland and the tectonically collapsing Alpine orogenic wedge. The laterally equivalent Saint-Florent conglomerate is composed of clasts derived from the late Permian Cinto volcanic district within the foreland. The uppermost unit (Farinole Formation) is dominated by bioclasts of pelagic organisms. The Saint-Florent succession was deposited during the last phase of the counterclockwise rotation of the Corsica,Sardinia,Calabria continental block and the resulting development of the Provençal oceanic basin. The succession sits at the paleogeographic boundary between the Alpine orogenic wedge (to the east), its foreland (to the west), and the Ligurian-Provençal basin (to the northwest). Abrupt compositional changes in the succession resulted from the complex, varying interplay of post-collisional extensional tectonism, eustacy and competing drainage systems. [source]

    Late- and postglacial history of the Great Belt, Denmark

    BOREAS, Issue 1 2004
    OLE BENNIKE
    On the basis of shallow seismic records, vibrocoring, macrofossil analyses and AMS radiocarbon-dating, five stratigraphical units have been distinguished from the deepest parts of the central Great Belt (Storebælt) in southern Scandinavia. Widespread glacial deposits are followed by two lateglacial units confined to deeply incised channels and separated by an erosional boundary. Lateglacial Unit I dates from the time interval from the last deglaciation to the Allerød; lateglacial Unit II is of Younger Dryas age. Early Holocene deposits show a development from river deposits and lake-shore deposits to large lake deposits, corresponding to a rising shore level. Lake deposits are found up to 20 m below the sea floor, and the lake extended over some 200,300 km2. The early Holocene freshwater deposits are dated to the time interval c. 10900 to c. 8800 cal. yr BP and the oldest shells of marine molluscs from the Great Belt are dated to c. 8100 cal. yr BP. [source]

    Late (> 10 years) recurrence of melanoma: the Scottish experience

    BRITISH JOURNAL OF DERMATOLOGY, Issue 2 2003
    J.A. Leman
    No abstract is available for this article. [source]

    Late or very late stent thrombosis can also occur with bare metal stents

    CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 2 2007
    Andres Rosas Ramos MD
    Abstract The issue of late stent thrombosis (LAST) has become a subject of highly polemical debate over the past few months. Yet, both acute and LAST has always been a potential complication. The objective of this manuscript is to remind the readers, by means of two case reports, that thrombosis of bare metal stents may occur even very late after stent implantation. In the first case, stent thrombosis occurred after five years. In the second case, it occurred three years after the stenting procedure in a bare metal stent implanted in the circumflex artery of a patient who had also received two drug-eluting stents in the left anterior descending coronary artery. © 2007 Wiley-Liss, Inc. [source]