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Latter Point (latter + point)
Selected AbstractsClinical perspectives for the study of craving and relapse in animal modelsADDICTION, Issue 8s2 2000Ting-Kai Li Several major clinical models of alcoholism in which craving plays a role are summarized and key questions are raised regarding the course of craving in the emergence of alcoholism, how it varies in different stages of the disorder (e.g. active alcoholic, withdrawal, protracted abstinence) and what craving may contribute to major signs and symptoms of alcoholism. Turning to animal models, a plea is made for development of a standardized definition of human craving that can be represented and operationalized in animal models. Until there is scientific consensus on such a definition, four ways are elucidated in which animal model research can contribute to advances in our knowledge of human craving and the role it plays in addictive behavior: (1) engaging both basic and clinical researchers to identify parallel constructs of craving and predictors of craving for adoption in comparative human and animal model studies; (2) conducting exploratory research on craving in animal models using relapse to drinking as the dependent measure; (3) identifying mechanisms that underlie clinical signs and symptoms of alcoholism in animal models; and (4) identifying genetic models in basic research that account for variations in response to alcohol that may also occur in humans. This latter point is made in a discussion of the genetic contribution to voluntary alcohol consumption, the alcohol deprivation effect, tolerance and dependence, as illustrated by differences between alcohol-preferring (P) rats and-nonpreferring (NP) rats. The review concludes with four questions and issues that need to be among those that guide future research on craving. [source] Experimental analysis of the impact of peer-to-peer applications on traffic in commercial IP networksEUROPEAN TRANSACTIONS ON TELECOMMUNICATIONS, Issue 6 2004Nadia Ben Azzouna To evaluate the impact of peer-to-peer (P2P) applications on traffic in wide area networks, we analyze measurements from a high speed IP backbone link carrying TCP traffic towards several ADSL areas. The first observations are that the prevalent part of traffic is due to P2P applications (almost 80% of total traffic) and that the usage of network becomes symmetric in the sense that customers are not only clients but also servers. This latter point is observed by the significant proportion of long flows mainly composed of ACK segments. When analyzing the bit rate created by long flows, it turns out that the TCP connections due to P2P applications have a rather small bit rate and that there is no evidence for long range dependence. These facts are intimately related to the way P2P protocols are running. We separately analyze signaling traffic and data traffic. It turns out that by adopting a suitable level of aggregation, global traffic can be described by means of usual tele-traffic models based on M/G/, queues with Weibullian service times. Copyright © 2004 AEI [source] Bridges to learning: international student mobilities, education agencies and inter-personal networksGLOBAL NETWORKS, Issue 4 2008FRANCIS LEO COLLINS Abstract International education is a fundamentally transnational project. It relies on the movement of individuals or knowledge across national borders, disturbs the centrality of the nation-state in educational reproduction, and is facilitated by economic and social networks that act as bridges between countries of origin and education. In this article, I address this latter point through reference to research conducted with South Korean international students in Auckland, New Zealand. In particular, I discuss the emergence of transnational social and economic activities that are facilitating the movement of international students from South Korea to Auckland , activities that might usefully be understood as forming ,bridges to learning'. These include the activities of education agencies, immigrant entrepreneurs and the interpersonal relationships with which many students engage in the negotiation of their transnational lives. In a broader sense I illustrate how the emerging mobilities of international students cannot be viewed as independent of other phenomena but must be seen as embedded within transnational processes that take place at different geographic and social scales. [source] Effects of aging on early B- and T-cell developmentIMMUNOLOGICAL REVIEWS, Issue 1 2005Hyeyoung Min Summary:, Lymphocyte production in the bone marrow and the thymus is reduced during aging, but why this decline occurs has not been fully elucidated. The ability to isolate hematopoietic stem and progenitor cells using sophisticated flow cytometric strategies and to manipulate them in vitro and in vivo has provided insights into the effects of aging on primary lymphopoiesis. These analyses have showed that intrinsic changes in hematopoietic precursors that affect their proliferative potential are one factor that contributes to the age-related decline in B- and T-cell production. This and other age-related defects may be exacerbated by changes in the lymphopoietic support potential of the bone marrow and thymic microenvironments as well as by age-induced fluctuations in the production of various endocrine hormones. Particular attention with regard to the latter point has focused on changes in the production of sex steroids, growth hormone, and insulin-like growth factor-I. The present review summarizes recent studies of how age-related perturbations affect primary lymphopoiesis and highlights how the data necessitate the reevaluation of a number of existing paradigms. [source] 8 Culture, Evil, and HorrorAMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY, Issue 1 2007Paul Santilli This chapter develops a concept of aesthetic and existential horror and suggests its importance for understanding modern and postmodern culture. It makes three distinct claims. First, the experience of horror signifies a breakdown in the symbolic categories and valuations of a culture. Second, this experience has ontological significance because in horror the human is exposed to the naked fact of being. This latter point is derived from Heidegger's comments on anxiety and Emmanuel Levinas's notion of the "il y a" or "there is." A third claim follows from these two, namely, that horror is distinct from evil. Evil is defined within a cultural matrix; horror is the undefined other of a culture. Evil represents the negation of being; horror shows the sickening presence of being as being. The essay concludes with a reflection on the possibility of a postmodern ethics that takes responsibility for the "horrors of being" generated by globalization. [source] Direct measurements of the addition and recombination of acrylate radicals: Access to propagation and termination rate constants?JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 11 2006J. Lalevée Abstract Acrylate radicals produced by the addition of an aminoalkyl radical to five acrylate monomers were directly observed by transient absorption spectroscopy, which allowed us to easily follow their chemical reactivity. It was possible (1) to characterize their absorption in the visible part of the spectrum, (2) to calculate their absorption properties, (3) to determine the energy barriers of the addition through quantum mechanical calculations, (4) to monitor the kinetics of the subsequent addition to another monomer unit, and (5) to follow the recombination of two acrylate radicals. These two latter points could mimic the propagation and termination reactions of polymerization-propagating acrylate radicals. Methacrylate and acrylonitrile radicals were also studied. The obtained results were in good agreement with the propagation rate constants determined by the well-established pulsed laser polymerization techniques. Our method could likely provide rapid access to both the propagation and termination rate constants in suitable systems and appears to be powerful and promising for studying and comparing the reactivities of different acrylate monomer structures. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 3577,3587, 2006 [source] | |||||||||||||