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Kinetic Asymmetric Transformation (kinetic + asymmetric_transformation)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Copper-Catalyzed Asymmetric Allylic Alkylation of Racemic Cyclic Substrates: Application of Dynamic Kinetic Asymmetric Transformation (DYKAT)

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 2-3 2010
Jean-Baptiste Langlois
Abstract The copper-catalyzed asymmetric allylic alkylation (AAA) is of great interest in organic synthesis. This reaction was extensively studied using a broad range of substrates, ligands and organometallic reagents. However, the use of racemic substrates was still limited. Although some processes of kinetic resolution are reported in the literature, no examples of quantitative deracemization are described as is the case for the Pd-catalyzed allylic alkylation. We present here a full account of our investigations through the development of the first example of such a process in copper-catalyzed AAA. High enantioselectivities (up to 99% ee), scope of the reaction and mechanistic considerations are reported herein. [source]

Titanium(IV)-Catalyzed Dynamic Kinetic Asymmetric Transformation of Alcohols, Silyl Ethers, and Acetals under Carbon Allylation.

CHEMINFORM, Issue 21 2004
Manfred Braun
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Highly Efficient Synthesis of Enantiopure Diacetylated C2 -Symmetric Diols by Ruthenium- and Enzyme-Catalyzed Dynamic Kinetic Asymmetric Transformation (DYKAT)

CHEMISTRY - A EUROPEAN JOURNAL, Issue 23 2006
Belén Martín-Matute Dr.
Abstract Highly efficient synthesis of enantiopure diacetates of 2,4-pentanediol and 2,5-hexanediol starting from commercially available mixtures of the diols (dl/meso ,1:1) has been realized by combining a fast ruthenium-catalyzed epimerization with an enzymatic transesterification. The in situ coupling of these two processes produces the diacetates in high yield in >99,% enantiomeric excess. [source]

Oxidoreductases Working Together: Concurrent Obtaining of Valuable Derivatives by Employing the PIKAT Method

CHEMCATCHEM, Issue 8 2010
Fabricio
Flying PIKATs: The stereoselective oxidation of several sulfides linked to the enantioselective oxidation of different sec -alcohols are combined in a parallel interconnected kinetic asymmetric transformation (PIKAT) fashion. Furthermore, the cofactor concentration employed in these processes is investigated, demonstrating a high capacity of performance, even at micromolar concentrations of the mediator. [source]