Home About us Contact
|
Home About us Contact | ||
|
|
||
Ketone Derivatives (ketone + derivative)
Selected AbstractsCatalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral ,-Bromo-,-Amino Ketone Derivatives,ANGEWANDTE CHEMIE, Issue 35 2010Yunfei Cai Sparsam mit dem Katalysator: In der unter milden Bedingungen über eine Bromonium-Zwischenstufe verlaufenden Titelreaktion wurden mit 0.05,Mol-% eines C2 -symmetrischen N,N,-Dioxid-Scandium(III)-Komplexes hervorragende Resultate erzielt (siehe Schema). [source] AuCl3 -Catalyzed Benzannulation: Synthesis of Naphthyl Ketone Derivatives from o-Alkynylbenzaldehydes with Alkynes.CHEMINFORM, Issue 6 2003Naoki Asao No abstract is available for this article. [source] The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-Related to NeurosteroidsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010Mingxing Qian Abstract We report an efficient synthesis of cyclopenta[b]phenanthrenes functionalized at C-3 and C-8 from an optically pure Hajos,Parrish ketone. The key step is a neutral alumina-catalyzed Michael addition of a Hajos,Parrish ketone derivative (4) to 1,7-octadien-3-one (2) in 98% yield. This Michael addition product went through Krapcho decarbomethoxylation, aldol condensation, lithium liquid ammonia reduction, Wacker oxidation and acid-catalyzed cyclization to form cyclopenta[b]phenanthrene (1a) in 37% overall yield for the 7 steps. [source] Purification, crystallization and preliminary X-ray analysis of cytochrome P450 219A1 from Novosphingobium aromaticivorans DSM 12444ACTA CRYSTALLOGRAPHICA SECTION F (ELECTRONIC), Issue 4 2009Chuan Hong Cytochrome P450 enzymes catalyze a variety of reactions and are widely distributed in living organisms. In recent studies, the first members of five new families of cytochrome P450 enzymes have been identified, including cytochrome P450 219A1 (CYP219A1) from Novosphingobium aromaticivorans DSM 12444. It has also been reported that isolongifolen-9-one (C15H22O), a sesquiterpenoid ketone derivative, is a potential substrate for CYP219A1, inducing a ,95% shift of the haem spin state to high spin upon binding. The CYP219A1 protein has been crystallized and single crystals have been studied by X-ray crystallography. Diffraction data were collected to 2.4,Å resolution. The crystals belonged to space group P6, with unit-cell parameters a = 93.1, b = 93.1, c = 98.0,Å. Preliminary X-ray diffraction data analysis revealed that the asymmetric unit contained one protein molecule. [source] Development of the First Iron Chloride-Catalyzed Hydration of Terminal AlkynesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 3 2009Xiao-Feng Wu Abstract The development of the first iron-catalyzed hydration of terminal alkynes is described using a catalytic amount of iron(III) chloride (10 mol%). The reaction leads selectively to the corresponding methyl ketone derivatives. [source] Preparation of N -alkylpyridinium aryl ketone derivatives via the surfactant promoted cross-coupling reaction of N -alkylpyridiniumboronic acids with carboxylic anhydride in water at room temperatureAPPLIED ORGANOMETALLIC CHEMISTRY, Issue 5 2009H. Matondo Abstract The palladium (II) chloride catalyzed coupling reaction of N -alkylpyridiniumboronic acids with benzoic anhydride was carried out smoothly in water to give high yields of ketones without the use of a phosphine ligand. The reaction was conducted under mild conditions at room temperature. In this article, by focusing on the Suzuki reaction, it is shown how this method can impact modern synthetic chemistry, making reactions faster, easier and cleaner. Copyright © 2009 John Wiley & Sons, Ltd. [source] Synthesis and In-vitro Activity of 4,-Modified Analogues of ddA as Potent Anti-HIV AgentsARCHIV DER PHARMAZIE, Issue 10 2009Joon Hee Hong Abstract This paper reports the synthesis of novel 4,-hydrophobic pocket deoxythreosyl C-nucleosides. The key threose-like intermediates 9 and 14 were constructed from acyclic ketone derivatives, respectively. The antiviral activities of the synthesized compounds against the HIV-1, HSV-1, HSV-2, and HCMV viruses were evaluated. The 9-deaza-adenine derivatives 10 and 20 showed good anti-HIV activity without exhibiting significant cytotoxicity. [source] ChemInform Abstract: Copper(II)-Catalyzed Highly Diastereoselective Three-Component Reactions of Aryl Diazoacetates with Alcohols and Chalcones: An Easy Access to Furan Derivatives.CHEMINFORM, Issue 36 2010Yingguang Zhu Abstract The title reaction affords ,-hydroxy ketone derivatives (IV) in high yield with excellent diastereoselectivity. [source] | ||||||||||