EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 29 2010
O -Alkylation Using Aryl Grignard Reagents
Abstract The reaction between bis(2-benzothiazolyl) ketone (1) and a series of ring-substituted phenyl Grignard reagents gives, in considerable amount, the unexpected O -alkylation product derived from the attack of the Grignard reagent to thecarbonyl oxygen atom, thus extending the range of rarely reported cases in which O -alkylation can occur. The expected classic 1,2-addition product and that derived from O -alkylation have been obtained in a relative molar ratio dependent on the substituent on the phenyl ring. Bis(2-benzothiazolyl) aryl carbinols, the classic 1,2-addition products to the carbonyl group of 1, were obtained in high yield through an alternative synthetic route that permitted the limit imposed by O - vs. C -alkylation competition to be overcome. [source]

An Efficient Method for the Synthesis of Benzo[f]quinoline and Benzo[a]phenanthridine Derivatives Catalyzed by Iodine by a Three-Component Reaction of Arenecarbaldehyde, Naphthalen-2-amine, and Cyclic Ketone

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 20 2008
Xiang-Shan Wang
Abstract A mild, efficient, and general method for the synthesis of benzo[f]quinoline and benzo[a]phenanthridine derivatives by a three-component reaction of arenecarbaldehyde, naphthalen-2-amine, and cyclic ketone using iodine as catalyst is described. A possible reaction mechanism for the formation of the product is proposed based on further experimental results.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

A New Ketone and a Known Anticancer Triterpenoid from the Leaves of Onosma limitaneum

HELVETICA CHIMICA ACTA, Issue 2 2005
Uddin Ahmad, Viqar
A new ketone, onosmone (1), and a known anticancer triterpenoid, bauerenone, besides , -sitosterol glycoside were isolated for the first time from the CHCl3 extract of the leaves of Onosma limitaneum. The structures of these compounds were established on the basis of spectral and chemical evidence. [source]

Facile Assembly of H -Pyrazolo[5,1- a]isoquinolines via Silver Triflate-Catalyzed One-Pot Tandem Reaction of 2-Alkynyl- benzaldehyde, Sulfonohydrazide, and Ketone or Aldehyde

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
Xingxin Yu
Abstract A novel and efficient route for the generation of H -pyrazolo[5,1- a]isoquinolines via silver triflate-catalyzed one-pot tandem reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and ketone or aldehyde is described. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity. [source]

Efficient Solvent-Free Robinson Annulation Protocols for the Highly Enantioselective Synthesis of the Wieland,Miescher Ketone and Analogues

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 14-15 2009
Ben Bradshaw
Abstract A highly efficient (93% overall yield) and enantioselective (94% ee) synthesis of the Wieland,Miescher ketone (10-g scale) through a solvent-free Robinson annulation procedure is reported. The process involves only 1,mol% triethylamine as the base in the initial Michael process and the organocatalyst N -tosyl-(Sa)-binam- L -prolinamide (2,mol%) and benzoic acid (0.5,mol%) for the intramolecular aldol process. This green protocol is applied to a wide range of valuable building block analogues of the Wieland,Miescher ketone (10 examples). Among these, a noteworthy compound for terpene synthesis is the 8a-allyl derivative, which is prepared in 93% yield and 97% ee in a process allowing the recovery and reutilization of the organocatalyst. Furthermore, a one-pot, two-step process has also been developed. [source]

Hydrosilylation of Ketone and Imine over Poly-N-Heterocyclic Carbene Particles

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 9 2009
MeiXuan Tan
Abstract N-Heterocyclic carbene (NHC)-catalyzed ketone/imine hydrosilylation, silane alcohol condensation and asymmetric ketone hydrosilylation reactions were demonstrated for the first time over solid, main-chain poly-NHC particles. The stable and robust poly-NHC particles were easily recovered, and exhibited good catalytic recyclability. A novel chiral induction protocol with a cheap and easily accessible secondary alcohol as the chiral source was also developed in this catalytic system. [source]

Gold(III) Chloride-Catalyzed Addition Reactions of Electron-Rich Arenes to Methyl Vinyl Ketone

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11 2003
Gerald Dyker
Abstract For the reaction of ,,,-unsaturated ketones with electron-rich arenes catalyzed by gold(III) chloride both, a Friedel,Crafts-type mechanism and an initial metallation, are evaluated. Gold(III) chloride has proven to be an efficient catalyst under very moderate reaction conditions, however, in the case of sterically demanding products HBF4 turned out to be the superior catalyst. [source]

Chiral Tetrafluorobenzobarrelenes as Effective Ligands for Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboroxines to ,,,-Disubstituted ,,,-Unsaturated Ketones,

ANGEWANDTE CHEMIE, Issue 23 2010
Ryo Shintani Dr.
Quartäre Kohlenstoffstereozentren werden durch die rhodiumkatalysierte 1,4-Addition leicht zugänglicher Arylboronsäureanhydride an ,,,-disubstituierte ,,,-ungesättigte Ketone in Gegenwart eines chiralen Tetrafluorbenzobarrelen-Liganden hoch enantioselektiv aufgebaut. [source]

Enantioselective Intermolecular Aldehyde,Ketone Cross-Coupling through an Enzymatic Carboligation Reaction,

ANGEWANDTE CHEMIE, Issue 13 2010
Patrizia Lehwald
Ein höchst nützliches Enzym ist der ThDP-abhängige Enzymkatalysator, mit dem die Titelreaktion gelang. Seine außerordentlich breite Substratpalette umfasst cyclische und offenkettige Ketone, Diketone sowie ,- und ,-Ketoester als Akzeptorsubstrate. Die Absolutkonfigurationen von zwei Enzymprodukten wurden durch Einkristall-Röntgenstrukturanalyse ermittelt. [source]

Copper-Catalyzed Hydrosilylation with a Bowl-Shaped Phosphane Ligand: Preferential Reduction of a Bulky Ketone in the Presence of an Aldehyde,

ANGEWANDTE CHEMIE, Issue 8 2010
Tetsuaki Fujihara Prof.
Sperriges zuerst: Ein hoch aktiver Kupferkatalysator mit einem schalenförmigen Phosphanliganden (bsp) vermittelt eine bislang einzigartige Reaktion: die Hydrosilylierung von sperrigen Ketonen in Gegenwart eines ungeschützten Aldehyds. [source]

Atomically Precise Au25(SR)18 Nanoparticles as Catalysts for the Selective Hydrogenation of ,,,-Unsaturated Ketones and Aldehydes,

ANGEWANDTE CHEMIE, Issue 7 2010
Yan Zhu Dr.
Eine glänzende Gelegenheit: Eine Erklärung für den chemoselektiven Verlauf der Hydrierung ,,,-ungesättigter Ketone (oder Aldehyde) zu ungesättigten Alkoholen mit monodispersen Au25(SR)18 -Partikeln als Katalysator wird vorgeschlagen (siehe Bild). Dank der nun bekannten Struktur dieser Nanopartikel können Struktur-Aktivitäts-Beziehungen aufgestellt werden. [source]

N -Acyliminium Ion Chemistry: Highly Efficient and Versatile Carbon,Carbon Bond Formation by Nucleophilic Substitution of Hydroxy Groups Catalyzed by Sn(NTf2)4

ANGEWANDTE CHEMIE, Issue 4 2010
Othman Dr., Raja Ben
Atomökonomisch: Nichtmodifizierte N,O-Halbacetale wurden in einer katalytischen, hocheffizienten ,-Amidoalkylierung kohlenstoffzentrierter Nucleophile eingesetzt, darunter Siliciumverbindungen, aktive Methylenderivate, elektronenreiche Arene und selbst einfache Ketone (siehe Schema). In der Regel genügt 1,Mol-% des supersauren Lewis-Reagens Sn(NTf2)4 als Katalysator. [source]

ChemInform Abstract: Unprecedented Cu(I)-Catalyzed Microwave-Assisted Three-Component Coupling of a Ketone, an Alkyne, and a Primary Amine.

CHEMINFORM, Issue 43 2010
Olga P. Pereshivko
Abstract The title reaction ("KA2 coupling") represents a general approach to various secondary propargylamines. [source]

ChemInform Abstract: Direct Stereoselective Synthesis of 1-Amino-2,5-diarylcyclohexanecarboxylic Acid Derivatives Based on a [5 + 1] Annulation of Divinyl Ketone and Isocyanoacetate.

CHEMINFORM, Issue 31 2010
Dawei Zhang
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Copper-Catalyzed Hydrosilylation with a Bowl-Shaped Phosphane Ligand: Preferential Reduction of a Bulky Ketone in the Presence of an Aldehyde.

CHEMINFORM, Issue 26 2010
Tetsuaki Fujihara
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: CAN-Mediated Highly Regio- and Stereoselective Oxidation of Vinylidenecyclopropanes: A Novel Method for the Synthesis of Unsymmetrical Divinyl Ketone and Functional Enone Derivatives.

CHEMINFORM, Issue 51 2008
Chenliang Su
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Aza-Baylis,Hillman Reaction of Salicyl N-Tosylimines with Methyl Vinyl Ketone, Ethyl Vinyl Ketone or Phenyl Vinyl Ketone.

CHEMINFORM, Issue 5 2008
Ming-Juan Qi
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: The Aza-Morita,Baylis,Hillman Reaction of N-Thiophosphoryl Imines Catalyzed by 1,3,5-Triaza-7-phosphaadamantane (PTA) , Convenient Synthesis of ,-Methylene-,-amino Ketone or Acid Derivatives.

CHEMINFORM, Issue 1 2008
Xinyuan Xu
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Synthesis of the Thioamide Derivatives of Methyl Vinyl Ketone and Their Cyclization to 2,3-Dihydro-4H-thiopyran-4-ones.

CHEMINFORM, Issue 45 2006
L. Gros
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Effect of Additives on the Proline-Catalyzed Ketone,Aldehyde Aldol Reactions.

CHEMINFORM, Issue 21 2006
Petri M. Pihko
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

CAN- and Iodine-Catalyzed Reaction of Indole or 1-Methylindole with ,,,-Unsaturated Ketone or Aldehyde.

CHEMINFORM, Issue 18 2006
Shengkai Ko
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

GaCl3 -Catalyzed ,-Ethenylation Reaction of Ketone.

CHEMINFORM, Issue 43 2004
Ryo Amemiya
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Lewis Acid Catalyzed Reaction of Allenes with Activated Ketone.

CHEMINFORM, Issue 1 2004
Bo Xu
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Synthesis and Characterization of Some New Cycloaddition Products of Bifunctional Acetylenic Ketone.

CHEMINFORM, Issue 50 2003
R. K. Tiwari
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

A Ruthenium Catalyst that Does not Require an N,H Ligand to Achieve High Enantioselectivity for Hydrogenation of an Alkyl Aryl Ketone.

CHEMINFORM, Issue 27 2003
Carolyn G. Leong
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Baylis,Hillman Reactions of N-Arylidenediphenylphosphinamides with Methyl Vinyl Ketone, Methyl Acrylate, and Acrylonitrile.

CHEMINFORM, Issue 39 2002
Min Shi
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

ChemInform Abstract: Chemistry of Ketone ,,,-Dianions.

CHEMINFORM, Issue 21 2002
Acylation Reactions of Dianion Cuprates by Acid Chlorides.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Synthesis and Properties of ,-Iodo-,-ethoxyvinyl Trifluoromethyl Ketone.

CHEMINFORM, Issue 19 2002
Liliya M. Kacharova
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Asymmetric Synthesis of 2-Azido-1-arylethanols from Azido Aryl Ketone-,-cyclodextrin Complexes and Sodium Borohydride in Water.

CHEMINFORM, Issue 6 2002
M. Arjun Reddy
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Synthesis and Properties of 2,2-Dichlorovinyl Trifluoromethyl Ketone.

CHEMINFORM, Issue 51 2001
G. G. Levkovskaya
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]