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Joint Instability (joint + instability)
Selected AbstractsConservative management of comminuted central tarsal bone fracture and joint instability in a horseEQUINE VETERINARY EDUCATION, Issue 3 2010C. Kearney Summary A comminuted fracture of the central tarsal bone, fragmentation of the fourth tarsal bone and associated joint instability was diagnosed in a 14-year-old Sport Horse mare who presented for investigation of acute nonweightbearing hindlimb lameness. The mare responded well to conservative management and, unlike previously reported cases of similar injuries, returned to a similar level of athletic activity. [source] Decorin antisense gene therapy improves functional healing of early rabbit ligament scar with enhanced collagen fibrillogenesis in vivoJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 4 2000Norimasa Nakamura Injured ligaments heal with scar tissue, which has mechanical properties inferior to those of normal ligament, potentially resulting in re-injury, joint instability, and subsequent degenerative arthritis. In ligament scars, normal large-diameter collagen fibrils have been shown to be replaced by a homogenous population of small collagen fibrils. Because collagen is a major tensile load-bearing matrix element and because the proteoglycan decorin is known to inhibit collagen fibrillogenesis, we hypothesized that the restoration of larger collagen fibrils in a rabbit ligament scar, by down-regulating the proteoglycan decorin, would improve the mechanical properties of scar. In contrast to sense and injection-treated controls, in vivo treatment of injured ligament by antisense decorin oligodeoxynucleotides led to an increased development of larger collagen fibrils in early scar and a significant improvement in both scar failure strength (83,85% improvement at 6 weeks; p < 0.01) and scar creep elongation (33,48% less irrecoverable creep; p < 0.03) under loading. This is the first report that in vivo manipulation of collagen fibrillogenesis improves tissue function during repair processes with gene therapy. These findings not only suggest the potential use of this type of approach to improve the healing of various soft tissues (skin, ligament, tendon, and so on) but also support the use of such methods to better understand specific structure-function relationships in scars. [source] Proximal interphalangeal joint instability in the dogJOURNAL OF SMALL ANIMAL PRACTICE, Issue 9 2003M. J. Guilliard A prospective study into the use of transarticular external skeletal fixation in the treatment of proximal interphalangeal instability was undertaken. Only dogs with soft tissue injuries were included. All the dogs except one were greyhounds or related breeds. A hypothesis was proposed that if the articular surfaces were held in normal congruency for a period of time then the development of periarticular fibrosis would alone give sufficient joint support. Joint congruency was maintained by the application of a unilateral external skeletal fixator for approximately three weeks. Complications were common and were due to frame impingement on the neighbouring digit, pin tract infection and pin loosening, and all resolved following frame removal and antibiotic therapy. Careful pinplacement and prophylactic antibiotic treatment prevented complications in subsequent cases. All dogs returned to normal function with no lameness, with the exception of one racing greyhound which had a recurrence of the instability. [source] | ||||||||||