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Itchy Rash (itchy + rash)
Selected AbstractsFC03.3 Identification of subjects with atopic dermatitis in questionnaire studiesCONTACT DERMATITIS, Issue 3 2004Karen Frydendall Jepsen The performances of three different questions from The Nordic Occupational Skin Questionnaire (NOSQ-2002) were compared with respect to their ability to identify subjects with atopic dermatitis. NOSQ-2002 was used in an intervention study on the prevention of work related skin diseases among gut cleaners. The questions were: "Have you ever had an itchy rash that has been coming and going for at least 6 months, and at sometime has affected skin creases?"(A1), "Have you ever had eczema on the fronts of the elbow or behind the knees?"(S5a), and "Have you ever had "childhood" eczema?"(S5b). Question A1 is the single UK-working party question on atopic dermatitis; questions S5a & S5b are national atopic dermatitis questions previously used in different Nordic studies. A total of 255 of 622 (41%) gut cleaners answered "yes" to question A1. Questions S5a and S5b gave rise to 14% and 5% positive answers, respectively. The high frequency of positive answers to question A1 could be due to the occupational exposure of gut cleaners. Their working environment is wet and often involves both forearms and hands, hence often leading to eczema of elbow creases. In conclusion, compared to other Danish studies the UK question seems to lead to over-reporting. Question S5a seems to give a reliable frequency of atopic dermatitis in adult populations at risk for work-related skin diseases. [source] Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergyALLERGY, Issue 9 2009G. Zhang Background:, Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ,Western' and ,Eastern' environments. Objectives:, We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods:, Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. Results:, For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (Pinteraction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (Pinteraction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (Pinteraction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion:, An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. [source] Prevalence of allergy-related symptoms in Singaporean children in the second year of lifePEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 2 2005Teng Nging Tan This study describes the cross-sectional prevalence of symptoms associated with eczema (chronic itchy rash), asthma (wheeze), and allergic rhinitis (rhinoconjunctivitis) in 1026 subjects between 18.5 and 23 months old (median age is 21 months) in Singapore. The first 2 yr cumulative prevalence of chronic itchy rash, wheeze, and rhinoconjunctivitis were 22.1% (n = 227), 22.9% (n = 235), and 8.4% (n = 86) respectively. In total, 42.2% (414 of 979) reported ever having any of these symptoms. Eczema, although prevalent, was diagnosed only in 34.4% (n = 78) of children with chronic itchy rash. Children with this eczematous rash were also more prone to wheeze (cOR = 2.0, 95% CI: 1.2,3.0) and rhinoconjunctivitis (cOR = 2.0, 95% CI: 1.4,2.8). Similarly, subjects who reported rhinoconjunctivitis and chronic itchy rash were 2.4 times (95% CI: 1.6,3.6) and 1.4 times (95% CI: 1.0,2.0) more at risk of wheezing respectively. Family history of allergy was a significant risk factor for chronic itchy rash (aOR = 1.8, 95% CI: 1.3,2.4) and wheeze (aOR = 1.7, 95% CI: 1.3,2.4). Thus, symptoms related to allergy were already prevalent during the second year of life. Significant proportions of these symptoms are likely to be due to true atopy as strong relationship with familial history and comorbidity with other potential allergic symptoms were observed. [source] Skin symptoms and work-related skin symptoms among grape farmers in Crete, GreeceAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 2 2006Leda Chatzi MD Abstract Background Grape farmers are exposed to a variety of agents capable of inducing occupational skin disease. We conducted a study to measure the prevalence of skin symptoms and work-related skin symptoms among grape farmers in the Malevisi region of Crete and to provide data on associated risk factors. Methods One hundred twenty grape farmers and 100 controls participated in the study. The protocol consisted of a questionnaire, skin prick tests for 16 common allergens, and measurement of specific IgE antibodies against 8 allergens. Results Self-reported itchy rash (OR, 2.31; 95%CI, 1.10,4.84, P,<,0.05) within the last 12 months, and work-related itchy rash (OR, 4.08; 95%CI, 1.01,20.33, P,<,0.05) were significantly higher in grape farmers than in controls, after adjusting for age and sex. Sensitization to pollens (OR, 4.20; 95% CI, 1.41,12.82, P,<,0.01) and allergic rhinitis (OR, 3.06; 95% CI, 1.21,8.28, P,<,0.05) were found to be significantly associated with self-reported itchy rash in the grape farmers group. Conclusions Grape farmers reported skin symptoms more frequently than non-exposed controls, and IgE-mediated sensitization to pollens was found to be significantly associated with the reported symptoms. Further studies are needed to evaluate the impact of specific occupational agents on skin diseases among grape farmers. Am. J. Ind. Med., 2006. © 2005 Wiley-Liss, Inc. [source] Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trialBRITISH JOURNAL OF DERMATOLOGY, Issue 3 2010C.K. Dotterud Summary Background, Previous reports have suggested that certain probiotics given to mothers and children at risk of atopy halves the incidence of atopic dermatitis (AD) at 2 years of age. Objectives, To examine if probiotics given to pregnant women in a nonselected population could prevent atopic sensitization or allergic diseases during the child's first 2 years. Methods, In a randomized, double-blind trial of children from a nonselected maternal population (ClinicalTrials.gov identifier: NCT00159523), women received probiotic milk or placebo from 36 weeks of gestation to 3 months postnatally during breastfeeding. The probiotic milk contained Lactobacillus rhamnosus GG, L. acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. Children with an itchy rash for more than 4 weeks were assessed for AD. At 2 years of age, all children were assessed for atopic sensitization, AD, asthma and allergic rhinoconjunctivitis. The intention-to-treat (ITT) analysis was enabled by multiple imputations. Results, Four hundred and fifteen pregnant women were computer randomized. At 2 years, 138 and 140 children in the probiotic and the placebo groups, respectively, were assessed. In the ITT analysis, the odds ratio (OR) for the cumulative incidence of AD was 0·51 in the probiotic group compared with the placebo [95% confidence interval (CI) 0·30,0·87; P = 0·013]. There were no significant effects on asthma (OR 0·68, 95% CI 0·26,1·80; P = 0·437) or atopic sensitization (OR 1·52, 95% CI 0·74,3·14; P = 0·254). Conclusions, Probiotics given to nonselected mothers reduced the cumulative incidence of AD, but had no effect on atopic sensitization. [source] Prevalence and risk factors of asthma and allergic diseases among schoolchildren in Bolu, TurkeyACTA PAEDIATRICA, Issue 4 2008Fahrettin Talay Abstract Aim: In this study we aimed to detect the prevalence and risk factors of asthma and allergic diseases in children aged between 7 and 14 years old at rural and urban areas of Bolu, Turkey. Methods: Questionnaire of International Study of Asthma and Allergies in Childhood (ISAAC) phase one and questionnaire including questions about family, demographic, socio-economic characteristics of children were applied to 931 schoolchildren who were selected by randomized sampling. Results: In children, the prevalence of diseases and symptoms were as follows: wheeze ever: 15.5%, asthma: 5.6%, nasal symptoms ever: 41.4%, allergic rhinitis: 23.2%, itchy rash ever: 5.9% and eczema: 5.0%. In multivariate regression analysis, presence of allergic disease in the family was risk factor for wheezing (OR = 1.74, 95% CI = 1.19,2.76), asthma (OR = 2.19, CI = 1.06,4.52), allergic rhinitis (OR = 2.68, CI = 1.80,3.98) and eczema (OR = 2.33, CI = 1.17,4.65); living in shanties was risk factor for allergic rhinitis (OR = 5.26, CI = 2.1,13.16); a monthly income below $300 was risk factor for asthma (OR = 2.54, CI = 1.06,6.08). Conclusion: It was detected that the prevalence of allergic rhinitis and its symptoms was more common in schoolchildren living in Bolu. Presence of allergic disease in fathers or mothers and low socio-economic level increase the risk of asthma and other allergic diseases in children. [source] | |||||||||||||||||||