Home About us Contact
|
Home About us Contact | ||
|
|
||
Investigation
Kinds of Investigation Terms modified by Investigation Selected AbstractsSELF-CONTROL, CRIMINAL MOTIVATION AND DETERRENCE: AN INVESTIGATION USING RUSSIAN RESPONDENTSCRIMINOLOGY, Issue 2 2005CHARLES R. TITTLE With data from respondents in Nizhni Novgorod, Russia, we address the generality of self-control theory. We also assess two hypotheses. The first focuses on the attractiveness of criminal acts, that is, motivation toward crime. The second concerns the contention that the mediating link between self-control and criminal conduct is the failure of those with less self-control to anticipate the long-term costs of misbehavior. Although the magnitude of associations between self-control and indicators of criminal behavior is about the same in this study as it is in others, which suggests that the theory is not culturally bound, those associations are largely overshadowed by criminal attraction. Consistent with that, failure to anticipate costly long-term consequences does not appear to be the mediating link between self-control and criminal behavior: the evidence shows no tendency for sanction fear to be greater among those with greater self-control. In fact, sanction fear is modestly and significantly related to the crime measures independent of self-control, though sanction fear also appears to be influenced by criminal attraction. The results suggest that in the production of criminal behavior, motivation may be more important than controls inhibiting criminal impulses. [source] CLINICAL INVESTIGATION OF UPPER GASTROINTESTINAL HEMORRHAGE AFTER PERCUTANEOUS ENDOSCOPIC GASTROSTOMYDIGESTIVE ENDOSCOPY, Issue 3 2010Shinji Nishiwaki Background:, Upper gastrointestinal (GI) hemorrhage after percutaneous endoscopic gastrostomy (PEG) is sometimes reported as one of the serious complications. Our purpose was to clarify the cause of upper GI hemorrhage after PEG. Patients and Methods:, We retrospectively investigated the causes of upper GI hemorrhage among a total of 416 patients out of 426 consecutive patients who underwent PEG in our institution, excluding 10 patients who showed upper GI tumors on PEG placement. Results:, Among 17 patients who developed upper GI hemorrhage after PEG, three and four patients showed PEG tube placement and replacement-related hemorrhage, respectively; these lesions were vascular or mucosal tears around the gastrostomy site. Ten patients experienced 12 episodes of upper GI hemorrhage during PEG tube feeding. The lesions showing bleeding were caused by reflux esophagitis (five patients), gastric ulcer (two patients), gastric erosion due to mucosal inclusion in the side hole of the internal bolster (two patients), and duodenal diverticular hemorrhage (one patient). Anticoagulants were administered in six patients, including four patients with replacement-related hemorrhage and one patient each with reflux esophagitis and gastric ulcer. Conclusions:, Reflux esophagitis was the most frequent reason for upper GI hemorrhage after PEG. The interruption of anticoagulants should be considered for the prevention of hemorrhage on the placement as well as replacement of a gastrostomy tube. [source] POSTED OFFER MARKETS IN NEAR-CONTINUOUS TIME: AN EXPERIMENTAL INVESTIGATIONECONOMIC INQUIRY, Issue 3 2009DOUGLAS D. DAVIS This paper reports an experiment conducted to evaluate a "near-continuous" variant of the posted offer trading institution, where the number of periods in a market session is increased by reducing sharply each period's maximum length. Experimental results suggest that although decisions in time-truncated periods are not equivalent to periods of longer duration, extensive repetition improves considerably the drawing power of equilibrium predictions in some challenging environments. Nevertheless, significant deviations remain in the near-continuous framework. We also observe that the extra data collected in the near-continuous framework allow new insights into price convergence and signaling. (JEL C92, L12, L11) [source] AN INVESTIGATION OF HOME BIAS IN SUPERANNUATION INVESTMENT CHOICESECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 1 2006PAUL GERRANS Australian superannuation funds have increased investment choices available for their members. Fund members can typically choose from a range of ready-made options or select their own asset allocations. Evidence suggests that individuals may display a home bias in these allocations by favouring domestic assets at the expense of international assets. Such a bias may produce a sub-optimal investment. This paper investigates the asset allocations of members of the Government Employees Superannuation Board (GESB), the superannuation fund for Western Australian public sector employees. Asset allocations appear to be in line with a normal allocation to international equity, especially at the time of their first choice. Subsequent choices however appear to be driven more by historical performance of the asset classes offered, rather than by a home bias. [source] TO BE PRESENTED DURING THE 42nd ANNUAL SCIENTIFIC MEETING OF THE EUROPEAN SOCIETY FOR CLINICAL INVESTIGATION (ESCI) Geneva, Switzerland, 26,29 March 2008 THE ESCI AWARD FOR EXCELLENCE IN CLINICAL SCIENCE 10 000 EUROEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 8 2007Article first published online: 14 JUL 200 No abstract is available for this article. [source] A THEORETICAL INVESTIGATION OF SYMPATRIC EVOLUTION OF TEMPORAL REPRODUCTIVE ISOLATION AS ILLUSTRATED BY MARINE BROADCAST SPAWNERSEVOLUTION, Issue 11 2007Maurizio Tomaiuolo Recent theory suggests that frequency-dependent disruptive selection in combination with assortative mating can lead to the establishment of reproductive isolation in sympatry. Here we explore how temporal variation in reproduction might simultaneously generate both disruptive selection and assortative mating, and result in sympatric speciation. The conceptual framework of the model may be applicable to biological systems with negative frequency-dependent selection, such as marine broadcast spawners or systems with pollinator limitation. We present a model that is motivated by recent findings in marine broadcast spawners and is parameterized with data from the Montastraea annularis species complex. Broadcast spawners reproduce via external fertilization and synchronous spawning is required to increase the probability of successful fertilization, but empirical evidence shows that as density increases, so does the risk of polyspermy. Polyspermy is the fusion of multiple sperm with an egg at fertilization, a process that makes the embryo unviable. Synchrony can therefore also act as a source of negative density-dependent disruptive selection. Model analysis shows that the interaction between polyspermy and spawning synchrony can lead to temporal reproductive isolation in sympatry and that, more generally, increased density promotes maintenance of genetic variation. [source] REAL-TIME EXPERIMENTAL INVESTIGATION OF DYNAMIC CRACK BRANCHING USING HIGH-SPEED OPTICAL DIAGNOSTICSEXPERIMENTAL TECHNIQUES, Issue 2 2003L.R. Xu First page of article [source] THE INVESTIGATION OF SYNCOPE IN OLDER PATIENTSJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 4 2007Henry Woodford BSc No abstract is available for this article. [source] ESR SPECTROSCOPY INVESTIGATION OF ANTIOXIDANT ACTIVITY AND PROTECTIVE EFFECT ON HYDROXYL RADICAL-INDUCED DNA DAMAGE OF ENZYMATIC EXTRACTS FROM PICRORRHIZA KURROAJOURNAL OF FOOD BIOCHEMISTRY, Issue 6 2008SOUNG-HEE CHOI ABSTRACT The potential antioxidant activity of enzymatic extracts from Picrorrhiza kurroa was evaluated on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydroxyl radical and alkyl radical-scavenging activities using an electron spin resonance spectrometer (JEOL Ltd., Tokyo, Japan). P. kurroa was enzymatically hydrolyzed by seven carbohydrases and five proteases to prepare water-soluble extracts. The DPPH radical-scavenging activities of the pancreatic trypsin and Amyloglucosidase (AMG) (artificial carbohydrase by Novozyme Nordisk, Bagsvaerd, Denmark) extracts from P. kurroa were the highest among protease and carbohydrase extracts, and 50% inhibitory concentration (IC50) values were 35.58 and 29.03 µg/mL, respectively. The hydroxyl radical-scavenging activity of the Protamex and Viscozyme extracts from P. kurroa were the highest scavenging activities, and the IC50 values were 0.46 and 1.89 mg/mL, respectively. In addition, the Protamex and Maltogenase extracts from P. kurroa showed the highest alkyl radical-scavenging activities, and the IC50 values were 18.03 and 10.66 µg/mL, respectively. The protective effect of the Protamex extracts from P. kurroa on DNA damage which was free radical-induced was 92% at 3 mg/mL. These results indicate that enzymatic extracts of P. kurroa show potent antioxidant activity. PRACTICAL APPLICATIONS Picrorrhiza kurroa could be used to produce protein and carbohydrate extracts with antioxidative activity. Many industrial commercial enzymes such as Promozyme, Celluclast 1.5 L FG, Maltogenase L, Viscozyme L, Termamyl SC, Dextrozyme E, AMG 300 L, Protamex, Flavourzyme 500 MG, Neutrase 0.8 L, Pancreatic Trypsin and Alcalase 2.4 L could be also used to attain the extracts processing the high antioxidative activity. The extracts can be used as natural antioxidants. [source] AN INVESTIGATION OF UNMET INTIMACY NEEDS IN MARITAL RELATIONSHIPSJOURNAL OF MARITAL AND FAMILY THERAPY, Issue 4 2005Jennifer S. Kirby In this investigation we examined partners' responses to unmet intimacy needs in hopes of better understanding how these responses may affect intimacy satisfaction and overall relationship satisfaction. Eighty-four married couples, plus four additional husbands and 12 additional wives, were recruited from the community and completed measures of relationship satisfaction, intimacy need satisfaction, and attributional and communication responses to unmet intimacy needs. Consistent with the proposed mediational model, less negative attributional and communication responses to unmet intimacy needs were found to be beneficial for overall intimacy satisfaction and relationship satisfaction. In addition, more positive communication responses contributed to greater intimacy satisfaction. Limitations and clinical implications of the current study and directions for future work are discussed. [source] INVESTIGATION OF ELASTIC INVERSION ATTRIBUTES USING THE EXPANSIBLE CLAY MODEL FOR WATER SATURATIONJOURNAL OF PETROLEUM GEOLOGY, Issue 2 2009J. O. Ugbo Quantitative X-ray diffraction has been used to characterize water saturation levels in complex shaly sand reservoirs (i.e. shaly sands with infrequent carbonates and minor proportions of iron-rich minerals such as pyrite and siderite). The results led to the design of a total expansible clay model for water saturation, which is similar in form to the Dual Water model except that the excess effect of the clay minerals has been accounted for by a volume-conductivity relationship, rather than one of the usual volume-porosity translations, effectively reducing the uncertainties in estimating water saturation. Given the ambiguities associated with predicting these petrophysical properties from data on rock properties, such as mineralogy, an investigation of the relationship of estimated water saturation based on the total expansible clay model to independently determined rock properties was undertaken using well log inversion and forward modelling techniques. The results show that there is consistency in the relationship between water saturation estimates made from the total expansible clay model and known elastic parameters such as primary and shear-wave sonic velocity (Vp, Vs), bulk density (,b) and impedance (I), when the Raymer-Gardner-Hunt model is used. Use of the Raymer-Gardner-Hunt model to reconstruct the required rock-physics relationship avoids the classic limitation of the more advanced Gassman model, which assumes that the dry shear modulus is equivalent to the wet shear modulus (,dry=,wet). The present work raises further questions on the application of the Voigt-Reuss-Hill (VRH) limits, or the Hashin Shtrikman bounds for averaging the effective shear modulus of the dry matrix in complex shaly sand reservoirs, where a two-mineral matrix is normally assumed. The study shows the inapplicability of the VRH or Hashin-Shtrikman averaging techniques but provides a minor adjustment to the averaging that solves the problems faced in reconstructing the relationships between directly measured elastic properties and derived petrophysical properties for this type of reservoir rock. [source] SUPPLY MANAGEMENT, SUPPLY FLEXIBILITY AND PERFORMANCE OUTCOMES: AN EMPIRICAL INVESTIGATION OF MANUFACTURING FIRMSJOURNAL OF SUPPLY CHAIN MANAGEMENT, Issue 3 2010YING LIAO Increasingly, the global market environment is becoming more turbulent, complex and uncertain. Literature has explored the importance of supply management and its direct impact on performance. However, the nature of strategic supply management and its impact on supply flexibility needs further clarification in the context of the use of supplier resources and supplier network coordination. This research presents a model of supply management, supply flexibility and supply chain performance. In this study, we examine the relationships between supply management and supply flexibility, and extend the concept of supply flexibility in terms of supplier flexibility and supply network flexibility on relevant supply chain performance measures. Data for the study were collected from 201 manufacturing firms, and the measurement scales of supply flexibility were tested and validated using structural equation modeling. The results indicate strong, positive and direct relationships between supply management practices and supply flexibility, and between supply flexibility and supply chain performance. Concluding theoretical and managerial implications are discussed. [source] IS THERE UNIT ROOT IN THE NITROGEN OXIDES EMISSIONS: A MONTE CARLO INVESTIGATION?NATURAL RESOURCE MODELING, Issue 1 2010NINA S. JONES Abstract Use of the time-series econometric techniques to investigate issues about environmental regulation requires knowing whether air pollution emissions are trend stationary or difference stationary. It has been shown that results regarding trend stationarity of the pollution data are sensitive to the methods used. I conduct a Monte Carlo experiment to study the size and power of two unit root tests that allow for a structural change in the trend at a known time using the data-generating process calibrated to the actual pollution series. I find that finite sample properties of the Perron test are better than the Park and Sung Phillips-Perron (PP) type test. Severe size distortions in the Park and Sung PP type test can explain the rejection of a unit root in air pollution emissions reported in some environmental regulation analyses. [source] AN INVESTIGATION OF THE RELATIONSHIP BETWEEN SAFETY CLIMATE AND MEDICATION ERRORS AS WELL AS OTHER NURSE AND PATIENT OUTCOMESPERSONNEL PSYCHOLOGY, Issue 4 2006DAVID A. HOFMANN Safety climate has been shown to be associated with a number of important organizational outcomes. In this study, we take a broad view of safety climate,one that includes not only the development and adherence to safety protocols, but also open and constructive responses to errors,and investigate correlates within the health care industry. Drawing on a random, national sample of hospitals, the results revealed that safety climate predicted medication errors, nurse back injuries, urinary tract infections, patient satisfaction, patient perceptions of nurse responsiveness, and nurse satisfaction. As hypothesized, the relationship between safety climate and both medication errors and back injuries was moderated by the complexity of the patient conditions on the unit. Specifically, the effect of the overall safety climate of the unit was accentuated when dealing with more complex patient conditions. [source] UNDERSTANDING REACTIONS TO JOB REDESIGN: A QUASI-EXPERIMENTAL INVESTIGATION OF THE MODERATING EFFECTS OF ORGANIZATIONAL CONTEXT ON PERCEPTIONS OF PERFORMANCE BEHAVIORPERSONNEL PSYCHOLOGY, Issue 2 2006FREDERICK P. MORGESON Redesigning jobs from a traditional workgroup structure to a semi-autonomous team structure has become increasingly popular, but the impact of such redesigns on employee effectiveness criteria has been mixed. The present longitudinal quasi-experimental study showed that although such a redesign had positive effects on 3 performance behaviors (effort, skill usage, and problem solving), its effectiveness also depended on aspects of the organizational context. In conditions where the organizational reward and feedback and information systems were effective, redesigning work into a semi-autonomous team structure had no discernible effect on performance behaviors. In conditions where these systems were poor, however, such a redesign produced large positive benefits. This suggests that work redesigns that enhance worker autonomy are most effective in contexts where other supportive management systems are absent. [source] PATTERNS OF INTERDEPENDENCE IN WORK TEAMS: A TWO-LEVEL INVESTIGATION OF THE RELATIONS WITH JOB AND TEAM SATISFACTIONPERSONNEL PSYCHOLOGY, Issue 1 2001GERBEN S. VAN DER VEGT A questionnaire study in 17 school and 24 engineering teams examined affective reactions to task and goal interdependence at the group and individual level of analysis. Group-level task interdependence was positively related to group members' job and team satisfaction. Within-group differences in the degree of task interdependence were unrelated to affective responses. Interactions revealed that within-group task interdependence is positively related to both job and team satisfaction only if the degree of goal interdependence in the work team is high. [source] ASSESSING EUROPEAN CENTRAL BANK'S CREDIBILITY DURING THE FIRST YEARS OF THE EUROSYSTEM: A BAYESIAN EMPIRICAL INVESTIGATIONTHE MANCHESTER SCHOOL, Issue 5 2010GIANNI AMISANO In this paper we extend Svenssons (CEPR Discussion Paper 940, April 1994) ,simplest test' of inflation target credibility inside a Bayesian econometric framework and obtain various estimates of the European Central Bank's monetary policy credibility. Overall, our empirical evidence suggests that the strategy followed by the European Central Bank was successful in building a satisfactory degree of reputation. However, we find some significant credibility reversals concerning both anti-inflationary and anti-deflationary credibility. These reversals, in turn, are closely related to the evolution of the cyclical macroeconomic conditions in the euro area. [source] AN INVESTIGATION OF HOUSEHOLD REMITTANCE BEHAVIOUR: EVIDENCE FROM THE UNITED KINGDOM,THE MANCHESTER SCHOOL, Issue 6 2007KEN CLARK Overseas remittances are a vital source of income for many developing economies. In this paper we empirically model the remittance behaviour of a diverse set of ethnic minority households in England and Wales using survey data. Our results indicate that the probability of remitting is higher for richer households and for those containing more immigrants. Measures of social distance also appear to influence the sending of remittances. Significant ethnic differences in the incidence of remitting and the timing of payments remain after controlling for these and other factors. [source] INVESTIGATION OF THE CONTENT OF ANCIENT TIBETAN METALLIC BUDDHA STATUES BY MEANS OF NEUTRON IMAGING METHODSARCHAEOMETRY, Issue 3 2010E. H. LEHMANN Many important cultural and religious objects from Asia consist of outer metallic shapes, usually bronze, which fully enclose inner contents made of organic materials such as wood, bark, paper, textile, plants and others. Bronze and other metallic materials, such as copper and silver, are generally more transparent to neutrons than to X-rays. However, organic materials are less transparent to neutrons than to X-rays and therefore organic materials, enclosed by metallic materials, can be made visible with neutrons. Therefore, neutron imaging (radiography and tomography) was found to be an ideal tool for the inspection of objects that consist of metal outside and organic materials inside. This has been successfully demonstrated here with four metallic Tibetan Buddha statues, providing archaeometry with a powerful new tool. The first successful applications of this novel technique are described in this article. Further possible and useful applications of neutron imaging of cultural objects are outlined. [source] MARBLE PROVENANCE INVESTIGATION OF ROMAN SARCOPHAGI FROM THESSALONIKI*ARCHAEOMETRY, Issue 1 2010Y. MANIATIS The provenance question of the marbles used for making the sarcophagi of local production of Thessaloniki in the Roman period had been posed by archaeologists in the past. The hypothesis was that the material came mainly from the quarries of Thassos Island. This paper presents the scientific analysis of 23 characteristic samples from selected sarcophagi at the Museum of Thessaloniki, using three different techniques: electron paramagnetic resonance (EPR) spectroscopy, stable isotope analysis and maximum grain size measurements, plus in-situ examination. New combinations of parameters were used in order to resolve fully the provenance of all samples. The results showed that the vast majority of the objects were indeed made in Thassian marble but from three different quarries, namely Vathy/Saliara (dolomitic marble), Aliki (calcitic marble) and Acropolis/Phanari (calcitic marble). The calcitic marbles from Aliki and to a lesser degree from Acropolis/Phanari are met in all the basic types of sarcophagi (framed type, plain type, garland sarcophagi). The use of the better quality and snow-white dolomitic marble from Vathy/Saliara quarries is relatively restricted and is often found in works that are above the average regarding the quality of their workmanship. In addition, two sarcophagi were made in Pentlelic marble and one in Proconnesian. The scientific analysis results provide a good confirmation of the archaeological estimates and, furthermore, the conclusions constitute henceforth a secure basis for the study of the entire sculptured works of Thessaloniki. [source] ARCHAEOMETRICAL INVESTIGATION OF SICILIAN EARLY BYZANTINE GLASS: CHEMICAL AND SPECTROSCOPIC DATA*ARCHAEOMETRY, Issue 1 2010R. ARLETTI A series of early Byzantine glasses, recovered in Ganzirri (Sicily, Italy), was analysed for major, minor and trace elements. All the analysed fragments were found to be natron-based silica,lime glass. Concerning minor and trace elements, the samples can be divided into two groups: glass with high Fe, Ti and Mn contents (HIMT glass) and glass with low levels of Fe, Ti and Mn. These results, strictly in agreement with literature data for glass of the Mediterranean region, can be interpreted as a consequence of the wide trade network established in this region and of the intense circulation of raw glass and artefacts from different Mediterranean areas. X-ray absorption spectroscopy studies at Fe and Mn K-edges, performed on HIMT glass, indicate that Fe is in the oxidized form while Mn is in the reduced form. [source] A SPECTROSCOPIC INVESTIGATION OF PIGMENT AND CERAMIC SAMPLES FROM COPÁN, HONDURAS,ARCHAEOMETRY, Issue 1 2009R. A. GOODALL A combination of micro-Raman spectroscopy, micro-infrared spectroscopy and SEM,EDX was employed to characterize decorative pigments on Classic Maya ceramics from Copán, Honduras. Variation in red paint mixtures was correlated with changing ceramic types and improvements in process and firing techniques. We have confirmed the use of specular hematite on Coner ceramics by the difference in intensities of Raman bands. Different compositions of brown paint were correlated with imported and local wares. The carbon-iron composition of the ceramic type, Surlo Brown, was confirmed. By combining micro-Raman analysis with micro-ATR infrared and SEM,EDX, we have achieved a more comprehensive characterization of the paint mixtures. These spectroscopic techniques can be used non-destructively on raw samples as a rapid confirmation of ceramic type. [source] A SCIENTIFIC INVESTIGATION ON THE PROVENANCE AND TECHNOLOGY OF A BLACK-FIGURE AMPHORA ATTRIBUTED TO THE PRIAM GROUP*ARCHAEOMETRY, Issue 1 2006P. MIRTI The restoration of a Greek black-figure amphora provided an opportunity to study the provenance and production technology of the vase. The composition of the ceramic body, determined by inductively coupled plasma optical emission spectroscopy (ICP,OES), matches that of Attic products. Investigation by X-ray diffraction and reflectance spectroscopy suggests a maximum firing temperature around 900°C and a body re-oxidation temperature around 800°C, respectively. The morphology and composition of black, red and dark red surface areas were studied by scanning electron microscopy and X-ray energy-dispersive analysis; the black areas show the features of a typical well-vitrified black gloss, while the red areas were most probably obtained by simple burnishing of the body; the dark red additions, on the other hand, are the likely result of a partial re-oxidation of a clay,ochre mixture. [source] CUERDA SECA CERAMICS FROM AL-ANDALUS, ISLAMIC SPAIN AND PORTUGAL (10TH,12TH CENTURIES AD): INVESTIGATION WITH SEM,EDX AND CATHODOLUMINESCENCE*ARCHAEOMETRY, Issue 3 2005R. CHAPOULIE Since little is known about the cuerda seca technique, our aim has been to complete an initial analysis of 11th-century cuerda seca by studying fragments from the 10th century (Pechina, Almería) and the 12th century (Mértola and Almería), so as to establish the diachronic evolution of this technique. Characteristics specific to cuerda seca ceramic glazes were investigated using scanning electron microscopy (SEM) and quantitative chemical analysis with energy-dispersive X-ray spectrometry (EDX). The chemical compositions of the different-coloured glazes (green, black, yellow and white) have given us valuable indications about the evolution of the technique. The opacification mode and the firing process were also investigated. With the help of cathodoluminescence (CL) and the study of modern ,cuerda seca' glazed ceramics, new hypotheses regarding the number of firing stages, taking into account glaze and paste transformations and their interactions, are put forward. [source] PSYCHOSOCIAL INVESTIGATION OF INDIVIDUAL AND COMMUNITY RESPONSES TO THE EXPERIENCE OF OVINE JOHNE'S DISEASE IN RURAL VICTORIAAUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 2 2004Bernadette Hood Objective: This paper explores the psychosocial outcomes for individuals and communities in rural Victoria who experienced the outbreak of Ovine Johne's Disease (OJD). Design: The study uses a qualitative methodology to analyse the minutes of evidence provided by the inquiry into the control of OJD to identify the psychosocial events, experiences and outcomes associated with the control of this outbreak. The inquiry was undertaken by the Environment and Natural Resources Committee of the Victorian State Government. Setting: Public hearings were undertaken by the committee across several rural Victorian communities and the state capital, Melbourne. Subjects: The transcripts detail 136 submissions from 98 individuals and 23 organisations. Outcome measures: The analysis aimed to provide insight into the impact of the disease on individuals and communities and also to explore the factors individuals perceived as associated with these outcomes. Results: While the paper identifies that aspects of stock loss associated with the outbreak caused substantial emotional and economic distress, for farmers the most significant finding was the impact of the government control program on individuals, families and rural communities. The control program was perceived as having very limited scientific credibility and its implementation was described as heartless, inflexible and authoritarian. Involvement with the program resulted in farmers reporting emotions, such as, trauma, shame, guilt and stigma. Families became discordant and the sense of community within rural townships fragmented. Psychological outcomes of grief, depression and anxiety emerged as prevalent themes within families and communities. Conclusions: These data highlight the need for significant attention to the management of rural disasters, such as, the OJD program. [source] INVESTIGATION OF A COMPLEX PLANT EXTRACT FOR MILD TO MODERATE ERECTILE DYSFUNCTION IN A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-ARM STUDYBJU INTERNATIONAL, Issue 11 2010Elie Ghannam Nemr No abstract is available for this article. [source] HYPERHOMOCYSTEINAEMIA AND MEMBRANE FLUIDITY OF RED BLOOD CELLS IN NORMOTENSIVE AND HYPERTENSIVE MEN: AN ELECTRON PARAMAGNETIC RESONANCE INVESTIGATIONCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 2007Kazushi Tsuda SUMMARY 1The purpose of the present study was to assess the possible link between plasma homocysteine and membrane fluidity in normotensive and hypertensive men. 2The membrane fluidity (a reciprocal value of membrane microviscosity) of red blood cells (RBC) was measured using an electron paramagnetic resonance and spin-labelling method. The membrane fluidity of RBC was decreased in hypertensive compared with normotensive men. 3Total plasma homocysteine levels were significantly higher in hypertensive men than normotensive men. In contrast, plasma levels of nitric oxide (NO) metabolites were significantly lower in hypertensive men than in normotensive men. The decreased membrane fluidity of RBC was associated with hyperhomocysteinaemia and reduced plasma levels of NO metabolites. 4The results of the present study suggest that hyperhomocysteinaemia may have a role in modulating the rheological behaviour of RBC and microcirculation in men by, at least in part, reducing NO bioavailability. [source] INVESTIGATION OF THE MICROCIRCULATION AND THE STATE OF OXIDATIVE STRESS IN THE RAT AFTER SCORPION ENVENOMATIONCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 4 2007Z Sahnoun SUMMARY 1Severe cases of scorpion envenomation (SE) generally show both respiratory and cardiocirculatory dysfunction. However, the pathophysiology of SE remains controversial. In the present study, we tried to explain the pathophysiology of the haemodynamic perturbations and cardiac failure in rats poisoned by the venom of Buthus occitanus tunetanus through a histomorphometric study of myocardial and muscular skeletal microcirculation and analysis of the oxidative stress state in order to evaluate the implication of the inflammatory process in the pathogenesis of SE. 2Experiments were performed on 96 rats divided into 16 groups (n = 6 in each group). Two groups were used to determine the optimum conditions of venom administration and times when to measure haemodynamic parameters. The B. occitanus tunetanus venom was administered at a dose of 800 µg/kg and tissues were removed 5 and 20 min after envenomation. Six groups were used for histomorphometric study: two control groups, two poisoned groups an two melatonin-pretreated and poisoned groups. The histomorphometric study was performed on isolated hearts and skeletal muscles. The final eight groups of rats (two control groups, two envenomated groups, two control groups pretreated with melatonin and two groups pretreated and envenomated) were used to investigate the state of tissue oxidative stress during SE and to evaluate the anti-oxidant effect of melatonin on rats poisoned with B. occitanus tunetanus venom. This study was based on the determination of tissue malondialdehyde in isolated organs as an indicator of thiobarbituric acid-reactive substances (TBARS). Melatonin was injected at a dose of 5 mg/kg, i.v., 15 min before the administration of serum or venom. Data were compared using analysis of variance and Tukey's test for multiple pair-wise comparisons. 3Five minutes after venom injection, a significant reduction in the mean relative volume of venules and arterioles in the heart and skeletal muscles of poisoned rats was noted. Twenty minutes after venom injection, these volumes were significantly increased in the heart and skeletal muscles of poisoned rats. Pretreatment of envenomated rats with melatonin resulted in a significant decrease in the mean relative volume of the venules and arterioles in the heart and skeletal muscles 5 and 20 min after venom injection compared with untreated envenomated rats. Investigation of the oxidative stress state showed a highly significant increase in TBARS in poisoned rats compared with control groups 5 and 20 min after venom injection. Melatonin pretreatment of rats poisoned with B. occitanus tunetanus venom resulted in an important and highly significant reduction of TBARS compared with untreated envenomated rats. 4It appears from the results of the present study that administration of B. occitanus tunetanus venom engendered an excessive myocardial and skeletal muscular vasoconstriction attributed to massive catecholamine release followed by arteriolar and venular vasodilatation. This venous stasis at the muscular microcirculation could be due to myocardiac failure. However, the concomitant presence of arteriolar vasodilatation suggests an inflammatory process in the pathophysiology of SE. This process was suggested by the genesis of a state of oxidative stress in relation to the important lipoperoxidation, which was inhibited by administration of the anti-oxidant melatonin. Thus, melatonin pretreatment seemed to accentuate the first phase of vascular reactivity in envenomed rats and inhibit the second vasodilator phase observed 20 min after administration of the venom. [source] ORIGINAL INVESTIGATIONS: Tissue Harmonic Imaging in Echocardiography: Better Valve Imaging, But at What Cost?ECHOCARDIOGRAPHY, Issue 2 2008Karin Hawkins M.D. Background: Tissue harmonic imaging (THI) improves echocardiographic image quality and is widely utilized. Unfortunately it also makes structures appear artificially thickened. We sought to examine its impact on the imaging of left-sided heart valves. Methods: A large echocardiographic database was searched for full, standard transthoracic echocardiographic exams performed 12-month periods before (n = 3,786) and after (n = 3,914) transition to THI at a single institution. Patients with prosthetic valves were excluded. Results: The mean age of patients was 63 ± 17 years and 65% were men. No appreciable difference in demographics was observed between time periods. While inadequate visualization of the mitral valve was reduced by 30% using THI (P = 0.014), reports of leaflet thickening increased by 28% (P = 0.005). Similarly, inadequate aortic valve visualization was reduced by 53% with THI (P < 0.001), at the expense of more aortic sclerosis (+6%, P = 0.034). Among the 480 patients with echocardiograms using each modality (time interval between studies: 370 ± 143 days), THI did not appreciably improve visualization of the either valve. Although no significant increase in mitral thickness was seen with THI, aortic sclerosis was increased by at least one grade in 24.5% (P < 0.006). Conclusion: This study suggests that while THI enhances imaging of difficult to visualize valves, it may overestimate mitral and aortic valve thickness. This could lead to overdiagnosis and unnecessary follow-up studies. Cardiologists interpreting THI echocardiograms should become familiar with the modality's shortcomings. [source] ORIGINAL INVESTIGATIONS: Comparison of Left Atrial Dimensions by Transesophageal and Transthoracic EchocardiographyECHOCARDIOGRAPHY, Issue 10 2005Harshinder Singh M.D. Transesophageal echocardiography (TEE) is an established cardiovascular diagnostic technique. Left atrial (LA) size, as measured by transthoracic echocardiography (TTE), is associated with cardiovascular disease and is a risk factor for atrial fibrillation, stroke, death, and the success of cardioversion. Assessment of LA size has not been as well validated on TEE as on TTE. We determined LA size measurements in four standard views in 122 patients undergoing TEE and TTE at the same setting. In this study, we found that measurement of LA dimensions by TEE suffers from significant limitations in all views except the basal long-axis view (mid-esophageal level) with transducer plane at 120,150 degrees. This view had the best correlation with transthoracic LA measurements: r = 0.79 for TEE long axis (CI 0.71,0.85), P <.0001. (ECHOCARDIOGRAPHY, Volume 22, November 2005) [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||