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Interface Change (interface + change)

Distribution by Scientific Domains

Medical Sciences	66%

Selected Abstracts

Fatal Subcutaneous Panniculitis-Like T-Cell Lymphoma (Sptcl) with Interface Change and Dermal Mucin, A Dead-Ringer for Lupus Erythematosus

JOURNAL OF CUTANEOUS PATHOLOGY, Issue 1 2005
L. Ma
We report a 48-year-old male who presented with ulcerated plaques and nodules of the lower extremities. Skin biopsies revealed a dense lymphocytic infiltrate involving the dermis and the subcutis in a lobular and septal pattern. No overt cytological atypia was present. Notably, several features resembling lupus erythematosus were present, including vacuolar interface change and abundant dermal mucin deposition. The patient developed pulmonary nodules, and a lung biopsy showed a perivascular and interstitial lymphoid infiltrate without overt atypia. The cutaneous and pulmonary lymphoid infiltrates showed similar immunohistochemical profiles: CD3+CD4,CD8+/,CD56+. Monoclonal rearrangements of T-cell receptor gamma gene with similar migration patterns were identified from both locations. The patient developed fatal hemophagocytic syndrome, involving liver, spleen, lymph nodes, and bone marrow. This case is amongst rare reports of subcutaneous panniculitis-like T-cell Lymphoma (SPTCL) with systemic involvement. [source]

Preliminary evaluation of in vivo reflectance confocal microscopy features of discoid lupus erythematosus

BRITISH JOURNAL OF DERMATOLOGY, Issue 6 2007
M. Ardigò
Summary Background, Discoid lupus erythematosus (DLE) can simulate other inflammatory diseases both clinically and histologically. In vivo reflectance confocal microscopy (RCM) is a noninvasive, reproducible imaging technique already reported to be useful in the evaluation of several inflammatory skin conditions such as contact dermatitis, psoriasis and Darier disease. Objectives, The aims of our study were to define RCM features of DLE and to evaluate its feasibility in biopsy site selection. Methods, Discoid lesions were selected for RCM evaluation from 10 patients with an established diagnosis of DLE. Subsequently, a 4-mm punch biopsy of the same areas evaluated with RCM was rendered for histopathological examination. Results, A series of RCM features of DLE was identified and shown to correlate well with histopathological evaluation. Interface changes, as well as epidermal, dermal and adnexal inflammatory cell infiltration, were identified with RCM in a high percentage of the lesions. A limitation of RCM examination besides imaging depth was the inability to distinguish lymphocytes from other white blood cells. Conclusions, The utility of RCM as a diagnostic tool for DLE awaits further evaluation, although it appears to be promising for biopsy site selection. [source]

Numerical simulation of free-surface flow using the level-set method with global mass correction

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 6 2010
Yali Zhang
Abstract A new numerical method that couples the incompressible Navier,Stokes equations with the global mass correction level-set method for simulating fluid problems with free surfaces and interfaces is presented in this paper. The finite volume method is used to discretize Navier,Stokes equations with the two-step projection method on a staggered Cartesian grid. The free-surface flow problem is solved on a fixed grid in which the free surface is captured by the zero level set. Mass conservation is improved significantly by applying a global mass correction scheme, in a novel combination with third-order essentially non-oscillatory schemes and a five stage Runge,Kutta method, to accomplish advection and re-distancing of the level-set function. The coupled solver is applied to simulate interface change and flow field in four benchmark test cases: (1) shear flow; (2) dam break; (3) travelling and reflection of solitary wave and (4) solitary wave over a submerged object. The computational results are in excellent agreement with theoretical predictions, experimental data and previous numerical simulations using a RANS-VOF method. The simulations reveal some interesting free-surface phenomena such as the free-surface vortices, air entrapment and wave deformation over a submerged object. Copyright © 2009 John Wiley & Sons, Ltd. [source]

Follicular porokeratosis: distinct clinical entity or histologic variant?

JOURNAL OF CUTANEOUS PATHOLOGY, Issue 11 2009
M. Pongpudpunth
Various clinical subtypes of porokeratosis, clinically characterized by annular plaques with a normal or atrophic center and a distinctive keratotic ridge, are described based on the age of onset, size, number and distribution of the lesions. Follicular involvement, identified by follicular localization of cornoid lamellae, is uncommon and has only been reported in association with other subtypes such as disseminated superficial actinic porokeratosis and porokeratosis of Mibelli. We present a case of follicular porokeratosis in a 40-year-old male who presented initially with scaly red "papules" in a follicular distribution on the upper extremity. Microscopic examination of a punch biopsy specimen revealed parakeratosis confined to the follicle and mild interface change. A repeat biopsy performed in 2008 revealed identical histologic features. In terms of etiopathogenesis, a clone of cells at the base of the follicle demonstrating abnormal keratinization is not a novel concept and has been demonstrated in other porokeratotic dermatoses. However, the presence of lesions that are solely follicular based, in terms of clinical presentation and histologic findings, and static over a 3-year period favors the concept that follicular porokeratosis is a distinct clinical entity and not merely a histologic variant of the porokeratotic dermatoses described in the literature thus far. [source]

Fatal Subcutaneous Panniculitis-Like T-Cell Lymphoma (Sptcl) with Interface Change and Dermal Mucin, A Dead-Ringer for Lupus Erythematosus

Co-evolution of user and organizational interfaces: A longitudinal case study of WWW dissemination of national statistics

JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 14 2002
Gary Marchionini
The data systems, policies and procedures, corporate culture, and public face of an agency or institution make up its organizational interface. This case study describes how user interfaces for the Bureau of Labor Statistics web site evolved over a 5-year period along with the larger organizational interface and how this co-evolution has influenced the institution itself. Interviews with BLS staff and transaction log analysis are the foci in this analysis that also included user information-seeking studies and user interface prototyping and testing. The results are organized into a model of organizational interface change and related to the information life cycle. [source]

Kikuchi-Fujimoto's Disease with Skin Manifestations

JOURNAL OF CUTANEOUS PATHOLOGY, Issue 1 2005
I.T. Yu
A fourteen-year-old female presented with persistent fever, abdominal pain, splenomegaly and multiple intra-abdominal lymphadenopathies. She underwent an exploratory laparotomy. Biopsies of the mesenteric lymph nodes revealed necrotizing histiocytic lymphadenitis, characterized by para-cortical fibrinous necrosis with karyorrhectic debris and histiocytic palisading, and paucity of the polymorphic neutrophils. She also developed concurrent skin lesions with scattered small non-itching vesicles and blisters over her back and lower legs. A punch biopsy revealed vacuolar interface changes, sub-epidermal blister formation, mild superficial perivascular infiltration, and follicle necrosis. Karyorrhectic debris and CD68-positive cells are noted around the follicle. A direct immunofluorescent study was negative for complement or immunoglobulin depositions. The patient was diagnosed as Kikuchi-Fujimoto's disease, or necrotizing histiocytic lymphadenitis, a benign self-limited lymph node disorder most commonly occurred in young females. Patients with Kikuchi's disease are typically presented with isolated cervical lymphadenopathy with or without accompanying fever. Multiple lymph node involvement, splenomegaly and/or cutaneous lesions are rare occurrences. The present patient experienced a severe inflammatory response syndrome manifested by respiratory failure, pancytopenia, and disseminated intravascular coagulopathy. She recovered completely after two weeks of intensive medical treatment. She has had no respiratory symptoms, residual lymphadenopathies or documented skin lesions in her follow-up three months after discharge. [source]

EMLA® cream-induced irritant contact dermatitis

JOURNAL OF CUTANEOUS PATHOLOGY, Issue 3 2002
Huiting Dong
Background:, The Eutectic Mixture of Local Anesthetics (EMLA® cream) is a topical anesthetic used for providing pain relief in patients undergoing superficial surgical procedures. Cutaneous side-effects have been reported rarely. Case Report:, We present a case of irritant contact dermatitis induced by EMLA® cream in a 6-year-old boy with Wiskott-Aldrich syndrome. Our patient showed clinically a well circumscribed patch corresponding to the site of application of the topical anesthetic. Histopathology showed confluent necrosis of keratinocytes in the upper epidermis, a mixed inflammatory infiltrate with priminent neutrophils in the upper dermis, and focal signs of interface changes including basal cell vacuolization and subepidermal cleft formation. Conclusions:, Graft-vs.-host-disease (GVHD), necrolytic migratory erythema, dermatitis enteropathica and pellagra should be considered in the histopathologic differential diagnosis of acute contact dermatitis caused by EMLA®. [source]

Reactive compatibilization of nylon copolymer/EPDM blends: experimental aspects and their comparison with theory

POLYMERS FOR ADVANCED TECHNOLOGIES, Issue 5 2008
Cibi Komalan
Abstract In situ reactive compatibilization was first time applied to a low melting nylon (nylon 6 and 66 copolymer) and EPDM blend system. The effects of in situ compatibilization and concentration of compatibilizer on the morphology and mechanical properties of nylon/EPDM blends have been investigated. The influence of EPM-g-MA on the phase morphology was examined by the scanning electron microscopy (SEM) after preferential extraction of the minor phase. The SEM micrographs were quantitatively analyzed for domain size measurements. The compatibilizer concentrations used were 0, 1, 2.5, 5, and 10,wt%. The graft copolymer (nylon-g-EPM) formed at the interface showed relatively high emulsifying activity. A maximum phase size reduction was observed when 2.5,wt% of compatibilizer was added to the blend system. This was followed by a leveling-off at higher loadings indicating interfacial saturation. The conformation of the compatibilizer at the interface was deduced based on the area occupied by the compatibilizer at the blend interface. The experimental compatibilization results were compared with theoretical predictions of Noolandi and Hong. It was concluded that the molecular state of compatibilizer at interface changes with concentration. The in situ compatibilized blends showed considerable improvement in mechanical properties. Measurement of tensile properties shows increased elongation as well as enhanced modulus and strength up on compatibilization. At higher concentrations of compatibilizer, a leveling-off of the tensile properties was observed. A good correlation has been observed between the mechanical properties and morphological parameters. Copyright © 2007 John Wiley & Sons, Ltd. [source]