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Intestinal Haemorrhage (intestinal + haemorrhage)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Methylene blue injection to localize the site of small intestinal haemorrhage

ANZ JOURNAL OF SURGERY, Issue 12 2004
Shanker Pasupathy
No abstract is available for this article. [source]

Spontaneous intramural intestinal haemorrhage in a haemophiliac patient

BRITISH JOURNAL OF HAEMATOLOGY, Issue 4 2004
Rita Santoro
No abstract is available for this article. [source]

Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat

BRITISH JOURNAL OF PHARMACOLOGY, Issue 8 2000
D G Souza
The effects of the long lasting and potent PAF receptor antagonist UK74505 were assessed on the local and remote injuries following ischaemia and reperfusion (I/R) of the superior mesenteric artery (SMA) in rats. In a severe model of ischaemia (120 min) and reperfusion (120) injury, in addition to the local and remote increases in vascular permeability and neutrophil accumulation, there was significant tissue haemorrhage, blood neutropenia, systemic hypotension and elevated local and systemic TNF-, levels. Post-ischaemic treatment with the selectin blocker fucoidin (10 mg kg,1) prevented neutrophil accumulation in tissue and, in consequence, all the local and systemic injuries following severe I/R. Treatment with an optimal dose of UK74505 (1 mg kg,1) also reversed local and remote neutrophil accumulation, increases in vascular permeability and intestinal haemorrhage. UK74505 partially inhibited blood neutropenia and reperfusion-induced hypotension. Interestingly, both fucoidin and UK74505 prevented the local, but not systemic, increases of TNF-, levels following severe I/R injury, demonstrating an important role of migrating cells for the local production of TNF-,. However, the results do not support a role for PAF as an intermediate molecule in the production of systemic TNF-,. The beneficial effects of UK74505 and other PAF receptor antagonists in models of I/R injury in animals and the safety of UK74505 use in man warrant further investigations of the use of this drug as preventive measure for I/R injury in humans. British Journal of Pharmacology (2000) 131, 1800,1808; doi:10.1038/sj.bjp.0703756 [source]

Blue rubber bleb nevus syndrome

ACTA PAEDIATRICA, Issue 4 2010
M Agnese
Abstract Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare condition characterized by multiple venous malformations involving the skin and internal organs. The gastrointestinal tract is always involved and intestinal haemorrhage is the most frequent clinical manifestation associated with iron deficiency anaemia. We describe a 10-year-old girl who, since birth, presented numerous venous malformations all over her body and a lymphangioma in the right leg. At the age of 5 years, she also had a severe episode of gastric bleeding requiring a blood transfusion. From this episode, she is suffering from chronic anaemia and this is the reason for admission into our hospital. The endoscopic examination of the gastrointestinal tract revealed multiple giant venous malformations in the oesophagus, stomach, duodenum and in all visible sections of the colon. Endoscopy is the gold standard technique for the diagnosis of BRBNS with GI lesions and also allows immediate therapeutic measures such as argon plasma coagulation, laser photocoagulation, sclerotherapy or band ligation. In addition, pharmacological treatments based on corticosteroids, interferon alfa, vincristine or octreotide have been described for BRBNS. Conclusion:, Blue Rubber Bleb Nevus Syndrome is a congenital cutaneous and gastrointestinal haemangiomatosis. Its morbidity and mortality depends on involvement of visceral organs and particularly on GI bleeding. The treatment is based on pharmacological or surgical therapy. Overall, the most important step is the follow-up to the presence and the evolution of GI lesions and the possible bleeding. [source]