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Integrated Devices (integrate + device)
Selected AbstractsFabrication of Photonic/Microfluidic Integrated Devices Using an Epoxy PhotoresistMACROMOLECULAR MATERIALS & ENGINEERING, Issue 6 2010Thomas Kowpak Abstract Using a single layer of SU-8 photoresist to fabricate optical waveguide cores and microfluidic channels on Pyrex glass is an ideal way to achieve photonic/microfluidic integration on a single chip. To address the problem of poor bonding, a thin nanoscale intermediate polymer layer was applied to reduce the stress generated from the material processing while maintaining strong adhesion between the patterning polymer layer and Pyrex. It was found that a 186,600,nm thick intermediate layer of a specialty epoxy photoresist effectively served the purpose without deteriorating the optical performance of the involved waveguides. Quality photonic/microfluidic integrated devices with satisfied optical performance were fabricated. [source] Protein loading, elution, and resolution behavior in a novel device that integrates ultrafiltration and chromatographic separationBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2003Xiao-Ping Dai Abstract Hollow fiber membranes and chromatographic resin beads are commonly employed in a variety of bioseparation processes. A new class of integrated separation devices is being studied in which the shell side of a hollow fiber device is filled with adsorbents/chromatographic resin beads. Such devices and the corresponding separation methods integrate feed broth clarification by the microfiltration/ultrafiltration membrane with bioproduct purification by the shell-side resin beads either as an adsorbent or as beads in elution chromatography. A mathematical model has been developed for the prediction of the chromatographic behavior of such an integrated device. Simulations have been done to study the effects of axial dispersion, feed flow rate, water permeation rate, fiber packing density, and void fraction. Numerical solutions were obtained by solving the governing equations. This model can reasonably describe the concentration profiles as well as the breakthrough and elution behaviors in the integrated device. © 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 83: 125,139, 2003. [source] Functional Nanostructured Plasmonic MaterialsADVANCED MATERIALS, Issue 10 2010Jimin Yao Abstract Plasmonic crystals fabricated with precisely controlled arrays of subwavelength metal nanostructures provide a promising platform for sensing and imaging of surface binding events with micrometer spatial resolution over large areas. Soft nanoimprint lithography provides a robust, cost-effective method for producing highly uniform plasmonic crystals of this type with predictable optical properties. The tunable multimode plasmonic resonances of these crystals and their ability for integration into lab-on-a-chip microfluidic systems can both be harnessed to achieve exceptionally high analytical sensitivities down to submonolayer levels using even a common optical microscope, circumventing numerous technical limitations of more conventional surface plasmon resonance techniques. In this article, we highlight some recent advances in this field with an emphasis on the fabrication and characterization of these integrated devices and their demonstrated applications. [source] Toward Site-Specific Stamping of GrapheneADVANCED MATERIALS, Issue 12 2009Dongsheng Li A physical hypothesis based on theory and ab initio modeling for the stamping of graphene and few-layers graphene (FLG) on silica is presented, and the feasibility of site-specific stamping of FLG patterns is demonstrated experimentally (figure shows ten-layer FLG pattern stamped on silica). The site-specific nature of the patterned stamps could enable high-throughput fabrication of future graphene-based integrated devices. [source] Sintering and Microwave Dielectric Properties of the LiNb0.63Ti0.4625O3 Ceramics with the B2O3,SiO2 Liquid-Phase AdditivesJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 11 2009Yanping Long The effect of B2O3,SiO2 liquid-phase additives on the sintering, microstructure, and microwave dielectric properties of LiNb0.63Ti0.4625O3 ceramics was investigated. It was found that the sintering temperature could be lowered easily, and the densification and dielectric properties of LiNb0.63Ti0.4625O3 ceramics could be greatly improved by adding a small amount of B2O3,SiO2 solution additives. No secondary phase was observed for the ceramics with B2O3,SiO2 additives. With the addition of 0.10 wt% B2O3,SiO2, the ceramics sintered at 900°C showed favorable microwave dielectric properties with ,r=71.7, Q×f=4950 GHz, and ,f=,2.1 ppm/°C. The energy dispersive spectra analysis showed an excellent co-firing interfacial behavior between the LiNb0.63Ti0.4625O3 ceramic and the Ag electrode. It indicated that LiNb0.63Ti0.4625O3 ceramics with B2O3,SiO2 solution additives have a number of potential applications on passive integrated devices based on the low-temperature co-fired ceramics technology. [source] Fabrication of Photonic/Microfluidic Integrated Devices Using an Epoxy PhotoresistMACROMOLECULAR MATERIALS & ENGINEERING, Issue 6 2010Thomas Kowpak Abstract Using a single layer of SU-8 photoresist to fabricate optical waveguide cores and microfluidic channels on Pyrex glass is an ideal way to achieve photonic/microfluidic integration on a single chip. To address the problem of poor bonding, a thin nanoscale intermediate polymer layer was applied to reduce the stress generated from the material processing while maintaining strong adhesion between the patterning polymer layer and Pyrex. It was found that a 186,600,nm thick intermediate layer of a specialty epoxy photoresist effectively served the purpose without deteriorating the optical performance of the involved waveguides. Quality photonic/microfluidic integrated devices with satisfied optical performance were fabricated. [source] Recent Progress in Strategies for the Creation of Protein-Based Fluorescent BiosensorsCHEMBIOCHEM, Issue 16 2009Hangxiang Wang Abstract The creation of novel bioanalytical tools for the detection and monitoring of a range of important target substances and biological events in vivo and in vitro is a great challenge in chemical biology and biotechnology. Protein-based fluorescent biosensors,integrated devices that convert a molecular-recognition event to a fluorescent signal,have recently emerged as a powerful tool. As the recognition units various proteins that can specifically recognize and bind a variety of molecules of biological significance with high affinity are employed. For the transducer, fluorescent proteins, such as green fluorescent protein (GFP) or synthetic fluorophores, are mostly adopted. Recent progress in protein engineering and organic synthesis allows us to manipulate proteins genetically and/or chemically, and a library of such protein scaffolds has been significantly expanded by genome projects. In this review, we briefly describe the recent progress of protein-based fluorescent biosensors on the basis of their platform and construction strategy, which are primarily divided into the genetically encoded fluorescent biosensors and chemically constructed biosensors. [source] | ||||||||||