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Increased Cancer Incidence (increased + cancer_incidence)
Selected AbstractsIncreased cancer incidence after radioiodine treatment for hyperthyroidismCANCER, Issue 10 2007Saara Metso MD Abstract BACKGROUND. Concerns remain about risk of cancer after radioactive iodine (RAI) treatment for hyperthyroidism, especially in organs that concentrate iodine. The objective was to assess the long-term cancer risk from RAI treatment for hyperthyroidism. METHODS. A total of 2793 hyperthyroid patients treated with RAI at Tampere University Hospital between 1965 and 2002, and 2793 age- and sex-matched reference subjects were followed for an average of 10 years through the Finnish Cancer Registry. RESULTS. Cancer incidence among hyperthyroid patients treated with RAI was higher than in the population-based control group (118.9 vs 94.9 per 10,000 person-years, rate ratio [RR], 1.25; 95% confidence interval [CI]: 1.08,1.46). Furthermore, incidence of stomach (RR, 1.75, 95% CI: 1.00,3.14), kidney (RR, 2.32; 95% CI: 1.06,5.09), and breast (RR, 1.53; 95% CI: 1.07,2.19) cancer was increased among RAI-treated patients. The relative risk of cancer increased with higher RAI dose administered. The increase in cancer incidence was statistically significant in patients treated at the age of 50,59 (RR, 1.44; 95% CI: 1.05,1.97) or older than 70 years (RR, 1.39; 95% CI: 1.05,1.82). There was a 5-year latent period after the RAI treatment before the cancer incidence began to differ between the RAI-treated hyperthyroid patients and the control group. CONCLUSIONS. Cancer incidence, especially cancer of the stomach, kidney, and breast, was higher in patients treated with RAI for hyperthyroidism. Cancer 2007. © 2007 American Cancer Society. [source] Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sitesENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 4 2005Pamela M. Vacek Abstract The somatic mutant frequency (Mf) of the hypoxanthine phosphoribosyl transferase (HPRT) gene has been widely used as a biomarker for the genotoxic effects of exposure but few studies have found an association with environmental exposures. We measured background Mfs in 49 current and former residents of Dover Township, New Jersey, who were exposed during childhood to industrially contaminated drinking water. The exposed subjects were the siblings of children who developed cancer after residing in Dover Township, where the incidence of childhood cancer has been elevated since 1979. Mfs from this exposed group were compared to Mfs in 43 age-matched, presumably unexposed residents of neighboring communities with no known water contamination and no increased cancer incidence. Statistical comparisons were based on the natural logarithm of Mf (lnMF). The mean Mf for the exposed group did not differ significantly from the unexposed group (3.90 × 10,6 vs. 5.06 × 10,6; P = 0.135), but unselected cloning efficiencies were higher in the exposed group (0.55 vs. 0.45; P = 0.005). After adjustment for cloning efficiency, lnMf values were very similar in both groups and age-related increases were comparable to those previously observed in healthy children. The results suggest that HPRT Mf may not be a sensitive biomarker for the genotoxic effects of environmental exposures in children, particularly when substantial time has elapsed since exposure. Environ. Mol. Mutagen., 2005. © 2005 Wiley-Liss, Inc. [source] RE: A new electromagnetic exposure metric: High frequency voltage transients associated with increased cancer incidence in teachers in a California school, May 28, 2008; 51:579,586AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 4 2009John W. Morgan DrPH No abstract is available for this article. [source] A new electromagnetic exposure metric: High frequency voltage transients associated with increased cancer incidence in teachers in california schoolAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 4 2009Samuel Milham MD No abstract is available for this article. [source] A new electromagnetic exposure metric: High frequency voltage transients associated with increased cancer incidence in teachers in a california schoolAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 8 2008Samuel Milham MD Abstract Background In 2003 the teachers at La Quinta, California middle school complained that they had more cancers than would be expected. A consultant for the school district denied that there was a problem. Objectives To investigate the cancer incidence in the teachers, and its cause. Method We conducted a retrospective study of cancer incidence in the teachers' cohort in relationship to the school's electrical environment. Results Sixteen school teachers in a cohort of 137 teachers hired in 1988 through 2005 were diagnosed with 18 cancers. The observed to expected (O/E) risk ratio for all cancers was 2.78 (P,=,0.000098), while the O/E risk ratio for malignant melanoma was 9.8 (P,=,0.0008). Thyroid cancer had a risk ratio of 13.3 (P,=,0.0098), and uterine cancer had a risk ratio of 9.2 (P,=,0.019). Sixty Hertz magnetic fields showed no association with cancer incidence. A new exposure metric, high frequency voltage transients, did show a positive correlation to cancer incidence. A cohort cancer incidence analysis of the teacher population showed a positive trend (P,=,7.1,×,10,10) of increasing cancer risk with increasing cumulative exposure to high frequency voltage transients on the classroom's electrical wiring measured with a Graham/Stetzer (G/S) meter. The attributable risk of cancer associated with this exposure was 64%. A single year of employment at this school increased a teacher's cancer risk by 21%. Conclusion The cancer incidence in the teachers at this school is unusually high and is strongly associated with high frequency voltage transients, which may be a universal carcinogen, similar to ionizing radiation. Am. J. Ind. Med. 51:579,586, 2008. © 2008 Wiley-Liss, Inc. [source] Screening for Prostate, Breast and Colorectal Cancer in Renal Transplant RecipientsAMERICAN JOURNAL OF TRANSPLANTATION, Issue 5 2003Bryce A. Kiberd American Society of Transplantation guidelines recommend screening renal transplant recipients for breast, colorectal and prostate cancer. However there is a lack of evidence to support this practice. Computer simulation modeling was used to estimate the years of life lost as a result of these cancers in 50-year-old renal transplant recipients and subjects in the general population. Renal transplant recipients lost fewer years of life to cancer than people in the general population largely because of reduced life expectancy. In nondiabetic transplant recipients, loss of life as a result of these cancers was comparable with that in the general population only under assumptions of increased cancer incidence and cancer-specific mortality risks. Even with two-fold higher cancer incidence and disease-specific mortality risks, diabetic transplant recipients lost considerably fewer life years to cancer than those in the general population. Recommended cancer screening for the general population may not yield the expected benefits in the average renal transplant recipient but the benefits will be considerably higher than for patients on dialysis. Transplanted patients at above-average cancer risk in good health may achieve the benefits of screening that are seen in the general population. [source] | ||||||||||