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Imine Derivatives (imine + derivative)
Selected AbstractsSynthesis and Odor Evaluation of Stereoisomers of Imine Derivatives in Roasted Spotted ShrimpHELVETICA CHIMICA ACTA, Issue 2 2003Toru Tachihara All possible stereoisomers of imine derivatives 1,4, which have the characteristic roast odor of seafood, were synthesized. As a result of odor evaluation of all isomers, we found that each isomer has a different and characteristic odor of roasted seafood. [source] ChemInform Abstract: Synthesis of New 1,4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and ,-Ketoester as Starting Materials in Solvent-Free Conditions.CHEMINFORM, Issue 35 2009Xueming Chen Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Odor Evaluation of Stereoisomers of Imine Derivatives in Roasted Spotted ShrimpHELVETICA CHIMICA ACTA, Issue 2 2003Toru Tachihara All possible stereoisomers of imine derivatives 1,4, which have the characteristic roast odor of seafood, were synthesized. As a result of odor evaluation of all isomers, we found that each isomer has a different and characteristic odor of roasted seafood. [source] Synthesis and pp60c-Src Tyrosine Kinase Inhibitory Activities of Novel Indole-3-Imine and Amine Derivatives Substituted at N1 and C5ARCHIV DER PHARMAZIE, Issue 6 2009Zuhal Kiliç Abstract A series of novel 1,3,5-trisubstituted indole derivatives, namely, N -benzyl 5-phenyl indole-3-imine, N -benzyl-5-(p -fluorophenyl)indole-3-imine and their corresponding amine congeners, were designed and synthesized as pp60c-Src tyrosine kinase inhibitors, and their inhibitory activities toward pp60c-Src tyrosine kinase were evaluated by in-vitro kinase assay. Pre-screening at two doses of compounds against kinase target revealed that, except for the N -benzyl-5-phenyl indole imine derivatives 7a,7d, all indole derivatives show the target inhibition at varying levels. Consequently, the compounds, 8c, 8f, 8g, and 8h, were selected for prescreening tests. The dose-response curves for up to six concentrations (250 to 7.8 ,M) of the active compounds were obtained by tyrosine kinase assay and the four-parameter logistic analysis of these data resulted in the IC50s of 4.69, 74.79, 75.06, and 84.23 ,M for compounds 8c, 8f, 8g, and 8h, respectively. Therefore, compound 8c, 1-(1-benzyl-5-phenyl-1H -indole-3-yl)- N -(4-fluorobenzyl)methanamine·HCl, was the promising inhibitor for pp60c-Src, followed by compounds 8g and 8h. Under the same conditions, compound 8f did not provide any reasonable inhibition pattern to be considered as active compound. Therefore, among all four active compounds, compound 8f was not found suitable for further analysis. [source] Studies on the Volatile Compounds of Roasted Spotted ShrimpCHEMISTRY & BIODIVERSITY, Issue 12 2004Toru Tachihara The aroma of spotted shrimp (Sergia lucence Hansen) was analyzed upon roasting to determine the components that constitute the characteristic roasted shrimp flavor. Our analyses resulted in the identification of ca.,200 volatiles, including high-impact sulfur and nitrogen compounds. In addition, we synthesized all possible stereoisomers of the pyrrolidine derivatives 1 and 4, and of the imine derivatives 16 and 18,20, which are very characteristic for the aroma. The odor evaluation of these chemicals revealed distinct differences, each possessing different aroma characteristics. [source] | ||||||||||