IM Injection (im + injection)

Distribution by Scientific Domains

Selected Abstracts

Immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1, NIBRG-14) vaccine administered by intramuscular or subcutaneous injection

Daisuke Ikeno
ABSTRACT The immunogenicity and safety profile of an inactivated whole-virion influenza A (H5N1, NIBRG-14) vaccine with alum adjuvant that was administered by IM or SC injection in a phase I clinical study involving 120 healthy Japanese men aged 20,40 years is described. The serological response of the IM group was stronger than that of the SC group. Local adverse events were less severe with IM injection than with SC injection, while similar systemic adverse events were seen in both groups. These results indicate that, when administering an inactivated whole virion vaccine with alum adjuvant for pandemic influenza, IM injection may achieve better immunogenicity and safety than SC injection. [source]

Exhaled nitric oxide after a single dose of intramuscular triamcinolone in children with difficult to control asthma

Jayachandran R Panickar MRCPCH
Abstract In a previous study, we reported that intramuscular (IM) triamcinolone improves symptoms in children with difficult asthma. In 2005, we revised our difficult asthma protocol to include assessment of airway inflammation, both directly using sputum induction and indirectly by measurement of exhaled nitric oxide (eNO). In this retrospective review, we aimed to describe (i) the changes in eNO and symptoms after a single 60 mg dose of IM triamcinolone and (ii) the changes in inflammatory markers in the subgroup with non-eosinophilic asthma (i.e., an induced sputum eosinophil differential count <2.0%). Seven children received IM triamcinolone during the study period. In all children, symptom scores fell in the week following the IM injection (P,<,0.01 vs. the pre-treatment week), and remained reduced for up to 6 weeks. eNO also fell within a week after IM therapy (P,<,0.01), and remained reduced for up to 4 weeks. Non-eosinophilic asthma was definitively identified in three children, and in this group, eNO and symptoms fell after the IM injection. We conclude that IM triamcinolone therapy reduces both eNO and symptoms for up to 4 weeks in children with difficult asthma. Our data provide preliminary evidence that IM triamcinolone is an effective anti-inflammatory therapy in children with induced sputum non-eosinophilic asthma. Pediatr Pulmonol. 2007; 42:573,578. © 2007 Wiley-Liss, Inc. [source]

Serum testosterone and bioavailable testosterone correlate with age and body size in hypogonadal men treated with testosterone undecanoate (1000 mg IM , Nebido®)

Robert Moisey
Summary Objective, To investigate the loading regimen for intramuscular (IM) testosterone undecanoate (Nebido®) to determine whether testosterone and bioavailable testosterone levels achieved correlate with age or body size of subjects studied. Design, Retrospective observational study of testosterone naļve patients and patients previously treated with an alternative testosterone therapy. Patients, 51 hypogonadal men (35, 68·6% secondary hypogonadism). 8 (16%) had not previously received testosterone therapy. Measurements, Patients received an IM injection of Nebido (1000 mg) at baseline and a second injection after 6 weeks. Serum was assayed at baseline and 18 weeks after commencing Nebido for total testosterone (TT) and SHBG. Bioavailable testosterone was calculated (cBioT) using TT and SHBG. Measurements were taken for weight, body mass index (BMI) and body surface area (BSA). Results, Baseline TT (mean 11·5 nmol/l, range 0·3,54·8) increased by 50% after commencing Nebido (17·2 nmol/l (5·4,32·8), P = 0·0001). 75% of subjects had a TT within the reference range (8·0,25·0 nmol/l). Subjects with primary hypogonadism had a higher 18-week TT [20·9 nmol/l (9·8,32·8) vs. 15·5 (5·4,32·6), P = 0·02] and SHBG [39·2 nmol/l (11,82) vs. 25·7 (9·0,60·0), P = 0·003] although the cBioT was not significantly different [4·9 nmol/l (2·9,7·3) vs. 4·2 (2·0,7·9), P = 0·12]. The 18-week TT positively correlated with age (R = 0·36, P = 0·01) and negatively correlated with weight (R = ,0·38, P = 0·006), BMI (R = ,0·42, P = 0·002) and BSA (R =,0·38, P = 0·007). Similarly cBioT correlated with age (R = 0·28, P = 0·04), weight (R = ,0·29, P = 0·03), BMI (R = ,0·30, P = 0·03) and BSA (R = ,0·27, P = 0·05). Age (t = 2·04, P = 0·05) and baseline testosterone (t = ,9·26, P < 0·0001) were independent variables of the increase in TT at 18 weeks. Conclusion, This starting regimen is simple and provides the majority of men with a TT within the reference range. Age and baseline TT are independent variables of the increase in TT with IM testosterone undecanoate. At week 18 age and body size correlated with the cBioT and TT and this may then be used to estimate dosing frequency for this therapy. [source]

Positive reinforcement training affects hematologic and serum chemistry values in captive chimpanzees (Pan troglodytes)

Susan P. Lambeth
Abstract Positive reinforcement training (PRT) techniques have received considerable attention for their stress reduction potential in the behavioral management of captive nonhuman primates. However, few published empirical studies have provided physiological data to support this position. To address this issue, PRT techniques were used to train chimpanzees (Pan troglodytes) to voluntarily present a leg for an intramuscular (IM) injection of anesthetic. Hematology and serum chemistry profiles were collected from healthy chimpanzees (n=128) of both sexes and various ages during their routine annual physical examinations over a 7-year period. Specific variables potentially indicative of acute stress (i.e., total white blood cell (WBC) counts, absolute segmented neutrophils (SEG), glucose (GLU) levels, and hematocrit (HCT) levels) were analyzed to determine whether the method used to administer the anesthetic (voluntary present for injection vs. involuntary injection) affected the physiological parameters. Subjects that voluntarily presented for an anesthetic injection had significantly lower mean total WBC counts, SEG, and GLU levels than subjects that were involuntarily anesthetized by more traditional means. Within-subjects analyses revealed the same pattern of results. This is one of the first data sets to objectively demonstrate that PRT for voluntary presentation of IM injections of anesthetic can significantly affect some of the physiological measures correlated with stress responses to chemical restraint in captive chimpanzees. Am. J. Primatol. 68:245,256, 2006. © 2006 Wiley-Liss, Inc. [source]