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Analytical Sciences (analytical + science)

Distribution by Scientific Domains

Life Sciences	75%

Selected Abstracts

Carbon nanotube disposable detectors in microchip capillary electrophoresis for water-soluble vitamin determination: Analytical possibilities in pharmaceutical quality control

ELECTROPHORESIS, Issue 14 2008
Agustín G. Crevillén
Abstract In this work, the synergy of one mature example from "lab-on-chip" domain, such as CE microchips with emerging miniaturized carbon nanotube detectors in analytical science, is presented. Two different carbon electrodes (glassy carbon electrode (GCE) 3,mm diameter, and screen-printed electrode (SPE) 0.3,mm×2.5,mm) were modified with multiwalled carbon nanotubes (MWCNTs) and their electrochemical behavior was evaluated as detectors in CE microchip using water-soluble vitamins (pyridoxine, ascorbic acid, and folic acid) in pharmaceutical preparations as representative examples. The SPE modified with MWCNT was the best electrode for the vitamin analysis in terms of analytical performance. In addition, accurate determination of the three vitamins in four different pharmaceuticals was obtained (systematic error less than 9%) in only 400,s using a protocol that combined the sample analysis and the methodological calibration. [source]

Liquid chromatography on chip

ELECTROPHORESIS, Issue 15 2010
Karine Faure
Abstract LC is one of the most powerful separation techniques as illustrated by its leading role in analytical sciences through both academic and industrial communities. Its implementation in microsystems appears to be crucial in the development of ,-Total Analysis System. If electrophoretic techniques have been widely used in miniaturized devices, LC has faced multiple challenges in the downsizing process. During the past 5 years, significant breakthroughs have been achieved in this research area, in both conception and use of LC on chip. This review emphasizes the development of novel stationary phases and their implementation in microchannels. Recent instrumental advances are also presented, highlighting the various driving forces (pressure, electrical field) that have been selected and their respective ranges of applications. [source]

Nanobiotechnology: From Molecules to Systems

ENGINEERING IN LIFE SCIENCES (ELECTRONIC), Issue 3 2004
H. Klefenz
Abstract Nanobiotechnology is a key enabling multidisciplinary field for medical, technological and biological research and development, medicine, pharmaceutical development, and analytical sciences. Its foundation is the selective integration of a multitude of endeavours, such as biotechnology, chemical and physical nanotechnology, materials sciences, chemistry, engineering, electronics and optronics targeting the construction of micro- and nano-arrays for analyzing complex mixtures of DNA, RNA, proteins, metabolites as well as the design of ultra-sequencing devices, microbial fuel cells, implantates, molecular motors, artificial organs, and nanorobots. The developments in nanobiotechnology benefit from and contribute to the scientific advances in the chemical and physical nanotechnologies, in particular with respect to materials, composites, nanostructuring techniques, carbon nanotubes, and nanoelectronics. [source]

DNA Microarray Experiments: Biological and Technological Aspects

BIOMETRICS, Issue 4 2002
Danh V. Nguyen
Summary. DNA microarray technologies, such as cDNA and oligonucleotide microarrays, promise to revolutionize biological research and further our understanding of biological processes. Due to the complex nature and sheer amount of data produced from microarray experiments, biologists have sought the collaboration of experts in the analytical sciences, including statisticians, among others. However, the biological and technical intricacies of microarray experiments are not easily accessible to analytical experts. One aim for this review is to provide a bridge to some of the relevant biological and technical aspects involved in microarray experiments. While there is already a large literature on the broad applications of the technology, basic research on the technology itself and studies to understand process variation remain in their infancy. We emphasize the importance of basic research in DNA array technologies to improve the reliability of future experiments. [source]