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Analysis Points (analysis + point)
Selected AbstractsStepping Into the Fray: When Do Mediators Mediate?AMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 2 2005J. Michael Greig In this article, I analyze the conditions that promote the request, offer, and occurrence of mediation between enduring rivals. Although the mediation literature has devoted considerable attention to the form that mediation takes, the approaches that mediators use, and the conditions under which it is successful, little attention has been given to the conditions under which mediation is most likely to occur. The results of the analysis point to a disconnect among enduring rivalries between the factors that the literature highlights as promoting mediation success and those that promote the onset of mediation. This disconnect is particularly apparent in the conditions that prompt third-parties to offer mediation. [source] Role of Chronic Infection and Inflammation in the Gastrointestinal Tract in the Etiology and Pathogenesis of Idiopathic ParkinsonismHELICOBACTER, Issue 4 2005Part 2: Response of Facets of Clinical Idiopathic Parkinsonism to Helicobacter pylori Eradication. ABSTRACT Background., Links between etiology/pathogenesis of neuropsychiatric disease and infection are increasingly recognized. Aim., Proof-of-principle that infection contributes to idiopathic parkinsonism. Methods., Randomized, double-blind, placebo-controlled efficacy study of proven Helicobacter pylori eradication on the time course of facets of parkinsonism. Intervention was 1 week's triple eradication therapy/placebos. Routine deblinding at 1 year (those still infected received open-active), with follow-up to 5 years post-eradication. Primary outcome was mean stride length at free-walking speed, sample size 56 for a difference, active vs. placebo, of 3/4 (between-subject standard deviation). Recruitment of subjects with idiopathic parkinsonism and H. pylori infection was stopped at 31, because of marked deterioration with eradication failure. Interim analysis was made in the 20 who had reached deblinding, seven of whom were receiving antiparkinsonian medication (long- t1/2, evenly spaced) which remained unchanged. Results., Improvement in stride-length, on active (n = 9) vs. placebo (11), exceeded size of effect on which the sample size was calculated when analyzed on intention-to-treat basis (p = .02), and on protocol analysis of six weekly assessments, including (p = .02) and excluding (p = .05) those on antiparkinsonian medication. Active eradication (blind or open) failed in 4/20, in whom B-lymphocyte count was lower. Their mean time course was: for stride-length, ,243 (95% CI ,427, ,60) vs. 45 (,10, 100) mm/year in the remainder (p = .001); for the ratio, torque to extend to flex relaxed arm, 349 (146, 718) vs. 58 (27, 96)%/ year (p < .001); and for independently rated, visual-analog scale of stance,walk videos (worst,best per individual , 0,100 mm), ,64 vs. ,3 mm from anterior and ,50 vs. 11 lateral (p = .004 and .02). Conclusions., Interim analysis points to a direct or surrogate (not necessarily unique) role of a particular infection in the pathogenesis of parkinsonism. With eradication failure, bolus release of antigen from killed bacteria could aggravate an effect of ongoing infection. [source] A bounds analysis of school completion rates in AustraliaJOURNAL OF APPLIED ECONOMETRICS, Issue 3 2008Tue Gørgens Official estimates of school completion rates in Australia increased in the 1980s, peaked in 1992, and fell immediately thereafter before stabilizing. The official estimates were a specific focus of Australian education policy. The decline caused concern at the time. We use data from the Australian Youth Survey (AYS) to gain insight into the behavior of the official estimates. The AYS suffers from nonrepresentativeness, attrition and nonresponse, which means that parameters of interest are not identified. Our bounds analysis is suggestive that school completion was overstated in the official estimates at their peak. Our analysis points to repetition as a key factor in inflating the official estimates. Copyright © 2008 John Wiley & Sons, Ltd. [source] International development management: A Northern perspective,PUBLIC ADMINISTRATION & DEVELOPMENT, Issue 2 2010Jennifer M. Brinkerhoff Abstract This article reviews international development management (DM) from a Northern (primarily though not exclusively US-based) perspective, identifies lessons learned from experience, and discusses new challenges. The primary data sources are an on-line survey of DM scholars and practitioners, and the results of a focus group discussion. Survey respondents expressed dismay that the lessons from theory and experience have failed to penetrate the world of practice (largely due to political and bureaucratic constraints). They were generally pessimistic about DM's relevance and effectiveness in the face of new challenges. Our analysis points to implications for DM as a discipline, and examines the development manager as activist, the evolution of politics within DM, and DM as an art. Identified lessons related predominantly to DM's process and values dimensions, suggesting these may best define DM's unique contours. In response to the perceived absence of learning and to new challenges, research participants issued a call for development manager activism to speak truth to power, promote DM values, educate new actors and the public, and mentor and train newcomers to the field. This study underscores Northern-based development managers' commitment to the profession, including affirmation of the ongoing utility and relevance of DM's knowledge and lessons, and its underlying values of self-determination, social equity, and empowerment. Copyright © 2010 John Wiley & Sons, Ltd. [source] A critical reappraisal of the fossil record of the bilaterian phylaBIOLOGICAL REVIEWS, Issue 2 2000GRAHAM E. BUDD ABSTRACT It has long been assumed that the extant bilaterian phyla generally have their origin in the Cambrian explosion, when they appear in an essentially modern form. Both these assumptions are questionable. A strict application of stem- and crown-group concepts to phyla shows that although the branching points of many clades may have occurred in the Early Cambrian or before, the appearance of the modern body plans was in most cases later: very few bilaterian phyla sensu stricto have demonstrable representatives in the earliest Cambrian. Given that the early branching points of major clades is an inevitable result of the geometry of clade diversification, the alleged phenomenon of phyla appearing early and remaining morphologically static is seen not to require particular explanation. Confusion in the definition of a phylum has thus led to attempts to explain (especially from a developmental perspective) a feature that is partly inevitable, partly illusory. We critically discuss models for Proterozoic diversification based on small body size, limited developmental capacity and poor preservation and cryptic habits, and show that the prospect of lineage diversification occurring early in the Proterozoic can be seen to be unlikely on grounds of both parsimony and functional morphology. Indeed, the combination of the body and trace fossil record demonstrates a progressive diversification through the end of the Proterozoic well into the Cambrian and beyond, a picture consistent with body plans being assembled during this time. Body-plan characters are likely to have been acquired monophyletically in the history of the bilaterians, and a model explaining the diversity in just one of them, the coelom, is presented. This analysis points to the requirement for a careful application of systematic methodology before explanations are sought for alleged patterns of constraint and flexibility. [source] The Impact of the National Minimum Wage in Small FirmsBRITISH JOURNAL OF INDUSTRIAL RELATIONS, Issue 3 2003James Arrowsmith The introduction of the National Minimum Wage (NMW) had potentially significant implications for small firms. Orthodox economic theory predicts adverse consequences, though institutional analysis points to potential efficiency as well as fairness effects. Using longitudinal data on 55 firms, this paper examines the impact of the NMW in small firms in clothing manufacture and hotel and catering. Different patterns of adjustment were observed, explained by both size and sector characteristics. Overall, the impact of the NMW was mediated by the informality of employment relations in the small firm. [source] |