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Hydroxy

Distribution by Scientific Domains
Chemistry87%
Polymers and Materials Science4%
Life Sciences4%
Medical Sciences2%
Distribution within Chemistry
Organic Chemistry51%
General & Introductory Chemistry10%
Crystallography9%
Analytical Chemistry5%
Mass Spectrometry4%
12 Other Subdomains21%

Terms modified by Hydroxy

  • hydroxy acid
  • hydroxy amide
  • hydroxy compound
    		•
  • hydroxy derivative
  • hydroxy ester
  • hydroxy function
    		•
  • hydroxy group
  • hydroxy groups
  • hydroxy ketone
    		•
  • hydroxy moiety
  • hydroxy sulfide

    • Selected Abstracts

    Studies on the metabolism of the ,9-tetrahydrocannabinol precursor ,9-tetrahydrocannabinolic acid A (,9-THCA-A) in rat using LC-MS/MS, LC-QTOF MS and GC-MS techniques

    JOURNAL OF MASS SPECTROMETRY (INCORP BIOLOGICAL MASS SPECTROMETRY), Issue 10 2009
    Julia Jung
    Abstract In Cannabis sativa, ,9-Tetrahydrocannabinolic acid-A (,9-THCA-A) is the non-psychoactive precursor of ,9-tetrahydrocannabinol (,9-THC). In fresh plant material, about 90% of the total ,9-THC is available as ,9-THCA-A. When heated (smoked or baked), ,9-THCA-A is only partially converted to ,9-THC and therefore, ,9-THCA-A can be detected in serum and urine of cannabis consumers. The aim of the presented study was to identify the metabolites of ,9-THCA-A and to examine particularly whether oral intake of ,9-THCA-A leads to in vivo formation of ,9-THC in a rat model. After oral application of pure ,9-THCA-A to rats (15 mg/kg body mass), urine samples were collected and metabolites were isolated and identified by liquid chromatography-mass spectrometry (LC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high resolution LC-MS using time of flight-mass spectrometry (TOF-MS) for accurate mass measurement. For detection of ,9-THC and its metabolites, urine extracts were analyzed by gas chromatography-mass spectrometry (GC-MS). The identified metabolites show that ,9-THCA-A undergoes a hydroxylation in position 11 to 11-hydroxy-,9-tetrahydrocannabinolic acid-A (11-OH-,9-THCA-A), which is further oxidized via the intermediate aldehyde 11-oxo-,9-THCA-A to 11-nor-9-carboxy-,9-tetrahydrocannabinolic acid-A (,9-THCA-A-COOH). Glucuronides of the parent compound and both main metabolites were identified in the rat urine as well. Furthermore, ,9-THCA-A undergoes hydroxylation in position 8 to 8-alpha- and 8-beta-hydroxy-,9-tetrahydrocannabinolic acid-A, respectively, (8,-Hydroxy-,9-THCA-A and 8,-Hydroxy-,9-THCA-A, respectively) followed by dehydration. Both monohydroxylated metabolites were further oxidized to their bishydroxylated forms. Several glucuronidation conjugates of these metabolites were identified. In vivo conversion of ,9-THCA-A to ,9-THC was not observed. Copyright © 2009 John Wiley & Sons, Ltd. [source]

    Structure and substrate docking of a hydroxy(phenyl)pyruvate reductase from the higher plant Coleus blumei Benth.

    ACTA CRYSTALLOGRAPHICA SECTION D, Issue 5 2010
    Verena Janiak
    Hydroxy(phenyl)pyruvate reductase [H(P)PR] belongs to the family of d -isomer-specific 2-hydroxyacid dehydrogenases and catalyzes the reduction of hydroxyphenylpyruvates as well as hydroxypyruvate and pyruvate to the corresponding lactates. Other non-aromatic substrates are also accepted. NADPH is the preferred cosubstrate. The crystal structure of the enzyme from Coleus blumei (Lamiaceae) has been determined at 1.47,Å resolution. In addition to the apoenzyme, the structure of a complex with NADP+ was determined at a resolution of 2.2,Å. H(P)PR is a dimer with a molecular mass of 34,113,Da per subunit. The structure is similar to those of other members of the enzyme family and consists of two domains separated by a deep catalytic cleft. To gain insights into substrate binding, several compounds were docked into the cosubstrate complex structure using the program AutoDock. The results show two possible binding modes with similar docking energy. However, only binding mode A provides the necessary environment in the active centre for hydride and proton transfer during reduction, leading to the formation of the (R)-enantiomer of lactate and/or hydroxyphenyllactate. [source]

    ChemInform Abstract: Influence of the Gas Atmosphere on the Deprotection of (Z)-,-Hydroxy-,,,-Unsaturated Esters.

    CHEMINFORM, Issue 7 2010
    Irakusne Lopez
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Asymmetric Synthesis of ,-Hydroxy-,,,-acetylenic Esters Catalyzed by Oxazolidine,Titanium Complex.

    CHEMINFORM, Issue 3 2010
    Jincheng Mao
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Diastereo- and Enantioselective Synthesis of ,-Hydroxy-,-Amino Acids: Application to the Synthesis of a Key Intermediate for Lactacystin.

    CHEMINFORM, Issue 27 2009
    Qiong Li
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Towards Asymmetric Au-Catalyzed Hydroxy- and Alkoxycyclization of 1,6-Enynes.

    CHEMINFORM, Issue 26 2009
    Chung-Meng Chao
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Unusual Opening of the 1,3-Dioxolane Ring in ,-Hydroxy ,,,-Acetylenic Aldehyde Dimers by the Action of Ethylenediamine.

    CHEMINFORM, Issue 19 2009
    I. A. Novokshonova
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Cyclic Acetal Formation Between 2-Pyridinecarboxyaldehyde and ,-Hydroxy-,,,-acetylenic Esters.

    CHEMINFORM, Issue 8 2009
    Sami Osman
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: A Stereodivergent Synthesis of ,-Hydroxy-,-methylene Lactones via Vinyl Epoxides.

    CHEMINFORM, Issue 43 2008
    Marion Davoust
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    DBU-Catalyzed Condensation of Acyldiazomethanes to Aldehydes in Water and a New Approach to Ethyl ,-Hydroxy ,-Arylacrylates.

    CHEMINFORM, Issue 21 2007
    Fengping Xiao
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Diastereoselective Synthesis of ,-Hydroxy ,,,-Epoxyesters and Their Conversion into ,-Hydroxy ,-Sulfenyl ,-Butyrolactones.

    CHEMINFORM, Issue 9 2007
    Santiago Rodriguez
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Enantio- and Diastereoselective Hydrogenation via Dynamic Kinetic Resolution by a Cationic Iridium Complex in the Synthesis of ,-Hydroxy-,-amino Acid Esters.

    CHEMINFORM, Issue 3 2007
    Kazuishi Makino
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Asymmetric Synthesis of ,-Hydroxy-,-trifluoromethylated Ketones via in situ Generation of Trifluoroacetaldehyde and Its Asymmetric Carbon,Carbon Bond Formation Reaction with Chiral Imines in Aqueous Media.

    CHEMINFORM, Issue 38 2006
    Kazumasa Funabiki
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Hypervalent Iodine in the Synthesis of Bridgehead Heterocycles: A Facile Route to the Synthesis of 6-Arylimidazo[2,1-b]thiazoles Using [Hydroxy(tosyloxy)iodo]benzene.

    CHEMINFORM, Issue 35 2006
    Ranjana Aggarwal
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    A Direct Catalytic Asymmetric Mannich-Type Reaction via a Dinuclear Zinc Catalyst: Synthesis of Either anti- or syn-,-Hydroxy-,-amino Ketones.

    CHEMINFORM, Issue 28 2006
    Barry M. Trost
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Highly Enantioselective Synthesis of ,-Hydroxy-,,,-acetylenic Esters by Asymmetric Alkyne Addition to Aldehydes.

    CHEMINFORM, Issue 19 2006
    Ge Gao
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Use of [Hydroxy(tosyloxy)iodo]benzene in a Novel and Facile Synthesis of 1,4-Diaryl-2-(arylamino)but-2-ene-1,4-diones.

    CHEMINFORM, Issue 33 2005
    Om Prakash
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    A Simple Procedure for the Synthesis of ,-Hydroxy-,,,-(E)-alkenoic Esters: Formal Synthesis of (+)-Macrosphelides A and B.

    CHEMINFORM, Issue 29 2005
    K. Srinivasa Rao
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    The Direct Catalytic Enantioselective Synthesis of Protected Aryl ,-Hydroxy-,-Amino Acids.

    CHEMINFORM, Issue 27 2005
    Michael C. Willis
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    A Direct Approach to ,-Hydroxy and ,-Chloro Trifluoromethyl Derivatives.

    CHEMINFORM, Issue 19 2005
    Lucie Tournier
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Synthesis of Hexabromo, Hydroxy, Epoxy, Methoxy and Nitroxy Derivatives of Tetralins and Naphthalenes.

    CHEMINFORM, Issue 7 2005
    Ramazan Erenler
    No abstract is available for this article. [source]

    Olefination of ,-Hydroxy or ,-Aminoaldehyde Derivatives via Reaction of Their Arylsulfonylhydrazones with Sulfonyl Anions.

    CHEMINFORM, Issue 50 2004
    Jerzy Wicha
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    A Facile Synthesis of Thiazole-2(3H)-thiones Through [Hydroxy(tosyloxy)iodo]benzene.

    CHEMINFORM, Issue 50 2004
    Ranjana Aggarwal
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine-Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of anti-,-Hydroxy-,-Amino Acid Derivatives.

    CHEMINFORM, Issue 47 2004
    Jun Kobayashi
    No abstract is available for this article. [source]

    Trans-Selective Conversions of ,-Hydroxy-,,,-alkynoic Esters to ,-Hydroxy-,,,-alkenoic Esters.

    CHEMINFORM, Issue 41 2004
    Christopher T. Meta
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Truncated Diastereoselective Passerini Reaction, a Rapid Construction of Polysubstituted Oxazole and Peptides Having an ,-Hydroxy-,-amino Acid Component.

    CHEMINFORM, Issue 38 2004
    Guylaine Cuny
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Unusual Reaction of ,-Hydroxy ,-Diazo Carbonyl Compounds with TsNHN=CHCOCl/Et3N.

    CHEMINFORM, Issue 37 2004
    Weifeng Shi
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Bismuth Triflate Catalyzed Condensation of ,-Hydroxy-,,,-Unsaturated Aldehydes with Aryl Amines.

    CHEMINFORM, Issue 21 2004
    J. S. Yadav
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Synthesis of ,-Ketobutyrolactones and ,-Hydroxy-,-Keto Acids.

    CHEMINFORM, Issue 18 2004
    Han-Young Kang
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Sulfinimine-Mediated Asymmetric Synthesis of ,-Hydroxy ,-Amino Phosphonates.

    CHEMINFORM, Issue 7 2004
    Franklin A. Davis
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]