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Hydroamination Reaction (hydroamination + reaction)
Selected AbstractsChemInform Abstract: Synthesis of 2,6-Disubstituted Piperazines by a Diastereoselective Palladium-Catalyzed Hydroamination Reaction.CHEMINFORM, Issue 26 2008Brian M. Cochran Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Tandem Gold(III)-Catalyzed Amination-Intramolecular Hydroamination Reactions of 1-En-4-yn-3-ols with Sulfonamides: Efficient Approach to Highly Substituted PyrrolesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 2 2008Xing-Zhong Shu Abstract A simple, convenient and efficient synthetic approach to highly substituted pyrroles has been developed by utilizing a gold(III)-catalyzed tandem amination-intramolecular hydroamination reaction. The first examples of gold-catalyzed, selective amination of 1-en-4-yn-3-ols have also been disclosed. [source] Isolation of Catalytic Intermediates in Hydroamination Reactions: Insertion of Internal Alkynes into a Zirconium,Amido Bond,ANGEWANDTE CHEMIE, Issue 36 2010David Alkin dazu, und weiter geht,s: Eine Insertion ungesättigter C-C-Bindungen in M-N-Bindungen wurde als Schlüsselschritt in Reaktionen an Lanthanoidzentren und kürzlich auch in Hydroaminierungen unter Katalyse durch Gruppe-4-Metalle vorgeschlagen. Mit der im Schema gezeigten Reaktion konnten erstmals solche Zwischenstufen an einem katalytisch aktiven d0 -Metallzentrum isoliert und charakterisiert werden. [source] BiCl3 -Catalyzed Hydroamination of Norbornene with Aromatic AminesEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 27 2007Hua Wei Abstract A BiCl3 -catalyzed hydroamination reaction of norbornene, in which a variety of electron-withdrawing groups were tolerated on amines, was presented. The current transformation possesses the advantages of being highly selective, cheap, and eco-friendly, and this process also represents a rare system for main-group Lewis acid catalyzed intermolecular hydroamination of unactivated alkenes.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source] A Highly Efficient Synthesis of a Naphthalenoid Histamine-3 AntagonistADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2009Yi-Yin Ku Abstract A highly efficient synthesis of the potent and selective histamine-3 receptor antagonist 1A was accomplished in four chemical steps and a salt formation step in 36% overall yield from 6-bromo-2-naphthalenol 9. The key features are a regioselective Suzuki coupling protocol for selective vinylation of 12 with potassium vinyltrifluoroborate in high yield (92%) with excellent regioselectivity (90:2) and a base-catalyzed hydroamination reaction of 11 in an anti-Markovnikov fashion under mild reaction conditions. An optimized copper-catalyzed cross coupling reaction is used to incorporate the pyridazinone 4. [source] Tandem Gold(III)-Catalyzed Amination-Intramolecular Hydroamination Reactions of 1-En-4-yn-3-ols with Sulfonamides: Efficient Approach to Highly Substituted PyrrolesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 2 2008Xing-Zhong Shu Abstract A simple, convenient and efficient synthetic approach to highly substituted pyrroles has been developed by utilizing a gold(III)-catalyzed tandem amination-intramolecular hydroamination reaction. The first examples of gold-catalyzed, selective amination of 1-en-4-yn-3-ols have also been disclosed. [source] On the Trapping of Vinylgold IntermediatesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 6 2010A. Stephen Abstract An internal aryl-substituted ortho -alkynylphenol and a similar aniline with stoichiometric amounts of N,N, -bis(2,6-diisopropylphenyl)imidazol-2-ylidene-gold tosylate [(IPr)AuOTs] and triethylamine gave the aurated heterocycles as stable intermediates of the corresponding gold(I)-catalysed hydrooxylation and hydroamination reactions. X-ray crystal structure analyses of both products could be obtained. A similar internal alkyl-substituted ortho -alkynylphenol gave only the cycloisomerised product, no aurated intermediate could be detected. [source] Biologically Active Compounds through Catalysis: Efficient Synthesis of N -(Heteroarylcarbonyl)- N,-(arylalkyl)piperazinesCHEMISTRY - A EUROPEAN JOURNAL, Issue 3 2004Kamal Kumar Dr. Abstract A practical route for the synthesis of new biologically active 5-HT2,A receptor antagonists has been developed. In only three catalytic steps, this class of central nervous system (CNS) active compounds can be synthesized efficiently with high diversity. As the initial step, an anti -Markovnikov addition of amines to styrenes provides an easy route to N -(arylalkyl)piperazines, which constitute the core structure of the active molecules. Here, base-catalyzed hydroamination reactions of styrenes with benzylated piperazine proceeded in high yield even at room temperature. After catalytic debenzylation, the free amines were successfully carbonylated with different aromatic and heteroaromatic halides and carbon monoxide to yield the desired compounds in good to excellent yields. The two key reactions, base-catalyzed hydroamination of styrenes and palladium-catalyzed aminocarbonylation of haloarenes/heterocycles, showed tolerance towards various functional groups, thereby demonstrating the potential to synthesize a wide variety of new derivatives of this promising class of pharmaceuticals. [source] | ||||||||||||||||||||||