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Hydrazone Derivatives (hydrazone + derivative)

Distribution by Scientific Domains

Chemistry	100%

Selected Abstracts

ChemInform Abstract: Synthesis of Some New Diaryl and Triaryl Hydrazone Derivatives as Possible Estrogen Receptor Modulators.

CHEMINFORM, Issue 19 2002
Jaya Pandey
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Synthesis and Characterization of Cubane-Like Cr4E4 (E = S, Se) Clusters , Molecular Structures of (,5 -RC5H4)4Cr4E4 (E = S, R = MeCO, MeO2C, EtO2C; E = Se, R = H)

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 15 2004
Li-Cheng Song
Abstract Treatment of the Cr,Cr singly-bonded dimers [,5 -RC5H4Cr(CO)3]2 (1, R = MeCO; 2, R = MeO2C; 3, R = EtO2C) with excess sulfur in refluxing THF gave the cubane Cr4S4 clusters (,5 -RC5H4)4Cr4S4 (4, R = MeCO; 5, R = MeO2C; 6, R = EtO2C). The cubane Cr4S4 cluster 4 reacted with excess 2,4-dinitrophenylhydrazine to produce the hydrazone derivative [,5,2,4-(NO2)2C6H3NHN=C(Me)C5H4]4Cr4S4 (7). The singly-bonded dimers of [,5 -RC5H4Cr(CO)3]2 (8, R = Me; 9, R = EtO2C), in the presence of excess selenium, reacted similarly to the linear Cr2Se complexes [,5 -RC5H4Cr(CO)2]2Se (10, R = Me; 11, R = EtO2C), which reacted with an equimolar quantity of selenium to afford the cubane Cr4Se4 clusters (,5 -RC5H4)4Cr4Se4 (12, R = Me; 13, R = EtO2C). A particularly interesting phenomenon is the cross-assembled reaction of the linear Cr2Se complexes [,5 -MeC(O)C5H4Cr(CO)2]2Se (14) and [CpCr(CO)2]2Se (15) in the presence of excess selenium in THF that gave rise to a series of cubane Cr4Se4 clusters [,5 -MeC(O)C5H4]nCp4,nCr4Se4 (16, n = 0; 17, n = 1; 18, n = 2; 19, n = 3; 20, n = 4). The possible pathway for the cross-assembled reaction is suggested. Furthermore the new clusters were characterized by elemental analysis and spectroscopy, and in the case of 4,6 and 16 also by X-ray diffraction techniques. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]

One-pot PTC synthesis of polyfused pyrazoles

HETEROATOM CHEMISTRY, Issue 3 2003
Gamal A. El-Saraf
Thienopyrazole 2, 3, 5, or 6 and thienopyrazolothiazepine 7, 9, and 11 derivatives were prepared via the reaction of the 3-aminopyrazoline-5-one 1 with CS2 and different molar ratio of a variety of halo compounds having an active methylene under PTC conditions. Also, treatment of 1 with CS2 and alcoholic KOH in 2:1:1 molar ratio afforded dipyrazolopyridine derivatives 12 and 14. On other hand, the pyrazolothiadiazineone derivative 13 was obtained by treating compound 1 with CS2 and alcoholic KOH in 1:2:2 molar ratio. Under PTC conditions, compound 1, CS2, and ethyl cyanoacetate or malononitrile to gave the pyrazolopyridine derivatives 16 and 17. Coupling of compound 1 with diazonium acetates afforded the hydrazone derivatives 18a,b, which were oxidized with bromine to give pyrazolotriazoles 19a,b or cyclized with aldehydes to give pyrazolotriazine derivatives 20a,e. Bromination of compound 1 afforded monobromopyrazole derivative 21, which could be condensed to a dipyrazolopyrazindione 23. Finally, the dibromopyrazole derivative 22 was cyclized with 2-mercaptoethanol or o-phenylenediamine to give the spiropyrazoles 24a,b. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:211,217, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10129 [source]

Uses of 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives in the synthesis of azoles, azines, and their fused derivatives

HETEROATOM CHEMISTRY, Issue 2 2002
Wagnat W. Wardakhan
The reactions of 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives with dimeric adducts 2a and 2b gave the hydrazone derivatives 3a and 3b, respectively. The reactivity of the latter products towards various chemical reagents was studied in order to provide azole and azine derivatives incorporating the thiophene ring, and most of them showed high antimicrobial activity. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:108,115, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10003 [source]