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Anorganic Bovine Bone (anorganic + bovine_bone)
Selected AbstractsPlatelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine boneJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 10 2010Jesús Torres Torres J, Tamimi F, Alkhraisat MH, Manchón Á, Linares R, Prados-Frutos JC, Hernández G, López Cabarcos E. Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone. J Clin Periodontol 2010; 37: 943,951. doi: 10.1111/j.1600-051X.2010.01615.x. Abstract Objective: Bone augmentation with the titanium-mesh (Ti-mesh) technique is susceptible to a large rate of complications such as morbidity of bone graft donor site, and mesh exposure to the oral cavity. The purpose of this study was to evaluate the effectiveness of anorganic bovine bone (ABB) in alveolar bone augmentation with the Ti-mesh technique. In addition, we investigated the effect of platelet-rich plasma (PRP) in preventing mesh exposure by using it to cover the Ti-mesh. Patients and Methods: Patients included in the clinical trial were randomly allocated by a blinded assistant into two groups. The 30 patients recruited for this study underwent 43 alveolar bone augmentation with the Ti-mesh technique using ABB as graft material in all of them. In 15 patients, the Ti-meshes were covered with PRP (PRP group) whereas in the other 15 the Ti-meshes were not (control group). After 6 months, patients were called for clinical, radiographic, and histological evaluation, and implant placement surgery. A total of 97 implants were placed in the augmented bone and their evolution was followed up for a period of 24 months. Results: Significant differences were found between the two study groups in terms of complications and bone formation. In the control group, 28.5% of the cases suffered from mesh exposure, while in the PRP group, no exposures were registered. Radiographic analysis revealed that bone augmentation was higher in the PRP group than in the control group. Overall, 97.3% of implants placed in the control group and 100% of those placed in the PRP group were successful during the monitoring period. We suggest that the positive effect of PRP on the Ti-mesh technique is due to its capacity to improve soft tissue healing, thereby protecting the mesh and graft material secured beneath the gingival tissues. Conclusions: Alveolar bone augmentation using ABB alone in the Ti-mesh technique is sufficient for implant rehabilitation. Besides, covering the Ti-meshes with PRP was a determining factor in avoiding mesh exposure. Ti-mesh exposure provoked significant bone loss, but in most cases it did not affect the subsequent placement of implants. [source] Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron-sized grains with a hierarchical pore structureCLINICAL ORAL IMPLANTS RESEARCH, Issue 3 2010Jin-Woo Park Abstract Objectives: This study investigated the efficacy of new bone graft substitutes , biphasic calcium phosphates (BCP) made of submicron-sized grains with fully interconnected wide-range micron-scale pores in two different macrodesigns: donut shaped with a 300,400 ,m central macropore (n-BCP-1) or rod-shaped (n-BCP-2) , in the healing of rabbit calvarial defects, and compared their bone-healing properties with those of various commercial bone substitutes, which included substitutes with similar BCP composition (MBCP and Osteon), anorganic bovine bone (Bio-Oss), and ,-TCP (Cerasorb). Material and methods: The surface morphology of the bone substitutes was investigated using scanning electron microscopy (SEM). Defects 8 mm in diameter were created in the calvaria of 30 adult male New Zealand White rabbits and were filled with six types of bone substitutes. The percentage of newly formed bone (NB%) was evaluated histomorphometrically 4 and 8 weeks after implantation. Results: SEM observation showed submicron-sized grains with fully interconnected micropore structures in the n-BCP-1 and n-BCP-2 groups; these groups also showed considerable new bone formation in inner micropores as well as on the outer surfaces. The n-BCP-1 group exhibited enhanced new bone formation and direct ingrowth of bone tissue with blood vessels into central pores. Histomorphometric analysis showed significantly greater NB% in the n-BCP-1 group when compared with the other groups at 4 and 8 weeks (P<0.05). Conclusion: A new BCP ceramics made of submicron-sized grains with a hierarchical pore structure was an effective osteoconductive material for the treatment of osseous defects of rabbit calvaria. To cite this article: Park J-W, Kim E-S, Jang J-H, Suh J-Y, Park K-B, Hanawa T. Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron-sized grains with a hierarchical pore structure. Clin. Oral Impl. Res. 21, 2010; 268,276. doi: 10.1111/j.1600-0501.2009.01846.x [source] Optimal microvessel density from composite graft of autogenous maxillary cortical bone and anorganic bovine bone in sinus augmentation: influence of clinical variablesCLINICAL ORAL IMPLANTS RESEARCH, Issue 2 2010Pablo Galindo-Moreno Abstract Objectives: The objectives of this study were to assess the microvessel density (MVD) of intra-sinus grafts after 6 months of wound healing and to study the relationship between revascularization processes and patient clinical variables and habits. Material and methods: We performed 45 maxillary sinus augmentations with different implant placements in 25 consecutive patients, obtaining bone cores of the grafted area for histological, histomorphometric and immunohistochemical study. Biopsies were also taken from pristine bone in the posterior maxilla (control). Results: All implants survived at 24 months. Biopsies of sinus augmentation areas showed significantly greater remodeling activity vs. pristine bone, with significantly more osteoid lines. The morphometry study revealed 34.88±15.2% vital bone, 32.02±15.1% non-mineralized tissue and 33.08±25.4% remnant anorganic bovine bone particles. The number of CD34-positive vessels was 86.28±55.52/mm2 in graft tissue vs. 31.52±13.69/mm2 in native tissue (P=0.002, Mann,Whitney U=46). The larger amount of non-mineralized tissue in grafts was directly correlated with a higher MVD (r=0.482, P=0.0001, Pearson's test). MVD was affected by the presence of periodontitis or tobacco and alcohol consumption. Conclusion: The angiogenesis and revascularization obtained by this type of graft achieve adequate tissue remodeling for osseointegration and are influenced by periodontal disease and tobacco or alcohol consumption. To cite this article: Galindo-Moreno P, Padial-Molina M, Fernández-Barbero JE, Mesa F, Rodríguez-Martínez D, O'Valle F. Optimal microvessel density from composite graft of autogenous maxillary cortical bone and anorganic bovine bone in sinus augmentation: influence of clinical variables. Clin. Oral Impl. Res. 21, 2010; 221,227 doi: 10.1111/j.1600-0501.2009.01827.x [source] A prospective clinical study of non-submerged immediate implants: clinical outcomes and esthetic resultsCLINICAL ORAL IMPLANTS RESEARCH, Issue 5 2007Stephen T. Chen Abstract Objectives: To evaluate healing of marginal defects in immediate transmucosal implants grafted with anorganic bovine bone, and to assess mucosal and radiographic outcomes 3,4 years following restoration. Material and methods: Thirty immediate transmucosal implants in maxillary anterior extraction sites of 30 patients randomly received BioOssÔ (N=10; BG), BioOssÔ and resorbable collagen membrane (N=10; BG+M) or no graft (N=10; control). Results: Vertical defect height (VDH) reductions of 81.2±5%, 70.5±17.4% and 68.2±16.6%, and horizontal defect depth (HDD) reductions of 71.7±34.3%, 81.7±33.7% and 55±28.4% were observed for BG, BG+M and control groups, respectively, with no significant inter-group differences. Horizontal resorption was significantly greater in control group (48.3±9.5%) when compared with BG (15.8±16.9%) and BG+M (20±21.9%) groups (P=0.000). Ten sites (33.3%) exhibited recession of the mucosa after 6 months; eight (26.7%) had an unsatisfactory esthetic result post-restoration due to recession. Mucosal recession was significantly associated (P=0.032) with buccally positioned implants (HDD 1.1±0.3 mm) when compared with lingually positioned implants (HDD 2.3±0.6 mm). In 19 patients followed for a mean of 4.0±0.7 years, marginal mucosa and bone levels remained stable following restoration. Conclusion: BioOssÔ significantly reduced horizontal resorption of buccal bone. There is a risk of mucosal recession and adverse soft tissue esthetics with immediate implant placement. However, this risk may be reduced by avoiding a buccal position of the implant in the extraction socket. [source] Bone healing and graft resorption of autograft, anorganic bovine bone and ,-tricalcium phosphate.CLINICAL ORAL IMPLANTS RESEARCH, Issue 3 2006A histologic, histomorphometric study in the mandibles of minipigs Abstract Objective: The purpose was to qualitatively and quantitatively compare the bone formation and graft resorption of two different bone substitutes used in both orthopedic and oral surgery, with autogenous bone as a positive control. Materials and methods: Three standardized bone defects were prepared in both mandibular angles of 12 adult minipigs. The defects were grafted with either autograft, anorganic bovine bone (ABB), or synthetic ,-tricalcium phosphate (,-TCP). Sacrifice was performed after 1, 2, 4, and 8 weeks for histologic and histomorphometric analysis. Results: At 2 weeks, more new bone formation was seen in defects filled with autograft than with ABB (P,0.0005) and ,-TCP (P,0.002). After 4 weeks, there was no significant difference between ,-TCP and the two other materials. Defects grafted with ABB still exhibited less bone formation as compared with autograft (P,0.004). At 8 weeks, more bone formation was observed in defects grafted with autograft (P,0.003) and ,-TCP (P,0.00004) than with ABB. No difference could be demonstrated between ,-TCP and autograft. ,-TCP resorbed almost completely over 8 weeks, whereas ABB remained stable. Conclusion: Both bone substitutes seemed to decelerate bone regeneration in the early healing phase as compared with autograft. All defects ultimately regenerated with newly formed bone and a developing bone marrow. The grafting materials showed complete osseous integration. Both bone substitutes may have a place in reconstructive surgery where different clinical indications require differences in biodegradability. [source] | ||||||||||