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Horizon
Kinds of Horizon Terms modified by Horizon Selected AbstractsEfficacy and Safety of a Once-Yearly Intravenous Zoledronic Acid 5 mg for Fracture Prevention in Elderly Postmenopausal Women with Osteoporosis Aged 75 and OlderJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 2 2010Steven Boonen MD OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc subgroup analysis of pooled data from the Health Outcome and Reduced Incidence with Zoledronic Acid One Yearly (HORIZON) Pivotal Fracture Trial and the HORIZON Recurrent Fracture Trial. SETTING: Multicenter, randomized, double-blind, placebo-controlled trials. PARTICIPANTS: Postmenopausal women (aged ,75) with documented osteoporosis (T -score ,,2.5 at femoral neck or ,1 prevalent vertebral or hip fracture) or a recent hip fracture. INTERVENTION: Patients were randomized to receive an intravenous infusion of ZOL 5 mg (n=1,961) or placebo (n=1,926) at baseline and 12 and 24 months. MEASUREMENTS: Primary endpoints were incidence of clinical vertebral and nonvertebral and any clinical fracture after treatment. RESULTS: At 3 years, incidence of any clinical, clinical vertebral, and nonvertebral fracture were significantly lower in the ZOL group than in the placebo group (10.8% vs 16.6%, 1.1% vs 3.7%, and 9.9% vs 13.7%, respectively) (hazard ratio (HR)=0.65, 95% confidence interval (CI)=0.54,0.78, P<.001; HR=0.34, 95% CI=0.21,0.55, P<.001; and HR=0.73, 95% CI=0.60,0.90, P=.002, respectively). The incidence of hip fracture was lower with ZOL but did not reach statistical significance. The incidence rate of postdose adverse events were higher with ZOL, although the rate of serious adverse events and deaths was comparable between the two groups. CONCLUSION: Once-yearly intravenous ZOL 5 mg was associated with a significant reduction in the risk of new clinical fractures (vertebral and nonvertebral) in elderly postmenopausal women with osteroporosis. [source] EARLY MEDIEVAL DAOIST TEXTS: STRATEGIES OF READING AND FUSION OF HORIZONSJOURNAL OF CHINESE PHILOSOPHY, Issue 3 2010FRIEDERIKE ASSANDRI First page of article [source] NEW HORIZONS IN CATHOLIC PHILOSOPHICAL THEOLOGY: FIDES ET RATIO AND THE CHANGED STATUS OF THOMISMTHE HEYTHROP JOURNAL, Issue 1 2006HAROLD E. ERNSTArticle first published online: 21 DEC 200 The author considers Pope John Paul II's 1998 encyclical, Fides et ratio, as bringing into view new horizons for Catholic philosophical theology by virtue of its endorsement of a constrained philosophical pluralism. Through a retrospective examination of the history of magisterial interventions as depicted in the encyclical, the author notes how a progressive openness to philosophical pluralism relates to the changed status of Thomism within magisterial teaching on the practice of Catholic philosophical theology. Fides et ratio describes an evolution in magisterial emphasis from proscription to prescription, which corresponds to change in the status of Thomism from an absolute to an exemplary norm. Attention to this decisive shift in the normative status of Thomism, as implied within the encyclical itself, provides both new illumination on the Pope's general intentions and new clarity with regard to some contested interpretive issues. Finally, the author highlights several new challenges that are implied by this development in magisterial teaching. [source] Market Misvaluation, Managerial Horizon, and AcquisitionsFINANCIAL MANAGEMENT, Issue 2 2010Huasheng Gao This paper analyzes the impact of managerial horizon on mergers and acquisitions activity. The main predication is that acquiring firms managed by short-horizon executives have higher abnormal returns at acquisition announcements, less likelihood of using equity to pay for the transactions, and inferior postmerger stock performance in the long run. I construct two proxies for managerial horizon based on the CEO's career concern and compensation scheme, and provide empirical evidence supporting the above prediction. Moreover, I also demonstrate that long-horizon managers are more likely to initiate acquisitions in response to high stock market valuation. [source] A preliminary archaeological and environmental study of pre-Columbian burial towers at Huachacalla, Bolivian AltiplanoGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 7 2002Matti J. Rossi Chullpas are pre-Columbian burial towers built by indigenous Aymaras on the Bolivian Altiplano. Bolivian chullpas date back to the Late Intermediate Period (A.D. 1000,1476) and the Late Horizon (A.D. 1476,1532). We recorded 228 chullpas among 84 sites in the Huachacalla region of west-central Bolivia. In our study area, the chullpas are on debris flows and coarse alluvium in the proximal and medial segments of alluvial fans at the foot of two volcanoes. Grain-size, element, and mineralogical analysis of chullpa wall material and local sediment revealed that the burial towers are composed of calcareous sand that is readily available in alluvial fan deposits near the sites. Our data suggest that the Aymaras considered environmental factors, such as drainage and stability of the soil, when they selected the locations of chullpas, whereas cultural factors played a significant role in chullpa architecture. © 2002 Wiley Periodicals, Inc. [source] Studying Contemporary Constitutionalism: Memory, Myth and HorizonJCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2010HANNES HANSEN-MAGNUSSON This article proposes to apply a praxeological approach to study contemporary constitutionalism. The approach is conceptualized following critical constructivist research on constitutionalism that focuses on experience and expectation when studying the contested meaning of norms in international relations. It argues that the concept of memory offers an important view on the language-based concept of experience which extends beyond the confines of behavioural approaches that study habitual change with regard to norms. The article offers a conceptual discussion of approaches to constitutionalism, emphasizing the distinction between modern and contemporary constitutionalism and their respective foci on regulatory versus cultural practices, introduces a praxeological dimension of horizons and elaborates on political memory and myth as concepts of functional memory. [source] Hospice and Palliative Medicine Ultrasound: a New Horizon for Emergency Medicine?ACADEMIC EMERGENCY MEDICINE, Issue 3 2010Anthony J. Dean MD No abstract is available for this article. [source] The Future of AEGIS: To the Horizon and BeyondNAVAL ENGINEERS JOURNAL, Issue 3 2009REAR ADMIRAL KATHLEEN K. PAIGE USN (RET.) First page of article [source] Toward a Moral Horizon, Nursing Ethics for Leadership and PracticeNURSING PHILOSOPHY, Issue 2 2005Steven Edwards [source] A study of the relationship between the seizure focus and 1H-MRS in temporal lobe epilepsy and frontal lobe epilepsyPSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 4 2000Senichiro Kikuchi MD Abstract Several studies of temporal lobe epilepsy (TLE) patients have investigated the relationship between the seizure focus and 1H magnetic resonance spectroscopy (1H-MRS). There have also been a few reports in other types of partial epilepsy. We examined the relationship between the seizure focus and the reduction in N -acetylaspartate : creatine (NAA : Cr) ratio using 1H-MRS in both TLE and frontal lobe epilepsy (FLE) patients. We studied 21 patients with unilateral TLE and seven patients with unilateral FLE. We used a 1.5 Tesla magnetic resonance unit (Signa Horizon; General Electric). Approximately 15 × 15 × 20 mm3 voxel of interest (VOI) was placed over the anterior portion of the bilateral hippocampus in the TLE patients, and the anterodorsal position of bilateral frontal lobe in the FLE patients. The seizure focus was identified by interictal scalp electro-encephalogram (EEG). In the TLE patients the NAA : Cr ratios were reduced in the seizure focus, while in the FLE patients they were not always reduced in the seizure focus. In the TLE patients the coincidence rate between the seizure focus and the reduction in the NAA : Cr ratio was 90% (19 of 21 patients), while in the FLE patients the coincidence rate was only 57% (four of seven patients). [source] The Rise of the Imaginal: Psychical Research on the Horizon of Theory (Again)RELIGIOUS STUDIES REVIEW, Issue 3 2007Article first published online: 22 NOV 200 First page of article [source] Functional Electrical Stimulation: A New Horizon For Quadriplegic PatientsANZ JOURNAL OF SURGERY, Issue 8 2000Claudia R. Gschwind No abstract is available for this article. [source] Plant-Arthropod Associations from the Lower Miocene of the Most Basin in Northern Bohemia (Czech Republic): A Preliminary ReportACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 4 2010Jakub PROKOP Abstract: Terrestrial plants and insects currently account for the majority of the Earth's biodiversity, and approximately half of insect species are herbivores. Thus, insects and plants share ancient associations that date back more than 400 Myr. However, investigations of their past interactions are at the preliminary stages in Western Europe. Herein, we present the first results of our study of various feeding damage based on a dataset of nearly 3500 examined plant specimens from the Lower Miocene of the Lagerstätte Bílina Mine in the Most Basin, Czech Republic. This site provides a unique view of the Neogene freshwater ecosystems. It has long been studied by scientists working in different branches of sedimentology, paleobotany, and paleozoology. The fossils are preserved in three characteristic horizons overlaying the coal seam (Clayey Superseam Horizon, Delta Sandy Horizon, and Lake Clayey Horizon), reflecting paleoenvironmental changes in a short time period of development. The trace fossils are classified as functional feeding groups or "guilds", without searching for a direct cause or a recent analog host relation. Approximately 23% of specimens of dicotyledonous plant leaves were found to be damaged and associated with some leaf "morphotypes". Deciduous plant-host taxa, and those with a chartaceous texture typical of riparian habitats, were frequently damaged, such as Populus, recorded with two species Populus zaddachii and Populus populina (57.9% and 31% herbivory levels, respectively), followed by Acer, Alnus, and Carya, averaging almost 30% of damaged leaves/leaflets. There has been evidence of 60 damage types (DT) representing all functional feeding groups recorded at the Bílina Mine, including 12 types of leaf mines and 16 gall-type DT. In total, Lower Miocene of the Lagerstätte Bílina Mine exhibits a high level of external foliage feeding types (23.7%), and a low level of more specialized DT, such as galls (4.3%) and leaf mines (<1%). A broader comparison based on DT of the main sedimentary environments shows significance supporting different biomes by frequency of damage levels and DT diversities. [source] Resynthesis of Brassica napus L. for self-incompatibility: self-incompatibility reaction, inheritance and breeding potentialPLANT BREEDING, Issue 1 2005Article first published online: 28 JUN 200, M. H. Rahman Self-incompatibility (SI) in Brassica has been considered as a pollination control mechanism for commercial hybrid seed production, and so far has been extensively used in vegetable types of Brassicas. Oilseed rape Brassica napus (AACC) is naturally self-compatible in contrast to its parental species that are generally self-incompatible. Introduction of S-alleles from its parental species into oilseed rape is therefore needed to use this pollination control mechanism in commercial hybrid seed production. Self-incompatible lines of B. napus, carrying SI alleles in both A and C genomes, were resynthesized from self-incompatible B. oleracea var. italica (CC) cv.,Green Duke' and self-incompatible B. rapa ssp. oleifera (AA) cv. ,Horizon', ,Colt' and ,AC Parkland'. All resynthesized B. napus lines exhibited strong dominant SI phenotype. Reciprocal cross-compatibility was found between some of these self-incompatible lines. The inheritance of S-alleles in these resynthesized B. napus was digenic confirming that each of the parental genomes contributed one S-locus in the resynthesized B. napus lines. However, the presence of two S-loci in the two genomes was found not to be essential for imparting a strong SI phenotype. Possible use of these dominant self-incompatible resynthesized B. napus lines in hybrid breeding is discussed. [source] Chuukese travellers and the idea of horizonASIA PACIFIC VIEWPOINT, Issue 3 2000Joachim Peter Travelling, as movement, has always been a tradition of atoll islanders. Their travels continue to identify the ways in which atoll peoples understand, appropriate, and manipulate space and boundaries. This paper argues that travelling is as relevant to islanders today as in the past and examines meanings in Chuuk islanders' travel. ,Horizon', the space ,out there', is a metaphorical model of space for atoll peoples with many traditions of travel. ,Horizon' is also a dual concept. The horizon is the space within which the islander traveller is located that is ,strange' and ,foreign'. It is also the horizon, as a defined space, that locates and brings those strange and foreign forces into the places of atoll residents and across familiar boundaries. The narrative traditions of Chuuk islanders will be used to explore these dual formulations of horizon and the different terms for travelling among an atoll people. Discussion will focus on how islanders define the boundaries of their horizon in their travels and the meanings that these boundaries give travelling or movements. [source] Myeloproliferative disorders: a time of new definitions Outflow from New Horizons in Haematology Meeting, 9,10 March 2007EUROPEAN JOURNAL OF HAEMATOLOGY, Issue 2007Radek Skoda No abstract is available for this article. [source] New Horizons for the Corporate HydrologistGROUND WATER, Issue 1 2003T.N. Narasimhan No abstract is available for this article. [source] The Psychological Basis of Historical Explanation: Reenactment, Simulation, and the Fusion of HorizonsHISTORY AND THEORY, Issue 1 2002Karsten R. Stueber In this article I will challenge a received orthodoxy in the philosophy of social science by showing that Collingwood was right in insisting that reenactment is epistemically central for historical explanations of individual agency. Situating Collingwood within the context of the debate between simulation theory and what has come to be called "theory theory" in contemporary philosophy of mind and psychology, I will develop two systematic arguments that attempt to show the essential importance of reenactment for our understanding of rational agency. I will furthermore show that Gadamer's influential critique of the reenactment model distinguishes insufficiently between the interpretation of certain types of texts and the explanation of individual actions. In providing an account of individual agency, we are committed to a realistic understanding of our ordinary scheme of action-explanations and have thus to recognize the centrality of reenactment. Nevertheless, Collingwood's emphasis on reenactment is certainly one-sided. I will demonstrate its limitations even for accounting for individual agency, and show how it has to be supplemented by various theoretical considerations, by analyzing the different explanatory strategies that Christopher Browning and Daniel Goldhagen use to explain the behavior of the ordinary men in Reserve Battalion 101 during World War II. [source] Partnering Managed Care and Community-Based Services for Frail Elders: The Care Advocate ProgramJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 6 2003Kathleen H. Wilber PhD OBJECTIVES: To describe a demonstration program that uses master's-level care managers (care advocates) to link Medicare managed care enrollees to home- and community-based services, testing whether referrals to noninsured services can reduce service usage and increase member satisfaction and retention. DESIGN: Using an algorithm designed to target frail, high-cost users of Medicare insured healthcare services, the program partners PacifiCare's Secure Horizons and four of its medical groups with two social service organizations. SETTING: Three care advocates located in two community-based social services agencies using telephone interviews to interact with targeted elders living in the community. PARTICIPANTS: Three hundred ninety PacifiCare members aged 69 to 96 receiving care from four PacifiCare-contracted medical groups. INTERVENTION: The 12-month intervention provides telephone assessment, links to eight types of home- and community-based services, and monthly follow-up contacts. MEASUREMENTS: Sociodemographic characteristics of intervention participants, types of service referrals, and acceptance rates. RESULTS: Lessons learned included the importance of building a shared vision among partners, building on existing relationships between members and providers, and building trust without face-to-face interactions. CONCLUSION: The program builds on current insured case management services and offers a practical bridge to community-based services. [source] Commentary: Broadening the Rhetorical and Descriptive Horizons in Endangered-Language LinguisticsJOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 2 2002Nancy C. Dorian [source] Himalayan Space: Cultural Horizons and Practices.JOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 1 2001Boyd Michailovsky Himalayan Space: Cultural Horizons and Practices. Balthasar Bickel and Martin Gaenszle. eds. Zürich: Völkerkundemuseum, 1999. 278 pp. [source] Expanding Nurse Practitioner HorizonsJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 8 2000APRN Editor, Charon A. Pierson PhD No abstract is available for this article. [source] The 60th Anniversary of the First Polymer Journal ("Die Makromolekulare Chemie"): Moving to New HorizonsMACROMOLECULAR CHEMISTRY AND PHYSICS, Issue 2 2003Ingrid Meisel First page of article [source] Horizons and Transitions: Past, Present, FutureMEDICAL ANTHROPOLOGY QUARTERLY, Issue 3 2007Mark Luborsky No abstract is available for this article. [source] Predictable Investment Horizons and Wealth Transfers among Mutual Fund ShareholdersTHE JOURNAL OF FINANCE, Issue 5 2004WOODROW T. JOHNSON ABSTRACT This study analyzes the distribution of investment horizons in a large, proprietary panel of all shareholders in one no-load mutual fund family. A proportional hazards model shows that there are observable shareholder characteristics that enable the fund to predict reliably on the day each account is opened whether the account will be short term or long term. Simulations show that the liquidity costs imposed on the fund by the expected short-term shareholders are significantly greater than those imposed by the expected long-term shareholders. Combining these results, the analysis argues that mutual funds do not provide equitable liquidity-risk insurance. [source] A Good Childhood: Widening Policy HorizonsTHE POLITICAL QUARTERLY, Issue 3 2009MALCOLM WICKS No abstract is available for this article. [source] The Effect of Investment Horizons on Risk, Return and End-of-Period Wealth for Major Asset Classes in CanadaCANADIAN JOURNAL OF ADMINISTRATIVE SCIENCES, Issue 2 2006Lakshman Alles Abstract The objective of this paper is to investigate whether the current practice among financial planners of recommending stocks at an early age and progressively moving into cash or bonds as retirement approaches would be appropriate. We computed returns, risks and end-of-period wealth distributions of various Canadian asset classes at increasing horizons between 1957 and 2003, based on the bootstrapping technique. Results show that investment outcomes at short horizons can be quite different from outcomes at longer horizons. Evidence is provided in favour of time diversification, while the current market practice of life cycle investing is not fully supported as stocks continue to exhibit more favourable risk-return payoffs than other asset classes, even at shorter time intervals. Résumé Cet article se propose d'étudier le bien-fondé de la pratique actuelle qui consiste à recommander des actions aux investisseurs dans leur jeunesse et l'argent liquide ou les obligations lorsqu'ils approchent l'âge de la retraite. Grâce à la technique de bootstrapping, nous calculons les retours sur investissement, les risques et la distribution de richesse en fin de période pour plusieurs types d'actifs canadiens à horizons divers entre 1957 et 2003. Les résultats présentent des différences importantes entre les investissements à court terme et les investissements à long terme. Les données disponibles soutiennent l'idée de la diversification temporelle et réfutent partiellement la pratique actuelle du cycle de vie d'investissement. De fait, les actions comportent toujours un profil risques-bénéfices plus favorable que les autres types d'actifs, même pour des intervalles de temps réduits. [source] Childhood cancer,mainly curable so where next?ACTA PAEDIATRICA, Issue 4 2000AW Craft More than 70% of childhood cancer is now curable with best modern therapy. The treatment is expensive but in terms of cost per life year saved, USD 1750, compares very favourably with other major health interventions. The rate of improvement in survival is slowing down. New, "designer", treatments are needed and, better still, prevention. The causes of childhood cancer are beginning to emerge. The origin for many is probably in utero and may be initiated by dietary and other environmental exposures perhaps in susceptible individuals. However, one of the great challenges for the future must be to extend the benefits of modern treatment to the 80% of the world's children who currently have little or no access to it in economically disadvantaged and emerging nations. The International Paediatric Oncology Society (SIOP) is leading the way in bringing hope for children with cancer worldwide. In India, with the support of the WHO, there is a "train the trainers" programme. In Africa, pilot studies of cost-effective treatments for Burkitt's lymphoma are producing gratifying results in Malawi and there are several examples of twinning programmes between major centres in developed and less well-developed countries. Conclusions: The future for children with cancer is bright. Most are curable and prevention may be just over the horizon. [source] Living labour and the labour of living: a little tractate for looking forward in the twenty-first centuryCRITICAL QUARTERLY, Issue 1 2004Darko Suvin An approach to the insights of Marx indispensable for looking forward today understands them as a fusion of three domains and horizons (cognition, liberty, and pleasure), with a set of regulative principles (dialectic, measure, absolute swerve), and a focus on living labour. The discussion progresses from Epicure and Fourier to Marx's form-giving fire of living labour. Against this horizon, capitalism is discussed as a cultural revolution based on measuring labour by means of quantitative time, opposed to use-value qualities, as well as through the metaphors from horror fantasy which Marx found to be appropriate to such a revolution. Its alliance with entropy leads to alienation and loneliness, and finally to a death-bringing economy. An Appendix on political economy and entropy discusses the situation today and a minimum program of counter-measures, beginning with the rejection of GNP as is. [source] Doctors, Borders, and Life in CrisisCULTURAL ANTHROPOLOGY, Issue 3 2005Peter Redfield The politics of life and death is explored from the perspective of Doctors Without Borders (Médecins sans frontières [MSF]), an activist nongovernmental organization explicitly founded to respond to health crises on a global scale. Following the work of Michel Foucault and Giorgio Agamben, I underline key intersections between MSF's operations that express concern for human life in the midst of humanitarian disaster and the group's self-proclaimed ethic of engaged refusal. Adopting the analytic frame of biopolitics, I suggest that the actual practice of medical humanitarian organizations in crisis settings presents a fragmentary and uncertain form of such power, extended beyond stable sovereignty and deployed within a restricted temporal horizon. [source] | ||||||||||||||||||||||||||||||||||||||||||||||