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High-quality Data (high-quality + data)
Selected AbstractsUsing pulsed gradient spin echo NMR for chemical mixture analysis: How to obtain optimum resultsCONCEPTS IN MAGNETIC RESONANCE, Issue 4 2002Brian Antalek Abstract Pulsed gradient spin echo NMR is a powerful technique for measuring diffusion coefficients. When coupled with appropriate data processing schemes, the technique becomes an exceptionally valuable tool for mixture analysis, the separation of which is based on the molecular size. Extremely fine differentiation may be possible in the diffusion dimension but only with high-quality data. For fully resolved resonances, components with diffusion coefficients that differ by less than 2% may be distinguished in mixtures. For highly overlapped resonances, the resolved spectra of pure components with diffusion coefficients that differ by less than 30% may be obtained. In order to achieve the best possible data quality one must be aware of the primary sources of artifacts and incorporate the necessary means to alleviate them. The origin of these artifacts are described, along with the methods necessary to observe them. Practical solutions are presented. Examples are shown that demonstrate the effects of the artifacts on the acquired data set. Many mixture analysis problems may be addressed with conventional high resolution pulsed field gradient probe technology delivering less than 0.5 T m,1 (50 G cm,1). © 2002 Wiley Periodicals, Inc. Concepts Magn Reson 14: 225,258, 2002. [source] Detecting Adverse Events in Dermatologic SurgeryDERMATOLOGIC SURGERY, Issue 1 2010DANIEL PINNEY BS BACKGROUND Despite increasing awareness of and public attention to patient safety, little is documented about how adverse events (AEs) can or should be monitored in dermatologic surgery. Data to address this shortcoming are needed, although well-defined methodologies have yet to be implemented. OBJECTIVE To summarize current strategies in detecting adverse outcomes of dermatologic surgical procedures. MATERIALS AND METHODS A Medline literature search was conducted using the terms "adverse event,""detection,""reporting,""monitoring," and "surgery." Articles selected addressed the efficacy of one or more AE reporting techniques in surgical patients. RESULTS Prospective and retrospective reporting methods were identified, with morbidity and mortality conference being the most commonly used method of AE reporting. Retrospective medical record review, the retrospective trigger tool approach, and an anonymous electronic reporting system were more sensitive approaches. The Surgical Quality Improvement Program, a program that has successfully translated AE data into lower postoperative morbidity and mortality, was analyzed. CONCLUSIONS Although generally considered safe, dermatologic surgery has no current standard for AE reporting. Standard definitions and high-quality data regarding AEs" currently limit this analysis. Pilot studies are needed to develop feasible measures, with the goal of increasing the sensitivity of AE detection and ultimately improving patient outcomes. The Center for Dermatology Research is supported by an unrestricted educational grant from Galderma Laboratories. [source] A model computation of the temporal changes of surface gravity and geoidal signal induced by the evolving Greenland ice sheetGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2001Emmanuel Le Meur Summary This paper deals with present-day gravity changes in response to the evolving Greenland ice sheet. We present a detailed computation from a 3-D thermomechanical ice sheet model that is interactively coupled with a self-gravitating spherical viscoelastic bedrock model. The coupled model is run over the last two glacial cycles to yield the loading evolution over time. Based on both the ice sheet's long-term history and its modern evolution averaged over the last 200 years, results are presented of the absolute gravity trend that would arise from a ground survey and of the corresponding geoid rate of change a satellite would see from space. The main results yield ground absolute gravity trends of the order of ±1 µgal yr,1 over the ice-free areas and total geoid changes in the range between ,0.1 and +0.3 mm yr,1. These estimates could help to design future measurement campaigns by revealing areas of strong signal and/or specific patterns, although there are uncertainties associated with the parameters adopted for the Earth's rheology and aspects of the ice sheet model. Given the instrumental accuracy of a particular surveying method, these theoretical trends could also be useful to assess the required duration of a measurement campaign. According to our results, the present-day gravitational signal is dominated by the response to past loading changes rather than current mass changes of the Greenland ice sheet. We finally discuss the potential of inferring the present-day evolution of the Greenland ice sheet from the geoid rate of change measured by the future geodetic GRACE mission. We find that despite the anticipated high-quality data from satellites, such a method is compromised by the uncertainties in the earth model, the dominance of isostatic recovery on the current bedrock signal, and other inaccuracies inherent to the method itself. [source] Examining the total arrival distribution of migratory birdsGLOBAL CHANGE BIOLOGY, Issue 1 2005T. H. Sparks Abstract This paper reports on the total distribution of spring migration timing of willow warbler, chiffchaff and pied flycatcher at locations in the UK, Germany, Russia and Finland. This is the first time that high-quality data based on known-effort monitoring has been examined on a continental scale. First arrival dates, commonly reported in the literature, were positively correlated with mean arrival dates although they would not make good predictors of the latter. At all locations, at least one aspect of the arrival distribution of each species had got significantly earlier in recent years. The trend towards earliness was associated with warmer local temperatures and more positive winter North Atlantic Oscillation index. In years that were early, the arrival distribution became more elongated and skewed. Researchers should now investigate the consequences of earlier arrival on current and future bird populations. [source] Trends in extreme daily rainfall and temperature in Southeast Asia and the South Pacific: 1961,1998INTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 3 2001M.J. Manton Abstract Trends in extreme daily temperature and rainfall have been analysed from 1961 to 1998 for Southeast Asia and the South Pacific. This 38-year period was chosen to optimize data availability across the region. Using high-quality data from 91 stations in 15 countries, significant increases were detected in the annual number of hot days and warm nights, with significant decreases in the annual number of cool days and cold nights. These trends in extreme temperatures showed considerable consistency across the region. Extreme rainfall trends were generally less spatially coherent than were those for extreme temperature. The number of rain days (with at least 2 mm of rain) has decreased significantly throughout Southeast Asia and the western and central South Pacific, but increased in the north of French Polynesia, in Fiji, and at some stations in Australia. The proportion of annual rainfall from extreme events has increased at a majority of stations. The frequency of extreme rainfall events has declined at most stations (but not significantly), although significant increases were detected in French Polynesia. Trends in the average intensity of the wettest rainfall events each year were generally weak and not significant. Copyright © 2001 Royal Meteorological Society [source] Performance of a new furnace for high-resolution synchrotron powder diffraction up to 1900,K: application to determine electron density distribution of the cubic CaTiO3 perovskite at 1674,KJOURNAL OF APPLIED CRYSTALLOGRAPHY, Issue 5 2004Masatomo Yashima Accurate crystal structure analysis at high temperatures is an important challenge in science and technology. A new electric furnace for the measurement of high-resolution (,d/d = 0.03%) synchrotron radiation powder diffraction profiles from materials at high temperatures (up to 1900,K in air) has been designed and fabricated. This furnace consists of a ceramic refractory with MoSi2 heaters, an aluminium body cooled by flowing water, and a sample stage with a spinner and a controller for sample-height adjustment. In situ synchrotron powder diffraction measurement for a calcium titanate perovskite specimen at 1674,K has been performed using the furnace at beamline 3A of the Photon Factory. The electron density distribution of the cubic perovskite at 1674,K was successfully obtained using a combination of Rietveld refinement, the maximum-entropy method (MEM) and MEM-based pattern-fitting techniques. The Ti atoms exhibit covalent bonding with the O atoms in the cubic CaTiO3 perovskite at this temperature, while the Ca atoms are ionic. These results indicate that the new furnace yields high-quality data for accurate crystal structure analysis. [source] The Structure of Yttrialite and Its Identification Using Laboratory and Synchrotron-Based Powder X-Ray DiffractionJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 2 2009William J. Heward A highly crystalline sample of the impurity stabilized phase y -Y2Si2O7, generally known as yttrialite, has been formed from the melt of a glass with a nominal composition of 62(SiO2),10(Al2O3),28(Y2O3) mol%. Powder X-ray diffraction patterns were collected using in-house instrumentation and the 11-BM diffractometer at the Advanced Photon Source, Argonne National Laboratory, Argonne, IL. Rietveld refinements were carried out on the patterns using two structural models. On patterns collected using in-house instrumentation the correct structure assignment was difficult to determine; however, the extremely high-quality data afforded by the 11-BM instrument showed conclusively that the sample was found to crystallize in the monoclinic system (SG=P21/m) with lattice parameters a=5.03032(6), b=8.06892(6), c=7.33620(6) Å, and ,=108.673(1). Furthermore, simulations have shown that it is likely that this structure model can be used to describe natural yttrialite or yttrialite that is formed at low temperatures, though the possibility that such materials are paracrystalline is also discussed. [source] What can we learn on the thermal history of the Universe from future cosmic microwave background spectrum measurements at long wavelengths?MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2003C. Burigana ABSTRACT We analyse the implications of future observations of the cosmic microwave background (CMB) absolute temperature at centimetre and decimetre wavelengths, where both ground, balloon and space experiments are currently under way to complement the accurate COBE/FIRAS data available at ,, 1 cm. Our analysis shows that forthcoming ground and balloon measurements will allow a better understanding of free,free distortions but will not be able to significantly improve the constraints already provided by the FIRAS data on the possible energy exchanges in the primeval plasma. The same holds even for observations with sensitivities up to ,10 times better than those of forthcoming experiments. Thus, we have studied the impact of very high-quality data, such as those, in principle, achievable with a space experiment such as the Diffuse Microwave Emission Survey (DIMES) planned to measure the CMB absolute temperature at 0.5 ,,, 15 cm with a sensitivity of ,0.1 mK, close to that of FIRAS. We have demonstrated that such high-quality data would improve by a factor of ,50 the FIRAS results on the fractional energy exchanges, ,,/,i, associated with dissipation processes possibly occurred in a wide range of cosmic epochs, at intermediate and high redshifts (yh, 1), and that the energy dissipation epoch could also be significantly constrained. By jointly considering two dissipation processes occurring at different epochs, we demonstrated that the sensitivity and frequency coverage of a DIMES -like experiment would allow one to accurately recover the epoch and the amount of energy possibly injected into the radiation field at early and intermediate epochs even in the presence of a possible late distortion, while the constraints on the energy possibly dissipated at late epochs can be improved by a factor of ,2. In addition, such measurements can provide an independent and very accurate cross-check of FIRAS calibration. Finally, a DIMES -like experiment will be able to provide indicative independent estimates of the baryon density: the product ,bH20 can be recovered within a factor of ,2,5 even in the case of (very small) early distortions with ,,/,i, (5,2) × 10,6. On the other hand, for ,b (H0/50)2, 0.2, an independent baryon density determination with an accuracy at , per cent level, comparable to that achievable with CMB anisotropy experiments, would require an accuracy of ,1 mK or better in the measurement of possible early distortions but up to a wavelength from , few × dm to ,7 dm, according to the baryon density value. [source] A public health collaboration for the surveillance of autism spectrum disordersPAEDIATRIC & PERINATAL EPIDEMIOLOGY, Issue 2 2007Catherine E. Rice Summary Autism spectrum disorders (ASDs) represent a range of behavioural phenotypes defined by impaired development in social interaction, communication, imagination, and range of interests or behaviours. The aetiology and epidemiology of these serious developmental disabilities (DDs) are poorly understood. Estimates of the population prevalence of ASDs have varied widely within the US and abroad, with increasing estimates in most of the recent studies. In an effort to improve our understanding of the prevalence, population characteristics and public health impact of these conditions, the Centers for Disease Control and Prevention has funded a multi-site surveillance network for ASDs and other DDs that consists of programmes known as the Autism and Developmental Disabilities Monitoring (ADDM) network which conducts surveillance activities and the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) which also conducts surveillance in addition to special research studies related to the ASDs. This collaboration will be referred to hereafter as the ADDM Network. The ADDM Network is implementing a multiple-source surveillance programme to determine population prevalence and characteristics of ASDs and other DDs. This paper describes the collaborative efforts and explains the methods in developing this coordinated public health surveillance network to provide an ongoing source of high-quality data on ASDs. [source] On a fast calculation of structure factors at a subatomic resolutionACTA CRYSTALLOGRAPHICA SECTION A, Issue 1 2004P. V. Afonine In the last decade, the progress of protein crystallography allowed several protein structures to be solved at a resolution higher than 0.9,Å. Such studies provide researchers with important new information reflecting very fine structural details. The signal from these details is very weak with respect to that corresponding to the whole structure. Its analysis requires high-quality data, which previously were available only for crystals of small molecules, and a high accuracy of calculations. The calculation of structure factors using direct formulae, traditional for `small-molecule' crystallography, allows a relatively simple accuracy control. For macromolecular crystals, diffraction data sets at a subatomic resolution contain hundreds of thousands of reflections, and the number of parameters used to describe the corresponding models may reach the same order. Therefore, the direct way of calculating structure factors becomes very time expensive when applied to large molecules. These problems of high accuracy and computational efficiency require a re-examination of computer tools and algorithms. The calculation of model structure factors through an intermediate generation of an electron density [Sayre (1951). Acta Cryst.4, 362,367; Ten Eyck (1977). Acta Cryst. A33, 486,492] may be much more computationally efficient, but contains some parameters (grid step, `effective' atom radii etc.) whose influence on the accuracy of the calculation is not straightforward. At the same time, the choice of parameters within safety margins that largely ensure a sufficient accuracy may result in a significant loss of the CPU time, making it close to the time for the direct-formulae calculations. The impact of the different parameters on the computer efficiency of structure-factor calculation is studied. It is shown that an appropriate choice of these parameters allows the structure factors to be obtained with a high accuracy and in a significantly shorter time than that required when using the direct formulae. Practical algorithms for the optimal choice of the parameters are suggested. [source] ARCHAEOMAGNETIC FIELD INTENSITY DURING THE ROMAN PERIOD AT SIWA AND BAHRYN OASIS, EGYPT: IMPLICATIONS FOR THE FIDELITY OF EGYPTIAN ARCHAEOMAGNETIC DATAARCHAEOMETRY, Issue 3 2010R. LEONHARDT A preliminary survey was conducted in Siwa and Bahryn Oasis to test the possible influence of various rock magnetic and experimental constraints on the fidelity of the Egyptian archaeomagnetic field record. Five potsherds from the Roman era, which lasted from 1981 bp to 1555 bp, have been investigated. Archaeologists dated the localities to ,1620 bp. Ten ceramic specimens, two of each potsherd, were subjected to archaeointensity determination, including tests for domain state effects, magnetic anisotropy and magnetic cooling rate dependency. Six successful archaeointensity determinations are obtained from three individual cooling units, revealing an average field value of 37.7 ,T for the late Roman period in Siwa and Bahryn oasis, which is comparable to the present-day field strength. The error propagation of the individual uncertainties related to all applied experimental techniques results in a maximum uncertainty estimate of 4.4 ,T. The obtained field value is significantly smaller than early results and slightly smaller than some more recent determinations of the field intensity in Egypt. The difference is attributed to a combined effect of alteration, magnetic anisotropy and magnetic cooling rate dependencies. Along with other high-quality data from the south-east Mediterranean, our data suggest a field intensity minimum during the Egyptian Roman era. [source] Modelling life history strategies with capture,recapture data: Evolutionary demography of the water skink Eulamprus tympanumAUSTRAL ECOLOGY, Issue 4 2001Simon P. Blomberg Abstract Matrix population models, elasticity analysis and loop analysis can potentially provide powerful techniques for the analysis of life histories. Data from a capture,recapture study on a population of southern highland water skinks (Eulamprus tympanum) were used to construct a matrix population model. Errors in elasticities were calculated by using the parametric bootstrap technique. Elasticity and loop analyses were then conducted to identify the life history stages most important to fitness. The same techniques were used to investigate the relative importance of fast versus slow growth, and rapid versus delayed reproduction. Mature water skinks were long-lived, but there was high immature mortality. The most sensitive life history stage was the subadult stage. It is suggested that life history evolution in E. tympanum may be strongly affected by predation, particularly by birds. Because our population declined over the study, slow growth and delayed reproduction were the optimal life history strategies over this period. Although the techniques of evolutionary demography provide a powerful approach for the analysis of life histories, there are formidable logistical obstacles in gathering enough high-quality data for robust estimates of the critical parameters. 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