High Demand (high + demand)

Distribution by Scientific Domains


Selected Abstracts


Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors

JOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 3 2009
Philip W Miller
Abstract This mini-review covers the issues concerning the application of microfluidics towards radiolabelling with short-lived isotopes used for PET (positron emission tomography), and surveys the literature in this area. The application of microfluidic reactors to radiolabelling reactions is currently receiving a great deal of interest because of the potential advantages they have over conventional labelling systems. The volume and variety of radiolabelling reactions for PET is expected to grow markedly over the coming years due to increased demands for PET scanning. High demands and expectations for radiolabelled compounds will have to be met by exploiting new types of chemistry and technologies, such as microfluidics, to improve the production and development of PET tracers. Copyright © 2008 Society of Chemical Industry [source]


Decision Making in a Standby Service System,

DECISION SCIENCES, Issue 3 2000
H. V. Ravinder
A standby service option allows a firm to lower its risk of not having sufficient capacity to satisfy demand without investing in additional capacity. Standby service options currently exist in the natural gas, electric, and water utility industries. Firms seeking standby service are typically large industrial or institutional organizations that, due to unexpectedly high demand or interruptions in their own supply system, look to a public utility to supplement their requirements. Typically, the firm pays the utility a reservation fee based on a nominated volume and a consumption charge based on the volume actually taken. In this paper, a single-period model is developed and optimized with respect to the amount of standby capacity a firm should reserve. Expressions for the mean and variance of the supplier's aggregate standby demand distribution are developed. A procedure for computing the level of capacity needed to safely meet its standby obligations is presented. Numerical results suggest that the standby supplier can safely meet its standby demand with a capacity that is generally between 20 to 50% of the aggregate nominated volume. [source]


Why are alcohol-related emergency department presentations under-detected?

DRUG AND ALCOHOL REVIEW, Issue 6 2008
An exploratory study using nursing triage text
Abstract Introduction and Aims. This study examined two methods of detecting alcohol-related emergency department (ED) presentations, provisional medical diagnosis and nursing triage text, and compared patient and service delivery characteristics to determine which patients are being missed from formal diagnosis in order to explore why alcohol-related ED presentations are under-detected. Design and Methods. Data were reviewed for all ED presentations from 2004 to 2006 (n = 118 881) for a major teaching hospital in Sydney, Australia. Each record included two nursing triage free-text fields, which were searched for over 60 alcohol-related terms and coded for a range of issues. Adjusted odds ratios were used to compare diagnostically coded alcohol-related presentations to those detected using triage text. Results. Approximately 4.5% of ED presentations were identified as alcohol-related, with 24% of these identified through diagnostic codes and the remainder identified by triage text. Diagnostic coding was more likely if the patient arrived by ambulance [odds ratio (OR) = 2.35] or showed signs of aggression (OR = 1.86). Failure to code alcohol-related issues was more than three times (OR = 3.23) more likely for patients with injuries. Discussion and Conclusions. Alcohol-related presentations place a high demand on ED staff and less than one-quarter have an alcohol-related diagnosis recorded by their treating doctor. In order for routine ED data to be more effective for detecting alcohol-related ED presentations, it is recommended that additional resources such as an alcohol health worker be employed in Australian hospitals. These workers can educate and support ED staff to identify more clearly and record the clinical signs of alcohol and directly provide brief interventions. [source]


A study on video performance of multipoint-to-point video streaming with multiple description coding over ad hoc networks

ELECTRICAL ENGINEERING IN JAPAN, Issue 4 2010
Keisuke Utsu
Abstract Supporting multimedia applications over wireless networks has become a very active research topic recently because video applications are forecast to receive high demand in future wireless networks, such as ad hoc networks. However, enabling video transmission over wireless ad hoc networks is more challenging than over other wireless networks due to node mobility, interference, and the absence of a supporting infrastructure. This paper addresses the problem of video transmission over ad hoc networks. We propose to combine Multiple Description Coding (MDC) with multiple source transport (Multipoint-to-Point transfer: MP2P) in order to maintain smooth video streaming over wireless ad hoc networks. In this paper, we describe a comprehensive simulation and test bed experiment designed to show the effect of the proposed MP2P video transfer with MDC for two description cases of video streaming over wireless ad hoc networks. The results show that the proposed mechanism successfully improves video transfer performance in terms of video packet reachability and throughput. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 170(4): 43,50, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20999 [source]


Impact of Redhat IPv6 router on heterogeneous host connections

INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 4 2007
Sulaiman Syed Mohamed
Abstract Internet's popularity has been expanding on dramatic pace and the number of people getting connected to it multiplies regularly. With this high demand, the current Internet Protocol (IPv4) has reached its limits. The next generation Internet Protocol version6 (IPv6) has been incorporated into various operating systems. The motivation behind this work is how well IPv6 co-operates with various operating systems. The performance of the IP stack, together with the behaviour of the OS greatly affects the efficiency of network applications built on top of it. The acceptance of IPv6 implementations on various operating systems heavily relies on the end-user performance. In this paper, we propose to analyse these various IPv6 implementations for its host and router-level supports. In this paper, we investigate the impact of Redhat-based IPv6 router on IPv6 stacks of three different operating systems namely, Windows2003, Redhat Linux 9.0 (Redhat9.0) and FreeBSD4.9. Copyright © 2006 John Wiley & Sons, Ltd. [source]


International Migration Policies: 1950-2000

INTERNATIONAL MIGRATION, Issue 6 2001
Reginald Appleyard
Policies on international migration since the Second World War reflect the enormous changes in economic, social and political situations around the world. The implications of changes in the volume and composition of international migration have increasingly become an issue of major concern to governments in all countries. Following emigration from Europe to countries of the New World as a result of war-damaged economies, reconstruction witnessed high demand for migrant labour, mainly from parts of southern Europe. But by the early 1970s, decline in economic growth, unexpected impacts of the guest-worker scheme, and an increase in refugees from Third World countries led, in due course, to an era of restriction on entry of asylum-seekers and tighter controls over undocumented migration to developed countries. A "new era" evolved during the 1990s, characterized by growing interdependence of major economic powers. Globalization led not only to a significant demand for highly-skilled and professional workers, but also to decision-making on some aspects of the migration process being transferred from the national to the regional level, and an increase in the influence of multinational corporations. The globalization process, and the growing influence of international trade regimes, may well represent the first steps towards a new "international migration regime" that incorporates all types of migration. [source]


Staff who Work with People who have Intellectual Disabilities: The Importance of Personality

JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES, Issue 4 2003
John Rose
Background, Previous research into stress in staff who work with people with intellectual disabilities has concentrated on the organizational determinants of stress and has tended to overlook the relative contribution of individual differences. A model was proposed to describe possible relationships between work-based stressors, staff support, personality, coping strategy and psychological outcome. Methods, A survey methodology was used with care staff in community-based homes for people with intellectual disability. Results, Analysis of the model explored how these variables might affect one another in their relationship to psychological outcomes. The most significant findings of this research was the direct effects found between personality (neuroticism), coping style (wishful thinking) and stress. A significant interaction was also observed between job demands and neuroticism. Conclusions, These research findings highlight the importance of personality factors in determining stress levels in staff and suggest several possible intervention strategies. One intervention point may be to teach self-management techniques to help some staff cope with periods of high demand, particularly those reporting high levels of neuroticism. [source]


Knowledge Spillovers and Growth in the Disagglomeration of the Us Advertising-Agency Industry

JOURNAL OF ECONOMICS & MANAGEMENT STRATEGY, Issue 3 2003
Charles King III
We investigate knowledge spillovers and externalities in the disagglomeration and growth of the advertising-agency industry. A simple model of high demand, low wages, and externalities associated with clusters of related industries can explain the dispersion of advertising agency employment across states. Other factors affected the industry growth rate within states. Consistent with Jacobs and Porter but contrary to Marshall, Arrow, and Romer, competition, but not specialization, enhanced growth. In accord with Porter (1990), growth increased with buyer cluster size. Diversity had no effect on growth. Despite improvements in telecommunications and transportation reducing effective distances, location still matters. [source]


Self-help CBT for depression: opportunities for primary care mental health nurses?

JOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 9 2009
A. E. WARRILOW rn(mental health) bn(hons)
Accessible summary ,,There is currently a big demand for effective and accessible treatments for common mental health problems, but waiting lists are often long. ,,The aim of this review is to discover whether self-help cognitive behavioural therapy materials are effective in the treatment of depression. ,,It explores a possible role for mental health nurses within primary care to provide access to and low-level support with, these materials. ,,A possible model for organizing such a service is suggested. Abstract Mental health treatments that are effective and accessible to the general population are in high demand. Cognitive behavioural therapy (CBT) has been shown to be effective and is popular but such treatments are difficult to access especially within primary care, causing delay, frustration and suffering. One approach to meeting demand would be through the use of self-help CBT materials that aim to address common mental health problems such as depression. The aim of this review is to discover whether self-help CBT materials are effective in the treatment of depression and how mental health nurses within primary care can use their skills to provide access and low-level support. Studies critiqued within this literature review indicate that self-help CBT is effective for the treatment of depression. However, there is a lack of evidence that specifically considers self-help CBT for the treatment of depression in primary care. This review addresses the question of how much nurse client contact is needed to provide adequate support for the facilitation of self-help CBT in depression with primary care patients and recommends the use of a service delivery model. However, more research needs to be carried out on the application of self-help CBT for depression in primary care. [source]


A short-cut DNA extraction from cod caviar

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 3 2006
Futoshi Aranishi
Abstract Caviars represent the most consumed form of fish roe products. Due to high demand, ingredient roes of fish are often susceptible to illegal substitution with those of related fish. This study developed a simple and inexpensive protocol enabling the rapid extraction of DNA of acceptable quality and amount to PCR amplification from both cod caviars and their ingredient pollack roes. The protocol was based on extracting total genomic DNA from eggs using urea and a Chelex 100 chelating resin, and could be completed in less than 15 min. Approximately 8 µg of DNA were reproducibly obtained from single eggs of cod caviars and pollack roes in eight individual experiments, and the quality and amount of DNA were sufficient to serve as template for hundreds of PCR reactions of polymorphic DNA markers for phylogenetic analysis. Being applicable to various caviars, this protocol can be useful to detect illegal substitution among ingredient roes of related fishes in PCR-based food inspection. Copyright © 2005 Society of Chemical Industry [source]


The Effects of Temperature and Salinity on Early Life Stages of Black Sea Bass Centropristis striata

JOURNAL OF THE WORLD AQUACULTURE SOCIETY, Issue 3 2004
David L. Berlinsky
Along the Atlantic coast black sea bass occur from the Gulf of Maine to Florida and support important commercial and recreational fisheries. Interest in commercial production of black sea bass has increased in recent years due to high demand and limited seasonable availability. Efforts towards large-scale production have been hampered by a high incidence of early larval mortality. Two of the most important environmental variables affecting hatchery production of marine finfish larvae are temperature and salinity. In the wild, larval black sea bass are found in waters with temperatures of 12,24 C and salinity levels of 30,35 ppt. Studies were conducted to define the temperature and salinity ranges that support growth and development of black sea bass during early life stages. Three developmental phases were investigated: 1) fertilization to hatch: 2) hatch through yolk sac absorption: and 3) during the initial exogenous feeding stage (5,14 days post hatch: DPH). Fertilized eggs were obtained by manual spawning of fish following administration of LHRHa. Fertilized eggs were transferred to 300-mL glass Petri dishes or 500-mL beakers to assess the effects of salinity and temperature through hatch and yolk sac absorption, respectively. To determine environmental effects on growth and survival during initial exogenous feeding 400 actively feeding larvae were cultured in green water and fed enriched rotifers for a 9-d period. For investigation of the effect of salinity, sea water (35 ppt) was diluted gradually to 15, 20, 25, and 30 ppt and maintained at 21 C. For examination of the effect of temperature, seawater was adjusted from 21 C to 12, 15, 21, 27, or 30 C at a rate of 3 C/h. No eggs hatched at 12 C or when salinity was maintained at 0 or 5 ppt. Hatching was uniformly high (, 85%) at temperatures between 15 and 27 C and at salinities , 15 ppt. Survival through yolk sac absorption was greatest at temperatures between 18 and 27 C and at salinities , 20 ppt. Survival through first feeding stage was highest at temperatures , 18 C and 30 ppt salinity. Larval growth through first feeding was not significantly affected by salinity level but did increase with rearing temperature. The results indicate that survival and development of black sea bass during early life stages are most favorable at temperatures >18 C with salinity levels approaching full strength seawater. [source]


Energy security rises to top of agenda in 2006

OIL AND ENERGY TRENDS, Issue 1 2006
Article first published online: 17 JAN 200
A dispute over gas prices between two former Soviet republics has spread alarm across Europe and caused the EU to reassess its energy security. Natural gas supplies are a long term concern for many European countries, but of much more immediate concern is the supply of crude oil and refined products. Last year saw record prices for both (see 'Oil Price Review', October 2005), caused by a combination of high demand in the US and Asia, a shortage of light, sweet crudes worldwide and damage by hurricanes to a large number of refineries along the US Gulf. [source]


Environmental fate of metalaxyl and chlorothalonil applied to a bentgrass putting green under southern California climatic conditions

PEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 4 2002
L Wu
Abstract Putting greens usually receive high inputs of fertilizers and pesticides to meet the high demand for visual quality and to overcome the stress from close mowing and traffic. In this study, two commonly used fungicides, metalaxyl (methyl N -(methoxyacetyl)- N -(2,6-xylyl)- DL -alaninate) and chlorothalonil (2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile), were evaluated for their partitioning and persistence in a bentgrass (Agrostis palustris Huds) putting green under southern California climatic conditions. The putting green site was constructed according to the US Golf Association (USGA) specifications. Lysimeter assemblies installed at the center of each plot were used to monitor the leachate, flux chambers were used to measure volatilization, clippings were collected to determine the residues on grass, and soil cores were sampled to determine residues in the soil profile. Results showed that cumulative volatilization loss accounted for 0.10 and 0.02%, clipping removal 0.11 and 0.13%, and cumulative leaching 0.71 and 0.002% of the applied metalaxyl and chlorothalonil, respectively. The two fungicides were mainly found in the top 10,cm of the soil profile due to the high organic carbon content in the thatch and mat layers. The dissipation half-life was 1.4 days for metalaxyl and 4.9 days for chlorothalonil on grass, shorter than those found in agricultural fields. This study showed that, under normal turf management practices, the offsite transport of the parent fungicides was minimal. Future research should focus on investigating the fate and mobility of the metabolites of the fungicides. © 2002 Society of Chemical Industry [source]


Fighting fiscal corruption: lessons from the Tanzania Revenue Authority

PUBLIC ADMINISTRATION & DEVELOPMENT, Issue 2 2003
Odd-Helge Fjeldstad
Over the last decade, several African countries have undertaken comprehensive reforms of their tax administrations to increase revenue and curb corruption. This article examines recent experiences in the fight against corruption in the Tanzania Revenue Authority (TRA). Two lessons of broader relevance are highlighted. Firstly, even with relatively high wages and good working conditions, corruption may continue to thrive. In a situation where there is high demand for corrupt services, it is unrealistic to provide tax officers with pay rates that can compensate for the amount gained through bribery. Without extensive and effective monitoring, wage increases may produce not only a highly paid, but also a highly corrupt tax administration. Secondly, hiring and firing procedures may lead to more corruption. Corrupt tax officers often operate in networks, which also include external actors. These corruption networks seem to have been strengthened because many of those fired were recruited to the private sector as ,tax experts'. This partly explains why the positive process experienced in the initial phase of the new revenue authority was later reversed. Copyright © 2003 John Wiley & Sons, Ltd. [source]


Learning from leading-edge customers at The Sims: opening up the innovation process using toolkits

R & D MANAGEMENT, Issue 3 2006
Reinhard Prügl
Recently, toolkits for user innovation and design have been proposed as a promising means of opening up the innovation process to customers. Using these tools, customers can take on problem-solving tasks and design products to fit their individual needs. To date, arguments in favor of this new concept have been limited to the idea of satisfying each user's needs in a highly efficient and valuable way. The aim of this empirical study is to extend our knowledge of how users deal with ,the invitation to innovate' and how attractive individual user designs might be to other users. In studying the users of toolkits for the immensely popular computer game The Sims, we found that (1) users are not ,one-time shoppers', in fact, their innovative engagement is rather long-lasting, continuous, evolving, and intense. We also found that (2) leading-edge users do not merely content themselves with the official toolkits provided by the manufacturer. They employ user-created tools to push design possibilities even further. (3) Moreover, individual user designs are not only attractive to the creators themselves; instead, certain innovative solutions are in high demand among other users. Based on our findings, we discuss how toolkits and their users might add to the process of innovation in general. We argue that toolkits could serve as a promising market research tool for guiding a firm's new product development efforts. Furthermore, toolkits may serve as a crèche for interested but inexperienced users who could evolve into leading-edge users over time. These innovative users might then be integrated into more radical product development efforts. [source]


THE INFLUENCE OF EXPERT REVIEWS ON CONSUMER DEMAND FOR EXPERIENCE GOODS: A CASE STUDY OF MOVIE CRITICS*

THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 1 2005
David A. Reinstein
An inherent problem in measuring the influence of expert reviews on the demand for experience goods is that a correlation between good reviews and high demand may be spurious, induced by an underlying correlation with unobservable quality signals. Using the timing of the reviews by two popular movie critics, Siskel and Ebert, relative to opening weekend box office revenue, we apply a difference-in-differences approach to circumvent the problem of spurious correlation. After purging the spurious correlation, the measured influence effect is smaller though still detectable. Positive reviews have a particularly large influence on the demand for dramas and narrowly-released movies. [source]


Does land-use change affect biodiversity dynamics at a macroecological scale?

ANIMAL CONSERVATION, Issue 2 2009
A case study of birds over the past 20 years in Japan
Abstract Because the effects of land-use change on biodiversity have primarily been examined at or below the regional scale, it remains unclear whether such effects scale up to the macroecological scale (i.e. nationwide or continental scale). In Japan, forests have become more mature since the cessation of most forestry efforts in the 1970s. At a nationwide scale, this forest maturation may lead to reductions in the abundance of species that depend on early successional forests (early successional species) and increases in the abundance of species that depend on mature forests (mature forest species). Japan has met its high demand for wood through imports from South-east Asia, resulting in deforestation there. Therefore, the abundance of mature forest species that migrate long distances to overwinter in South-east Asia may decrease. We examined changes in the range sizes of birds in Japan over the past 20 years using the living planet index (LPI). The LPI indicated that the range sizes of early successional species decreased. For mature forest species, the range sizes of long-distance migrants decreased, whereas those of short-distance migrants and residents increased. Our predictions were generally supported. Our results indicate that the effects of land-use change extend to the macroecological scale and that such changes in one country can affect the biodiversity dynamics in other countries. Forest maturation in Japan and concomitant deforestation in South-east Asia have been caused by internationally coupled socioeconomic processes. Therefore, biodiversity conservation at the macroecological scale must consider the role of land use, and such efforts will require both international and socioeconomic perspectives. [source]


INVENTORIES AND FIXED INVESTMENT

AUSTRALIAN ECONOMIC PAPERS, Issue 4 2004
HONG BO
We model fixed investment incorporating the inventory decision of the firm. Using Dutch listed nonfinancial firms during 1985,2000, we find that the inventory stock is negatively associated with fixed investment. The results suggest that the inventory stock may be used by the firm as a buffer in response to unexpectedly high demand. In addition, the firm may hold the inventory stock as a contingency substitute for the financial source of fixed investment. [source]


Scope of practice of occupational therapists working in Victorian community health settings

AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL, Issue 2 2010
Lynne Quick
Background/aim:,Current health policy places emphasis on community-based health care and it is expected that there will be an increase in the number of people receiving care in community settings. This study aimed to examine the profile and scope of practice of occupational therapists working in Victorian community health settings and the amount and type of health promotion activity incorporated into their role. Method:,An anonymous postal questionnaire was sent to 205 community-based Victorian occupational therapists. One hundred and one (49.3% response rate) questionnaires were returned, with 72 respondents (35.1%) meeting study inclusion criteria. A descriptive research design was used to address study aims. Results:,Results indicate that the majority of community health occupational therapists are experienced practitioners, have a varied scope of practice and report a high level of job satisfaction. Compared with previous studies, there is an increase in new graduate occupational therapists starting their career in community health settings, a greater number of part-time workers and a diversification of clinical and non-clinical roles. Barriers to practice that exist include high demand for service, limited funding and time spent on administrative tasks. Although health promotion was regarded as an important role of community health workers, a large number of therapists were not involved in this activity because of limited knowledge and clinical work taking priority. Conclusion:,Study findings have implications for occupational therapy training, and there is a clear need for input at policy level to address the significant resource allocation issues raised. [source]


Nano-sized bacterial magnetic particles displaying pyruvate phosphate dikinase for pyrosequencing

BIOTECHNOLOGY & BIOENGINEERING, Issue 1 2009
Tomoko Yoshino
Abstract There is a high demand for inexpensive and high-throughput DNA sequencing technologies in molecular biology and applied biosciences. In this study, novel nano-sized magnetic particles displaying enzymes for pyrosequencing, a rather novel bioluminometric DNA sequencing method based on the sequencing-by-synthesis principle by employing a cascade of several enzymatic reactions, was developed. A highly thermostable enzyme, pyruvate phosphate dikinase (PPDK) which converts PPi to ATP was successfully expressed onto bacterial magnetic particles (BacMPs) using a novel protein display system of Magnetospirillum magneticum AMB-1. The enzymatic stability of BacMPs displaying PPDK (PPDK-BacMPs) to pH and temperature was evaluated and its broad range of properties was shown. Subsequently, PPDK-BacMPs were applied in pyrosequencing and a target oligonucleotide was successfully sequenced. The PPDK enzyme displayed on BacMPs was shown to be recyclable in each sequence reaction as they can be manipulated by magnetic force. It was concluded that nano-sized PPDK-BacMPs are useful for the scale down of pyrosequencing reaction volumes, thus, permitting high-throughput. The recycling of enzymes was also shown to be promising and applicable for the development of an inexpensive DNA sequencing at a low running cost. Biotechnol. Bioeng. 2009;103: 130,137. © 2008 Wiley Periodicals, Inc. [source]


NS0 cell damage by high gas velocity sparging in protein-free and cholesterol-free cultures

BIOTECHNOLOGY & BIOENGINEERING, Issue 4 2008
Ying Zhu
Abstract Recent developments in high cell density and high productivity fed-batch animal cell cultures have placed a high demand on oxygenation and carbon dioxide removal in bioreactors. The high oxygen demand is often met by increasing agitation and sparging rates of air/O2 in the bioreactors. However, as we demonstrate in this study, an increase of gas sparging can result in cell damage at the sparger site due to high gas entrance velocities. Previous studies have showed that gas bubble breakup at the culture surface was primarily responsible for cell damage in sparged bioreactors. Such cell damage can be reduced by use of surfactants such as Pluronic F-68 in the culture. In our results, where NS0 cells were grown in a protein-free and cholesterol-free medium containing 0.5 g/L Pluronic F-68, high gas entrance velocity at the sparger site was observed as the second mechanism for cell damage. Experiments were performed in scaled-down spinners to model the effect of hydrodynamic force resulting from high gas velocities on antibody-producing NS0 cells. Cell growth and cell death were described by first-order kinetics. Cell death rate constant increased significantly from 0.04 to 0.18 day,1 with increasing gas entrance velocity from 2.3 to 82.9 m/s at the sparger site. The critical gas entrance velocity for the NS0 cell line studied was found to be ,30 m/s; velocities greater than 30 m/s caused cell damage which resulted in reduced viability and consequently reduced antibody production. Observations from a second cholesterol-independent NS0 cell line confirmed the occurrence of cell damage due to high gas velocities. Increasing the concentration of Pluronic F-68 from 0.5 to 2 g/L had no additional protective effect on cell damage associated with high gas velocity at the sparger. The results of gas velocity analysis for cell damage have been applied in two case studies of large-scale antibody manufacturing. The first is a troubleshooting study for antibody production carried out in a 600 L bioreactor, and the second is the development of a gas sparger design for a large bioreactor scale (e.g., 10,000 L) for antibody manufacturing. Biotechnol. Bioeng. 2008;101: 751,760. © 2008 Wiley Periodicals, Inc. [source]


A model of knowledge activation and insight in problem solving

COMPLEXITY, Issue 5 2004
Matthew A. CroninArticle first published online: 1 JUL 200
Abstract This article presents a model of insight that offers predictions on how and when insights are likely to occur as an individual solves problems. This model is based on a fundamental trade-off between the conscious cognition that underlies how people decide among alternatives and the unconscious cognition that underlies insight. I argue that the attention controls how much thought (i.e., knowledge activation) goes to conscious cognition, and whatever activation is left over will go to finding an insight. I validate this model by replicating the common pattern of insight in problem solving (preparation,impasse,incubation,verification). The model implies that 1) one should be able to increase the frequency of insight by lessening the demand for conscious cognition, 2) impasse is not necessary for insight, and 3) incubation time increases if a person engages in any activity with a high demand on attention. Understanding how insight occurs during problem solving provides practical suggestions to make people and groups more creative and innovative; it also provides avenues for future research on the cognitive dynamics of insight. © 2004 Wiley Periodicals, Inc. Complexity 9: 17,24, 2004 [source]


What aspects of the job have most effect on nurses?

HUMAN RESOURCE MANAGEMENT JOURNAL, Issue 1 2003
Abraham Sagie
The study reported here compared the influences of psychological constructs (job demands and scheduling control) and objective work characteristics (shiftwork, night-work and hospital department type) on job satisfaction, organisational commitment, burnout and withdrawal intentions. Our hypothesis was that psychological constructs have a higher influence on work-related attitudes than objective characteristics of work schedules. In addition to the main effects, we proposed an interactive hypothesis: poor attitudes would result from high demands and low control rather than from other combinations of both psychological variables. Using a sample of 153 hospital nurses in Israel, the hypotheses were generally supported. As night-work, shiftwork and working in intensive care units are unavoidable characteristics of the modern medical environment, these findings are meaningful for improving the personal adjustment of hospital nurses. [source]


Demands of immigration among Chinese immigrant nurses

INTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 5 2010
Amy X Ma DNP APRN-BC FNP
Ma AX, Quinn Griffin MT, Capitulo KL, Fitzpatrick JJ. International Journal of Nursing Practice 2010; 16: 443,453 Demands of immigration among Chinese immigrant nurses The purpose of this study was to identify the demands of immigration among Chinese nurses that have immigrated to the USA. The relationship between the demands of immigration and length of stay in the USA was investigated also. A descriptive correlational study design was used. A convenience sample of 128 nurses was recruited. A self-administered survey was conducted using the demands of immigration scale developed by Aroian, along with a demographic questionnaire. The results showed Chinese immigrant nurses have high demands of immigration. There were significant negative relationships between the demands of immigration and length of stay in the USA. Immigration demands decreased as length of stay increased but remained high even for those who had been in the USA for > 5 years. This information is vital to health-care agencies designing and implementing adaptation programmes targeting these demands to facilitate Chinese nurses' adaptation process. [source]


Progress in the Development of a High Performance Airborne Digital Sensor

THE PHOTOGRAMMETRIC RECORD, Issue 96 2000
P. Fricker
Joint development work by LH Systems and Deutsches Zentrum für Luft- und Raumfahrt (German Aerospace Center) has produced encouraging results using forward, nadir and backward looking linear arrays on the focal plane to provide panchromatic imagery and geometric information, supplemented by further arrays to acquire multispectral imagery suitable for both high precision photogrammetric mapping and image processing for interpretative purposes. The geometric characteristics of line scanner imagery necessitate line-by-line rectification for aircraft tilts and shifts. Satisfactory execution of this process is enhanced by using supplementary data from high performance, on-board GPS and inertial measurement systems. Similarly, high demands are placed on other sub-systems, such as the camera mount, lens, electronics and storage technology. In addition to rectification for aircraft tilts and shifts, rectification for terrain characteristics is also required in order to generate colour and false colour composite images, since the various multispectral arrays are in different places on the focal plane. The special geometry affects triangulation. Thereafter, the imagery can be processed using existing software packages from both photogrammetry and remote sensing. The concept has been demonstrated in several successful test flights and the production model is scheduled for market introduction at the ISPRS Congress in July 2000. The imagery from the new sensor will fulfil many market requirements between the highest resolution film imagery (<0.1 m) and high resolution space imagery (1m to 10 m). The sensor's unique blend of multispectral information with high quality geometric information will give rise to numerous new applications. [source]


What stresses remote area nurses?

AUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 4 2009
Current knowledge, future action
Abstract Objective:,Review and synthesise the literature identifying the stresses experienced by remote area nurses (RANs). Identify interventions implemented to address identified stresses. Explore the use of the job demands,resources (JD-R) model. Methods:,A comprehensive literature review was conducted using the meta-databases Ovid and Informit. Setting:,Remote Australian primary health care centres. Results:,The reported demands experienced by RANs can be grouped into four themes: (i) the remote context; (ii) workload and extended scope of practice; (iii) poor management; and (iv) violence in the workplace and community. In this high-demand, low-resource context, the JD-R model of occupational stress is particularly pertinent to examining occupational stress among RANs. The demands on RANs, such as the isolated geographical context, are immutable. However, there are key areas where resources can be enhanced to better meet the high level of need. These are: (i) adequate and appropriate education, training and orientation; (ii) appropriate funding of remote health services; and (iii) improved management practices and systems. Conclusion:,There is a lack of empirical evidence relating to stresses experienced by RANs. The literature identifies some of the stresses experienced by RANs as unique to the remote context, while some are related to high demands coupled with a deficit of appropriate resources. Use of models, such as the JD-R model of occupational stress, might assist in identifying key areas where resources can be enhanced to better meet the high level of need and reduce RANs' levels of stress. [source]


Umfangreicher Validierungsdatensatz eines großen Verwaltungsgebäudes für Software zur DIN V 18599

BAUPHYSIK, Issue 2 2009
Kirsten Höttges Dipl.-Ing.
Energieeinsparung; Technische Regelwerke; Berechnungsverfahren Abstract Mit dem Berechnungsverfahren der DIN V 18599 liegt ein umfassendes Berechnungsmodell für die energetische Bewertung von Gebäuden vor. Der große Umfang der Verfahren stellt auch an die softwaretechnischen Umsetzungen für die Planungspraxis hohe Anforderungen. Das Fraunhofer-Institut für Bauphysik hat hierzu den Rechenkern ibp18599kernel entwickelt, der zwischenzeit-lich von zahlreichen Softwarehäusern für Endanwendungsprogramme zur energetischen Bewertung und Erstellung von Energieausweisen eingesetzt wird. Dieser "Rechenmotor" unterliegt einer steten Qualitätskontrolle zur Sicherstellung der Berechnungsgenauigkeit. Der vorliegende Aufsatz stellt den Prozess der Qualitätssicherung anhand eines neuen Validierungsbeispiels in Form eines komplexen Verwaltungsgebäudes vor. Die Fallstudie kann auch zur Validierung anderer Berechnungssysteme, die nicht auf dem Rechenkern basieren, genutzt werden. Detailed Data Set of a Large Administration Building as a Validation Model for DIN V18599-Software. The calculation method of DIN V 18599 represents a very complex model for the estimation of the energy efficiency of buildings. The method is used for certificates too, thus, the number of users is quite high. This fact and the complexity of the method causes high demands on the related software products. Most of the end user software tools work with the calculation engine ibp18599kernel developed by Fraunhofer-Institut for Building Physics. There is a continuous quality control for both, the kernel and the user interfaces, i.e. the end user software. This paper gives an overview of the process of quality control as well as a documentation of a validation model used within this process, i.e. a complex administration building as a sample. [source]


Q- und R-Matten aus Kunststoff für Bewehrungsaufgaben in der Geotechnik

BAUTECHNIK, Issue 9 2004
Georg Heerten Dr.-Ing.
Wachsende Güterströme und Warenverkehre im Zentrum eines wachsenden Europas und zunehmender Warenaustausch als Folge der Globalisierung der Weltwirtschaft stellen erhebliche Anforderungen an den Erhalt und Ausbau leistungsfähiger Infrastruktursysteme (Straße, Schiene, Wasserstraße). Nachhaltigkeitskonzepte bei der Bautätigkeit und Finanzierungsprobleme der öffentlichen Auftraggeber sind aktuelle Randbedingungen, denen mit Geokunststoff-Bauweisen optimal Rechnung getragen werden kann. Es können neben den technischen auch die ökonomischen und ökologischen Vorteile , Baukosten sparen, Baustoffressourcen schonen , parallel genutzt werden. Eine Stützwand als "Bewehrte-Erde-Konstruktion" kann ganz erheblich kostengünstiger als eine Stahlbeton-Stützmauer hergestellt werden. Die Ertüchtigung von wenig tragfähigen Böden mit flächig angeordneten Bewehrungslagen und/oder pfahlartigen geokunststoffummantelten Bodensäulen vermeidet umfangreichen Bodenaustausch, spart Kosten, verhindert umfangreichen Transport von Bodenmassen mit LKWs. Hierdurch werden knappe Baustoffressourcen wie Sand und Kies geschont sowie eine z. T. erhebliche Entlastung örtlicher Verkehrswege bewirkt. Q and R mats made of synthetics for reinforcement functions in the field of geotechnics. An increasing flow of goods in a growing central Europe, resulting from the globalisation of the world economy, makes high demands on the maintenance and development of an efficient infrastructure (road, railway, waterway). Sustainability concepts for the construction activities and funding problems of the contracting authorities are current boundary conditions which can be accommodated optimally with geosynthetic construction methods. At the same time, besides the technical advantages, the economical and ecological advantages can be used too , saving of construction costs and taking care of building materials resources. A retaining wall as "Reinforced-Earth-Structure" can be constructed at much lower cost than a retaining wall made of reinforced concrete. The improvement of subsoils with low bearing capacity, by using reinforcing layers in the area and/or soil columns similar to piles wrapped with geosynthetics, avoids a considerable exchange of soil, saves costs and avoids substantial soil transports by trucks. Thus, care is taken on rare building materials resources like sand and gravel and the traffic routes are partly released to a high extent. [source]